Best TWAS P=1.43e-15 · Best GWAS P=8.77e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RAD9A | 0.43 | 0.22 | lasso | 6 | 0.23 | 7.1e-19 | -7.8 | -7.5 | 5.5e-14 | 0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Tibial | RAD9A | 0.39 | 0.26 | lasso | 2 | 0.24 | 3.5e-19 | -7.8 | -7.8 | 7.9e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | RAD9A | 0.24 | 0.16 | lasso | 3 | 0.16 | 3.6e-12 | -7.8 | -6.4 | 1.6e-10 | 0.92 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Colon Transverse | RAD9A | 0.40 | 0.16 | lasso | 8 | 0.16 | 7.2e-08 | -7.8 | -6.1 | 7.8e-10 | 0.88 | 0.00 | 1.00 | TRUE |
| 5 | GTEx | Esophagus Muscularis | RAD9A | 0.25 | 0.26 | lasso | 2 | 0.26 | 6.2e-16 | -7.8 | -8.0 | 1.4e-15 | 0.99 | 0.00 | 1.00 | TRUE |
| 6 | GTEx | Muscle Skeletal | RAD9A | 0.12 | 0.02 | lasso | 4 | 0.03 | 4.2e-04 | -7.8 | -5.7 | 9.6e-09 | 0.83 | 0.00 | 0.99 | FALSE |
| 7 | GTEx | Nerve Tibial | RAD9A | 0.53 | 0.24 | lasso | 10 | 0.23 | 5.6e-16 | -7.8 | -7.7 | 1.5e-14 | 0.99 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Testis | RAD9A | 0.72 | 0.50 | lasso | 4 | 0.49 | 1.1e-24 | -7.8 | -7.7 | 1.7e-14 | 1.00 | 0.00 | 1.00 | FALSE |
| 9 | NTR | Blood | CCS | 0.03 | 0.04 | lasso | 2 | 0.04 | 1.2e-11 | 5.0 | -5.2 | 1.9e-07 | 0.23 | 0.02 | 0.98 | TRUE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | RAD9A | 0.34 | 0.17 | enet | 21 | 0.20 | 1.1e-25 | -7.8 | -7.1 | 1.1e-12 | 0.89 | 0.00 | 1.00 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | CCS | 0.08 | 0.04 | lasso | 9 | 0.06 | 8.9e-08 | 5.1 | -5.1 | 3.1e-07 | 0.20 | 0.03 | 0.97 | TRUE |