TWAS hub - TFR2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.1430	0.0590	0.00360	0.001	NA	0.005	NA	0.001	2.9e-01	NA	2.3e-01	NA	2.9e-01
2	GTEx	Skin Sun Exposed Lower leg	0.1120	0.0440	0.00096	0.067	NA	0.063	NA	0.063	3.3e-06	NA	6.2e-06	NA	5.9e-06
3	GTEx	Stomach	0.0970	0.0410	0.00170	0.035	NA	0.039	NA	0.067	8.6e-03	NA	5.7e-03	NA	4.1e-04
4	TCGA	Breast Invasive Carcinoma	0.0165	0.0087	0.00022	0.011	0.016	0.014	NA	0.013	2.1e-03	0.00025	5.0e-04	NA	9.8e-04
5	TCGA	Colon Adenocarcinoma	0.1120	0.0550	0.00150	0.059	0.039	0.023	NA	0.040	2.7e-04	0.00260	1.7e-02	NA	2.2e-03
6	TCGA	Liver Hepatocellular Carcinoma	0.0760	0.0400	0.00570	0.025	0.056	0.019	NA	0.030	2.2e-02	0.00130	4.2e-02	NA	1.4e-02
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.0410	0.0260	0.00470	0.010	0.015	0.000	NA	0.000	6.2e-02	0.03000	3.3e-01	NA	3.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood Red Count	55.4	535.3	1253.2	-11.0	-26.3	3.0	-9.6	21.7	35.4	-33.3
Pulse rate, automated reading	30.8	99.4	163.8	-9.6	8.4	-12.6	12.8	11.2	7.6	5.3
Pulse rate	18.2	30.7	48.9	-4.6	4.3	-6.8	7.0	6.7	5.4	2.1
Blood Platelet Count	9.8	113.6	249.6	15.8	11.6	0.9	6.3	-5.6	-12.4	13.6
Cholesterol lowering medication	6.8	9.9	17.8	-3.4	3.1	-4.2	4.2	2.6	0.7	2.3
Irritable Bowel Disease (IBD)	5.7	13.6	23.1	-3.6	3.4	-4.8	4.2	4.2	3.0	1.9
Ulcerative Colitis (UC)	5.5	10.4	19.6	-2.6	3.9	-4.4	3.6	3.0	1.2	2.8
Stomach or abdominal pain in last month	5.3	6.6	14.5	1.5	-3.2	3.0	-3.8	-1.8	-0.4	-2.7
Schizophrenia (2014)	4.8	10.5	19.7	-3.5	0.8	-3.6	3.3	4.4	4.2	-0.1
Had other major operations	4.6	5.7	15.0	3.9	-1.6	3.0	-2.6	-1.8	-0.7	-1.5
Schizophrenia (2018)	4.1	8.4	13.4	-3.5	1.1	-3.5	3.0	3.7	3.4	0.4
Hypothyroidism/myxoedema (self-reported)	4.1	8.1	15.7	2.2	-1.3	3.2	-4.0	-3.4	-3.5	-0.5
Lung cancer (father)	4.0	4.7	11.0	1.4	3.3	-1.9	2.7	0.5	-0.9	2.9
Hypothyroidism (self reported)	3.9	9.0	16.9	1.9	-1.3	3.3	-4.1	-3.8	-3.9	-0.3
Number of incorrect matches in round	3.9	6.5	13.2	-3.6	1.6	-3.5	2.5	2.9	1.6	0.7
Reaction Time	3.7	7.1	16.3	-3.5	-0.2	-2.6	1.7	4.0	3.3	-0.7
Supplements: Fish oil (including cod liver oil)	3.7	4.9	9.7	2.8	1.9	0.1	0.5	-1.9	-3.1	3.0
Bipolar Disorder or Schizophrenia	3.6	8.8	14.3	-3.0	1.4	-3.7	3.1	3.8	3.6	0.5
Crohns Disease (2017)	3.5	7.7	12.6	-3.1	1.6	-3.3	2.9	3.5	3.1	0.4
