TWAS hub - C16orf71

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.1390	0.0710	9.8e-03	0.034	NA	0.009	NA	0.024	4.4e-02	NA	1.8e-01	NA	7.7e-02
2	GTEx	Cells Transformed fibroblasts	0.0730	0.0350	7.6e-03	0.025	NA	0.000	NA	0.003	5.1e-03	NA	3.1e-01	NA	1.8e-01
3	GTEx	Testis	0.2260	0.0690	2.1e-06	0.162	NA	0.143	NA	0.154	1.1e-07	NA	6.6e-07	NA	2.5e-07
4	TCGA	Bladder Urothelial Carcinoma	0.0630	0.0460	7.8e-03	0.037	0.019	0.048	NA	0.049	4.2e-04	9.1e-03	6.6e-05	NA	5.4e-05
5	TCGA	Breast Invasive Carcinoma	0.0132	0.0085	1.7e-03	0.013	0.010	0.003	NA	0.007	8.4e-04	3.1e-03	6.0e-02	NA	1.1e-02
6	TCGA	Lung Adenocarcinoma	0.1357	0.0565	1.3e-03	-0.002	0.010	0.016	NA	0.001	8.3e-01	2.3e-02	4.7e-03	NA	2.6e-01
7	TCGA	Prostate Adenocarcinoma	0.0596	0.0333	1.9e-06	0.072	0.052	0.032	NA	0.067	4.9e-08	3.9e-06	2.3e-04	NA	1.5e-07
8	TCGA	Rectum Adenocarcinoma	0.2210	0.0990	6.7e-05	0.167	0.096	0.213	NA	-0.008	9.8e-05	3.0e-03	9.9e-06	NA	5.4e-01
9	TCGA	Uterine Corpus Endometrial Carcinoma	0.5260	0.1370	1.1e-03	0.004	0.093	0.065	NA	0.012	2.4e-01	1.5e-03	7.1e-03	NA	1.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Medication for cholesterol	8.7	13.3	25.1	4.4	3.7	4.0	3.0	4.4	0.9	3.6	5.0	1.5
Medication: Blood pressure	8.6	16.4	26.5	-4.5	-4.2	-4.9	-2.9	-5.2	-1.5	-4.4	-5.0	-2.0
Cholesterol lowering medication	6.5	9.6	17.1	-3.3	-3.6	-3.1	-2.4	-3.3	-1.1	-3.5	-4.1	-2.3
Hand grip strength (left)	6.3	16.7	28.1	4.5	4.5	4.6	2.4	5.3	1.9	4.7	5.3	1.1
Pulse wave Arterial Stiffness index	5.3	6.1	10.9	-2.1	-3.0	-1.9	-1.7	-3.3	-2.5	-2.8	-2.9	-1.4
Qualifications: O levels/GCSEs or equivalent	5.3	8.4	19.3	2.9	3.0	2.6	2.6	4.4	1.1	2.9	3.9	0.0
Pulse wave peak to peak time	5.3	6.2	12.7	2.2	3.1	2.1	1.5	3.6	1.9	2.8	3.1	1.2
Mouth/teeth dental problems: Mouth ulcers	5.0	7.9	12.2	-3.1	-3.2	-3.5	-1.4	-3.3	-2.0	-3.2	-3.4	-0.7
Pulse wave reflection index	4.5	5.5	16.4	-0.9	-2.3	-1.1	-2.2	-2.6	-4.0	-2.5	-1.7	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	4.4	14.0	27.8	4.1	4.5	4.4	0.9	5.3	0.9	4.3	4.5	0.5
Forced vital capacity (FVC), Best measure	4.2	15.5	32.2	4.2	4.8	4.7	1.0	5.7	0.3	4.5	4.8	0.5
Mineral and other dietary supplements	4.2	5.6	12.0	2.3	3.5	2.1	-0.7	3.0	0.9	3.0	3.0	0.8
Number of treatments/medications taken	3.8	6.9	14.6	-3.6	-2.6	-2.5	-0.5	-3.4	-0.9	-2.9	-3.8	-0.7
High blood pressure	3.8	10.6	22.5	-4.2	-2.5	-3.6	-1.0	-4.7	-2.6	-3.3	-4.2	0.3
Vascular/heart problems diagnosed by doctor	3.8	10.4	22.3	3.9	2.8	3.6	1.0	4.7	2.4	3.4	4.2	0.3
Forced expiratory volume in 1-second (FEV1)	3.7	12.4	25.0	3.6	4.4	4.3	1.2	5.0	0.1	4.0	4.3	0.9
Hand grip strength (right)	3.6	9.8	15.7	3.3	3.7	3.6	2.3	3.9	0.9	3.6	4.0	1.0
Forced vital capacity (FVC)	3.6	13.7	27.9	3.9	4.4	4.7	0.9	5.3	-0.7	4.0	4.5	0.2
Medication: Amlodipine	3.5	4.9	9.3	-2.9	-2.1	-2.3	0.1	-3.0	-2.0	-2.5	-2.6	-0.3
Medication: Omeprazole	3.5	4.2	7.9	-1.6	-2.1	-2.1	-0.7	-2.4	-2.5	-2.8	-1.7	-1.7
Hypertension (Self-reported)	3.5	9.7	21.8	-3.9	-2.4	-3.4	-0.9	-4.7	-2.4	-3.0	-4.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	3.5	7.2	13.4	3.2	3.1	3.5	-1.0	3.1	-1.9	2.3	3.7	-0.3
Qualifications: nursing, teaching	3.5	5.5	12.5	2.2	2.5	2.5	1.5	3.3	0.4	2.3	3.5	0.9
Qualifications: None of the above	3.3	7.1	14.1	-2.8	-2.7	-2.4	-2.9	-3.3	-1.7	-2.5	-3.8	-0.3
Overall health rating	3.2	6.8	12.9	-3.2	-2.0	-2.9	-1.8	-3.2	-1.3	-2.9	-3.6	-1.4
Systolic Blood Pressure	3.1	15.6	35.4	-4.9	-4.1	-5.0	0.9	-6.0	-0.8	-3.6	-4.7	2.0
Osteoarthritis (self-reported)	3.1	4.0	8.1	-2.9	-1.8	-2.5	0.0	-2.5	-0.9	-2.2	-2.4	0.7
Number of self-reported non-cancer illnesses	3.1	5.4	13.7	-3.0	-2.0	-2.3	-0.0	-3.3	-0.7	-2.5	-3.7	0.1
Medication for pain relief, constipation, heartburn	3.0	5.1	10.2	3.1	2.4	2.6	0.7	2.9	-0.7	2.0	3.2	0.2
