Hub : Genes

TFR2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.1430	0.0590	0.00360	0.001	NA	0.005	NA	0.001	2.9e-01	NA	2.3e-01	NA	2.9e-01
2	GTEx	Skin Sun Exposed Lower leg	0.1120	0.0440	0.00096	0.067	NA	0.063	NA	0.063	3.3e-06	NA	6.2e-06	NA	5.9e-06
3	GTEx	Stomach	0.0970	0.0410	0.00170	0.035	NA	0.039	NA	0.067	8.6e-03	NA	5.7e-03	NA	4.1e-04
4	TCGA	Breast Invasive Carcinoma	0.0165	0.0087	0.00022	0.011	0.016	0.014	NA	0.013	2.1e-03	0.00025	5.0e-04	NA	9.8e-04
5	TCGA	Colon Adenocarcinoma	0.1120	0.0550	0.00150	0.059	0.039	0.023	NA	0.040	2.7e-04	0.00260	1.7e-02	NA	2.2e-03
6	TCGA	Liver Hepatocellular Carcinoma	0.0760	0.0400	0.00570	0.025	0.056	0.019	NA	0.030	2.2e-02	0.00130	4.2e-02	NA	1.4e-02
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.0410	0.0260	0.00470	0.010	0.015	0.000	NA	0.000	6.2e-02	0.03000	3.3e-01	NA	3.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.9	1.4	2.4	-0.5	0.8	-1.5	1.3	1.5	1.5	0.4
Bipolar Disorder or Schizophrenia	3.6	8.8	14.3	-3.0	1.4	-3.7	3.1	3.8	3.6	0.5
Depressed Affect (Nagel 2018)	0.5	1.0	1.7	-0.6	1.2	-1.3	1.2	1.1	0.0	0.9
Depression (Nagel 2018)	1.6	2.4	4.8	-2.2	-0.1	-1.5	1.1	2.2	1.9	-0.6
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.6	-1.4	-1.1	1.2	-1.5	-2.1	-1.4	-0.3
Neuroticism (Nagel 2018)	0.3	0.8	2.0	-1.0	-0.1	-0.7	0.4	1.4	1.3	-0.7
Schizophrenia (2018)	4.1	8.4	13.4	-3.5	1.1	-3.5	3.0	3.7	3.4	0.4
Schizophrenia vs Biploar Disorder	2.6	3.5	10.3	-1.5	-1.4	-0.9	0.4	2.5	3.2	-1.7
Worry (Nagel 2018)	0.4	0.9	2.5	-0.8	-0.9	0.1	0.0	1.1	1.6	-1.2
Alzheimer’s Disease (in mother)	1.2	1.4	2.7	0.2	-0.9	1.5	-1.2	-1.6	-1.6	-0.5
Alzheimer’s Disease (in father)	1.0	1.1	3.2	1.2	-0.4	1.2	-0.7	-1.0	-1.8	-0.1
Alzheimer’s Disease (including proxy)	1.7	2.5	8.7	1.0	-0.5	1.5	-1.0	-2.0	-2.9	0.2
Crohns Disease (2017)	3.5	7.7	12.6	-3.1	1.6	-3.3	2.9	3.5	3.1	0.4
Irritable Bowel Disease (IBD)	5.7	13.6	23.1	-3.6	3.4	-4.8	4.2	4.2	3.0	1.9
Ulcerative Colitis (UC)	5.5	10.4	19.6	-2.6	3.9	-4.4	3.6	3.0	1.2	2.8
Major Depression (MDD)	1.5	1.8	3.6	-0.6	1.4	-1.9	1.4	1.9	0.7	0.9
Reaction Time	3.7	7.1	16.3	-3.5	-0.2	-2.6	1.7	4.0	3.3	-0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.3	5.3	-2.3	-1.0	0.3	-1.0	-1.1	-0.0	-0.7
Breast Cancer	1.9	4.6	15.9	-4.0	-2.2	-0.5	-1.5	0.9	1.8	-2.3
Ovarian Cancer	1.9	2.6	4.8	0.1	-1.4	2.1	-2.1	-2.2	-1.1	-1.0
Prostate Cancer	0.4	0.6	0.9	0.9	-0.8	0.4	0.5	0.9	1.0	-0.7
Age at First Birth	2.5	3.6	12.2	0.2	1.6	0.1	-0.1	-2.5	-3.5	2.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	-1.3	-0.1	-1.2	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	2.8	4.5	9.9	-2.9	-0.3	-1.7	1.2	2.8	3.1	-1.1
Mean Putamen Volume	1.4	1.6	4.7	-2.2	-0.9	-0.4	-0.5	0.8	1.7	-1.3
Fasting Glucose	0.7	0.8	2.3	1.5	0.6	0.4	-0.4	-0.8	-1.3	0.8
HbA1C	1.0	1.1	2.3	0.4	-0.9	0.2	-0.9	1.1	1.4	-1.5
HDL Cholesterol	0.0	0.1	0.3	-0.2	-0.5	-0.2	0.0	0.0	0.0	0.0
LDL Cholesterol	0.4	0.7	1.8	-1.1	1.2	-1.3	0.0	0.0	0.0	0.0
Lupus	0.4	0.6	2.2	1.5	-0.5	0.7	-0.9	-0.1	0.2	-0.4
Neuroticism (2016)	1.3	1.9	4.1	-0.3	1.0	-1.7	1.9	2.0	1.2	0.4
Primary Biliary Cirrhosis	0.3	0.4	0.7	-0.8	0.5	-0.3	-0.4	-0.7	-0.6	0.7
Rheumatoid Arthritis	1.1	1.6	3.6	0.9	1.6	-0.7	0.7	-0.1	-1.8	1.9
Schizophrenia (2014)	4.8	10.5	19.7	-3.5	0.8	-3.6	3.3	4.4	4.2	-0.1
