TWAS
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Models
Genes
Traits
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Traits
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Hand grip strength (left)
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chr16:3,969,463-5,510,848
Best TWAS P=1.14e-07 · Best GWAS P=2.85e-07 conditioned to 0.385
4M
4.2M
4.4M
4.6M
4.8M
5M
5.2M
5.4M
5.6M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
C16orf71
0.01
0.01
blup
52
0.01
3.1e-03
5.0
5.3
1.1e-07
0.89
0.01
0.92
TRUE
4
The Cancer Genome Atlas
Rectum Adenocarcinoma
C16orf71
0.22
0.17
enet
10
0.21
9.9e-06
4.4
5.3
1.2e-07
0.81
0.03
0.84
FALSE
1
GTEx
Artery Tibial
ZNF500
0.19
0.18
lasso
5
0.17
1.8e-13
5.0
5.2
2.0e-07
0.94
0.01
0.99
FALSE
2
GTEx
Stomach
MGRN1
0.34
0.18
enet
14
0.22
1.2e-10
4.5
-5.2
2.4e-07
-0.77
0.11
0.86
FALSE