Leg pain on walking	3.0	3.8	7.5	-1.7	-2.4	-1.6	-0.9	-2.1	-2.2	-2.7	-1.4	-1.8
Supplements: Glucosamine	2.9	3.8	6.8	-1.9	-2.3	-1.9	-0.5	-2.3	-1.3	-2.6	-2.4	-1.2
Happiness	2.9	3.5	8.3	1.5	1.6	1.9	1.4	1.7	2.9	2.0	2.1	1.3
Systolic blood pressure, automated reading	2.8	8.1	18.0	-3.1	-2.9	-4.0	0.7	-4.2	-0.1	-2.6	-3.5	1.3
Qualifications: CSEs or equivalent	2.8	3.7	7.0	-1.7	-2.1	-1.9	-0.5	-2.6	-2.3	-2.5	-1.5	-0.8
Smoking Status	2.7	6.5	11.6	-1.9	-3.0	-2.3	-2.6	-2.2	-1.1	-2.6	-3.4	-3.0
Number of full sisters	2.7	3.3	7.0	-1.7	-2.2	-1.4	-2.2	-1.5	-0.1	-1.7	-2.6	-1.8
Diabetes diagnosed by doctor	2.7	4.4	6.8	-1.5	-1.8	-1.9	-1.6	-2.0	-2.6	-2.6	-2.1	-2.4
Peak expiratory flow (PEF)	2.6	6.1	10.5	1.6	3.0	2.6	2.1	3.2	-0.1	2.8	3.0	2.4
Pulse rate, automated reading	2.6	8.5	16.8	-4.1	-2.6	-3.4	1.2	-3.1	2.6	-1.6	-4.0	2.2
Medication: Lisinopril	2.6	3.4	7.5	-2.7	-1.9	-2.0	-1.2	-2.3	-1.0	-1.3	-2.4	0.9
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	6.4	-1.4	-1.7	-1.6	-0.6	-2.0	-2.5	-2.4	-1.5	-1.5
Pain all over the body in last month	2.5	2.7	3.9	-1.8	-2.0	-1.7	-1.5	-1.3	-0.8	-1.9	-2.0	-1.4
Long-standing illness, disability or infirmity	2.5	3.8	6.4	-1.9	-1.7	-2.1	-0.3	-2.4	-1.6	-2.5	-2.3	-1.8
Asthma (self-reported)	2.5	5.0	11.8	-2.3	-2.4	-2.4	-1.4	-2.4	0.7	-2.3	-3.4	-1.6
Pain type(s) experienced in last month: Hip pain	2.5	3.1	8.8	-2.1	-1.2	-3.0	-1.7	-1.4	0.2	-1.7	-2.1	-1.0
Pain experienced in last month	2.5	4.2	8.0	2.3	2.0	2.2	0.5	2.8	1.6	2.5	2.5	0.4
Qualifications: A levels/AS levels or equivalent	2.4	5.4	13.6	1.9	2.5	2.3	1.8	3.7	1.1	2.3	3.2	0.5
Asthma	2.4	4.7	11.4	-2.4	-2.2	-2.5	-1.3	-2.5	0.7	-2.2	-3.4	-1.2
Breast cancer (self-reported)	2.4	2.8	5.0	-2.2	-2.1	-2.0	-1.1	-1.9	-0.5	-1.8	-1.9	-0.3
Medication: Gliclazide	2.4	2.7	4.9	-0.8	-1.3	-1.5	-1.6	-1.7	-1.9	-2.2	-1.1	-2.1
Noisy workplace	2.3	2.9	7.9	-1.4	-1.1	-1.1	-0.9	-2.4	-2.8	-2.0	-1.7	-0.4
Qualifications: College or University degree	2.3	7.2	14.0	2.8	3.3	2.7	1.5	3.7	2.1	3.2	2.8	0.4
Supplements: Vitamin C	2.3	2.7	6.1	-1.3	-2.1	-1.6	-0.3	-1.9	-1.3	-2.5	-1.5	-1.4
Ever had prostate specific antigen (PSA) test	2.3	2.6	5.5	2.3	1.8	1.6	-0.1	2.2	-0.6	1.0	2.3	-0.8
Fasting Glucose	2.2	2.6	5.8	-1.4	-2.4	-2.0	-1.1	-1.8	-0.9	0.0	-2.1	-1.5
Angina	2.2	2.9	4.6	-1.5	-1.0	-1.5	-0.9	-2.0	-2.0	-2.1	-2.1	-1.8
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	6.4	-1.9	-1.9	-2.5	-0.9	-2.1	0.9	-1.6	-2.1	0.3
Pulse rate	2.2	3.6	7.7	-2.8	-1.7	-2.5	1.0	-1.7	1.8	-0.9	-2.1	2.0
Medication: Bendroflumethiazide	2.2	3.4	6.1	-2.1	-1.6	-2.0	-0.8	-2.5	-1.3	-2.2	-2.2	-0.9
Medication: Metformin	2.1	2.9	6.5	-0.9	-1.3	-1.1	-2.5	-1.2	-1.8	-2.0	-1.2	-2.5
Trunk fat mass	2.1	9.1	20.2	3.1	3.9	3.6	0.4	4.5	0.8	3.0	3.6	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	4.2	-1.9	-1.6	-1.9	-1.0	-1.9	-0.7	-1.7	-2.1	-0.6
Comparative height size at age 10	2.1	11.5	20.2	3.9	4.1	4.1	-1.6	4.5	-1.8	2.6	4.4	-1.8
Medication: Atorvastatin	2.1	2.6	3.8	-1.6	-1.4	-1.8	-1.2	-1.7	-1.8	-1.9	-1.8	-1.1
Risk taking	2.1	3.1	6.8	-1.9	-2.1	-2.1	0.5	-2.6	-0.8	-2.0	-1.8	0.7
Trunk fat percentage	2.0	8.2	16.2	3.0	3.5	3.1	1.4	4.0	2.1	3.1	3.3	-0.4
Maternal smoking around birth	2.0	2.9	6.9	-1.9	-2.6	-1.7	0.2	-1.9	-1.2	-2.1	-1.8	0.1
Mouth/teeth dental problems	2.0	3.1	5.6	1.1	2.2	1.5	0.9	2.3	1.7	2.4	1.6	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	7.6	-1.6	-1.0	-1.2	-1.3	-2.1	-2.8	-1.5	-2.2	-1.1
Health satisfaction	2.0	2.6	9.2	1.2	1.7	0.7	0.9	1.6	3.0	1.5	2.0	0.6
Angina (self-reported)	2.0	2.6	4.3	-1.5	-0.9	-1.4	-0.7	-1.9	-1.9	-2.0	-2.1	-1.6
Diastolic blood pressure, automated reading	2.0	6.1	11.4	-3.0	-2.9	-3.4	0.7	-3.3	0.4	-2.0	-3.0	1.6
Standing height	1.9	18.4	29.6	4.6	4.6	5.1	-2.8	5.4	-4.1	2.6	5.3	-3.0
