TWAS hub - LOC100130093

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0890	0.0300	2.5e-07	0.074	0.070	0.098	0.074	0.085	2.2e-09	7.5e-09	5.6e-12	2.6e-09	1.8e-10
2	TCGA	Breast Invasive Carcinoma	0.0202	0.0141	1.5e-03	0.014	0.009	0.007	NA	0.009	6.6e-04	4.0e-03	1.2e-02	NA	4.0e-03
3	TCGA	Lung Adenocarcinoma	0.0333	0.0197	1.3e-03	0.018	0.028	0.034	NA	0.033	3.1e-03	3.1e-04	7.2e-05	NA	7.8e-05
4	TCGA	Pheochromocytoma and Paraganglioma	0.1580	0.0960	2.6e-04	0.101	0.050	0.048	NA	0.013	7.9e-05	4.7e-03	5.5e-03	NA	9.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Illnesses of father: High blood pressure	9.0	11.1	15.9	-2.6	-3.5	-3.1	-4.0
Medication: Metformin	8.3	11.6	15.6	3.0	4.0	3.4	3.3
Medication: Gliclazide	7.5	8.5	13.8	3.7	3.2	2.4	2.1
Hand grip strength (right)	6.3	17.0	30.4	3.2	3.8	3.5	5.5
Type 2 Diabetes (T2D) (2018)	6.0	11.3	15.0	2.8	3.9	3.4	3.3
Smoking status: Previous	6.0	9.0	9.9	2.8	3.1	3.0	3.1
Hand grip strength (left)	5.9	15.6	31.1	2.9	3.5	3.2	5.6
Medication: Co-codamol	5.8	6.8	9.3	-2.0	-2.7	-2.5	-3.0
Height	5.7	109.2	210.2	9.2	9.4	7.3	14.5
Standing height	5.1	50.8	100.0	6.3	6.4	4.8	10.0
Past tobacco smoking	5.0	9.1	11.1	-2.8	-3.1	-3.3	-2.9
Medication: Cholesterol lowering	5.0	7.7	9.4	2.3	3.0	2.7	3.1
Illnesses of father: None of the above (group 1)	5.0	6.1	8.1	2.0	2.6	2.4	2.8
Sitting height	4.6	32.9	60.2	5.3	5.2	4.1	7.8
Tinnitus: Yes, but not now, but have in the past	4.3	4.6	6.0	1.3	2.5	2.1	2.4
Medication: Atorvastatin	4.2	5.2	8.4	1.1	2.6	2.1	2.9
Qualifications: A levels/AS levels or equivalent	4.1	9.1	11.0	-2.9	-3.1	-3.3	-2.7
Number of full sisters	4.1	5.0	6.7	1.9	2.6	2.5	1.8
Heart disease (mother)	4.0	4.9	6.4	2.5	2.3	1.9	2.0
Cholesterol lowering medication	3.8	5.6	8.4	1.4	2.7	2.1	2.9
Average weekly fortified wine intake	3.6	4.2	6.2	-1.0	-2.3	-2.5	-2.1
Family relationship satisfaction	3.6	4.4	4.7	-2.2	-2.1	-2.1	-2.0
Impedance of leg (left)	3.5	16.8	19.4	3.3	4.4	4.2	4.4
Father’s age at death	3.5	4.7	5.8	-2.4	-2.4	-2.1	-1.8
Vascular/heart problems diagnosed by doctor	3.5	9.6	12.7	-3.6	-3.0	-3.2	-2.5
Hypertension (Self-reported)	3.3	9.1	12.5	3.5	2.8	3.0	2.6
Type 2 Diabetes (T2D) (2012)	3.2	3.7	5.0	1.5	2.0	1.9	2.2
Medication: Aspirin	3.2	4.2	6.1	1.2	2.4	1.9	2.5
Supplements: Vitamin C	3.2	3.7	6.7	-1.6	-1.8	-1.5	-2.6
Diabetes (self-reported)	3.1	4.7	7.1	1.6	2.4	2.0	2.7
Number of self-reported non-cancer illnesses	3.1	5.4	8.1	1.8	2.9	2.5	2.0
Ever depressed for a whole week	3.1	3.8	8.0	-2.8	-1.6	-1.4	-1.7
Bipolar Disorder (2011)	3.0	2.9	5.3	-1.5	-1.5	-2.3	-1.3
High blood pressure	3.0	8.5	10.9	3.3	2.8	3.0	2.5
