TWAS hub - ZNF678

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0810	0.036	0.0015	-0.002	0.013	0.001	0.016	-0.002	0.770	0.0080	0.21	0.0038	0.910
2	TCGA	Prostate Adenocarcinoma	0.0284	0.020	0.0067	0.011	0.021	0.014	NA	0.012	0.024	0.0024	0.01	NA	0.017

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hand grip strength (left)	9.2	24.2	44.1	-2.1	-6.6
Medication: Cholesterol lowering	8.6	13.4	18.8	-4.3	-2.8
Height	8.3	160.8	295.8	-5.1	-17.2
Hand grip strength (right)	8.3	22.5	41.0	-2.0	-6.4
Standing height	7.9	78.7	144.0	-3.7	-12.0
Illnesses of father: High blood pressure	7.3	9.0	12.2	2.4	3.5
Sitting height	7.1	50.5	83.0	-4.2	-9.1
Medication: Metformin	6.7	9.4	12.9	-3.6	-2.4
Medication: Simvastatin	6.3	9.2	15.5	-3.9	-1.7
Cholesterol lowering medication	5.9	8.6	12.8	-3.6	-2.1
Medication: Atorvastatin	5.4	6.7	7.5	-2.7	-2.4
Comparative height size at age 10	4.9	27.0	51.1	-1.7	-7.2
Type 2 Diabetes (T2D) (2018)	4.5	8.5	9.9	-3.1	-2.7
Loud music exposure frequency	4.2	4.6	5.9	-2.4	-1.8
Diabetes (self-reported)	4.0	6.1	6.7	-2.4	-2.6
Average weekly fortified wine intake	3.9	4.6	7.8	2.8	1.1
Type 2 Diabetes (T2D) (2012)	3.8	4.4	8.2	-0.7	-2.9
Forced vital capacity (FVC)	3.7	14.3	28.0	-0.8	-5.3
Medication: Aspirin	3.7	4.8	5.6	-2.4	-2.0
Medication: Aspirin	3.7	4.8	6.0	-2.5	-1.9
Tinnitus: Yes, but not now, but have in the past	3.5	3.8	5.2	-1.5	-2.3
Diabetes diagnosed by doctor	3.4	5.6	7.4	-2.7	-2.0
Angina (self-reported)	3.3	4.3	7.7	-2.8	-0.9
Angina	3.2	4.2	7.6	-2.8	-1.0
Ever had prostate specific antigen (PSA) test	3.2	3.7	6.0	-2.4	-1.2
Medication: Co-codamol	3.1	3.6	7.1	0.3	2.7
Trunk fat-free mass	3.1	17.7	33.2	-1.5	-5.8
Forced expiratory volume in 1-second (FEV1)	3.1	10.3	19.0	-1.3	-4.4
Trunk predicted mass	3.1	17.7	32.9	-1.6	-5.7
Pain type(s) experienced in last month: Hip pain	3.1	4.0	5.5	-2.4	-1.6
Fractured/broken bones in last 5 years	3.1	4.0	5.8	-1.5	-2.4
Trunk fat mass	2.9	12.5	14.4	-3.2	-3.8
Supplements: Vitamin C	2.9	3.4	6.8	-0.1	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.3	3.3	1.8	1.8
Arm fat-free mass (left)	2.8	14.4	25.2	-1.9	-5.0
Medication for cholesterol, blood pressure or diabetes	2.7	4.4	7.3	2.7	1.2
Smoking status: Previous	2.7	4.0	5.4	-1.6	-2.3
Illnesses of father: None of the above (group 1)	2.7	3.3	4.6	-1.4	-2.2
High cholesterol (Self-reported)	2.7	4.8	5.6	-2.4	-2.0
Hearing difficulty/problems: Yes	2.6	4.0	7.5	0.7	2.7
Impedance of leg (right)	2.6	12.6	22.8	-1.6	-4.8
Impedance of leg (left)	2.6	12.9	22.8	-1.7	-4.8
Number of self-reported non-cancer illnesses	2.6	4.4	8.1	-2.8	-0.9
Waist Hip Ratio (WHR)	2.5	11.3	19.2	-1.8	-4.4
Weight	2.5	12.1	18.0	-2.5	-4.2
Illnesses of mother	2.5	3.1	6.1	2.5	0.4
Basal metabolic rate	2.5	13.7	24.1	-1.8	-4.9
Arm predicted mass (left)	2.5	12.6	22.6	-1.6	-4.8
Arm fat-free mass (right)	2.4	12.4	21.8	-1.8	-4.7
Handedness (chirality/laterality): Left-handed	2.4	2.9	5.3	-2.3	-0.7
Depression (Nagel 2018)	2.3	3.4	3.9	1.7	2.0