Shortness of breath walking on level ground	1.9	2.3	5.1	-2.2	-1.1	-1.8	-0.0	-2.1	-0.3	-1.6	-2.0	0.7
Lung FVC	1.8	9.2	18.9	4.3	2.7	3.7	1.5	4.3	1.1	3.0	3.3	-0.9
Past tobacco smoking	1.8	3.4	7.6	2.5	2.3	2.0	1.3	1.3	0.5	1.6	2.8	1.0
Impedance of arm (left)	1.8	8.2	18.9	4.3	2.6	3.2	1.9	2.7	2.2	3.1	3.4	0.3
Supplements: Fish oil (including cod liver oil)	1.8	2.3	6.2	-1.3	-2.5	-1.3	1.3	-1.7	0.3	-1.9	-1.6	-0.5
Ever smoked	1.8	3.2	7.2	-2.3	-2.1	-2.1	-1.5	-1.0	-0.1	-1.4	-2.7	-1.4
Schizophrenia (2014)	1.7	3.7	9.7	3.1	2.4	2.4	0.0	2.1	1.4	0.0	2.3	0.6
Hip circumference	1.7	7.1	17.1	2.6	3.4	3.1	0.4	4.1	-0.3	2.4	3.6	-0.8
Emphysema/chronic bronchitis	1.7	2.0	5.1	-1.1	-1.9	-0.8	0.2	-1.6	-0.3	-2.3	-1.6	-1.3
Back pain experienced in last month	1.7	2.4	4.8	-1.9	-1.4	-1.5	0.4	-1.7	-2.0	-2.2	-1.5	-0.2
Basal cell carcinoma (self-reported)	1.7	2.0	4.1	-1.5	-2.0	-1.6	-1.0	-1.4	-1.2	-1.5	-1.6	0.1
Schizophrenia vs Biploar Disorder	1.6	2.1	3.6	1.9	1.9	1.8	0.0	1.7	1.4	0.0	1.4	1.1
Body Mass Index (BMI) (2010)	1.6	2.2	5.3	2.3	0.8	2.0	0.5	2.3	0.2	0.0	1.5	-1.4
HDL Cholesterol	1.6	2.6	8.8	-0.4	0.6	0.5	2.5	0.5	2.8	0.0	0.5	3.0
Respiratory disease	1.6	3.5	7.3	-1.7	-2.1	-2.2	-0.5	-2.1	0.6	-2.1	-2.7	-1.5
Taking other prescription medications	1.6	2.4	6.2	-2.5	-1.0	-1.3	-1.0	-1.7	1.1	-1.3	-2.5	-0.2
Length of working week for main job	1.6	1.7	6.7	-1.9	-0.8	-1.1	-0.5	-1.2	-0.3	-0.2	-1.1	2.6
Had menopause	1.5	1.9	4.2	-0.6	-1.6	-0.7	-1.2	-1.9	-1.0	-1.4	-2.0	-1.0
Medication: Simvastatin	1.5	2.3	3.5	-1.3	-1.6	-1.2	-1.2	-1.6	-1.1	-1.7	-1.9	-1.7
Body fat percentage	1.5	5.9	11.4	2.3	3.0	2.4	1.5	3.4	2.2	2.6	2.8	-0.1
Whole body fat mass	1.5	6.4	15.2	2.5	3.2	2.9	0.3	3.9	0.7	2.4	3.1	-1.2
Average weekly red wine intake	1.5	2.2	4.0	-1.4	-1.1	-1.4	-1.9	-1.0	-2.0	-1.5	-1.7	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	7.2	2.7	1.5	2.1	1.9	2.1	0.5	1.6	1.9	0.1
Prostate Cancer	1.4	2.0	4.1	-1.1	-2.0	-1.6	-0.1	-2.0	-0.4	-1.5	-1.9	0.1
Height	1.4	26.9	43.4	4.8	5.3	5.4	-4.8	6.6	-5.8	2.2	5.7	-5.0
Unable to work because of sickness or disability	1.4	1.8	3.8	-1.1	-0.6	-1.9	-1.5	-1.6	0.3	-1.2	-1.6	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	5.1	1.6	1.8	1.5	2.2	1.9	1.2	1.7	2.1	0.9
Diabetes (self-reported)	1.3	2.1	3.9	-1.0	-1.5	-1.2	-0.8	-1.3	-1.7	-2.0	-1.3	-1.8
Weight	1.3	6.5	16.0	2.1	3.1	2.9	-0.9	4.0	-1.5	1.7	3.1	-2.0
Impedance of arm (right)	1.3	6.2	17.3	4.2	1.9	3.0	1.5	2.2	2.0	2.6	2.9	-0.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	4.5	-0.9	-1.7	-0.9	-1.6	-1.3	-2.1	-2.0	-1.3	-1.9
High blood pressure (siblings)	1.3	1.9	4.0	-1.1	-1.4	-1.4	0.4	-2.0	-1.9	-1.6	-1.3	-0.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.9	1.3	1.5	1.3	0.0	1.2	1.3	1.7	1.3	1.1
Arm fat percentage (left)	1.3	5.3	11.1	2.3	2.7	2.4	1.5	3.3	1.7	2.4	2.7	-0.3
Friendships satisfaction	1.3	1.6	3.4	1.5	1.4	1.9	0.5	1.3	0.5	1.4	1.5	0.3
Smoking status: Current	1.3	2.0	5.2	-0.7	-1.1	-1.2	-1.8	-1.1	-0.8	-1.5	-1.6	-2.3
Miserableness	1.3	2.3	8.7	-1.0	-0.7	-0.9	-2.0	-1.8	-3.0	-1.2	-0.9	-0.5
Medication: Paracetamol	1.3	1.9	5.9	-2.4	-1.0	-1.9	-0.1	-1.2	0.4	-0.6	-2.1	0.8
Heart attack/myocardial infarction (self-reported)	1.3	1.7	4.2	0.2	-1.4	-0.8	-0.4	-1.6	-1.0	-1.9	-1.0	-2.1
Leg fat-free mass (left)	1.2	6.2	12.5	1.8	2.9	2.6	-1.6	3.5	-3.0	1.2	2.8	-2.0
Current tobacco smoking	1.2	1.9	6.2	-0.4	-1.1	-0.8	-1.6	-0.9	-0.9	-1.5	-1.5	-2.5
Medication: Levothyroxine sodium	1.2	2.0	4.3	-0.5	-1.8	-1.0	-1.2	-1.1	-2.1	-1.7	-1.3	-1.4
Leg predicted mass (left)	1.2	6.2	12.4	1.8	2.8	2.7	-1.6	3.5	-3.0	1.2	2.8	-2.0
Waist circumference	1.2	4.5	11.4	2.2	2.2	2.6	-0.2	3.4	0.1	1.4	2.4	-2.1
Arm fat percentage (right)	1.2	4.8	10.2	2.3	2.5	2.3	1.3	3.2	1.6	2.2	2.6	-0.6