Loud music exposure frequency	3.0	3.3	4.8	1.4	1.9	2.2	1.6
Medication: Aspirin	3.0	3.8	5.6	1.1	2.3	1.8	2.4
Miserableness	3.0	5.3	8.5	-1.8	-2.9	-2.3	-2.1
Smoking Status	2.8	6.6	10.1	2.6	2.5	3.2	1.8
Impedance of leg (right)	2.8	13.7	17.6	3.0	4.0	3.5	4.2
Comparative height size at age 10	2.8	15.6	32.9	3.0	3.5	2.8	5.7
Peak expiratory flow (PEF)	2.7	6.3	6.9	2.6	2.6	2.4	2.5
Diabetes diagnosed by doctor	2.7	4.4	5.7	1.6	2.4	1.9	2.3
Neuroticism (2016)	2.5	3.6	4.3	-2.1	-2.0	-1.9	-1.6
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	5.2	-1.9	-2.1	-2.3	-1.5
Arm fat-free mass (left)	2.5	12.8	22.1	3.6	3.2	2.4	4.7
Vitamin and mineral supplements	2.3	3.1	4.7	1.7	1.8	1.1	2.2
Trunk fat-free mass	2.3	12.9	25.7	3.5	3.0	2.1	5.1
Trunk predicted mass	2.3	13.1	25.8	3.5	3.0	2.2	5.1
Leg fat percentage (left)	2.3	8.4	11.0	2.4	3.2	3.3	2.6
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	4.4	1.2	2.1	1.4	1.6
Trunk fat mass	2.2	9.6	13.3	2.5	3.2	3.0	3.7
Forced vital capacity (FVC)	2.2	8.5	17.8	2.7	2.4	1.9	4.2
Forced expiratory volume in 1-second (FEV1)	2.1	7.2	11.7	2.7	2.3	2.1	3.4
Lung cancer (father)	2.1	2.4	5.5	2.3	1.1	1.5	0.7
Pulse wave reflection index	2.1	2.6	3.6	1.9	1.7	1.1	1.6
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	3.9	1.6	1.3	2.0	1.6
Worry too long after embarrassment	2.1	3.5	7.3	-2.7	-1.6	-1.8	-1.0
Medication: Seretide 50 evohaler	2.1	2.4	4.7	2.2	1.4	1.4	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	4.1	1.2	2.0	1.9	0.9
Arm predicted mass (left)	2.1	10.8	19.2	3.3	2.9	2.1	4.4
Relative age of first facial hair	2.0	4.1	7.3	-0.8	-2.1	-2.7	-2.0
Severe depression (siblings)	1.9	2.2	3.3	-1.8	-1.5	-0.9	-1.5
Medication: Simvastatin	1.9	2.8	4.0	1.2	1.9	1.5	2.0
Weight	1.9	9.1	15.4	2.6	2.8	2.5	3.9
Leg fat percentage (right)	1.9	6.8	8.7	2.1	2.9	2.9	2.4
Arm fat-free mass (right)	1.9	9.9	18.8	3.0	2.8	2.0	4.3
Whole body fat mass	1.9	7.9	10.5	2.2	2.9	2.8	3.2
Ever taken oral contraceptive pill	1.9	2.2	2.9	-1.4	-1.3	-1.7	-1.4
Fasting Glucose	1.8	2.2	3.1	-1.5	-1.3	-1.8	-1.3
Medication: Lansoprazole	1.8	2.1	2.6	-1.4	-1.4	-1.6	-1.4
Qualifications: College or University degree	1.8	5.8	6.8	-2.6	-2.6	-2.0	-2.4
Supplements: Calcium	1.8	2.0	2.6	1.2	1.4	1.6	1.4
Leg fat mass (left)	1.8	7.2	8.7	2.0	2.8	2.9	2.9
Crohns Disease (2012)	1.7	2.7	3.7	1.6	1.9	1.7	1.3
Waist Hip Ratio (WHR)	1.7	7.4	12.7	1.8	2.9	2.3	3.6
Hearing difficulty/problems: Yes	1.7	2.6	5.9	-1.1	-1.5	-1.1	-2.4
Exposure to tobacco smoke outside home	1.7	2.2	3.1	-1.0	-1.8	-1.5	-1.6
Number of children fathered	1.7	1.9	2.1	1.4	1.3	1.4	1.4
Pain type(s) experienced in last month: Hip pain	1.7	2.2	4.7	0.3	1.4	1.4	2.2