Medication: Atorvastatin	3.5	4.3	7.6	-1.9	2.3	-2.7	2.8	1.5	0.8	1.8
Hair/balding pattern: Pattern 3	3.4	5.1	8.8	2.0	-1.8	3.0	-2.7	-2.7	-1.7	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.3	3.8	7.2	-1.5	2.3	-2.7	2.4	1.7	0.9	1.6
Average weekly champagne plus white wine intake	3.3	4.6	9.7	-0.5	-2.6	2.4	-3.1	-2.0	-0.0	-2.3
Hand grip strength (right)	3.0	8.1	35.2	-5.9	0.2	-2.9	1.4	2.0	2.6	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.9	3.8	7.9	-2.2	1.2	-2.3	2.3	2.8	1.3	0.7
Handedness (chirality/laterality): Left-handed	2.9	3.4	5.9	-2.1	1.9	-2.4	2.3	0.9	-0.4	1.9
Crohns Disease (2012)	2.8	4.5	9.9	-2.9	-0.3	-1.7	1.2	2.8	3.1	-1.1
Ulcerative Colitis	2.8	4.1	7.0	-2.3	1.7	-2.6	2.0	2.6	1.6	0.6
Diastolic blood pressure, automated reading	2.8	8.7	19.4	-2.5	0.3	-2.4	3.4	4.1	4.4	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.1	7.3	-2.7	-2.1	0.3	-1.2	0.2	1.8	-2.2
Schizophrenia vs Biploar Disorder	2.6	3.5	10.3	-1.5	-1.4	-0.9	0.4	2.5	3.2	-1.7
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	8.4	2.9	-0.8	2.1	-1.8	-2.2	-1.6	-0.0
Breastfed as a baby	2.6	3.2	6.5	1.3	-1.9	2.5	-2.1	-1.8	-0.6	-1.7
Blood clot in the leg (DVT)	2.6	3.3	9.1	3.0	0.5	1.3	-1.0	-1.6	-2.7	1.3
Age at First Birth	2.5	3.6	12.2	0.2	1.6	0.1	-0.1	-2.5	-3.5	2.1
Medication: Levothyroxine sodium	2.5	4.2	11.4	1.3	-0.6	2.0	-2.3	-2.5	-3.4	0.4
Mean time to correctly identify matches	2.5	4.7	10.8	-2.9	0.2	-2.2	1.8	3.3	2.3	-0.2
Ever had bowel cancer screening	2.4	2.8	5.8	-1.4	0.8	-2.3	2.0	2.4	0.6	1.1
Age at first live birth	2.3	4.0	8.6	-1.0	-1.9	2.0	-2.9	-2.6	-1.4	-1.4
Leg fat percentage (left)	2.2	7.8	14.0	-2.2	1.8	-3.6	3.7	3.7	2.1	1.0
Risk taking	2.2	3.3	9.5	-3.1	-1.0	-1.5	0.3	2.3	2.1	-0.8
Systolic Blood Pressure	2.1	10.3	23.3	4.8	-0.5	3.8	-2.5	-4.2	-3.2	0.3
Falls in the last year	2.1	2.8	5.9	-0.1	2.4	-2.1	2.0	1.2	-0.5	1.9
Chronic bronchitis/emphysema (mother)	2.1	2.5	6.0	-1.4	0.3	-1.7	1.4	2.1	2.4	-0.4
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	7.6	2.8	0.4	1.2	-1.1	-1.4	-2.4	1.1
Supplements: Glucosamine	2.0	2.5	5.3	1.0	-0.9	1.6	-2.3	-2.2	-1.8	-0.2
Family relationship satisfaction	2.0	2.5	5.3	-2.3	-0.1	-1.8	1.2	2.0	1.7	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	5.3	2.1	0.6	1.1	-0.5	-1.9	-2.3	1.0
Breast Cancer	1.9	4.6	15.9	-4.0	-2.2	-0.5	-1.5	0.9	1.8	-2.3
