Best TWAS P=2.98e-09 · Best GWAS P=6.16e-08 conditioned to 0.327
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | MEPCE | 0.15 | 0.02 | lasso | 12 | 0.05 | 8.5e-03 | -4.2 | 5.3 | 1.5e-07 | 0.27 | 0.06 | 0.15 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | TFR2 | 0.14 | 0.00 | enet | 16 | 0.00 | 2.3e-01 | -4.6 | -5.9 | 3.0e-09 | -0.36 | 0.04 | 0.38 | TRUE |
| 3 | GTEx | Breast Mammary Tissue (Female) | PILRA | 0.48 | 0.46 | enet | 17 | 0.42 | 1.1e-13 | -4.6 | -5.1 | 3.0e-07 | -0.01 | 0.03 | 0.95 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | SRRT | 0.14 | 0.01 | enet | 10 | 0.02 | 4.5e-02 | 4.7 | 5.2 | 1.7e-07 | 0.81 | 0.03 | 0.62 | TRUE |
| 5 | GTEx | Ovary | GIGYF1 | 0.23 | 0.15 | lasso | 5 | 0.14 | 2.9e-04 | 5.4 | 5.3 | 1.1e-07 | 0.90 | 0.01 | 0.94 | TRUE |
| 6 | GTEx | Uterus | PILRA | 0.79 | 0.38 | lasso | 11 | 0.45 | 1.8e-10 | -4.7 | -5.3 | 1.0e-07 | -0.02 | 0.03 | 0.94 | FALSE |
| 7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PILRA | 0.05 | 0.01 | blup | 32 | 0.02 | 5.5e-03 | -4.6 | -5.3 | 1.1e-07 | 0.04 | 0.01 | 0.57 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | PMS2L1 | 0.06 | 0.05 | lasso | 2 | 0.05 | 4.3e-04 | -4.6 | 5.2 | 1.7e-07 | -0.01 | 0.00 | 0.63 | FALSE |
| 9 | The Cancer Genome Atlas | Glioblastoma Multiforme | PILRA | 0.14 | 0.00 | blup | 32 | 0.01 | 1.2e-01 | -4.7 | -5.4 | 7.8e-08 | -0.04 | 0.01 | 0.56 | TRUE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PILRA | 0.06 | 0.03 | blup | 32 | 0.04 | 9.7e-04 | 3.0 | -5.3 | 9.6e-08 | -0.11 | 0.01 | 0.30 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PILRB | 0.08 | 0.09 | lasso | 4 | 0.09 | 9.2e-10 | -4.7 | -5.2 | 1.7e-07 | 0.00 | 0.01 | 0.98 | FALSE |