Bipolar Disorder (2011)	2.3	2.2	3.6	1.9	0.9
Had other major operations	2.3	2.8	5.2	-2.3	-0.6
Whole body fat-free mass	2.3	13.2	24.1	-1.5	-4.9
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	2.7	-1.5	-1.6
Whole body fat mass	2.2	9.4	10.7	-2.8	-3.3
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	8.3	-0.9	-2.9
Medication: Gliclazide	2.2	2.5	3.5	-1.9	-1.2
Ever had hysterectomy (womb removed)	2.1	2.3	4.7	-2.2	-0.0
Whole body water mass	2.1	12.0	22.2	-1.4	-4.7
Trunk fat percentage	2.0	7.9	9.9	-3.2	-2.4
Qualifications: A levels/AS levels or equivalent	1.9	4.2	6.0	2.4	1.6
Hair/balding pattern: Pattern 4	1.9	4.6	5.4	-2.3	-1.9
Forced vital capacity (FVC), Best measure	1.9	6.8	13.5	0.0	-3.7
Arm predicted mass (right)	1.9	9.7	18.1	-1.1	-4.2
Ever taken oral contraceptive pill	1.9	2.1	3.0	1.7	1.1
Hair/balding pattern: Pattern 2	1.8	2.2	3.3	1.1	1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	5.2	-1.7	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.9	11.1	-0.8	-3.3
Peak expiratory flow (PEF)	1.8	4.1	4.4	-1.9	-2.1
Suffer from ‘nerves’	1.8	2.8	5.7	-0.0	-2.4
Leg fat mass (left)	1.8	7.0	7.6	-2.5	-2.8
Mean Putamen Volume	1.7	1.9	2.9	-1.7	1.0
Past tobacco smoking	1.7	3.2	4.4	1.4	2.1
Medication: Lansoprazole	1.7	2.0	2.1	1.4	1.4
Mouth/teeth dental problems: Bleeding gums	1.7	2.3	3.5	-1.0	-1.9
Number of children fathered	1.7	1.9	2.7	-1.6	-1.1
Heart disease (mother)	1.7	2.1	2.4	-1.3	-1.6
Body fat percentage	1.6	6.2	8.5	-2.9	-2.0
Leg fat mass (right)	1.6	6.3	6.8	-2.4	-2.6
Family relationship satisfaction	1.6	1.9	3.8	0.1	1.9
Loneliness, isolation	1.6	2.3	4.1	-2.0	-0.7
Age started oral contraceptive pill	1.6	2.0	3.8	1.9	0.5
Supplements: Calcium	1.6	1.8	2.4	-1.1	-1.6
Heart attack/myocardial infarction (self-reported)	1.6	2.1	4.0	-2.0	-0.5
Prostate Cancer	1.5	2.1	3.0	1.7	1.1
Waist circumference	1.5	5.5	7.2	-2.0	-2.7
Vitamin and mineral supplements	1.4	1.9	3.2	-0.8	-1.8
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	2.2	1.2	1.5
Tense / ‘highly strung’	1.4	2.3	4.4	0.4	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	2.8	0.9	1.7
Health satisfaction	1.4	1.9	2.9	0.9	1.7
Hypertension (Self-reported)	1.4	3.8	5.3	-1.5	-2.3
Leg fat percentage (left)	1.4	5.2	6.7	-2.6	-1.9
Vascular/heart problems diagnosed by doctor	1.4	3.8	6.1	1.3	2.5
High blood pressure	1.3	3.5	5.7	-1.1	-2.4
Had menopause	1.3	1.6	2.8	-0.7	-1.7
Heart attack	1.3	1.6	3.2	-1.8	-0.2
Father’s age at death	1.3	1.7	2.5	1.0	1.6
Pulse wave reflection index	1.3	1.6	1.8	-1.2	-1.4
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	1.7	1.3	1.2
Miserableness	1.3	2.3	2.5	1.4	1.6
Rheumatoid Arthritis	1.2	1.6	1.9	1.2	1.4
Lung FEV1/FVC ratio	1.2	6.3	12.3	-3.5	0.6
Severe depression (siblings)	1.2	1.4	1.8	1.3	1.0
Leg fat-free mass (left)	1.2	6.6	11.2	-1.4	-3.4
Leg predicted mass (left)	1.2	6.4	11.0	-1.4	-3.3
Leg fat percentage (right)	1.2	4.4	5.7	-2.4	-1.8
Number of full sisters	1.2	1.5	2.0	-0.9	-1.4