Triglycerides	0.4	0.6	2.3	-1.5	0.3	-1.4	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.8	0.9	0.6	-0.6	0.0	0.0	0.0	0.0
Ulcerative Colitis	2.8	4.1	7.0	-2.3	1.7	-2.6	2.0	2.6	1.6	0.6
Blood Eosinophil Count	1.1	8.7	22.6	0.2	1.4	-2.8	3.5	4.8	4.1	0.0
Blood Platelet Count	9.8	113.6	249.6	15.8	11.6	0.9	6.3	-5.6	-12.4	13.6
Blood Red Count	55.4	535.3	1253.2	-11.0	-26.3	3.0	-9.6	21.7	35.4	-33.3
Blood White Count	1.1	8.2	25.9	2.0	-0.0	-1.6	2.2	5.1	4.2	-1.6
Heel T-Score	1.1	9.1	41.1	-6.4	-2.4	-1.6	-1.6	1.9	1.1	-2.6
BMI	0.6	3.7	11.4	0.2	-0.5	-1.4	1.1	3.4	3.0	-1.4
Height	0.5	9.1	23.4	-2.6	-1.7	2.9	-4.4	-4.8	-1.2	-1.1
Waist Hip Ratio (WHR)	0.7	3.1	8.6	0.3	-0.4	1.9	-1.7	-2.9	-2.5	0.2
Systolic Blood Pressure	2.1	10.3	23.3	4.8	-0.5	3.8	-2.5	-4.2	-3.2	0.3
Smoking Status	1.2	2.9	6.7	1.0	1.7	-1.7	2.6	2.2	0.5	1.3
Allergy or Eczema	0.8	2.2	4.5	0.6	-2.1	1.7	-1.9	-0.3	0.7	-1.7
Cardiovascular Disease	0.7	2.3	3.5	-1.8	0.6	-1.8	1.6	1.9	1.9	-0.1
Hypothyroidism (self reported)	3.9	9.0	16.9	1.9	-1.3	3.3	-4.1	-3.8	-3.9	-0.3
Respiratory disease	0.1	0.1	0.3	-0.6	-0.0	-0.3	-0.2	0.1	0.3	0.6
Type 2 Diabetes (T2D) (2018)	0.8	1.4	4.0	1.4	-0.9	1.0	-2.0	-1.0	-0.9	-0.7
Lung FEV1/FVC ratio	0.7	3.4	8.8	2.7	1.7	0.2	1.2	-1.2	-3.0	1.6
Lung FVC	0.6	3.1	5.5	-0.5	2.3	-2.2	2.2	1.3	1.1	2.0
Neuroticism	0.5	1.2	3.6	-0.6	0.2	-1.0	1.0	1.9	1.4	-0.3
Chronotype (morning person)	0.1	0.2	1.4	-1.2	0.1	-0.3	-0.2	-0.0	-0.0	0.0
Hair Pigment	0.5	15.1	37.2	6.1	-1.0	3.9	-3.4	-4.4	-4.5	0.6
Tanning	0.1	1.1	3.1	1.7	-0.7	1.4	-1.1	-0.8	-0.1	-0.5
Hand grip strength (left)	1.9	5.1	29.1	-5.4	0.5	-2.2	0.6	0.0	0.9	0.5
Number of treatments/medications taken	0.0	0.1	0.3	0.6	0.0	0.0	0.1	0.3	0.1	0.0
Average weekly spirits intake	0.3	0.4	1.5	1.2	0.7	-0.2	0.5	0.2	-0.2	0.8
Sensitivity / hurt feelings	0.9	1.5	4.7	2.2	-0.6	1.5	-1.0	-0.8	-0.9	-0.6
Frequency of depressed mood in last 2 weeks	0.9	1.3	4.1	-2.0	-0.0	-1.1	0.7	1.6	1.0	-0.2
Hearing difficulty/problems: Yes	0.5	0.7	1.7	-0.5	0.9	-0.6	0.6	-0.3	-1.3	1.2
Relative age of first facial hair	0.1	0.2	0.4	-0.2	-0.4	0.4	-0.7	-0.4	-0.4	-0.4
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.0	-0.4	1.6	-1.2	0.9	-0.1	-1.5	2.0
Ever used hormone-replacement therapy (HRT)	0.8	1.0	5.5	2.3	0.4	0.4	0.7	0.3	-0.8	0.5
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	1.0	0.4	0.1	-0.1	0.2	-0.7	0.6
Systolic blood pressure, automated reading	1.8	5.3	11.4	3.2	0.6	2.1	-0.3	-2.8	-3.4	1.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.4	0.6	0.4	0.1	-0.0	-1.1	-1.6	0.8
Angina	0.3	0.3	0.8	0.7	0.0	0.6	-0.9	-0.6	-0.1	-0.4
Medication for hormone replacement therapy	0.4	0.5	1.0	1.0	-0.5	0.9	-0.8	-0.3	0.3	-0.7
Vitamin and mineral supplements	0.3	0.3	1.1	-0.7	-0.6	0.6	-0.3	0.1	0.2	-1.0
Supplements: Zinc	1.4	1.6	3.0	-0.6	-1.7	0.6	-1.7	0.0	1.2	-1.7
Medication: Co-codamol	0.4	0.5	1.0	1.0	-0.6	0.8	-0.6	-0.1	0.5	-0.8
Medication: Metformin	1.8	2.5	5.3	1.3	2.3	-1.1	0.8	-0.4	-1.9	2.3
Diabetes (father)	0.6	0.8	1.6	1.3	-0.8	1.0	-1.1	-0.6	-0.7	-0.1
Diabetes (mother)	0.7	1.0	5.4	2.3	-0.1	0.7	-0.2	-0.2	-0.8	0.1
Severe depression (siblings)	1.0	1.2	3.6	-1.9	-0.5	-1.0	0.3	0.9	1.4	-0.6
Pack years adult smoking proportion	0.2	0.3	1.1	-0.4	0.1	-0.6	0.1	0.7	1.0	-0.3