Ovarian Cancer	1.9	2.6	4.8	0.1	-1.4	2.1	-2.1	-2.2	-1.1	-1.0
Hand grip strength (left)	1.9	5.1	29.1	-5.4	0.5	-2.2	0.6	0.0	0.9	0.5
Leg fat percentage (right)	1.9	6.9	14.0	-2.4	1.2	-3.3	3.2	3.7	2.5	0.4
Medication: Omeprazole	1.9	2.2	3.7	1.8	-1.5	1.9	-1.8	-1.1	-0.6	-1.3
Friendships satisfaction	1.9	2.4	5.5	-2.3	-0.0	-1.9	1.4	2.1	1.2	0.0
Systolic blood pressure, automated reading	1.8	5.3	11.4	3.2	0.6	2.1	-0.3	-2.8	-3.4	1.5
Medication: Metformin	1.8	2.5	5.3	1.3	2.3	-1.1	0.8	-0.4	-1.9	2.3
Serious illness, injury or assault to yourself	1.8	2.1	6.6	0.7	-1.0	-0.4	-0.0	2.4	2.6	-1.1
Medication: Amlodipine	1.8	2.6	5.1	-1.2	1.7	-2.1	2.3	1.6	0.9	1.0
Number of children fathered	1.8	2.0	7.3	2.7	-0.2	1.6	-1.0	-1.4	-1.2	0.0
Pulse wave peak to peak time	1.8	2.1	5.3	1.0	1.1	0.5	-0.4	-1.8	-2.3	1.8
Mouth/teeth dental problems: Loose teeth	1.8	2.1	5.1	-2.3	0.8	-2.0	1.0	1.5	1.1	0.6
Alcohol drinker status: Never	1.8	2.2	4.5	1.2	-1.0	2.0	-1.6	-2.1	-1.3	-0.3
Alzheimer’s Disease (including proxy)	1.7	2.5	8.7	1.0	-0.5	1.5	-1.0	-2.0	-2.9	0.2
Allergy	1.7	3.8	7.7	-1.5	2.8	-2.5	2.6	0.5	-0.2	2.0
Mineral and other dietary supplements	1.7	2.2	4.9	-1.7	-0.0	-1.0	0.8	2.2	2.2	-1.1
Osteoporosis (self-reported)	1.7	2.1	4.0	0.8	1.5	-1.6	2.0	1.6	0.4	1.5
Financial situation satisfaction	1.7	2.1	3.9	1.1	2.0	-1.3	2.0	0.7	-0.7	1.9
Depression (Nagel 2018)	1.6	2.4	4.8	-2.2	-0.1	-1.5	1.1	2.2	1.9	-0.6
Fed-up feelings	1.6	3.0	5.8	1.1	1.8	-1.8	2.4	2.2	0.7	1.4
Alcohol usually taken with meals	1.6	2.7	5.3	0.1	-2.2	1.6	-2.3	-0.8	0.7	-2.2
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	9.3	-3.1	-0.6	-1.0	0.3	1.8	1.5	-1.0
Medication: Lansoprazole	1.6	1.8	3.6	-0.3	1.3	-1.9	1.7	1.8	0.8	0.7
Major Depression (MDD)	1.5	1.8	3.6	-0.6	1.4	-1.9	1.4	1.9	0.7	0.9
Hayfever, allergic rhinitis or eczema	1.5	3.2	7.1	1.1	-2.7	2.1	-2.0	-0.1	0.9	-2.2
Chronic bronchitis/emphysema (father)	1.5	1.8	4.5	-0.5	0.7	-1.5	1.7	2.1	1.3	0.5
Time employed in main current job	1.5	1.7	3.5	-1.9	0.4	-1.3	1.0	1.7	1.7	-0.2
Pulse wave Arterial Stiffness index	1.5	1.8	4.5	-1.0	-1.1	-0.4	0.3	1.5	2.1	-1.7
Breast cancer (self-reported)	1.5	1.8	8.2	2.9	1.4	-0.2	0.9	0.3	-0.2	1.4
Guilty feelings	1.5	2.2	5.2	-2.3	-0.8	-1.1	0.6	1.8	1.8	-1.2
Hearing aid user	1.5	1.7	4.0	0.4	1.1	-1.5	1.7	2.0	1.1	0.6
Mean Putamen Volume	1.4	1.6	4.7	-2.2	-0.9	-0.4	-0.5	0.8	1.7	-1.3
