Best TWAS P=8.01e-12 · Best GWAS P=1.92e-13 conditioned to 0.00342
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | JMJD4 | 0.10 | 0.05 | bslmm | 381 | 0.04 | 6.8e-06 | -7.2 | -6.8 | 8.0e-12 | 0.85 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Brain Cortex | SNAP47 | 0.21 | 0.05 | lasso | 9 | 0.04 | 2.2e-02 | -4.1 | 6.7 | 2.9e-11 | -0.88 | 0.03 | 0.77 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | JMJD4 | 0.13 | 0.06 | lasso | 4 | 0.03 | 2.9e-02 | -5.9 | -5.4 | 6.8e-08 | 0.51 | 0.05 | 0.44 | FALSE |
| 4 | GTEx | Nerve Tibial | SNAP47 | 0.06 | 0.01 | enet | 16 | 0.03 | 6.5e-03 | -6.4 | 5.9 | 3.0e-09 | -0.64 | 0.05 | 0.86 | FALSE |
| 5 | METSIM | Adipose | SNAP47 | 0.06 | 0.06 | lasso | 6 | 0.08 | 2.0e-11 | -6.4 | 6.0 | 2.7e-09 | -0.77 | 0.78 | 0.22 | FALSE |
| 6 | YFS | Blood | JMJD4 | 0.11 | 0.12 | lasso | 4 | 0.12 | 3.7e-36 | -6.4 | -6.4 | 1.6e-10 | 0.82 | 0.73 | 0.27 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNAP47 | 0.05 | 0.05 | lasso | 3 | 0.06 | 2.4e-04 | -4.1 | 6.1 | 1.3e-09 | -0.83 | 0.01 | 0.90 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LOC100130093 | 0.16 | 0.10 | blup | 42 | 0.05 | 4.7e-03 | 4.6 | 5.6 | 2.4e-08 | -0.58 | 0.23 | 0.23 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF678 | 0.03 | 0.01 | blup | 91 | 0.02 | 2.4e-03 | -5.7 | -6.6 | 3.2e-11 | 0.76 | 0.04 | 0.51 | FALSE |