Impedance of leg (right)	0.5	2.5	15.4	-3.9	-0.6	-0.7	0.2	0.1	0.9	-0.4
Leg fat-free mass (left)	0.2	1.0	1.9	0.9	-0.8	0.4	-1.2	0.5	1.4	-1.3
Trunk fat percentage	0.5	2.1	4.3	-1.6	0.2	-1.7	1.3	2.1	1.9	-0.3
Hand grip strength (right)	3.0	8.1	35.2	-5.9	0.2	-2.9	1.4	2.0	2.6	-0.2
Townsend deprivation index at recruitment	1.0	1.4	3.6	-1.1	0.4	-1.0	0.9	1.7	1.9	-0.6
Current tobacco smoking	0.9	1.5	3.6	0.3	0.7	-1.3	1.9	1.9	1.0	0.4
Average weekly fortified wine intake	1.1	1.2	2.8	0.5	-1.3	1.2	-1.7	-1.2	-0.3	-1.1
Maternal smoking around birth	0.2	0.2	0.4	0.3	0.5	-0.4	0.0	0.6	0.7	-0.5
Fed-up feelings	1.6	3.0	5.8	1.1	1.8	-1.8	2.4	2.2	0.7	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.9	3.8	7.9	-2.2	1.2	-2.3	2.3	2.8	1.3	0.7
Relative age voice broke	1.0	1.5	2.9	-1.1	0.7	-1.4	1.7	1.7	0.6	0.6
Taking other prescription medications	0.5	0.7	1.8	0.3	-1.2	0.9	-1.4	-0.4	-0.3	-0.8
Age when periods started (menarche)	0.7	1.8	3.3	-1.1	1.8	-1.8	1.2	0.4	-0.2	1.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	4.5	2.1	0.3	0.4	0.5	0.6	-0.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	7.8	-2.8	-0.4	-1.1	0.2	1.2	0.4	-0.6
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.0	1.2	-1.4	1.3	-0.8	-0.1	0.2	-1.1
Qualifications: CSEs or equivalent	0.7	1.0	1.8	0.3	1.3	-1.0	1.3	1.0	0.2	1.1
Serious illness, injury or assault to yourself	1.8	2.1	6.6	0.7	-1.0	-0.4	-0.0	2.4	2.6	-1.1
High blood pressure	0.2	0.7	1.3	-0.5	0.8	-0.9	1.0	0.8	1.1	0.0
Hayfever, allergic rhinitis or eczema	1.5	3.2	7.1	1.1	-2.7	2.1	-2.0	-0.1	0.9	-2.2
Multivitamins +/- minerals	0.3	0.4	1.0	0.9	0.4	0.1	-0.1	-0.7	-0.7	1.0
Stomach or abdominal pain in last month	5.3	6.6	14.5	1.5	-3.2	3.0	-3.8	-1.8	-0.4	-2.7
Supplements: Glucosamine	2.0	2.5	5.3	1.0	-0.9	1.6	-2.3	-2.2	-1.8	-0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.9	1.4	-0.1	0.2	0.2	0.0	-0.1	-0.2
Medication: Atenolol	0.9	1.1	1.9	1.1	1.2	0.2	-0.0	-1.4	-1.2	1.1
Medication: Levothyroxine sodium	2.5	4.2	11.4	1.3	-0.6	2.0	-2.3	-2.5	-3.4	0.4
Sitting height	0.8	5.9	15.1	-0.4	-2.4	2.8	-3.9	-2.9	-0.8	-1.9
Chronic bronchitis/emphysema (father)	1.5	1.8	4.5	-0.5	0.7	-1.5	1.7	2.1	1.3	0.5
High blood pressure (mother)	0.1	0.1	0.7	0.8	0.4	0.1	0.1	0.0	0.1	0.3
Body mass index (BMI)	0.7	3.0	8.1	0.7	1.1	-1.9	2.2	2.9	1.4	0.4
Impedance of leg (left)	0.6	3.1	16.6	-4.1	0.6	-1.6	1.2	0.1	0.4	0.8
Leg predicted mass (left)	0.2	1.0	2.1	0.8	-0.8	0.4	-1.1	0.6	1.4	-1.3
Trunk fat mass	0.4	1.9	3.7	-1.4	0.4	-1.7	1.1	1.9	1.8	-0.2
Waist circumference	0.1	0.3	0.5	0.4	0.7	-0.6	0.7	0.6	-0.2	0.4
Number of incorrect matches in round	3.9	6.5	13.2	-3.6	1.6	-3.5	2.5	2.9	1.6	0.7
Past tobacco smoking	0.2	0.4	1.9	-1.4	-0.5	0.1	-0.2	-0.3	0.6	-0.5
Alcohol usually taken with meals	1.6	2.7	5.3	0.1	-2.2	1.6	-2.3	-0.8	0.7	-2.2
Nervous feelings	0.8	1.5	2.9	0.8	-1.7	1.5	-1.5	-0.3	0.6	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	9.3	-3.1	-0.6	-1.0	0.3	1.8	1.5	-1.0
Hearing difficulty/problems with background noise	0.3	0.4	1.9	-1.4	-0.2	-0.5	-0.2	0.5	0.7	-0.2
Hair/balding pattern: Pattern 2	0.5	0.6	3.5	-1.9	-0.5	-0.2	-0.2	-0.4	0.6	-0.4
Had menopause	0.7	0.9	1.8	1.0	0.9	-0.3	1.3	0.0	-1.0	1.3
Had other major operations	4.6	5.7	15.0	3.9	-1.6	3.0	-2.6	-1.8	-0.7	-1.5