Supplements: Zinc	1.4	1.6	3.0	-0.6	-1.7	0.6	-1.7	0.0	1.2	-1.7
Medication: Simvastatin	1.4	2.0	4.6	-0.6	2.1	-1.6	1.6	0.4	-0.7	1.8
Wheeze or whistling in the chest in last year	1.4	2.5	6.8	-0.9	-0.2	-1.4	0.8	2.6	2.6	-0.6
Alcohol intake frequency.	1.4	3.2	18.1	4.3	0.6	1.3	0.4	-0.5	-1.2	0.8
Neuroticism (2016)	1.3	1.9	4.1	-0.3	1.0	-1.7	1.9	2.0	1.2	0.4
Fluid intelligence score	1.3	2.6	15.4	-3.9	0.3	-1.4	0.9	0.1	0.1	0.4
Father’s age at death	1.3	1.8	3.8	1.7	-1.5	1.9	-0.8	-1.0	-0.7	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.1	-0.4	-1.4	1.4	-1.7	-1.6	-1.1	-0.9
Prospective memory result	1.3	1.6	4.5	0.6	0.6	-1.1	2.1	1.9	0.6	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.1	1.5	1.3	-1.0	1.8	1.0	-0.2	1.4
Mother’s age at death	1.3	1.6	3.0	0.5	-1.4	1.7	-1.7	-1.3	-0.9	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	4.5	2.1	-0.9	1.6	-1.2	-0.9	-0.9	-0.8
Alzheimer’s Disease (in mother)	1.2	1.4	2.7	0.2	-0.9	1.5	-1.2	-1.6	-1.6	-0.5
Smoking Status	1.2	2.9	6.7	1.0	1.7	-1.7	2.6	2.2	0.5	1.3
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.0	-0.4	1.6	-1.2	0.9	-0.1	-1.5	2.0
Worrier / anxious feelings	1.2	2.2	5.4	-2.3	-0.3	-1.2	0.9	2.1	1.8	-0.7
Pulse wave reflection index	1.2	1.5	3.5	-1.0	-1.9	0.8	-1.2	0.4	0.4	-1.9
Qualifications: College or University degree	1.2	3.8	9.9	-3.1	-2.1	0.7	-2.7	-1.6	-0.2	-1.4
Leg fat mass (right)	1.2	4.5	9.5	-1.4	1.3	-2.8	2.4	3.1	2.1	0.4
Loneliness, isolation	1.2	1.6	4.7	-1.0	0.4	-1.4	1.7	2.2	0.7	0.3
Leg fat mass (left)	1.2	4.8	9.5	-1.3	1.6	-2.9	2.7	3.1	1.9	0.8
Rheumatoid Arthritis	1.1	1.6	3.6	0.9	1.6	-0.7	0.7	-0.1	-1.8	1.9
Blood Eosinophil Count	1.1	8.7	22.6	0.2	1.4	-2.8	3.5	4.8	4.1	0.0
Blood White Count	1.1	8.2	25.9	2.0	-0.0	-1.6	2.2	5.1	4.2	-1.6
Heel T-Score	1.1	9.1	41.1	-6.4	-2.4	-1.6	-1.6	1.9	1.1	-2.6
Average weekly fortified wine intake	1.1	1.2	2.8	0.5	-1.3	1.2	-1.7	-1.2	-0.3	-1.1
Glaucoma (self-reported)	1.1	1.3	3.8	-0.5	-1.3	0.7	-0.6	0.8	1.3	-1.9
Medication for cholesterol	1.1	1.6	4.2	1.0	-1.2	1.4	-2.0	-1.4	-0.4	-0.8
Alzheimer’s Disease (in father)	1.0	1.1	3.2	1.2	-0.4	1.2	-0.7	-1.0	-1.8	-0.1
HbA1C	1.0	1.1	2.3	0.4	-0.9	0.2	-0.9	1.1	1.4	-1.5
Severe depression (siblings)	1.0	1.2	3.6	-1.9	-0.5	-1.0	0.3	0.9	1.4	-0.6
Townsend deprivation index at recruitment	1.0	1.4	3.6	-1.1	0.4	-1.0	0.9	1.7	1.9	-0.6