Basal metabolic rate	1.7	9.2	18.6	2.8	2.5	1.9	4.3
Hair/balding pattern: Pattern 2	1.6	2.0	3.8	-0.2	-1.6	-1.3	-1.9
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.6	-1.9	-1.4	-1.0	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	3.2	-0.3	-1.5	-1.6	-1.8
Leg fat mass (right)	1.6	6.4	7.7	1.9	2.6	2.7	2.8
Ever smoked	1.6	2.8	3.4	1.6	1.6	1.8	1.7
Coronary Artery Disease (CAD)	1.5	1.8	2.5	0.6	1.6	1.3	1.6
Cardiovascular Disease	1.5	4.9	6.1	2.5	2.2	2.4	1.7
Angina	1.5	1.9	3.4	0.6	1.8	1.4	1.4
Trunk fat percentage	1.5	5.8	7.3	1.7	2.6	2.7	2.5
Body fat percentage	1.5	5.9	7.8	1.8	2.7	2.8	2.3
Angina (self-reported)	1.5	2.0	3.6	0.6	1.9	1.4	1.4
Arm predicted mass (right)	1.5	7.6	14.7	2.7	2.3	1.6	3.8
Whole body fat-free mass	1.5	8.3	17.8	2.8	2.3	1.6	4.2
Financial situation satisfaction	1.5	1.9	2.4	1.5	1.6	1.5	0.9
Fractured/broken bones in last 5 years	1.5	1.9	3.7	0.8	1.7	0.8	1.9
Depression (Nagel 2018)	1.4	2.1	3.6	-0.8	-1.7	-1.1	-1.9
Noisy workplace	1.4	1.7	2.8	1.3	1.0	1.7	1.2
Handedness (chirality/laterality): Left-handed	1.4	1.6	2.4	1.3	1.2	1.6	0.9
High cholesterol (Self-reported)	1.4	2.5	4.6	0.8	1.8	1.3	2.1
Basal cell carcinoma (self-reported)	1.4	1.6	1.7	-1.3	-1.3	-1.3	-1.2
Sensitivity / hurt feelings	1.3	2.3	3.0	-1.5	-1.3	-1.5	-1.7
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	2.5	-1.1	-1.6	-1.5	-1.5
Had menopause	1.3	1.6	3.0	0.7	1.5	0.9	1.7
Had other major operations	1.3	1.6	2.2	0.9	1.5	1.4	1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	3.8	1.5	1.7	1.6	1.9
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	2.3	-1.5	-1.5	-1.4	-1.5
Ever had bowel cancer screening	1.3	1.5	2.6	1.6	1.5	0.9	0.7
Whole body water mass	1.3	7.3	16.1	2.6	2.1	1.4	4.0
Waist circumference	1.2	4.3	6.6	1.4	2.2	1.9	2.6
Nervous feelings	1.2	2.3	3.8	-1.1	-1.9	-1.9	-0.6
Pulse wave Arterial Stiffness index	1.2	1.4	2.6	1.6	1.1	0.9	0.9
Tense / ‘highly strung’	1.2	1.9	2.9	0.8	1.3	1.6	1.7
Heart attack/myocardial infarction (self-reported)	1.2	1.5	2.2	0.9	1.5	1.5	0.9
Reaction Time	1.1	2.0	2.9	-0.5	-1.6	-1.7	-1.6
Systolic blood pressure, automated reading	1.1	3.2	4.1	1.8	2.0	1.6	1.6
Depression (self-reported)	1.1	1.3	2.1	-1.4	-1.0	-0.5	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.5	1.2	1.1	1.0	1.1
Medication for cholesterol	1.1	1.6	1.7	-1.1	-1.3	-1.3	-1.3
Wears glasses or contact lenses	1.1	1.3	2.1	0.5	1.4	1.5	1.0
Unable to work because of sickness or disability	1.1	1.4	2.2	1.5	1.0	1.3	0.8
Ovarian Cancer	1.0	1.3	3.0	-1.7	-0.9	-0.3	-1.1
Triglycerides	1.0	1.7	2.0	1.3	1.4	1.3	1.2
High blood pressure (mother)	1.0	1.4	2.9	-0.3	-1.5	-0.6	-1.7