Hair/balding pattern: Pattern 4	1.2	2.9	7.9	1.1	2.8	1.5	0.7	2.8	-0.1	1.5	2.0	0.1
Medication: Paracetamol	1.2	2.0	6.0	-2.4	-1.0	-1.9	-0.3	-1.3	0.8	-0.5	-2.1	0.9
Medication: Ventolin 100micrograms inhaler	1.2	1.6	6.1	-0.3	-0.6	-0.5	-2.0	0.0	-0.2	-1.0	-1.4	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.2	-1.6	-0.2	-1.4	0.3	-1.8	-1.6	-0.7	-1.8	0.5
Neck or shoulder pain in last month	1.2	1.7	3.1	-1.7	-1.1	-1.8	-0.0	-1.6	-0.8	-1.6	-1.6	0.1
Family relationship satisfaction	1.2	1.4	4.2	0.6	2.0	0.6	0.6	1.0	1.6	1.0	1.5	1.0
Knee pain experienced in last month	1.2	1.8	4.2	-0.9	-1.4	-1.1	0.1	-2.0	-1.2	-1.9	-1.1	-1.4
Arm fat mass (left)	1.2	5.0	12.9	2.1	2.8	2.5	0.4	3.6	0.6	2.1	2.7	-1.1
Ever taken oral contraceptive pill	1.2	1.4	2.5	1.0	1.2	0.9	0.9	0.6	1.1	1.3	1.6	1.5
Basal metabolic rate	1.2	6.6	13.0	1.9	2.9	2.7	-1.9	3.6	-2.9	1.2	2.8	-2.3
Medication for hormone replacement therapy	1.1	1.2	3.3	-1.7	-0.5	-1.5	-0.3	-1.0	0.2	-0.3	-1.8	0.9
Medication: Atenolol	1.1	1.4	2.4	-0.5	-1.0	-1.1	-1.4	-1.5	-1.1	-1.2	-0.9	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.5	-1.5	-0.8	-1.1	1.0	-0.9	0.6	0.1	-1.2	2.1
Exposure to tobacco smoke at home	1.1	1.3	5.5	0.1	-1.4	-0.6	-1.3	-0.8	2.3	-0.6	-0.6	-0.8
Whole body fat-free mass	1.1	6.0	11.9	1.5	2.5	2.3	-2.4	3.2	-3.5	0.8	2.5	-2.4
Leg fat-free mass (right)	1.1	6.1	12.1	1.8	3.0	2.7	-1.6	3.5	-2.8	1.4	2.7	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.2	-1.3	-1.4	-1.5	0.3	-1.2	1.3	-0.9	-1.3	-0.3
Leg predicted mass (right)	1.1	5.9	11.8	1.7	2.9	2.6	-1.6	3.4	-2.9	1.4	2.7	-1.8
Schizophrenia (2018)	1.0	2.1	5.3	2.3	1.0	1.4	1.6	1.1	1.6	0.0	1.8	0.8
Heel T-Score	1.0	7.7	10.6	3.1	2.3	2.8	3.1	3.3	2.8	2.9	3.0	0.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.2	-1.3	-1.0	-1.5	0.4	-1.1	-1.1	-1.8	-1.0	-0.5
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.4	-1.3	-1.1	-1.5	0.2	-1.4	-0.2	-1.1	-1.5	-0.4
Serious illness, injury or assault to yourself	1.0	1.2	4.2	-2.0	-0.4	-1.2	0.8	-0.7	-1.3	-0.6	-1.2	0.8
Heart attack	1.0	1.3	2.9	0.2	-1.2	-0.6	-0.2	-1.4	-1.0	-1.7	-0.9	-1.7
Fluid intelligence score	1.0	2.1	4.0	0.1	1.9	1.2	1.9	2.0	0.7	1.6	1.1	1.4
Trunk fat-free mass	1.0	6.0	13.8	1.4	2.3	2.2	-2.7	2.9	-3.7	0.6	2.3	-2.5
Arm fat mass (right)	1.0	4.0	10.6	2.0	2.3	2.3	0.0	3.2	0.1	1.7	2.4	-1.5
Trunk predicted mass	1.0	5.9	13.8	1.4	2.2	2.1	-2.7	2.9	-3.7	0.6	2.3	-2.5
Mouth/teeth dental problems: Loose teeth	1.0	1.1	4.5	1.3	0.1	0.6	0.4	1.4	-0.0	-0.1	1.2	-2.1
Medication: Aspirin	1.0	1.4	4.0	-1.4	-1.1	-0.6	-0.7	-1.6	0.3	-0.9	-2.0	-0.7
Whole body water mass	1.0	5.8	11.4	1.5	2.5	2.4	-2.3	3.1	-3.4	0.8	2.4	-2.4
Illnesses of father: High blood pressure	1.0	1.2	7.5	-1.2	0.2	-0.1	1.3	-0.0	0.4	0.6	-0.1	2.7
Major Depression (MDD)	0.9	1.1	3.8	1.1	0.9	1.2	0.0	1.6	1.9	0.0	0.0	0.2
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.3	1.5	2.1	1.5	0.8	2.0	0.4	1.3	1.9	-0.5
LDL Cholesterol	0.9	1.4	5.0	1.8	0.2	0.9	-0.4	0.9	-1.5	0.0	1.0	-2.2
Triglycerides	0.9	1.4	6.4	1.0	0.2	0.2	-0.9	0.2	-2.5	0.0	0.7	-2.0
Blood Red Count	0.9	8.5	14.7	2.7	2.4	2.7	3.0	3.8	2.7	3.5	3.4	1.4
Relative age voice broke	0.9	1.4	4.9	-0.2	0.4	0.3	1.1	0.7	2.2	1.6	0.0	1.9
Age when periods started (menarche)	0.9	2.2	4.3	-0.1	-1.9	0.3	-1.5	-1.1	-1.8	-1.3	-2.1	-1.9
Stomach or abdominal pain in last month	0.9	1.2	2.4	-1.6	0.1	-1.2	0.8	-1.1	-1.2	-0.7	-0.8	1.5
Allergy	0.9	2.0	3.9	1.4	2.0	1.2	-1.3	1.7	-1.2	1.6	1.3	-0.5
Prospective memory result	0.9	1.2	3.2	0.3	-0.9	-0.8	-1.1	-1.8	-0.5	-0.9	-1.4	-1.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.6	1.8	0.7	0.8	-0.6	0.4	-0.7	0.1	1.9	-0.9
Loud music exposure frequency	0.9	0.9	2.8	-0.9	0.2	-0.6	-0.4	-1.4	-1.7	-0.4	-0.3	1.5
Comparative body size at age 10	0.9	2.4	4.1	1.5	1.6	1.9	1.8	1.6	1.1	1.3	2.0	0.4