Chest pain or discomfort	1.2	1.7	3.3	-0.0	1.8
Back pain experienced in last month	1.2	1.8	2.4	-1.1	-1.6
Impedance of whole body	1.2	5.9	9.5	-1.5	-3.1
Age at First Birth	1.1	1.7	2.2	-1.5	-1.0
Sensitivity / hurt feelings	1.1	1.8	3.6	-0.2	1.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.3	-1.5	0.4
Age when periods started (menarche)	1.1	2.5	4.4	-0.8	-2.1
High blood pressure (mother)	1.1	1.6	2.9	0.5	1.7
Birth weight of first child	1.1	1.9	2.5	-1.6	-1.2
Exposure to tobacco smoke outside home	1.1	1.4	2.3	0.8	1.5
Qualifications: College or University degree	1.1	3.6	3.6	1.9	1.9
Eye problems/disorders: None of the above	1.1	1.3	2.6	0.2	1.6
Leg fat-free mass (right)	1.1	5.7	9.7	-1.3	-3.1
Leg predicted mass (right)	1.1	5.7	9.6	-1.3	-3.1
Relative age of first facial hair	1.0	2.1	2.9	1.2	1.7
Diabetes (father)	1.0	1.2	2.0	-0.7	-1.4
Maternal smoking around birth	1.0	1.4	2.8	0.0	1.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.4	-1.0	-1.2
Long-standing illness, disability or infirmity	1.0	1.6	3.1	-1.8	-0.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.6	1.6	0.3
Ever depressed for a whole week	1.0	1.3	2.5	0.2	1.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.4	-1.6	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.5	-0.8	-1.9
Pain all over the body in last month	0.9	0.9	1.2	1.1	0.8
Impedance of arm (right)	0.9	4.4	6.7	-1.5	-2.6
Falls in the last year	0.9	1.2	1.9	-0.8	1.4
Length of working week for main job	0.9	1.0	1.0	-1.0	-0.9
Illnesses of siblings: Diabetes	0.9	1.1	1.8	-0.7	-1.3
Friendships satisfaction	0.9	1.1	2.2	-0.2	1.5
Arm fat mass (left)	0.9	3.6	4.8	-2.2	-1.5
Alcohol drinker status: Never	0.9	1.1	1.9	-1.4	0.6
Diastolic blood pressure, automated reading	0.9	2.6	4.7	2.2	0.8
Coronary Artery Disease (CAD)	0.8	0.9	1.4	-0.7	-1.2
Fasting Glucose	0.8	1.0	1.0	0.9	1.0
Ulcerative Colitis	0.8	1.1	1.2	1.1	1.0
Cardiovascular Disease	0.8	2.5	2.8	-1.5	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.1	0.5	1.4
Hip circumference	0.8	3.5	3.8	-1.8	-1.9
Arm fat mass (right)	0.8	3.4	5.0	-2.2	-1.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.3	1.5	0.5
Medication: Blood pressure	0.8	1.4	2.8	-1.7	-0.2
Medication: Ibuprofen	0.8	0.9	1.8	1.3	0.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.5	-1.2	-0.5
Hearing aid user	0.8	0.9	1.8	-0.1	1.4
Mother’s age at death	0.8	1.0	1.8	-1.4	-0.3
LDL Cholesterol	0.7	1.1	1.8	-1.3	-0.7
Taking other prescription medications	0.7	1.0	2.0	-1.4	-0.1
Stomach or abdominal pain in last month	0.7	0.9	1.8	-0.1	1.3
Hearing difficulty/problems with background noise	0.7	1.1	2.2	-0.0	1.5
Happiness	0.7	0.8	1.3	-0.5	1.2
Depression (self-reported)	0.7	0.8	1.7	0.0	1.3
Comparative body size at age 10	0.7	2.0	2.8	1.1	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.8	-1.3	-0.0
Guilty feelings	0.7	1.1	2.2	-0.2	1.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	0.9	1.0	0.8
Myopia	0.7	1.1	2.0	1.4	-0.3