Illnesses of mother	1.0	1.3	1.6	-1.1	-1.2	-1.3	-0.9
Length of working week for main job	1.0	1.1	1.8	0.2	1.4	1.4	0.7
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.8	-1.3	-0.8	-1.0	-1.2
Age started oral contraceptive pill	1.0	1.2	2.3	-1.0	-1.0	-1.5	-0.6
Commuting to job workplace: Cycle	1.0	1.2	2.0	-1.4	-1.1	-1.2	-0.2
Rheumatoid Arthritis	0.9	1.2	2.0	-0.5	-1.0	-1.3	-1.4
Medication: Levothyroxine sodium	0.9	1.4	2.6	-0.9	-1.6	-1.3	-0.8
Heart attack	0.9	1.2	2.0	0.8	1.4	1.4	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	5.4	1.8	1.2	1.0	2.3
Hair/balding pattern: Pattern 4	0.9	2.2	3.6	0.8	1.4	1.6	1.9
Gout (self-reported)	0.9	1.3	1.9	0.9	1.3	1.4	0.8
Migraine (self-reported)	0.9	1.1	1.8	1.3	0.9	1.0	0.7
Illnesses of siblings: Diabetes	0.9	1.1	1.9	-0.2	1.4	0.9	1.4
Osteoporosis (self-reported)	0.9	1.2	1.5	-1.2	-1.1	-1.2	-0.7
Guilty feelings	0.9	1.4	2.6	-1.2	-1.0	-0.7	-1.6
Schizophrenia vs Biploar Disorder	0.8	1.1	2.2	-1.5	-0.9	-0.6	-0.9
Prostate Cancer	0.8	1.2	2.2	-0.4	-1.5	-1.0	-1.1
Eye problems/disorders: None of the above	0.8	0.9	1.4	-1.2	-0.6	-0.7	-1.1
Age at last live birth	0.8	1.2	1.5	-0.9	-1.2	-1.2	-0.9
Average weekly red wine intake	0.8	1.2	1.9	0.8	1.4	1.4	0.8
Loneliness, isolation	0.8	1.1	1.5	1.2	1.0	1.2	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.2	-1.0	-1.1	-1.0	-0.9
Bipolar Disorder (2018)	0.7	1.1	2.1	-0.7	-1.0	-1.4	-0.9
Number of treatments/medications taken	0.7	1.2	2.0	0.9	1.4	1.2	0.7
Pack years adult smoking proportion	0.7	1.0	2.2	1.5	0.7	1.1	0.6
Falls in the last year	0.7	1.0	1.4	-1.2	-0.9	-0.8	-1.0
Headache pain in last month	0.7	1.2	1.9	1.4	1.2	1.1	0.7
Forced vital capacity (FVC), Best measure	0.7	2.6	6.9	1.4	1.1	0.6	2.6
Comparative body size at age 10	0.7	1.9	3.6	-0.6	-1.8	-0.7	-1.9
Health satisfaction	0.7	0.9	2.0	-0.1	-1.0	-0.8	-1.4
Suffer from ‘nerves’	0.7	1.1	3.3	1.0	0.3	0.4	1.8
Impedance of whole body	0.7	3.7	5.5	1.1	2.1	1.9	2.3
Breast Cancer	0.6	1.4	4.3	2.1	0.6	0.7	0.6
LDL Cholesterol	0.6	0.9	1.3	0.4	1.1	1.1	1.0
Lupus	0.6	0.9	1.3	-1.1	-1.0	-1.1	-0.0
Age when periods started (menarche)	0.6	1.4	2.9	1.3	0.8	0.7	1.7
Qualifications: CSEs or equivalent	0.6	0.8	1.2	0.3	-0.9	-1.1	-0.9
Hearing difficulty/problems with background noise	0.6	1.0	1.8	-1.0	-0.6	-0.8	-1.4
Pulse wave peak to peak time	0.6	0.7	1.5	-1.2	-0.7	-0.7	-0.4
Emphysema/chronic bronchitis	0.6	0.6	1.6	-1.3	-0.7	-0.2	-0.6
Medication for pain relief, constipation, heartburn	0.6	1.0	1.5	-1.0	-1.2	-0.8	-1.0
Chest pain or discomfort	0.6	0.8	1.9	-0.5	-0.7	-0.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.1	1.2	0.6	0.4	1.8
Qualifications: nursing, teaching	0.6	0.9	1.5	-0.9	-1.2	-0.8	-0.9