Relative age voice broke	1.0	1.5	2.9	-1.1	0.7	-1.4	1.7	1.7	0.6	0.6
Illnesses of siblings	1.0	1.5	6.2	2.5	-1.0	1.1	-0.8	-0.3	0.6	-0.9
Impedance of arm (right)	1.0	4.8	9.4	-1.9	-2.6	2.2	-3.1	-1.8	0.4	-2.3
Happiness	1.0	1.2	2.0	-1.3	-1.4	-0.1	-0.3	0.8	1.3	-1.4
Qualifications: A levels/AS levels or equivalent	1.0	2.2	6.1	-1.3	-0.7	1.1	-1.9	-2.5	-1.6	-0.1
Impedance of arm (left)	1.0	4.6	8.6	-2.2	-2.5	2.0	-2.9	-1.9	0.4	-2.1
High blood pressure (siblings)	1.0	1.4	4.0	-1.7	0.6	-0.0	-0.1	-1.3	-2.0	1.0
Worry too long after embarrassment	1.0	1.7	4.2	-1.6	-0.4	-1.0	0.6	1.7	2.0	-0.9
Overall health rating	1.0	2.1	4.0	-0.1	1.8	-1.6	2.0	1.7	-0.2	1.5
Smoking status: Current	1.0	1.6	3.9	0.2	0.7	-1.3	2.0	2.0	1.0	0.5
Miserableness	1.0	1.8	3.1	-1.5	1.0	-1.8	1.7	1.7	0.3	0.8
Ever taken oral contraceptive pill	1.0	1.1	2.2	0.0	-1.2	1.3	-1.5	-1.1	-1.0	-0.6
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.6	0.4	-0.0	1.0	-1.0	-1.9	-1.4	0.3
Eye problems/disorders: Glaucoma	1.0	1.2	3.2	0.1	-1.3	1.0	-0.4	0.9	1.2	-1.8
High cholesterol (Self-reported)	1.0	1.7	3.5	-1.9	1.2	-1.6	1.6	1.1	0.8	0.4
Number of operations (self-reported)	1.0	1.4	3.1	0.9	-1.1	0.8	-1.6	0.6	1.1	-1.8
Bipolar Disorder (2018)	0.9	1.4	2.4	-0.5	0.8	-1.5	1.3	1.5	1.5	0.4
Sensitivity / hurt feelings	0.9	1.5	4.7	2.2	-0.6	1.5	-1.0	-0.8	-0.9	-0.6
Frequency of depressed mood in last 2 weeks	0.9	1.3	4.1	-2.0	-0.0	-1.1	0.7	1.6	1.0	-0.2
Current tobacco smoking	0.9	1.5	3.6	0.3	0.7	-1.3	1.9	1.9	1.0	0.4
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.0	1.2	-1.4	1.3	-0.8	-0.1	0.2	-1.1
Medication: Atenolol	0.9	1.1	1.9	1.1	1.2	0.2	-0.0	-1.4	-1.2	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	8.7	-3.0	0.1	-1.5	0.4	1.5	0.9	-0.5
Medication: Ramipril	0.9	1.1	2.3	0.5	1.5	-1.4	1.0	0.4	-0.3	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.9	0.2	-1.2	1.1	-1.4	-0.7	-0.5	-1.3
Medication: Cholesterol lowering	0.9	1.4	4.6	0.2	2.1	-1.2	1.1	0.2	-0.2	1.5
Exposure to tobacco smoke at home	0.9	1.0	5.9	2.4	0.0	0.8	-0.4	-0.4	-0.2	-0.3
Body fat percentage	0.9	3.6	7.7	-1.6	0.7	-2.3	2.0	2.8	2.1	0.1
Comparative body size at age 10	0.9	2.4	9.9	-3.1	1.3	-1.9	0.8	0.3	-0.6	0.7
Allergy or Eczema	0.8	2.2	4.5	0.6	-2.1	1.7	-1.9	-0.3	0.7	-1.7