Medication: Seretide 50 evohaler	0.9	1.0	2.2	-1.2	-1.1	-1.2	-0.3	-1.1	0.5	-1.1	-1.5	-0.5
Guilty feelings	0.9	1.3	3.5	0.6	1.4	1.0	0.9	0.1	0.3	1.7	0.9	1.9
Number of operations (self-reported)	0.9	1.4	3.4	-1.8	-0.9	-1.1	-0.9	-1.3	-0.7	-0.9	-1.8	-0.1
Irritability	0.9	1.6	3.9	-1.7	-0.7	-1.0	-0.0	-1.7	-2.0	-1.2	-0.9	0.9
Alzheimer’s Disease (in mother)	0.8	1.0	3.1	0.7	0.8	0.6	1.8	0.4	0.2	1.0	1.0	1.4
Cardiovascular Disease	0.8	2.7	8.6	-1.5	-1.3	-1.6	0.2	-2.9	-0.5	-1.3	-2.5	0.7
Hypothyroidism (self reported)	0.8	1.8	3.6	-0.9	-1.6	-1.0	-0.9	-1.2	-1.9	-1.8	-0.7	-1.4
Chronotype (morning person)	0.8	1.8	4.0	-1.9	-1.1	-1.4	-0.6	-1.8	-0.7	-1.2	-2.0	0.4
Wheeze or whistling in the chest in last year	0.8	1.4	4.5	-1.3	-0.8	-1.1	0.4	-1.4	1.0	-0.9	-2.1	0.0
Migraine (self-reported)	0.8	1.0	6.1	0.7	0.2	1.0	0.2	0.7	2.5	0.9	0.1	-0.1
Medication: Ibuprofen	0.8	0.9	3.3	-1.4	-0.8	-0.9	0.5	-0.6	0.1	0.1	-1.0	1.8
Mean time to correctly identify matches	0.8	1.5	4.8	1.7	1.1	0.4	-2.2	0.4	1.1	0.6	0.9	-1.4
Smoking status: Previous	0.8	1.3	3.2	-1.7	-1.7	-1.0	-0.6	-0.6	-0.0	-0.8	-1.8	-0.0
Mood swings	0.8	1.4	5.9	-0.3	1.4	0.1	1.6	-0.1	0.3	1.3	0.5	2.4
Supplements: Calcium	0.8	0.9	3.0	-1.6	-0.6	-0.7	-0.7	-0.8	-0.7	-0.8	-1.7	0.1
Impedance of whole body	0.8	4.1	8.5	2.9	1.5	1.9	1.6	1.6	2.7	2.3	2.1	0.7
Mean Putamen Volume	0.7	0.8	1.6	-0.6	-1.2	-0.9	-1.3	-0.6	-0.5	-1.1	-0.8	-0.5
Allergy or Eczema	0.7	1.8	5.0	-0.4	-2.2	-1.0	1.6	-1.6	-1.1	-2.0	0.1	-0.0
Vitamin and mineral supplements	0.7	0.9	2.2	0.6	1.3	0.6	-0.0	1.5	0.3	1.2	1.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.7	-0.3	1.1	0.1	1.3	1.1	0.3	0.7	1.0	1.3
Sitting height	0.7	5.0	22.6	0.6	2.1	1.2	-2.0	2.3	-4.8	0.0	2.1	-1.6
Had other major operations	0.7	0.9	3.5	-1.0	-0.1	-0.6	1.0	0.1	1.9	0.6	-0.7	1.0
Financial difficulties in last 2 years	0.7	0.9	3.7	0.4	-1.3	0.1	-0.9	-0.4	-0.3	-1.3	0.2	-1.9
Medication: Ramipril	0.7	0.9	2.3	-1.5	-0.3	-1.2	-0.8	-1.1	0.2	-0.7	-1.2	-0.4
Time employed in main current job	0.7	0.8	2.4	0.9	0.6	0.6	1.5	1.1	1.0	1.0	0.6	0.3
Hair/balding pattern: Pattern 3	0.7	1.1	2.4	0.9	1.1	1.2	-0.4	1.5	0.7	1.4	1.1	0.4
Headache pain in last month	0.7	1.1	2.0	0.0	1.4	0.0	1.1	1.2	1.1	1.3	0.8	1.3
Arm fat-free mass (right)	0.7	3.6	8.9	0.5	1.8	1.5	-2.4	2.4	-3.0	0.4	1.4	-2.1
Number of children fathered	0.7	0.8	2.3	0.0	-0.9	-0.6	-1.5	-1.1	0.6	-1.1	-0.1	-0.7
Age at first live birth	0.7	1.2	2.8	1.1	1.0	0.9	0.9	1.4	0.9	1.0	1.7	0.2
Medication: Blood pressure	0.7	1.2	3.2	-1.5	-0.2	-0.4	0.0	-1.6	-1.8	-1.0	-1.2	0.5
Arm predicted mass (right)	0.7	3.5	8.4	0.5	1.9	1.5	-2.2	2.4	-2.9	0.4	1.5	-1.9
Ever had bowel cancer screening	0.7	0.8	2.6	-1.1	-0.5	-1.1	-0.4	-1.0	-0.4	-0.7	-1.6	0.1
Commuting to job workplace: Public transport	0.7	0.9	3.0	1.7	0.8	0.5	-0.4	0.1	1.7	0.5	0.6	-0.6
Alcohol drinker status: Previous	0.7	0.8	2.0	-0.1	1.4	0.8	-1.2	0.6	-1.4	0.5	0.4	-0.3
Pack years of smoking	0.7	1.0	4.4	1.5	-0.2	1.2	-0.2	0.6	-0.2	-0.4	0.8	-2.1
Bipolar Disorder or Schizophrenia	0.6	1.4	3.7	1.9	1.1	1.2	1.4	0.9	1.2	0.0	1.4	0.4
Reaction Time	0.6	1.1	2.8	1.7	1.0	0.6	-1.4	0.4	0.3	0.3	1.3	-1.2
Age at First Birth	0.6	0.8	3.3	0.6	0.8	-0.1	1.3	0.3	0.6	0.0	0.9	1.8
Lupus	0.6	0.9	2.3	-1.5	-0.3	-0.7	-0.1	-0.0	1.3	0.2	-1.2	1.5
Neuroticism (2016)	0.6	0.9	1.7	-1.3	-1.3	-0.8	0.8	-1.1	-0.6	-1.1	-0.7	-0.3
Ever had hysterectomy (womb removed)	0.6	0.7	3.8	0.4	0.5	0.4	1.9	0.7	1.0	0.6	0.1	0.6
Pack years adult smoking proportion	0.6	0.9	4.2	1.3	-0.3	1.1	-0.2	0.5	-0.2	-0.4	0.8	-2.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.5	1.0	0.8	0.9	-0.4	1.1	0.5	1.2	0.8	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.4	-1.5	-0.1	-1.6	-1.2	-1.1	0.1	-0.6	-0.6	0.7