Back pain experienced in last month	0.6	0.9	1.9	0.2	0.8	1.1	1.4
Breast cancer (self-reported)	0.6	0.7	0.9	-0.9	-0.9	-0.9	-0.6
Medication: Blood pressure	0.6	1.2	2.6	1.6	0.8	0.9	0.9
Pack years of smoking	0.6	0.9	1.7	1.3	0.7	0.9	0.7
Alzheimer’s Disease (in mother)	0.5	0.5	1.0	0.5	1.0	0.9	0.4
Age at First Birth	0.5	0.7	1.1	0.4	1.0	0.7	1.0
Ulcerative Colitis	0.5	0.7	1.1	-0.9	-0.8	-1.1	-0.7
Systolic Blood Pressure	0.5	2.5	4.3	2.1	1.9	1.1	1.0
Supplements: Zinc	0.5	0.5	1.3	-0.2	-0.8	-0.5	-1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.3	-0.2	0.7	0.5	1.2
Time employed in main current job	0.5	0.5	1.0	-0.1	0.8	1.0	0.7
Asthma	0.5	1.0	1.5	1.2	1.1	0.8	0.6
Arm fat mass (right)	0.5	2.1	2.6	1.1	1.5	1.6	1.5
Exposure to tobacco smoke at home	0.5	0.5	0.9	0.6	1.0	0.8	0.5
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.0	-0.8	-1.4	-0.7	-0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.7	0.8	0.8	0.8	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	-0.6	-0.2	-0.4	-1.4
Commuting to job workplace: Walk	0.5	0.5	0.8	-0.4	-0.9	-0.7	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.4	-0.6	-1.0	-0.8	-1.2
Arm fat mass (left)	0.5	1.9	2.7	0.9	1.4	1.5	1.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	-1.0	-0.7	-0.6	-0.8
Medication: Lisinopril	0.5	0.6	1.0	-0.9	-1.0	-0.8	0.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.7	0.8	0.7	0.6	0.8
Pain experienced in last month	0.5	0.8	1.4	-0.3	-1.2	-0.7	-1.0
Heart disease (siblings)	0.5	0.7	1.3	0.8	1.1	0.8	-0.1
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	0.2	0.7	0.9	0.5
Leg fat-free mass (left)	0.4	2.3	6.8	1.2	0.9	0.5	2.6
Leg predicted mass (left)	0.4	2.2	6.5	1.1	0.8	0.4	2.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	-1.0	0.3	0.4	-0.7
Alcohol intake versus 10 years previously	0.4	0.6	0.8	-0.8	-0.4	-0.9	-0.8
Happiness	0.4	0.5	1.3	0.2	-0.7	-0.2	-1.1
Prospective memory result	0.4	0.5	1.2	1.1	0.5	0.2	0.8
Blood clot in the leg (DVT)	0.4	0.5	0.7	0.9	0.6	0.7	0.6
Medication: Paracetamol	0.4	0.6	1.7	1.3	0.7	0.5	0.4
Medication: Amlodipine	0.4	0.5	1.3	1.1	0.4	0.3	0.7
Birth weight	0.4	1.0	3.5	-1.9	0.0	0.1	0.5
Medication: Blood pressure	0.4	0.6	0.9	1.0	0.8	0.9	0.6
Leg pain on walking	0.4	0.4	0.6	-0.6	-0.8	-0.6	-0.7
Leg fat-free mass (right)	0.4	2.1	6.0	1.1	0.8	0.6	2.4
Friendships satisfaction	0.4	0.5	1.1	-0.3	-0.7	-0.5	-1.0
Leg predicted mass (right)	0.4	2.0	5.8	1.1	0.8	0.5	2.4
Number of operations (self-reported)	0.4	0.6	0.9	0.9	0.7	0.6	0.8
Risk taking	0.4	0.6	1.0	-0.3	1.0	0.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	0.6	0.8	0.8	0.7	0.7