Type 2 Diabetes (T2D) (2018)	0.8	1.4	4.0	1.4	-0.9	1.0	-2.0	-1.0	-0.9	-0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	5.5	2.3	0.4	0.4	0.7	0.3	-0.8	0.5
Sitting height	0.8	5.9	15.1	-0.4	-2.4	2.8	-3.9	-2.9	-0.8	-1.9
Nervous feelings	0.8	1.5	2.9	0.8	-1.7	1.5	-1.5	-0.3	0.6	-1.5
Mouth/teeth dental problems: Dentures	0.8	1.3	4.0	2.0	0.9	0.6	0.1	-1.0	-1.6	0.8
Medication for pain relief, constipation, heartburn	0.8	1.3	2.4	-0.2	1.4	-1.4	1.6	1.3	0.9	0.8
Medication: Ibuprofen	0.8	1.0	1.9	-0.6	-1.3	0.9	-1.4	-1.0	-0.4	-0.9
Chest pain or discomfort	0.8	1.2	2.8	-0.0	-1.0	0.4	-0.5	1.1	1.6	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.6	1.1	1.3	0.3	0.0	-1.6	-1.9	1.8
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.9	0.9	-0.9	1.4	-1.0	-1.1	-0.9	-0.5
Fasting Glucose	0.7	0.8	2.3	1.5	0.6	0.4	-0.4	-0.8	-1.3	0.8
Waist Hip Ratio (WHR)	0.7	3.1	8.6	0.3	-0.4	1.9	-1.7	-2.9	-2.5	0.2
Cardiovascular Disease	0.7	2.3	3.5	-1.8	0.6	-1.8	1.6	1.9	1.9	-0.1
Lung FEV1/FVC ratio	0.7	3.4	8.8	2.7	1.7	0.2	1.2	-1.2	-3.0	1.6
Diabetes (mother)	0.7	1.0	5.4	2.3	-0.1	0.7	-0.2	-0.2	-0.8	0.1
Age when periods started (menarche)	0.7	1.8	3.3	-1.1	1.8	-1.8	1.2	0.4	-0.2	1.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	4.5	2.1	0.3	0.4	0.5	0.6	-0.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	7.8	-2.8	-0.4	-1.1	0.2	1.2	0.4	-0.6
Qualifications: CSEs or equivalent	0.7	1.0	1.8	0.3	1.3	-1.0	1.3	1.0	0.2	1.1
Body mass index (BMI)	0.7	3.0	8.1	0.7	1.1	-1.9	2.2	2.9	1.4	0.4
Had menopause	0.7	0.9	1.8	1.0	0.9	-0.3	1.3	0.0	-1.0	1.3
Qualifications: None of the above	0.7	1.4	4.2	2.1	1.4	-0.2	1.4	0.3	-0.5	1.1
Diabetes (self-reported)	0.7	1.1	2.8	1.6	0.8	0.2	-0.7	-0.9	-1.7	0.7
Length of working week for main job	0.7	0.7	1.4	-0.6	1.1	-1.2	0.9	0.4	-0.1	1.1
Tense / ‘highly strung’	0.7	1.2	3.1	-1.3	-0.4	-0.7	0.2	1.4	1.8	-1.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.6	0.1	-1.9	1.3	-0.8	-0.3	-0.3	-1.3
Shortness of breath walking on level ground	0.7	0.8	1.4	0.3	1.1	-1.0	1.2	1.0	0.2	1.1
Whole body fat mass	0.7	2.8	6.8	-1.0	0.7	-2.0	1.6	2.6	2.2	-0.1
Suffer from ‘nerves’	0.7	1.2	3.4	0.2	0.0	-0.8	1.1	1.8	1.6	-0.1
Diabetes diagnosed by doctor	0.7	1.2	3.1	1.5	0.5	0.3	-0.9	-1.0	-1.8	0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	3.4	-1.8	-1.1	0.0	-0.4	0.4	0.8	-1.4
Illnesses of father: None of the above (group 1)	0.7	0.9	4.8	2.2	0.8	0.2	0.1	-0.4	-0.3	0.7