Illnesses of siblings	0.6	0.8	2.2	0.7	1.5	0.7	0.0	0.9	0.8	1.0	1.2	0.7
Illnesses of mother	0.6	0.8	1.8	-1.0	0.9	-0.7	0.6	0.1	1.4	0.6	-0.5	1.3
Birth weight of first child	0.6	1.1	3.0	1.0	0.3	1.4	0.2	1.7	-1.2	0.5	1.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.9	-1.0	0.3	-0.4	-0.5	-1.3	-0.2	-0.1	-0.6	1.7
Medication: Allopurinol	0.6	0.8	2.7	-1.0	-0.0	-0.7	-1.6	-0.5	0.8	-0.1	-1.5	-0.5
Commuting to job workplace: Walk	0.6	0.6	4.9	-0.0	-0.1	-0.0	-0.1	0.7	2.2	0.6	-0.2	0.2
Arm fat-free mass (left)	0.6	3.3	7.2	0.6	1.8	1.5	-2.0	2.4	-2.7	0.4	1.4	-2.1
Ever depressed for a whole week	0.6	0.7	1.8	0.8	1.3	0.8	0.4	0.7	-0.8	0.8	1.3	0.2
Commuting to job workplace: Cycle	0.6	0.7	3.1	1.8	0.1	0.8	-0.2	0.2	0.1	-0.2	0.3	-1.6
Arm predicted mass (left)	0.6	3.2	7.3	0.6	1.8	1.4	-2.1	2.5	-2.7	0.5	1.4	-1.9
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.8	0.9	1.9	1.1	0.1	1.9	0.6	1.0	0.7	-1.5
Alzheimer’s Disease (including proxy)	0.5	0.7	3.2	-0.1	0.1	0.4	1.6	-0.2	0.2	0.6	0.4	1.8
Crohns Disease (2017)	0.5	1.0	3.2	0.6	0.7	0.6	-0.8	1.6	-1.1	0.4	0.6	-1.8
Irritable Bowel Disease (IBD)	0.5	1.3	4.3	0.1	0.0	0.4	-1.0	1.4	-2.1	0.0	0.2	-2.0
Ulcerative Colitis (UC)	0.5	1.0	5.1	-0.4	-0.6	-0.2	-0.9	0.4	-2.3	-0.4	-0.3	-1.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.5	-0.7	-0.6	-0.8	-0.9	-0.4	-1.2	0.0	-0.3	-1.2
Blood White Count	0.5	3.9	9.4	-1.2	-2.5	-1.9	-0.1	-2.1	3.1	-1.8	-2.4	-1.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.1	-0.7	-1.0	-1.0	-0.5	-1.0	-0.8	-1.5	-0.9	-0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.7	0.2	-0.5	0.4	-1.6	-0.2	-0.1	-0.4	-0.4	-1.3
Supplements: Zinc	0.5	0.6	1.2	-1.1	-0.6	-0.4	-0.5	-0.5	-1.1	-0.7	-1.1	-0.0
Severe depression (siblings)	0.5	0.6	3.7	0.3	0.2	0.1	0.9	0.2	1.9	0.4	0.3	0.3
Average weekly fortified wine intake	0.5	0.6	2.6	-0.3	-0.0	-0.4	-1.6	-0.3	1.0	-0.3	-0.5	-1.1
Number of incorrect matches in round	0.5	0.8	2.7	-0.7	-0.1	-0.7	-0.6	-1.2	-1.6	-0.9	-1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.4	1.0	1.0	1.0	1.2	0.8	0.7	0.9	1.6	1.1
Falls in the last year	0.5	0.7	3.0	-0.6	-0.2	-1.0	0.3	-0.7	1.7	-0.2	-0.3	0.9
Lung cancer (father)	0.5	0.5	1.9	-1.4	-0.2	-0.1	1.3	-0.2	0.1	-0.5	-0.5	0.7
Blood clot in the leg (DVT)	0.5	0.6	1.5	0.5	0.7	1.2	-0.8	1.0	0.8	0.7	0.6	-0.1
Number of full brothers	0.5	0.6	2.1	0.1	-1.1	0.6	-1.2	0.3	-0.1	-0.3	-0.3	-1.4
Worry too long after embarrassment	0.5	0.8	1.8	-0.7	-1.2	-0.6	-0.4	-1.4	-1.3	-0.8	-0.6	0.8
Leg fat mass (right)	0.5	1.8	6.2	0.8	1.7	1.2	-0.1	2.5	0.1	0.9	1.6	-1.2
Alcohol intake frequency.	0.5	1.2	3.2	0.8	1.8	1.3	-0.5	1.5	-0.0	1.0	1.0	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.9	0.3	-0.4	0.2	0.3	0.3	1.7	-0.3	-0.1	-1.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.8	-1.0	0.1	-1.0	0.8	-0.1	-1.3	-0.3	0.1	0.7
Fractured/broken bones in last 5 years	0.5	0.7	1.7	-0.4	-1.3	-0.3	0.1	-0.9	-1.3	-1.2	-0.8	-0.3
Heart disease (siblings)	0.5	0.6	1.6	-1.1	-1.0	-0.4	-0.4	0.0	-1.1	-0.3	-1.3	-0.2
Leg fat mass (left)	0.5	1.9	6.2	0.8	1.9	1.3	-0.2	2.5	0.3	1.1	1.6	-1.1
Alzheimer’s Disease (in father)	0.4	0.4	1.3	1.0	0.4	1.1	0.3	0.7	0.3	0.6	0.6	-0.2
Primary Biliary Cirrhosis	0.4	0.5	2.1	1.4	0.7	0.8	-0.2	0.5	-0.1	0.7	0.9	0.1
Blood Platelet Count	0.4	5.1	21.4	-1.9	-1.8	-2.2	0.9	-2.2	4.6	-0.7	-2.4	1.0
Waist Hip Ratio (WHR)	0.4	1.6	6.3	1.5	-0.3	1.3	-0.9	1.2	1.4	0.0	0.2	-2.5
Hair Pigment	0.4	10.3	19.0	-4.4	-3.8	-3.8	-0.9	-4.0	-2.0	-3.4	-3.5	0.7
Sensitivity / hurt feelings	0.4	0.7	1.5	-0.3	-1.2	-0.6	-0.9	-0.9	-0.4	-1.0	-0.5	-1.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.6	-1.1	0.7	-0.9	-0.1	-0.7	-0.5	-0.1	-0.2	1.2
Hearing difficulty/problems: Yes	0.4	0.7	1.6	1.1	-1.1	0.5	-0.2	-0.5	-0.7	-0.9	-0.3	-1.3
