[Hub]/) : Traits : Hand grip strength (left) : ← →

chr3:52,047,421-53,860,103

Best TWAS P=6.08e-10 · Best GWAS P=1.55e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	GTEx	Heart Atrial Appendage	RFT1	0.14	0.12	enet	16	0.10	4.4e-05	5.8	6.2	6.1e-10	0.97	0.01	0.99	TRUE
34	GTEx	Uterus	RFT1	0.52	0.30	enet	21	0.34	9.0e-08	4.9	6.0	1.9e-09	0.85	0.04	0.93	FALSE
5	GTEx	Adrenal Gland	RFT1	0.15	0.02	enet	11	0.03	4.0e-02	5.6	6.0	2.3e-09	0.82	0.04	0.83	FALSE
30	GTEx	Small Intestine Terminal Ileum	RFT1	0.20	0.20	enet	19	0.11	2.2e-03	5.5	6.0	2.5e-09	0.84	0.04	0.85	FALSE
33	GTEx	Thyroid	RFT1	0.36	0.33	enet	17	0.35	2.4e-27	5.6	5.9	2.9e-09	0.87	0.04	0.96	FALSE
11	GTEx	Brain Cerebellum	RFT1	0.72	0.60	enet	20	0.64	2.3e-24	5.6	5.9	4.0e-09	0.92	0.03	0.97	FALSE
8	GTEx	Artery Tibial	RFT1	0.40	0.38	enet	22	0.40	8.2e-33	5.5	5.8	7.5e-09	0.86	0.04	0.96	FALSE
23	GTEx	Muscle Skeletal	NEK4	0.07	0.03	lasso	5	0.03	9.6e-04	5.6	5.8	7.5e-09	0.93	0.04	0.93	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	SERBP1P3	0.47	0.57	lasso	7	0.60	4.3e-98	5.5	-5.8	8.0e-09	-0.92	0.03	0.96	FALSE
9	GTEx	Brain Caudate basal ganglia	RFT1	0.30	0.23	enet	14	0.22	5.4e-07	5.6	5.7	9.4e-09	0.83	0.04	0.95	FALSE
13	GTEx	Brain Frontal Cortex BA9	RFT1	0.23	0.10	enet	17	0.10	1.4e-03	5.5	5.7	9.7e-09	0.87	0.04	0.87	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	RFT1	0.26	0.16	lasso	4	0.10	1.1e-03	5.6	5.7	1.0e-08	0.90	0.03	0.88	FALSE
10	GTEx	Brain Cerebellar Hemisphere	RFT1	0.36	0.34	enet	19	0.33	2.4e-09	5.5	5.7	1.1e-08	0.92	0.03	0.97	FALSE
27	GTEx	Ovary	SFMBT1	0.24	0.10	enet	12	0.15	2.0e-04	4.9	-5.7	1.1e-08	-0.94	0.03	0.88	FALSE
12	GTEx	Brain Cortex	RFT1	0.31	0.17	enet	14	0.30	5.9e-09	5.6	5.7	1.2e-08	0.80	0.04	0.95	FALSE
16	GTEx	Cells Transformed fibroblasts	RFT1	0.22	0.21	enet	16	0.22	2.8e-16	5.5	5.7	1.3e-08	0.81	0.04	0.96	FALSE
17	GTEx	Colon Sigmoid	RFT1	0.55	0.45	enet	15	0.43	1.0e-16	5.6	5.7	1.5e-08	0.86	0.03	0.97	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	RFT1	0.25	0.30	lasso	4	0.29	3.8e-28	5.5	5.6	1.6e-08	0.88	0.02	0.98	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	RFT1	0.33	0.29	enet	27	0.23	1.2e-12	5.6	5.6	2.0e-08	0.84	0.03	0.97	FALSE
15	GTEx	Breast Mammary Tissue (Male)	RFT1	0.23	0.12	enet	8	0.13	5.5e-04	5.6	5.6	2.2e-08	0.83	0.03	0.73	FALSE
36	METSIM	Adipose	SFMBT1	0.04	0.04	lasso	1	0.03	3.5e-05	5.6	-5.6	2.2e-08	-0.98	0.01	0.99	FALSE
26	GTEx	Nerve Tibial	SFMBT1	0.21	0.10	enet	11	0.07	1.4e-05	5.5	-5.6	2.3e-08	-0.86	0.03	0.96	FALSE
20	GTEx	Esophagus Muscularis	RFT1	0.46	0.45	enet	28	0.44	6.5e-29	5.5	5.6	2.7e-08	0.88	0.03	0.97	FALSE
29	GTEx	Skin Sun Exposed Lower leg	RFT1	0.18	0.16	enet	7	0.13	1.1e-10	5.6	5.6	2.8e-08	0.83	0.03	0.97	FALSE
31	GTEx	Spleen	RFT1	0.23	0.22	enet	7	0.13	3.6e-04	5.6	5.6	2.8e-08	0.83	0.03	0.88	FALSE
32	GTEx	Testis	RFT1	0.20	0.12	enet	8	0.10	2.9e-05	5.5	5.6	2.8e-08	0.82	0.04	0.96	FALSE
6	GTEx	Artery Aorta	RFT1	0.40	0.32	lasso	13	0.31	8.1e-18	5.5	-5.5	2.9e-08	-0.83	0.04	0.96	FALSE
35	METSIM	Adipose	RFT1	0.13	0.19	lasso	7	0.18	7.8e-27	5.5	5.5	3.8e-08	0.83	0.03	0.97	FALSE
7	GTEx	Artery Coronary	RFT1	0.38	0.33	lasso	5	0.34	2.6e-12	5.5	5.5	4.2e-08	0.83	0.04	0.96	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	RFT1	0.43	0.37	enet	18	0.34	7.0e-13	5.6	5.4	6.2e-08	0.88	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RFT1	0.21	0.22	lasso	3	0.22	5.7e-26	5.6	5.4	6.7e-08	0.79	0.03	0.97	FALSE
24	GTEx	Muscle Skeletal	RFT1	0.17	0.16	enet	17	0.15	3.0e-14	5.6	5.4	6.7e-08	0.78	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	RFT1	0.21	0.19	enet	24	0.17	3.7e-14	5.5	5.4	7.3e-08	0.83	0.04	0.96	FALSE
22	GTEx	Lung	RFT1	0.24	0.23	enet	12	0.23	2.7e-17	5.6	5.4	8.1e-08	0.81	0.03	0.97	FALSE
4	GTEx	Adipose Visceral Omentum	RFT1	0.16	0.15	enet	12	0.10	1.0e-05	5.6	5.3	9.4e-08	0.81	0.03	0.97	FALSE
25	GTEx	Nerve Tibial	RFT1	0.35	0.31	enet	17	0.27	1.9e-19	5.5	5.3	9.9e-08	0.78	0.03	0.96	FALSE
3	GTEx	Adipose Subcutaneous	SFMBT1	0.10	0.02	lasso	7	0.03	2.9e-03	5.5	-5.3	1.3e-07	-0.91	0.01	0.98	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RFT1	0.15	0.21	lasso	8	0.22	1.4e-24	5.6	5.3	1.4e-07	0.73	0.01	0.99	FALSE
18	GTEx	Colon Transverse	RFT1	0.30	0.27	enet	16	0.24	8.0e-12	5.5	5.2	1.6e-07	0.79	0.04	0.96	FALSE
39	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RFT1	0.23	0.09	blup	45	0.08	3.8e-04	5.2	5.2	2.0e-07	0.62	0.03	0.92	FALSE