Forced vital capacity (FVC)	0.1	0.5	1.8	-1.3	0.6	-0.7	-0.2	-0.2	0.6	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	8.7	-3.0	0.1	-1.5	0.4	1.5	0.9	-0.5
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.3	0.2	0.1	0.2	0.3	0.0	-0.5	0.0
Qualifications: None of the above	0.7	1.4	4.2	2.1	1.4	-0.2	1.4	0.3	-0.5	1.1
Financial difficulties in last 2 years	0.3	0.4	0.9	0.2	-0.9	0.8	-0.8	-0.3	0.3	-0.9
Mouth/teeth dental problems	0.1	0.2	1.0	1.0	-0.4	0.4	-0.4	-0.2	0.3	-0.1
Heart attack	0.4	0.5	1.9	0.7	-0.3	0.7	-1.4	-0.8	-0.1	-0.5
Allergy	1.7	3.8	7.7	-1.5	2.8	-2.5	2.6	0.5	-0.2	2.0
Pain all over the body in last month	0.6	0.7	1.5	-0.7	1.0	-1.2	0.7	0.8	0.7	0.5
Diabetes (self-reported)	0.7	1.1	2.8	1.6	0.8	0.2	-0.7	-0.9	-1.7	0.7
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	8.4	2.9	-0.8	2.1	-1.8	-2.2	-1.6	-0.0
Medication: Ramipril	0.9	1.1	2.3	0.5	1.5	-1.4	1.0	0.4	-0.3	1.5
Medication: Simvastatin	1.4	2.0	4.6	-0.6	2.1	-1.6	1.6	0.4	-0.7	1.8
Fluid intelligence score	1.3	2.6	15.4	-3.9	0.3	-1.4	0.9	0.1	0.1	0.4
Illnesses of siblings	1.0	1.5	6.2	2.5	-1.0	1.1	-0.8	-0.3	0.6	-0.9
Neuroticism score	0.3	0.7	2.3	-0.2	0.2	-0.8	0.8	1.5	1.0	0.0
Weight	0.2	0.8	2.0	-0.3	0.1	-1.0	0.5	1.4	1.4	-0.3
Impedance of arm (right)	1.0	4.8	9.4	-1.9	-2.6	2.2	-3.1	-1.8	0.4	-2.3
Arm fat percentage (right)	0.4	1.7	5.3	-0.2	0.6	-1.5	1.5	2.3	1.4	0.0
Trunk fat-free mass	0.0	0.1	0.2	0.4	0.2	-0.2	-0.4	-0.0	0.3	0.0
Hip circumference	0.1	0.6	1.8	-0.1	-0.2	-0.6	0.3	1.4	1.2	-0.6
Time employed in main current job	1.5	1.7	3.5	-1.9	0.4	-1.3	1.0	1.7	1.7	-0.2
Alcohol intake versus 10 years previously	0.5	0.7	2.3	1.5	0.5	0.1	0.6	-0.0	-1.0	1.1
Father’s age at death	1.3	1.8	3.8	1.7	-1.5	1.9	-0.8	-1.0	-0.7	-1.0
Worrier / anxious feelings	1.2	2.2	5.4	-2.3	-0.3	-1.2	0.9	2.1	1.8	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.6	-0.2	-0.5	0.0	0.8	0.0	0.2
Falls in the last year	2.1	2.8	5.9	-0.1	2.4	-2.1	2.0	1.2	-0.5	1.9
Hair/balding pattern: Pattern 3	3.4	5.1	8.8	2.0	-1.8	3.0	-2.7	-2.7	-1.7	-1.4
Number of live births	0.5	0.8	1.4	-0.5	1.1	-1.0	1.0	0.4	-0.5	1.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.3	0.6	0.3	0.6	-0.7	-1.2	-0.8	0.5
Pulse rate	18.2	30.7	48.9	-4.6	4.3	-6.8	7.0	6.7	5.4	2.1
Happiness	1.0	1.2	2.0	-1.3	-1.4	-0.1	-0.3	0.8	1.3	-1.4
Noisy workplace	0.3	0.4	0.9	1.0	-0.7	0.6	-0.5	-0.4	0.0	-0.5
Qualifications: A levels/AS levels or equivalent	1.0	2.2	6.1	-1.3	-0.7	1.1	-1.9	-2.5	-1.6	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.9	0.2	-1.2	1.1	-1.4	-0.7	-0.5	-1.3
Mouth/teeth dental problems: Dentures	0.8	1.3	4.0	2.0	0.9	0.6	0.1	-1.0	-1.6	0.8
Asthma	0.1	0.2	0.6	-0.2	-0.5	0.1	-0.7	0.2	0.8	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.1	-0.4	-1.4	1.4	-1.7	-1.6	-1.1	-0.9
Medication: Cholesterol lowering	0.9	1.4	4.6	0.2	2.1	-1.2	1.1	0.2	-0.2	1.5
Depression (self-reported)	0.3	0.3	0.8	-0.7	-0.2	-0.6	0.4	0.9	0.3	-0.5
Medication: Lansoprazole	1.6	1.8	3.6	-0.3	1.3	-1.9	1.7	1.8	0.8	0.7
Prospective memory result	1.3	1.6	4.5	0.6	0.6	-1.1	2.1	1.9	0.6	0.7
Lung cancer (father)	4.0	4.7	11.0	1.4	3.3	-1.9	2.7	0.5	-0.9	2.9
Illnesses of mother	0.3	0.4	0.8	-0.2	-0.9	0.3	-0.6	0.4	0.8	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.3	1.0	0.5	0.7	-0.6	-1.5	-1.2	0.8