Diabetes (father)	0.4	0.4	1.3	-0.9	0.8	0.1	-0.7	0.5	-1.2	0.4	-0.2	0.5
Townsend deprivation index at recruitment	0.4	0.5	2.0	-0.0	0.5	0.5	-1.4	0.5	0.7	0.9	-0.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	-0.3	1.2	-0.4	-0.6	-0.5	1.1	0.7	0.1	0.9
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.1	-0.4	-1.4	-0.8	1.4	-1.0	-0.0	-1.2	0.2	0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	2.7	0.3	-0.1	-0.3	-0.4	-0.1	1.1	-0.4	-0.5	-1.7
High blood pressure (mother)	0.4	0.6	2.2	-0.0	-1.0	-0.3	0.2	-1.0	-1.5	-1.1	0.2	0.0
Alcohol usually taken with meals	0.4	0.7	1.5	1.2	1.1	0.2	0.9	1.0	-0.2	0.9	1.0	0.2
Father’s age at death	0.4	0.6	3.0	-0.3	-0.7	-1.1	0.1	-0.6	1.7	-0.4	-0.5	-0.1
Medication: Cholesterol lowering	0.4	0.5	2.6	-0.1	0.0	-0.2	0.1	-0.5	-1.6	-0.8	-0.4	-1.1
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.1	0.6	-0.4	-0.5	-0.2	-1.0	-0.3	-1.0	-0.0	-0.9
Chest pain or discomfort	0.4	0.6	2.9	0.1	-0.4	0.5	1.7	-1.0	-0.9	-0.5	-0.2	0.2
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.7	0.2	0.7	0.7	-0.6	0.6	-0.8	0.8	0.6	0.7
Medication: Aspirin	0.4	0.6	1.8	-0.8	-0.7	-0.1	-0.3	-1.1	0.3	-0.5	-1.4	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	1.3	-0.1	1.1	0.8	0.6	-0.4	0.3	0.7	-0.4
Average weekly champagne plus white wine intake	0.4	0.6	1.8	0.6	0.5	0.2	1.1	-0.0	1.0	0.6	0.5	1.3
Financial situation satisfaction	0.4	0.5	2.0	1.0	-0.8	0.3	-0.2	0.2	1.4	-0.1	0.2	-1.0
Leg fat percentage (left)	0.4	1.3	3.8	0.4	1.2	0.6	1.0	1.7	2.0	1.0	1.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	0.3	0.7	1.1	-0.9	1.0	0.6	0.6	0.6	-0.2
Depression (Nagel 2018)	0.3	0.4	0.8	-0.9	0.6	-0.9	-0.6	-0.8	-0.3	-0.4	-0.1	0.6
Neuroticism (Nagel 2018)	0.3	0.6	2.2	-0.8	-0.5	-0.2	-0.6	-1.5	-1.0	-0.4	-0.7	0.5
Ovarian Cancer	0.3	0.3	2.0	-0.7	0.2	-0.2	-0.3	-0.3	-1.4	-0.3	-0.3	-0.0
Crohns Disease (2012)	0.3	0.4	1.1	0.3	1.1	0.6	-0.7	0.9	-0.6	0.0	0.5	-0.4
HbA1C	0.3	0.3	1.2	-0.2	-1.1	-0.2	0.9	-0.3	0.3	0.0	-0.6	0.2
Ulcerative Colitis	0.3	0.5	2.4	-0.1	-0.1	0.4	-0.7	0.2	-1.6	0.0	0.2	-1.0
Blood Eosinophil Count	0.3	2.0	13.9	0.9	-1.2	0.1	-0.3	-0.6	3.7	0.2	-1.1	-0.4
BMI	0.3	1.8	6.9	0.7	1.3	1.2	0.7	2.6	1.1	0.9	1.1	-1.6
Average weekly spirits intake	0.3	0.4	1.4	0.7	0.2	1.2	-0.6	0.4	0.4	0.5	0.4	-0.8
Medication: Co-codamol	0.3	0.3	1.4	0.5	0.4	0.6	-1.2	0.4	-0.4	0.3	-0.0	-0.7
Diabetes (mother)	0.3	0.4	1.8	-0.1	0.1	0.2	-0.6	0.5	-1.3	-0.3	0.2	-0.9
Impedance of leg (left)	0.3	1.4	7.6	1.3	0.2	0.4	0.8	0.1	2.8	1.1	0.5	0.9
Hearing difficulty/problems with background noise	0.3	0.5	1.2	-0.0	-0.8	-0.7	0.8	-1.1	-0.8	-0.6	-0.4	0.9
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-0.7	-0.7	-0.4	0.2	-0.7	-1.1	-0.3	-0.8	0.4
Alcohol intake versus 10 years previously	0.3	0.4	1.7	-0.8	0.6	-0.4	-0.4	-0.1	-1.3	-0.0	-0.0	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.4	0.4	0.5	0.1	0.1	1.2	0.5	0.5	0.5	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	2.9	0.1	0.1	0.3	-0.1	-0.5	-1.7	-0.7	0.1	-0.6
Tense / ‘highly strung’	0.3	0.5	1.5	-0.8	-0.5	-0.6	-0.7	-1.2	-0.6	-0.8	-0.5	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.2	0.7	-0.5	0.5	-0.2	0.7	0.3	0.1	0.6	-1.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	2.4	0.6	0.1	0.0	-0.3	0.9	1.6	0.8	0.8	0.2
Glaucoma (self-reported)	0.3	0.4	1.7	-0.5	-0.1	-0.2	1.1	0.1	1.3	-0.3	-0.1	-0.1
Gout (self-reported)	0.3	0.4	2.0	-0.0	0.4	-0.3	-1.4	0.3	0.4	0.2	-0.3	-1.1
Leg fat percentage (right)	0.3	1.0	2.6	0.4	0.9	0.5	0.9	1.6	1.6	0.7	0.9	-0.5
Suffer from ‘nerves’	0.3	0.4	1.1	0.6	0.4	1.0	0.3	0.2	-1.0	0.6	0.6	0.4
Had major operations	0.3	0.4	1.1	1.0	-0.1	1.0	0.2	0.4	-0.7	0.1	0.2	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.2	-0.0	-0.5	-0.5	0.7	-0.8	-0.1	-1.1	-0.1	-0.2