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.6	-1.9	-0.1	-1.0	0.6	0.6	0.3	0.4
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.6	-1.4	-1.1	1.2	-1.5	-2.1	-1.4	-0.3
BMI	0.6	3.7	11.4	0.2	-0.5	-1.4	1.1	3.4	3.0	-1.4
Lung FVC	0.6	3.1	5.5	-0.5	2.3	-2.2	2.2	1.3	1.1	2.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.4	0.6	0.4	0.1	-0.0	-1.1	-1.6	0.8
Diabetes (father)	0.6	0.8	1.6	1.3	-0.8	1.0	-1.1	-0.6	-0.7	-0.1
Impedance of leg (left)	0.6	3.1	16.6	-4.1	0.6	-1.6	1.2	0.1	0.4	0.8
Pain all over the body in last month	0.6	0.7	1.5	-0.7	1.0	-1.2	0.7	0.8	0.7	0.5
Medication: Paracetamol	0.6	1.0	2.1	0.6	-1.4	0.9	-1.0	0.0	0.9	-1.4
Emphysema/chronic bronchitis	0.6	0.6	1.5	1.0	-0.3	1.2	-0.9	-0.9	-0.6	0.0
Heart disease (mother)	0.6	0.7	4.6	-2.1	-0.1	-0.5	-0.1	0.1	0.0	-0.2
Leg pain on walking	0.6	0.7	2.1	1.4	-0.9	0.9	-0.9	0.1	-0.5	-0.3
Knee pain experienced in last month	0.6	0.9	4.2	2.0	0.6	0.6	-0.3	-0.5	-1.0	0.3
Smoking status: Previous	0.6	0.9	2.1	1.4	0.0	0.9	-1.0	-0.9	-1.3	0.3
Commuting to job workplace: Public transport	0.6	0.7	1.3	0.5	-1.0	1.1	-1.1	-0.9	-0.2	-0.6
Medication: Blood pressure	0.6	1.1	2.9	-1.7	0.3	-1.3	1.1	1.1	0.7	-0.0
Medication: Paracetamol	0.6	1.0	1.9	1.2	-1.0	0.5	-0.4	0.8	1.4	-1.2
Ever smoked	0.6	1.1	5.3	2.3	0.6	0.3	0.2	-0.2	-1.1	0.8
Average weekly beer plus cider intake	0.6	0.8	1.7	-0.7	0.7	-1.1	1.3	0.9	0.9	0.5
Heart disease (siblings)	0.6	0.8	3.0	-1.7	0.3	-0.9	0.7	0.7	0.8	0.1
Depressed Affect (Nagel 2018)	0.5	1.0	1.7	-0.6	1.2	-1.3	1.2	1.1	0.0	0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.3	5.3	-2.3	-1.0	0.3	-1.0	-1.1	-0.0	-0.7
Height	0.5	9.1	23.4	-2.6	-1.7	2.9	-4.4	-4.8	-1.2	-1.1
Neuroticism	0.5	1.2	3.6	-0.6	0.2	-1.0	1.0	1.9	1.4	-0.3
Hair Pigment	0.5	15.1	37.2	6.1	-1.0	3.9	-3.4	-4.4	-4.5	0.6
Hearing difficulty/problems: Yes	0.5	0.7	1.7	-0.5	0.9	-0.6	0.6	-0.3	-1.3	1.2
Impedance of leg (right)	0.5	2.5	15.4	-3.9	-0.6	-0.7	0.2	0.1	0.9	-0.4
Trunk fat percentage	0.5	2.1	4.3	-1.6	0.2	-1.7	1.3	2.1	1.9	-0.3
Taking other prescription medications	0.5	0.7	1.8	0.3	-1.2	0.9	-1.4	-0.4	-0.3	-0.8
Hair/balding pattern: Pattern 2	0.5	0.6	3.5	-1.9	-0.5	-0.2	-0.2	-0.4	0.6	-0.4
Alcohol intake versus 10 years previously	0.5	0.7	2.3	1.5	0.5	0.1	0.6	-0.0	-1.0	1.1
Number of live births	0.5	0.8	1.4	-0.5	1.1	-1.0	1.0	0.4	-0.5	1.2