Pulse wave Arterial Stiffness index	1.5	1.8	4.5	-1.0	-1.1	-0.4	0.3	1.5	2.1	-1.7
Impedance of arm (left)	1.0	4.6	8.6	-2.2	-2.5	2.0	-2.9	-1.9	0.4	-2.1
Arm fat mass (right)	0.4	1.6	4.1	0.1	0.9	-1.5	1.4	2.0	1.4	0.2
Trunk predicted mass	0.0	0.1	0.1	0.4	0.3	-0.2	-0.4	-0.0	0.3	0.1
Standing height	0.5	5.3	13.2	-2.1	-2.0	2.0	-3.6	-2.9	0.1	-1.6
Length of working week for main job	0.7	0.7	1.4	-0.6	1.1	-1.2	0.9	0.4	-0.1	1.1
Exposure to tobacco smoke at home	0.9	1.0	5.9	2.4	0.0	0.8	-0.4	-0.4	-0.2	-0.3
Breastfed as a baby	2.6	3.2	6.5	1.3	-1.9	2.5	-2.1	-1.8	-0.6	-1.7
Tense / ‘highly strung’	0.7	1.2	3.1	-1.3	-0.4	-0.7	0.2	1.4	1.8	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	1.4	-1.2	-0.2	-0.1	-0.1	0.1	-0.3	-0.1
Hair/balding pattern: Pattern 4	0.3	0.7	3.5	-1.9	-0.4	-0.5	-0.0	0.6	0.6	-0.6
Birth weight of first child	0.4	0.8	3.4	-1.9	0.8	-0.8	0.6	-0.1	-0.5	0.6
Peak expiratory flow (PEF)	0.5	1.2	2.7	0.3	-0.6	1.1	-1.4	-1.6	-1.5	-0.2
Pulse wave reflection index	1.2	1.5	3.5	-1.0	-1.9	0.8	-1.2	0.4	0.4	-1.9
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.0	0.2	0.9	-0.7	0.7	1.0	0.1	0.6
Loud music exposure frequency	0.2	0.3	0.6	0.5	-0.7	0.1	-0.3	0.3	0.8	-0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.9	-0.0	-0.5	0.6	-1.0	-0.8	-0.4	-0.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	-0.8	-0.8	0.8	-0.9	-0.6	-1.1	-0.2
Blood clot in the leg (DVT)	2.6	3.3	9.1	3.0	0.5	1.3	-1.0	-1.6	-2.7	1.3
Medication: Paracetamol	0.6	1.0	2.1	0.6	-1.4	0.9	-1.0	0.0	0.9	-1.4
Headache pain in last month	0.2	0.3	1.2	0.1	-0.0	0.4	-0.5	-0.7	-1.1	0.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.6	0.1	-1.9	1.3	-0.8	-0.3	-0.3	-1.3
Glaucoma (self-reported)	1.1	1.3	3.8	-0.5	-1.3	0.7	-0.6	0.8	1.3	-1.9
Gout (self-reported)	0.1	0.1	0.5	0.7	-0.1	0.2	0.1	-0.5	-0.2	0.3
Hypothyroidism/myxoedema (self-reported)	4.1	8.1	15.7	2.2	-1.3	3.2	-4.0	-3.4	-3.5	-0.5
Medication: Amlodipine	1.8	2.6	5.1	-1.2	1.7	-2.1	2.3	1.6	0.9	1.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.1	0.6	-0.4	0.0	0.1	0.4	0.4
Birth weight	0.2	0.5	1.5	-0.8	0.4	-0.6	0.6	0.7	1.2	-0.1
Chronic bronchitis/emphysema (mother)	2.1	2.5	6.0	-1.4	0.3	-1.7	1.4	2.1	2.4	-0.4
High blood pressure (siblings)	1.0	1.4	4.0	-1.7	0.6	-0.0	-0.1	-1.3	-2.0	1.0
Forced vital capacity (FVC), Best measure	0.1	0.4	0.9	-0.5	0.8	-0.1	-0.3	-0.8	-0.2	0.9
Body fat percentage	0.9	3.6	7.7	-1.6	0.7	-2.3	2.0	2.8	2.1	0.1
Leg fat percentage (right)	1.9	6.9	14.0	-2.4	1.2	-3.3	3.2	3.7	2.5	0.4
Arm fat-free mass (right)	0.1	0.7	1.6	-0.2	0.7	-1.3	0.8	1.1	0.9	0.4
Exposure to tobacco smoke outside home	0.3	0.4	2.3	1.5	-0.2	0.3	0.1	0.4	0.6	-0.2
Comparative body size at age 10	0.9	2.4	9.9	-3.1	1.3	-1.9	0.8	0.3	-0.6	0.7
Number of full brothers	0.1	0.2	0.3	0.0	0.4	-0.1	0.5	0.4	-0.5	0.5
Worry too long after embarrassment	1.0	1.7	4.2	-1.6	-0.4	-1.0	0.6	1.7	2.0	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.3	-1.1	0.3	-0.6	0.5	0.3	-0.0	0.3
Wheeze or whistling in the chest in last year	1.4	2.5	6.8	-0.9	-0.2	-1.4	0.8	2.6	2.6	-0.6
Number of children fathered	1.8	2.0	7.3	2.7	-0.2	1.6	-1.0	-1.4	-1.2	0.0
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.1	7.3	-2.7	-2.1	0.3	-1.2	0.2	1.8	-2.2
Age at first live birth	2.3	4.0	8.6	-1.0	-1.9	2.0	-2.9	-2.6	-1.4	-1.4
