Best TWAS P=1.11e-12 · Best GWAS P=5.65e-14 conditioned to 0.402
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC9A3R2 | 0.15 | 0.09 | enet | 7 | 0.10 | 7.8e-12 | -5.7 | 5.2 | 1.7e-07 | -0.68 | 0.98 | 0.02 | FALSE |
| 2 | GTEx | Artery Aorta | TSC2 | 0.08 | 0.02 | enet | 7 | 0.03 | 5.0e-03 | -5.1 | 6.3 | 2.6e-10 | -0.43 | 0.15 | 0.28 | FALSE |
| 3 | METSIM | Adipose | PKD1 | 0.06 | 0.02 | bslmm | 370 | 0.03 | 9.5e-06 | -7.5 | 7.1 | 1.4e-12 | -0.73 | 0.01 | 0.99 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | SLC9A3R2 | 0.16 | 0.11 | lasso | 6 | 0.12 | 6.3e-15 | -6.1 | 7.0 | 2.0e-12 | -0.76 | 0.49 | 0.51 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | TSC2 | 0.28 | 0.17 | bslmm | 372 | 0.17 | 2.1e-21 | -5.9 | 5.4 | 7.8e-08 | -0.52 | 0.99 | 0.01 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | MLST8 | 0.22 | 0.18 | lasso | 6 | 0.18 | 7.1e-23 | 4.7 | 5.5 | 3.5e-08 | -0.33 | 1.00 | 0.00 | FALSE |
| 7 | YFS | Blood | TSC2 | 0.03 | 0.02 | lasso | 4 | 0.02 | 7.6e-08 | -6.4 | 6.5 | 6.0e-11 | -0.55 | 0.76 | 0.24 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TSC2 | 0.02 | 0.03 | lasso | 1 | 0.02 | 1.8e-05 | -6.4 | 6.4 | 1.9e-10 | -0.48 | 0.30 | 0.22 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CASKIN1 | 0.02 | 0.00 | blup | 38 | 0.01 | 4.5e-02 | 4.1 | -6.0 | 2.2e-09 | 0.31 | 0.03 | 0.04 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | CASKIN1 | 0.06 | 0.02 | blup | 38 | 0.04 | 1.5e-04 | -7.0 | -6.4 | 1.3e-10 | 0.61 | 0.00 | 0.97 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC9A3R2 | 0.06 | 0.03 | lasso | 5 | 0.03 | 3.7e-04 | -5.7 | 7.1 | 1.1e-12 | -0.72 | 0.07 | 0.71 | TRUE |