Alzheimer’s Disease (including proxy)	0.6	0.9	0.9	-0.9	0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.3	-0.9	-1.5
Triglycerides	0.6	0.9	1.6	-0.6	-1.2
Number of treatments/medications taken	0.6	1.2	2.3	-1.5	-0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.6	1.3	-0.2
Chronic bronchitis/emphysema (father)	0.6	0.7	0.8	0.7	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.5	1.2	0.2
Ever had bowel cancer screening	0.6	0.6	1.1	-1.0	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.2	0.8	1.1
Medication for cholesterol	0.6	0.8	0.9	1.0	0.9
Mineral and other dietary supplements	0.6	0.8	1.5	-1.2	-0.3
Financial situation satisfaction	0.6	0.7	1.3	-1.1	-0.4
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	-1.1	-0.4
Number of operations (self-reported)	0.6	0.9	1.3	-1.1	-0.7
Pain experienced in last month	0.6	1.0	1.8	1.3	0.4
Pack years of smoking	0.6	0.9	1.5	-1.2	-0.5
Bipolar Disorder (2018)	0.5	0.8	1.0	1.0	0.9
Depressed Affect (Nagel 2018)	0.5	1.1	1.1	1.0	1.1
Reaction Time	0.5	1.0	1.2	0.9	1.1
Ovarian Cancer	0.5	0.7	1.3	0.3	1.1
HDL Cholesterol	0.5	0.9	1.3	-0.6	1.2
Neuroticism (2016)	0.5	0.7	1.3	-0.4	1.1
Heel T-Score	0.5	3.6	5.9	1.2	-2.4
BMI	0.5	2.8	5.1	0.7	2.3
Respiratory disease	0.5	1.1	2.1	1.5	0.2
Townsend deprivation index at recruitment	0.5	0.6	0.8	0.7	0.9
Supplements: Glucosamine	0.5	0.6	0.7	0.9	-0.7
Nervous feelings	0.5	0.9	1.8	1.3	-0.2
Financial difficulties in last 2 years	0.5	0.7	1.2	1.1	-0.3
Allergy	0.5	1.2	2.4	-0.2	-1.5
Arm fat percentage (right)	0.5	2.0	4.1	-2.0	-0.0
Pulse wave Arterial Stiffness index	0.5	0.6	0.8	-0.6	-0.9
Breastfed as a baby	0.5	0.6	0.8	0.6	-0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	-1.0	-0.2
Worry too long after embarrassment	0.5	0.8	1.1	0.7	1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	1.5	1.2	0.5
Pulse rate, automated reading	0.5	1.5	1.9	-1.4	-1.1
Age at last live birth	0.5	0.7	1.4	-0.0	1.2
Arm fat percentage (left)	0.5	2.0	4.0	-2.0	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.1	0.2	1.0
Breast cancer (self-reported)	0.5	0.5	0.7	0.8	0.6
Osteoarthritis (self-reported)	0.5	0.7	1.2	-1.1	0.4
Average weekly champagne plus white wine intake	0.5	0.7	1.2	1.1	0.4
Ever smoked	0.5	0.9	1.8	0.1	-1.3
Worry (Nagel 2018)	0.4	0.9	1.2	0.7	-1.1
Smoking Status	0.4	1.0	1.7	-0.5	-1.3
Medication for hormone replacement therapy	0.4	0.5	0.5	-0.7	0.6
Diabetes (mother)	0.4	0.5	1.0	-1.0	-0.1
Serious illness, injury or assault to yourself	0.4	0.5	0.9	-1.0	-0.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.6	0.1	1.3
Multivitamins +/- minerals	0.4	0.6	0.6	0.8	0.7
Medication: Atenolol	0.4	0.5	0.5	0.7	0.7
Time employed in main current job	0.4	0.4	0.6	0.8	-0.5
Alcohol intake versus 10 years previously	0.4	0.6	1.1	-0.2	1.0
Prospective memory result	0.4	0.5	0.8	-0.4	-0.9
Lung cancer (father)	0.4	0.4	0.9	-0.9	-0.1
Impedance of arm (left)	0.4	1.8	2.5	-1.0	-1.6
Exposure to tobacco smoke at home	0.4	0.4	0.8	0.9	-0.2