Pulse wave peak to peak time	1.8	2.1	5.3	1.0	1.1	0.5	-0.4	-1.8	-2.3	1.8
Health satisfaction	0.1	0.1	0.3	0.6	-0.4	0.2	-0.2	0.1	-0.5	0.1
Shortness of breath walking on level ground	0.7	0.8	1.4	0.3	1.1	-1.0	1.2	1.0	0.2	1.1
Qualifications: College or University degree	1.2	3.8	9.9	-3.1	-2.1	0.7	-2.7	-1.6	-0.2	-1.4
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.3	-0.4	0.4	0.2	0.2	-0.0	-0.2
Mouth/teeth dental problems: Loose teeth	1.8	2.1	5.1	-2.3	0.8	-2.0	1.0	1.5	1.1	0.6
Emphysema/chronic bronchitis	0.6	0.6	1.5	1.0	-0.3	1.2	-0.9	-0.9	-0.6	0.0
Medication for pain relief, constipation, heartburn	0.8	1.3	2.4	-0.2	1.4	-1.4	1.6	1.3	0.9	0.8
Neck or shoulder pain in last month	0.3	0.4	1.4	1.0	0.4	-0.3	0.6	1.2	-0.0	0.3
Medication: Blood pressure	0.4	0.7	1.8	-0.4	1.4	-1.1	0.3	0.4	1.2	0.4
Angina (self-reported)	0.4	0.5	0.9	0.9	-0.0	0.8	-0.9	-0.9	-0.3	-0.3
Migraine (self-reported)	0.2	0.2	0.7	-0.8	-0.6	0.1	-0.4	0.0	-0.2	-0.5
Medication: Ibuprofen	0.8	1.0	1.9	-0.6	-1.3	0.9	-1.4	-1.0	-0.4	-0.9
Medication: Allopurinol	0.4	0.5	1.0	1.0	0.8	-0.3	0.6	-0.2	-0.4	1.0
Medication: Omeprazole	1.9	2.2	3.7	1.8	-1.5	1.9	-1.8	-1.1	-0.6	-1.3
Medication: Seretide 50 evohaler	0.4	0.4	1.9	0.6	-0.1	-0.2	0.1	0.9	1.4	-0.2
Mean time to correctly identify matches	2.5	4.7	10.8	-2.9	0.2	-2.2	1.8	3.3	2.3	-0.2
Heart disease (mother)	0.6	0.7	4.6	-2.1	-0.1	-0.5	-0.1	0.1	0.0	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.5	0.4	0.6	-0.3	0.8	-0.2	-1.0	1.2
Whole body fat mass	0.7	2.8	6.8	-1.0	0.7	-2.0	1.6	2.6	2.2	-0.1
Leg fat mass (right)	1.2	4.5	9.5	-1.4	1.3	-2.8	2.4	3.1	2.1	0.4
Arm predicted mass (right)	0.2	1.0	2.2	-0.5	0.9	-1.5	0.9	1.2	1.2	0.4
Pulse rate, automated reading	30.8	99.4	163.8	-9.6	8.4	-12.6	12.8	11.2	7.6	5.3
Alcohol intake frequency.	1.4	3.2	18.1	4.3	0.6	1.3	0.4	-0.5	-1.2	0.8
Comparative height size at age 10	0.4	2.3	6.2	1.3	-0.2	1.7	-2.0	-2.5	-1.1	0.1
Number of full sisters	0.0	0.0	0.1	-0.3	0.2	-0.0	-0.3	0.2	0.2	-0.2
Suffer from ‘nerves’	0.7	1.2	3.4	0.2	0.0	-0.8	1.1	1.8	1.6	-0.1
Overall health rating	1.0	2.1	4.0	-0.1	1.8	-1.6	2.0	1.7	-0.2	1.5
Chest pain or discomfort	0.8	1.2	2.8	-0.0	-1.0	0.4	-0.5	1.1	1.6	-1.7
Had major operations	0.5	0.6	2.0	-0.2	-0.3	-0.5	-0.1	1.3	1.4	-0.7
Age at last live birth	0.4	0.6	3.0	-1.7	0.3	-0.6	0.1	-0.5	-0.4	0.4
Family relationship satisfaction	2.0	2.5	5.3	-2.3	-0.1	-1.8	1.2	2.0	1.7	-0.4
Leg pain on walking	0.6	0.7	2.1	1.4	-0.9	0.9	-0.9	0.1	-0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.1	1.5	1.3	-1.0	1.8	1.0	-0.2	1.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	0.5	-0.8	0.5	-0.2	-0.2	0.1	-0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	-1.0	1.0	-0.6	0.2	-0.8	-0.2	0.9
Medication: Aspirin	0.3	0.4	1.4	-0.2	-0.2	0.5	-0.6	-0.7	-1.2	0.1
Supplements: Vitamin C	0.1	0.1	0.5	-0.4	0.2	-0.7	0.1	0.3	0.0	0.4
Knee pain experienced in last month	0.6	0.9	4.2	2.0	0.6	0.6	-0.3	-0.5	-1.0	0.3
Hypertension (Self-reported)	0.5	1.4	2.6	-1.0	0.8	-1.4	1.2	1.4	1.6	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	5.3	2.1	0.6	1.1	-0.5	-1.9	-2.3	1.0
Illnesses of father: Heart disease	0.4	0.6	1.4	-1.0	-1.2	0.5	-0.3	0.1	0.5	-1.1
Illnesses of siblings: Diabetes	0.2	0.2	1.2	0.2	-0.1	-0.1	-0.0	1.1	0.3	-0.3