Alcohol drinker status: Previous	0.4	0.4	0.7	0.3	0.8	0.5	0.8
Depressed Affect (Nagel 2018)	0.3	0.7	1.1	-0.8	-1.1	-0.4	-0.9
HDL Cholesterol	0.3	0.5	1.3	-1.2	-0.2	0.2	-0.7
Heel T-Score	0.3	2.5	4.0	1.3	1.9	1.0	2.0
BMI	0.3	1.7	3.3	-1.1	-1.4	-0.5	-1.8
Hypothyroidism (self reported)	0.3	0.6	1.0	-0.5	-1.0	-0.6	-0.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	0.2	-0.5	-0.9	-0.3
Maternal smoking around birth	0.3	0.5	1.5	-0.7	-0.2	0.0	-1.2
Taking other prescription medications	0.3	0.4	0.7	0.2	0.8	0.8	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.6	0.5	0.7	0.5	1.3
Medication: Atenolol	0.3	0.4	0.5	0.7	0.5	0.7	-0.5
Pain all over the body in last month	0.3	0.3	0.8	-0.2	-0.4	-0.5	-0.9
Fluid intelligence score	0.3	0.6	1.7	-1.3	-0.4	-0.6	-0.3
Neuroticism score	0.3	0.6	0.8	-0.9	-0.9	-0.6	-0.4
Impedance of arm (right)	0.3	1.2	2.7	0.2	1.1	1.0	1.6
Hip circumference	0.3	1.4	3.1	0.8	1.0	0.9	1.8
Worrier / anxious feelings	0.3	0.6	1.1	-0.8	-0.7	-1.1	-0.1
Number of live births	0.3	0.5	1.2	-0.4	-0.7	-1.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.6	-0.3	-0.7	-0.5	-0.8
Birth weight of first child	0.3	0.5	0.7	-0.7	0.5	0.8	0.8
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.8	-0.9	-0.2	0.3	-0.7
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	0.5	0.9	0.9	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	-1.0	-0.3	-0.5	-0.2
Age at first live birth	0.3	0.5	1.0	-1.0	-0.5	-0.5	-0.6
Medication: Ibuprofen	0.3	0.4	0.6	-0.6	-0.8	-0.6	-0.6
Medication: Allopurinol	0.3	0.5	0.8	0.3	0.8	0.9	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.8	0.9	0.1	0.6	-0.3
Eye problems/disorders: Cataract	0.3	0.3	0.7	0.2	0.8	0.2	0.8
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	0.2	0.2	1.0	0.3
Alcohol drinker status: Never	0.3	0.3	0.5	-0.6	-0.6	-0.4	-0.7
Average weekly beer plus cider intake	0.3	0.5	1.0	1.0	0.4	0.8	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.2	0.2	0.9	0.5	1.1
Neuroticism (Nagel 2018)	0.2	0.5	0.8	-0.9	-0.8	-0.5	-0.4
Alzheimer’s Disease (in father)	0.2	0.3	0.6	0.8	0.6	-0.2	-0.2
Ulcerative Colitis (UC)	0.2	0.4	0.5	-0.5	-0.6	-0.7	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.4	-0.0	0.6	0.8	1.2
Allergy or Eczema	0.2	0.5	1.5	-1.2	-0.1	-0.0	-0.6
Respiratory disease	0.2	0.4	0.6	0.5	0.7	0.8	0.4
Lung FEV1/FVC ratio	0.2	1.1	2.7	1.6	0.6	1.0	-0.5
Average weekly spirits intake	0.2	0.2	0.3	0.4	0.5	0.4	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	-0.2	-0.8	-0.3	-0.5
Townsend deprivation index at recruitment	0.2	0.2	0.7	-0.1	-0.4	0.2	-0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.0	-1.0	-0.3	-0.3	-0.7