Illnesses of siblings: Diabetes	0.3	0.3	1.0	0.2	-0.8	0.3	-1.0	0.0	-0.2	-0.2	-0.6	-1.0
Loneliness, isolation	0.3	0.4	1.1	-0.2	1.0	-0.1	-1.0	-0.5	0.3	0.6	-0.2	0.6
Osteoporosis (self-reported)	0.3	0.4	1.0	-1.0	-0.7	-0.8	0.4	-0.4	0.0	-0.6	-0.9	0.1
Wears glasses or contact lenses	0.3	0.4	1.4	0.5	0.4	0.1	1.0	0.0	1.2	0.6	0.3	0.4
Hearing aid user	0.3	0.3	1.4	0.4	-0.1	1.2	-0.3	0.4	-0.8	0.2	0.1	0.2
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.2	-0.1	-0.4	-0.4	1.1	-0.5	1.1	-0.2	0.2	0.7
Worry (Nagel 2018)	0.2	0.4	1.5	0.7	0.0	1.2	-1.0	-0.0	-0.4	0.5	-0.0	-0.6
Coronary Artery Disease (CAD)	0.2	0.3	1.4	0.8	-0.2	0.5	0.0	-0.3	-1.2	0.0	0.0	-0.0
Relative age of first facial hair	0.2	0.5	1.1	-0.8	-0.6	-1.0	0.5	-0.6	0.8	-0.2	-0.2	1.0
Impedance of leg (right)	0.2	0.9	4.8	1.3	-0.2	0.2	0.7	-0.1	2.2	0.5	0.5	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.0	0.1	0.5	0.8	0.6	-0.6	0.2	0.7	0.1
Multivitamins +/- minerals	0.2	0.2	0.7	-0.4	-0.4	0.1	0.4	-0.6	-0.8	-0.4	-0.4	-0.0
Body mass index (BMI)	0.2	0.8	2.9	0.1	1.1	0.7	0.4	1.7	0.5	0.6	0.8	-0.8
Worrier / anxious feelings	0.2	0.4	2.0	0.3	0.2	0.4	-1.4	-0.4	0.2	0.4	0.1	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.3	-1.2	0.1	-0.8	-0.7	-0.3	-0.1	-0.2	-0.2	0.4
Number of live births	0.2	0.3	0.8	-0.2	-0.6	-0.5	-0.5	-0.2	0.5	-0.6	-0.5	-0.9
Depression (self-reported)	0.2	0.2	0.6	0.3	0.8	-0.3	0.3	-0.0	-0.8	0.0	0.1	-0.3
Medication: Lansoprazole	0.2	0.2	0.6	-0.6	0.4	0.2	0.2	0.2	0.7	0.3	-0.8	0.4
Breastfed as a baby	0.2	0.2	0.6	0.7	-0.3	0.6	0.3	0.1	0.6	-0.1	0.0	-0.8
Heart disease (mother)	0.2	0.2	0.9	-0.2	-0.0	0.1	0.9	-0.3	0.6	-0.1	-0.5	0.4
Age at last live birth	0.2	0.3	1.0	0.0	0.0	-0.2	1.0	0.3	1.0	0.1	0.7	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.1	0.0	-1.1	-0.2	0.5	-0.1	-0.6	-0.7	-0.0	0.0
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.3	-0.7	-0.2	0.5	-0.4	0.7	-0.4	-0.4	0.3
High cholesterol (Self-reported)	0.2	0.3	1.6	0.2	-0.4	0.2	-0.3	-0.4	-0.2	-0.4	-0.8	-1.3
Myopia	0.2	0.3	2.0	-0.4	-0.6	0.2	-0.1	-0.3	-1.4	-0.1	-0.7	0.1
Bipolar Disorder (2018)	0.1	0.1	0.4	0.2	0.5	0.2	0.6	-0.1	-0.0	0.0	0.0	-0.2
Depressed Affect (Nagel 2018)	0.1	0.3	1.0	-0.2	0.7	0.0	0.0	-0.7	-0.6	0.4	0.3	1.0
Rheumatoid Arthritis	0.1	0.2	0.7	-0.2	0.1	0.5	0.0	0.5	-0.8	0.0	0.2	-0.2
Lung FEV1/FVC ratio	0.1	0.6	1.8	-0.7	-0.8	-0.7	0.1	-0.6	1.0	-0.4	-1.4	0.4
Neuroticism	0.1	0.4	0.9	0.2	1.0	0.6	-0.1	-0.3	-0.6	0.7	0.6	0.8
Tanning	0.1	0.6	1.9	-0.0	-1.0	-0.6	-0.1	-0.7	0.1	-1.4	-0.9	-1.0
Fed-up feelings	0.1	0.1	0.3	-0.1	0.1	0.2	0.2	-0.5	0.4	0.2	0.3	0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.3	0.1	-0.4	0.1	-0.1	-0.4	0.1	0.3	0.6
Neuroticism score	0.1	0.2	0.6	0.1	0.5	0.2	-0.3	-0.7	-0.3	0.5	0.5	0.8
Birth weight	0.1	0.3	1.6	-0.5	0.2	-0.4	-1.3	0.4	-0.2	-0.2	0.1	-0.4
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.4	-0.2	-0.2	-0.1	-0.2	-0.5	0.0	0.0	-0.4
Illnesses of father: Heart disease	0.1	0.2	0.3	0.3	-0.5	-0.1	-0.5	-0.4	-0.4	-0.5	0.6	-0.6
Mother’s age at death	0.1	0.1	0.6	0.0	-0.8	-0.4	-0.2	0.2	0.4	-0.1	-0.4	-0.3
Eye problems/disorders: Glaucoma	0.1	0.2	1.0	-0.4	0.2	-0.1	0.2	0.4	1.0	-0.1	-0.1	-0.4
Alcohol drinker status: Never	0.1	0.2	0.6	-0.8	-0.2	-0.8	0.2	0.3	0.1	-0.1	-0.4	0.0
Average weekly beer plus cider intake	0.1	0.1	0.4	0.2	-0.1	-0.4	0.2	-0.7	0.3	-0.2	0.2	-0.1
Age started oral contraceptive pill	0.1	0.2	0.4	0.1	0.6	-0.1	0.4	-0.6	0.5	-0.0	-0.6	0.1
Breast Cancer	0.0	0.1	0.5	-0.1	-0.1	-0.2	-0.2	-0.1	0.7	-0.5	0.2	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Nervous feelings	0.0	0.1	0.3	0.1	-0.1	0.1	-0.5	-0.6	-0.1	0.1	0.1	0.0
Exposure to tobacco smoke outside home	0.0	0.0	0.2	-0.4	-0.3	-0.0	-0.1	0.2	-0.2	-0.3	0.1	0.0

Hub : Genes

C16orf71

Models

Trait associations