Smoking status: Previous	0.6	0.9	2.1	1.4	0.0	0.9	-1.0	-0.9	-1.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.6	1.1	1.3	0.3	0.0	-1.6	-1.9	1.8
Whole body fat-free mass	0.0	0.2	0.6	0.5	-0.0	-0.1	-0.5	0.3	0.8	-0.3
Leg fat-free mass (right)	0.1	0.6	1.8	1.4	-0.3	0.5	-1.1	-0.0	0.7	-0.6
Arm fat percentage (left)	0.5	1.9	5.6	-0.3	0.6	-1.6	1.5	2.4	1.6	-0.0
Average weekly red wine intake	0.5	0.7	2.2	-0.7	-0.0	0.5	-0.5	-1.4	-1.5	0.2
Handedness (chirality/laterality): Left-handed	2.9	3.4	5.9	-2.1	1.9	-2.4	2.3	0.9	-0.4	1.9
Mood swings	0.3	0.5	1.2	1.1	0.6	0.5	-0.3	-0.5	-1.1	0.5
Loneliness, isolation	1.2	1.6	4.7	-1.0	0.4	-1.4	1.7	2.2	0.7	0.3
Long-standing illness, disability or infirmity	0.3	0.4	1.0	0.1	-0.3	0.7	-1.0	-0.8	-0.9	-0.1
Ever had bowel cancer screening	2.4	2.8	5.8	-1.4	0.8	-2.3	2.0	2.4	0.6	1.1
Diabetes diagnosed by doctor	0.7	1.2	3.1	1.5	0.5	0.3	-0.9	-1.0	-1.8	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	0.5	-0.7	0.7	-1.2	-0.1	0.2	-0.9
Friendships satisfaction	1.9	2.4	5.5	-2.3	-0.0	-1.9	1.4	2.1	1.2	0.0
Qualifications: nursing, teaching	0.5	0.7	2.6	-1.6	-0.4	0.2	-1.1	-0.9	-0.4	0.1
Commuting to job workplace: Walk	0.1	0.1	0.4	0.5	-0.2	0.4	-0.6	-0.5	-0.1	0.1
Eye problems/disorders: Cataract	0.4	0.4	1.2	-0.7	0.5	-0.8	0.0	0.6	1.1	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	3.4	-1.8	-1.1	0.0	-0.4	0.4	0.8	-1.4
Medication for cholesterol	1.1	1.6	4.2	1.0	-1.2	1.4	-2.0	-1.4	-0.4	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.3	3.8	7.2	-1.5	2.3	-2.7	2.4	1.7	0.9	1.6
Back pain experienced in last month	0.2	0.2	1.0	0.6	0.1	-0.1	0.4	1.0	0.4	-0.2
Mineral and other dietary supplements	1.7	2.2	4.9	-1.7	-0.0	-1.0	0.8	2.2	2.2	-1.1
Breast cancer (self-reported)	1.5	1.8	8.2	2.9	1.4	-0.2	0.9	0.3	-0.2	1.4
Asthma (self-reported)	0.1	0.2	0.8	-0.2	-0.1	-0.3	-0.4	0.4	0.9	-0.1
Osteoporosis (self-reported)	1.7	2.1	4.0	0.8	1.5	-1.6	2.0	1.6	0.4	1.5
Osteoarthritis (self-reported)	0.4	0.5	1.4	0.2	-0.1	0.7	-0.9	-0.9	-1.2	0.2
Medication: Aspirin	0.1	0.1	0.7	-0.4	0.1	0.2	-0.2	-0.3	-0.8	0.1
Medication: Gliclazide	0.3	0.4	0.7	0.4	0.8	-0.8	0.4	0.4	-0.6	0.8
Illnesses of father: None of the above (group 1)	0.7	0.9	4.8	2.2	0.8	0.2	0.1	-0.4	-0.3	0.7
Smoking status: Current	1.0	1.6	3.9	0.2	0.7	-1.3	2.0	2.0	1.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.7	-0.0	1.6	-0.5	0.6	-0.7	-0.9	1.6
Whole body water mass	0.0	0.2	0.6	0.5	0.0	-0.2	-0.5	0.4	0.8	-0.3
Leg predicted mass (right)	0.1	0.6	1.8	1.4	-0.3	0.5	-1.1	0.0	0.8	-0.7
Arm fat mass (left)	0.5	2.0	5.2	-0.2	0.9	-1.8	1.6	2.3	1.5	0.3
Number of self-reported non-cancer illnesses	0.2	0.3	1.3	-0.1	0.1	0.4	-0.6	-0.6	-1.2	0.4
Average weekly champagne plus white wine intake	3.3	4.6	9.7	-0.5	-2.6	2.4	-3.1	-2.0	-0.0	-2.3
Miserableness	1.0	1.8	3.1	-1.5	1.0	-1.8	1.7	1.7	0.3	0.8
Guilty feelings	1.5	2.2	5.2	-2.3	-0.8	-1.1	0.6	1.8	1.8	-1.2
Wears glasses or contact lenses	0.3	0.4	1.8	-1.4	-0.6	-0.1	0.0	0.2	0.2	-0.7
Ever taken oral contraceptive pill	1.0	1.1	2.2	0.0	-1.2	1.3	-1.5	-1.1	-1.0	-0.6
Hearing aid user	1.5	1.7	4.0	0.4	1.1	-1.5	1.7	2.0	1.1	0.6
Mother’s age at death	1.3	1.6	3.0	0.5	-1.4	1.7	-1.7	-1.3	-0.9	-0.7
Financial situation satisfaction	1.7	2.1	3.9	1.1	2.0	-1.3	2.0	0.7	-0.7	1.9