Multivitamins +/- minerals	0.2	0.3	0.8	0.0	-0.7	-0.0	-0.9
Stomach or abdominal pain in last month	0.2	0.3	0.9	0.1	-0.2	-0.5	-1.0
Supplements: Glucosamine	0.2	0.2	0.5	0.7	0.1	0.3	0.5
Mouth/teeth dental problems	0.2	0.3	0.5	-0.2	0.7	0.6	0.7
Medication: Ramipril	0.2	0.3	0.5	0.2	0.2	0.7	-0.7
Arm fat percentage (right)	0.2	0.7	1.6	0.4	0.9	1.2	0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	-0.6	-0.5	-0.8	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.9	-1.0	0.1	0.0	0.1
High blood pressure (siblings)	0.2	0.3	0.6	-0.4	-0.6	-0.5	-0.7
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.5	0.4	0.7	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.1	-0.4	-0.5	-0.7
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.9	0.4	0.5	0.0
Medication: Omeprazole	0.2	0.2	0.5	0.7	0.5	0.5	0.1
Pulse rate, automated reading	0.2	0.7	1.3	0.5	0.7	0.8	1.1
Had major operations	0.2	0.2	0.3	0.6	0.3	0.5	0.4
Knee pain experienced in last month	0.2	0.3	0.6	0.8	0.4	0.4	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	-0.1	0.8	0.7	-0.1
Asthma (self-reported)	0.2	0.5	0.7	0.8	0.8	0.6	0.3
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.3	0.4	0.7	0.4
Commuting to job workplace: Public transport	0.2	0.2	0.6	-0.8	-0.5	-0.1	0.2
Medication: Paracetamol	0.2	0.3	0.9	1.0	0.4	0.3	-0.3
Irritability	0.2	0.4	0.5	0.7	0.6	0.3	0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	0.8	0.6	0.4	0.1
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	-0.3	-0.2	-0.8	-0.7
Worry (Nagel 2018)	0.1	0.1	0.3	-0.1	-0.5	-0.1	0.6
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	0.4	0.5	-0.1	-0.5
Mean Putamen Volume	0.1	0.2	0.4	-0.6	-0.2	-0.3	-0.3
HbA1C	0.1	0.2	0.3	-0.2	-0.3	0.5	-0.5
Schizophrenia (2014)	0.1	0.3	0.7	-0.7	0.1	-0.2	-0.9
Blood Platelet Count	0.1	0.7	2.7	-0.4	-0.2	-0.3	-1.6
Blood Red Count	0.1	1.4	3.1	-1.8	-0.3	-0.7	-1.3
Blood White Count	0.1	0.4	0.7	-0.3	-0.4	-0.7	-0.9
Neuroticism	0.1	0.3	0.7	-0.7	-0.8	-0.2	-0.2
Hair Pigment	0.1	3.8	5.9	2.2	1.5	1.4	2.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	0.5	0.1	0.4	0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.5	0.4	0.4	0.3
Medication for hormone replacement therapy	0.1	0.1	0.3	0.3	0.6	0.3	0.0
Diabetes (father)	0.1	0.2	0.2	-0.4	-0.2	-0.5	0.4
Current tobacco smoking	0.1	0.2	0.4	0.0	-0.1	0.5	-0.6
Fed-up feelings	0.1	0.1	0.4	-0.1	-0.6	-0.3	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.6	-0.3	0.1	-0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.3	-0.3	-0.2	-0.5
Qualifications: None of the above	0.1	0.2	0.4	-0.4	0.5	0.3	0.7
Financial difficulties in last 2 years	0.1	0.2	0.4	0.3	0.6	0.4	0.3
Allergy	0.1	0.2	0.3	0.5	0.0	0.3	0.5