Birth weight	0.4	1.0	1.7	-0.5	-1.3
High blood pressure (siblings)	0.4	0.6	1.1	-0.4	1.1
Neck or shoulder pain in last month	0.4	0.6	1.0	-1.0	0.3
Medication: Allopurinol	0.4	0.5	0.7	-0.8	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	0.1	-0.9
Qualifications: nursing, teaching	0.4	0.6	0.8	0.6	0.9
Eye problems/disorders: Cataract	0.4	0.5	0.9	-0.2	-0.9
Wears glasses or contact lenses	0.4	0.5	0.9	-1.0	-0.2
Commuting to job workplace: Public transport	0.4	0.5	0.7	0.6	-0.8
Medication: Blood pressure	0.4	0.7	1.1	0.5	-1.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-0.0	1.0
Bipolar Disorder or Schizophrenia	0.3	0.6	1.1	0.4	1.1
Intelligence (Savage-Jansen 2018)	0.3	1.1	1.6	-0.7	-1.3
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	0.8	0.2
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	-0.8	0.0
Lupus	0.3	0.5	0.9	-1.0	0.2
Schizophrenia (2014)	0.3	0.8	1.5	-0.0	1.2
Blood Platelet Count	0.3	3.8	5.0	-1.6	2.2
Allergy or Eczema	0.3	0.9	1.5	0.5	1.2
Average weekly spirits intake	0.3	0.4	0.7	0.3	-0.8
Systolic blood pressure, automated reading	0.3	1.0	1.3	-0.8	-1.1
Supplements: Zinc	0.3	0.3	0.6	0.1	0.8
Pack years adult smoking proportion	0.3	0.5	0.7	-0.8	-0.5
Qualifications: CSEs or equivalent	0.3	0.3	0.5	0.4	0.7
Medication: Levothyroxine sodium	0.3	0.5	0.6	0.5	0.8
Body mass index (BMI)	0.3	1.2	1.3	-1.1	1.1
Pulse rate	0.3	0.5	0.6	-0.6	-0.8
Asthma	0.3	0.6	1.1	1.1	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	0.9	0.0
Number of full brothers	0.3	0.3	0.7	0.1	-0.8
Age at first live birth	0.3	0.5	1.0	-0.1	1.0
Overall health rating	0.3	0.7	0.9	-1.0	0.7
Leg pain on walking	0.3	0.4	0.7	-0.3	0.8
Illnesses of father: Heart disease	0.3	0.5	0.9	0.0	-0.9
Commuting to job workplace: Walk	0.3	0.3	0.5	0.7	0.3
Asthma (self-reported)	0.3	0.5	0.9	0.9	0.4
Unable to work because of sickness or disability	0.3	0.3	0.5	-0.7	-0.4
Alcohol drinker status: Previous	0.3	0.3	0.7	-0.1	-0.8
Ulcerative Colitis (UC)	0.2	0.4	0.4	0.7	0.6
Crohns Disease (2012)	0.2	0.3	0.6	-0.1	-0.8
HbA1C	0.2	0.2	0.5	0.7	-0.1
Blood Red Count	0.2	2.4	4.7	-0.4	2.2
Blood White Count	0.2	1.7	2.0	-1.2	1.4
Hypothyroidism (self reported)	0.2	0.4	0.8	-0.3	0.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	0.7	0.3
Fed-up feelings	0.2	0.4	0.7	0.9	-0.2
Qualifications: None of the above	0.2	0.4	0.4	-0.6	-0.6
Medication: Ramipril	0.2	0.3	0.5	-0.1	0.7
Worrier / anxious feelings	0.2	0.3	0.3	0.5	-0.6
Noisy workplace	0.2	0.3	0.6	0.2	-0.8
Mouth/teeth dental problems: Dentures	0.2	0.4	0.6	-0.3	0.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.0	0.6
Medication: Amlodipine	0.2	0.3	0.5	-0.7	-0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	0.2	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.2	0.5	0.4
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.7	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.2	0.4	0.5
Emphysema/chronic bronchitis	0.2	0.2	0.3	0.4	0.5
Had major operations	0.2	0.3	0.4	-0.7	-0.4