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.6	0.4	-0.0	1.0	-1.0	-1.9	-1.4	0.3
Commuting to job workplace: Public transport	0.6	0.7	1.3	0.5	-1.0	1.1	-1.1	-0.9	-0.2	-0.6
Eye problems/disorders: Glaucoma	1.0	1.2	3.2	0.1	-1.3	1.0	-0.4	0.9	1.2	-1.8
Medication: Blood pressure	0.6	1.1	2.9	-1.7	0.3	-1.3	1.1	1.1	0.7	-0.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.9	0.9	-0.9	1.4	-1.0	-1.1	-0.9	-0.5
Supplements: Fish oil (including cod liver oil)	3.7	4.9	9.7	2.8	1.9	0.1	0.5	-1.9	-3.1	3.0
High cholesterol (Self-reported)	1.0	1.7	3.5	-1.9	1.2	-1.6	1.6	1.1	0.8	0.4
Medication: Bendroflumethiazide	0.0	0.1	0.3	-0.6	0.1	-0.2	0.0	-0.3	0.0	0.0
Medication: Paracetamol	0.6	1.0	1.9	1.2	-1.0	0.5	-0.4	0.8	1.4	-1.2
Medication: Lisinopril	0.4	0.5	1.2	-0.3	-0.8	-0.0	-0.7	0.3	1.1	-1.0
Medication: Atorvastatin	3.5	4.3	7.6	-1.9	2.3	-2.7	2.8	1.5	0.8	1.8
Illnesses of father: High blood pressure	0.4	0.5	2.6	-1.6	-0.0	-0.5	0.5	0.3	-0.1	-0.2
Alcohol drinker status: Never	1.8	2.2	4.5	1.2	-1.0	2.0	-1.6	-2.1	-1.3	-0.3
Ever smoked	0.6	1.1	5.3	2.3	0.6	0.3	0.2	-0.2	-1.1	0.8
Basal metabolic rate	0.0	0.3	1.0	0.3	0.2	-0.5	-0.1	0.7	1.0	-0.2
Leg fat percentage (left)	2.2	7.8	14.0	-2.2	1.8	-3.6	3.7	3.7	2.1	1.0
Arm fat-free mass (left)	0.2	0.9	1.9	-0.2	0.9	-1.4	1.0	1.2	0.9	0.5
Number of operations (self-reported)	1.0	1.4	3.1	0.9	-1.1	0.8	-1.6	0.6	1.1	-1.8
Average weekly beer plus cider intake	0.6	0.8	1.7	-0.7	0.7	-1.1	1.3	0.9	0.9	0.5
Irritability	0.3	0.5	1.5	0.4	0.2	-0.6	0.1	1.1	1.2	-0.2
Risk taking	2.2	3.3	9.5	-3.1	-1.0	-1.5	0.3	2.3	2.1	-0.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.6	-1.9	-0.1	-1.0	0.6	0.6	0.3	0.4
Fractured/broken bones in last 5 years	0.2	0.3	0.7	0.5	0.4	-0.4	0.8	0.4	-0.3	0.7
Age started oral contraceptive pill	0.4	0.4	1.4	-1.2	0.0	0.1	0.7	-0.6	-0.8	0.5
Diastolic blood pressure, automated reading	2.8	8.7	19.4	-2.5	0.3	-2.4	3.4	4.1	4.4	-1.0
Ever depressed for a whole week	0.3	0.3	1.4	1.2	0.4	0.5	-0.4	-0.5	-0.4	-0.0
Unable to work because of sickness or disability	0.4	0.5	0.9	0.9	0.8	-0.7	0.9	0.8	0.1	0.6
Commuting to job workplace: Cycle	0.3	0.3	1.5	-1.2	-0.1	-0.1	0.1	-0.1	-0.8	0.5
Myopia	0.0	0.1	0.1	-0.3	0.3	-0.2	-0.2	0.1	0.3	0.0
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.6	0.5	-0.8	1.0	-1.0	-1.0	-1.3	-0.0
Cholesterol lowering medication	6.8	9.9	17.8	-3.4	3.1	-4.2	4.2	2.6	0.7	2.3
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	4.5	2.1	-0.9	1.6	-1.2	-0.9	-0.9	-0.8
Pain experienced in last month	0.1	0.1	0.3	-0.5	-0.5	0.2	-0.4	-0.3	0.4	-0.3
Supplements: Calcium	0.2	0.2	0.4	-0.0	0.4	-0.6	0.6	0.5	-0.4	0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.7	0.0	0.7	0.0	-0.7	-0.3	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	0.4	-0.3	0.5	-1.2	-0.8	-0.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	7.6	2.8	0.4	1.2	-1.1	-1.4	-2.4	1.1
Heart disease (siblings)	0.6	0.8	3.0	-1.7	0.3	-0.9	0.7	0.7	0.8	0.1
Alcohol drinker status: Previous	0.5	0.5	1.0	0.8	0.8	0.0	0.9	0.0	-0.8	1.0
Pack years of smoking	0.1	0.2	0.4	-0.1	0.5	-0.6	0.3	0.6	0.6	0.1
Impedance of whole body	0.5	2.5	10.3	-3.2	-1.5	0.7	-1.3	-1.1	0.6	-1.1
Leg fat mass (left)	1.2	4.8	9.5	-1.3	1.6	-2.9	2.7	3.1	1.9	0.8
Arm predicted mass (left)	0.1	0.6	1.2	-0.1	0.6	-1.1	0.7	1.1	1.1	0.2