Illnesses of siblings	0.1	0.2	0.5	0.7	-0.0	0.3	0.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	-0.7	0.2	-0.0	0.2
Pulse rate	0.1	0.2	0.5	0.0	0.7	0.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.3	-0.4	0.3	-0.2
Impedance of arm (left)	0.1	0.2	0.6	-0.8	0.1	-0.0	0.6
Breastfed as a baby	0.1	0.1	0.3	-0.5	-0.0	-0.3	0.4
Glaucoma (self-reported)	0.1	0.1	0.3	-0.1	-0.5	0.2	-0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	0.4	-0.2	-0.2	0.6
Mean time to correctly identify matches	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.3
Alcohol intake frequency.	0.1	0.3	0.5	-0.7	-0.5	-0.5	-0.6
Overall health rating	0.1	0.1	0.3	-0.3	-0.3	0.2	-0.5
Arm fat percentage (left)	0.1	0.3	0.8	-0.1	0.5	0.9	0.0
Mood swings	0.1	0.2	0.3	-0.6	-0.4	-0.2	-0.4
Mineral and other dietary supplements	0.1	0.1	0.3	0.1	0.3	0.1	0.6
Smoking status: Current	0.1	0.2	0.5	-0.1	-0.2	0.5	-0.7
Average weekly champagne plus white wine intake	0.1	0.1	0.4	0.6	0.1	-0.0	-0.3
Hearing aid user	0.1	0.2	0.4	-0.0	-0.0	0.7	-0.4
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.1	-0.5	-0.1	-0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.7	0.8	0.3	0.4	-0.3
Myopia	0.1	0.2	0.6	0.8	0.2	-0.4	-0.1
Schizophrenia (2018)	0.0	0.1	0.3	0.1	0.6	0.1	-0.3
Crohns Disease (2017)	0.0	0.1	0.2	0.4	0.3	0.4	0.0
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	0.3	-0.0	0.1	-0.3
Major Depression (MDD)	0.0	0.0	0.1	0.1	-0.1	0.3	0.0
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.3
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.2	-0.0	-0.0	0.1
Blood Eosinophil Count	0.0	0.3	0.5	-0.5	0.6	0.7	0.4
Lung FVC	0.0	0.1	0.3	-0.0	-0.1	0.0	0.5
Chronotype (morning person)	0.0	0.1	0.2	-0.3	-0.1	-0.4	-0.4
Tanning	0.0	0.3	0.5	-0.7	-0.6	-0.2	-0.6
Diabetes (mother)	0.0	0.0	0.1	-0.2	0.0	-0.2	0.0
Relative age voice broke	0.0	0.1	0.2	0.1	0.1	-0.2	0.5
Serious illness, injury or assault to yourself	0.0	0.1	0.1	0.2	0.2	0.3	0.2
Body mass index (BMI)	0.0	0.1	0.2	-0.2	0.1	0.5	-0.5
Number of incorrect matches in round	0.0	0.1	0.2	-0.2	0.4	0.2	0.1
Alcohol usually taken with meals	0.0	0.0	0.0	-0.1	0.2	-0.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	-0.1	-0.0	0.1	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.1
Number of full brothers	0.0	0.1	0.2	0.4	-0.2	-0.1	0.2
Illnesses of father: Heart disease	0.0	0.0	0.1	0.2	0.2	0.0	0.2
Long-standing illness, disability or infirmity	0.0	0.1	0.1	-0.1	0.3	0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	0.0	0.1	0.4	0.1
Mother’s age at death	0.0	0.0	0.0	0.2	-0.2	-0.0	-0.2

Hub : Genes

LOC100130093

Models

Trait associations