Average weekly red wine intake	0.2	0.4	0.6	-0.8	-0.3
Osteoporosis (self-reported)	0.2	0.3	0.6	0.8	0.0
Smoking status: Current	0.2	0.4	0.4	0.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.5	-0.5	-0.7
Risk taking	0.2	0.3	0.6	0.1	-0.8
Commuting to job workplace: Cycle	0.2	0.2	0.4	0.1	-0.6
Neuroticism (Nagel 2018)	0.1	0.2	0.2	0.5	0.5
Schizophrenia (2018)	0.1	0.3	0.5	-0.3	0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.0	0.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.2	0.4	0.4
Breast Cancer	0.1	0.3	0.6	0.8	0.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.1	0.3	0.4
Primary Biliary Cirrhosis	0.1	0.2	0.2	-0.5	-0.3
Systolic Blood Pressure	0.1	0.4	0.8	0.2	-0.9
Hair Pigment	0.1	4.1	7.0	-1.1	-2.6
Current tobacco smoking	0.1	0.1	0.3	0.2	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.1	0.2	0.3
Relative age voice broke	0.1	0.1	0.2	-0.2	-0.5
Number of incorrect matches in round	0.1	0.1	0.2	-0.3	0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.1	0.5
Mouth/teeth dental problems	0.1	0.2	0.3	0.1	-0.5
Fluid intelligence score	0.1	0.1	0.2	-0.4	0.3
Neuroticism score	0.1	0.2	0.3	0.6	0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	0.3	0.4
Number of live births	0.1	0.1	0.1	0.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.3	0.6
Headache pain in last month	0.1	0.2	0.3	-0.5	-0.2
Glaucoma (self-reported)	0.1	0.1	0.2	0.4	0.2
Gout (self-reported)	0.1	0.2	0.4	-0.1	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.5	0.2	0.7
Migraine (self-reported)	0.1	0.2	0.2	-0.5	-0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.1	-0.3	-0.2
Alcohol intake frequency.	0.1	0.3	0.3	-0.5	0.5
Knee pain experienced in last month	0.1	0.2	0.2	-0.4	-0.5
Mood swings	0.1	0.2	0.5	-0.1	0.7
Medication: Bendroflumethiazide	0.1	0.1	0.1	-0.2	0.4
Medication: Paracetamol	0.1	0.1	0.2	-0.2	0.5
Medication: Lisinopril	0.1	0.2	0.3	-0.2	-0.6
Average weekly beer plus cider intake	0.1	0.1	0.2	0.0	-0.4
Irritability	0.1	0.1	0.2	-0.0	-0.5
Heart disease (siblings)	0.1	0.1	0.2	-0.1	0.5
Crohns Disease (2017)	0.0	0.0	0.0	0.0	0.2
Major Depression (MDD)	0.0	0.0	0.0	-0.1	0.1
Blood Eosinophil Count	0.0	0.1	0.1	0.3	-0.2
Lung FVC	0.0	0.1	0.2	-0.2	-0.4
Neuroticism	0.0	0.1	0.2	0.5	-0.1
Chronotype (morning person)	0.0	0.0	0.1	0.2	0.3
Tanning	0.0	0.4	0.6	0.4	0.7
Alcohol usually taken with meals	0.0	0.0	0.1	-0.1	-0.2
Illnesses of siblings	0.0	0.1	0.1	0.3	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	0.0	-0.3
Blood clot in the leg (DVT)	0.0	0.0	0.0	0.2	0.0
Medication: Paracetamol	0.0	0.0	0.0	-0.1	-0.1
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	0.4	0.0
Pulse wave peak to peak time	0.0	0.1	0.1	0.3	0.1
Medication: Omeprazole	0.0	0.1	0.1	0.3	-0.1
Mean time to correctly identify matches	0.0	0.0	0.0	-0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.0	0.1
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	0.2	-0.1

Hub : Genes

ZNF678

Models

Trait associations