Standing height	0.5	5.3	13.2	-2.1	-2.0	2.0	-3.6	-2.9	0.1	-1.6
Peak expiratory flow (PEF)	0.5	1.2	2.7	0.3	-0.6	1.1	-1.4	-1.6	-1.5	-0.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	-0.8	-0.8	0.8	-0.9	-0.6	-1.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.5	0.4	0.6	-0.3	0.8	-0.2	-1.0	1.2
Had major operations	0.5	0.6	2.0	-0.2	-0.3	-0.5	-0.1	1.3	1.4	-0.7
Hypertension (Self-reported)	0.5	1.4	2.6	-1.0	0.8	-1.4	1.2	1.4	1.6	0.0
Arm fat percentage (left)	0.5	1.9	5.6	-0.3	0.6	-1.6	1.5	2.4	1.6	-0.0
Average weekly red wine intake	0.5	0.7	2.2	-0.7	-0.0	0.5	-0.5	-1.4	-1.5	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	0.5	-0.7	0.7	-1.2	-0.1	0.2	-0.9
Qualifications: nursing, teaching	0.5	0.7	2.6	-1.6	-0.4	0.2	-1.1	-0.9	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.7	-0.0	1.6	-0.5	0.6	-0.7	-0.9	1.6
Arm fat mass (left)	0.5	2.0	5.2	-0.2	0.9	-1.8	1.6	2.3	1.5	0.3
Alcohol drinker status: Previous	0.5	0.5	1.0	0.8	0.8	0.0	0.9	0.0	-0.8	1.0
Impedance of whole body	0.5	2.5	10.3	-3.2	-1.5	0.7	-1.3	-1.1	0.6	-1.1
Worry (Nagel 2018)	0.4	0.9	2.5	-0.8	-0.9	0.1	0.0	1.1	1.6	-1.2
Prostate Cancer	0.4	0.6	0.9	0.9	-0.8	0.4	0.5	0.9	1.0	-0.7
LDL Cholesterol	0.4	0.7	1.8	-1.1	1.2	-1.3	0.0	0.0	0.0	0.0
Lupus	0.4	0.6	2.2	1.5	-0.5	0.7	-0.9	-0.1	0.2	-0.4
Triglycerides	0.4	0.6	2.3	-1.5	0.3	-1.4	0.0	0.0	0.0	0.0
Medication for hormone replacement therapy	0.4	0.5	1.0	1.0	-0.5	0.9	-0.8	-0.3	0.3	-0.7
Medication: Co-codamol	0.4	0.5	1.0	1.0	-0.6	0.8	-0.6	-0.1	0.5	-0.8
Trunk fat mass	0.4	1.9	3.7	-1.4	0.4	-1.7	1.1	1.9	1.8	-0.2
Heart attack	0.4	0.5	1.9	0.7	-0.3	0.7	-1.4	-0.8	-0.1	-0.5
Arm fat percentage (right)	0.4	1.7	5.3	-0.2	0.6	-1.5	1.5	2.3	1.4	0.0
Arm fat mass (right)	0.4	1.6	4.1	0.1	0.9	-1.5	1.4	2.0	1.4	0.2
Birth weight of first child	0.4	0.8	3.4	-1.9	0.8	-0.8	0.6	-0.1	-0.5	0.6
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.0	0.2	0.9	-0.7	0.7	1.0	0.1	0.6
Medication: Blood pressure	0.4	0.7	1.8	-0.4	1.4	-1.1	0.3	0.4	1.2	0.4
Angina (self-reported)	0.4	0.5	0.9	0.9	-0.0	0.8	-0.9	-0.9	-0.3	-0.3
Medication: Allopurinol	0.4	0.5	1.0	1.0	0.8	-0.3	0.6	-0.2	-0.4	1.0
Medication: Seretide 50 evohaler	0.4	0.4	1.9	0.6	-0.1	-0.2	0.1	0.9	1.4	-0.2
Comparative height size at age 10	0.4	2.3	6.2	1.3	-0.2	1.7	-2.0	-2.5	-1.1	0.1
Age at last live birth	0.4	0.6	3.0	-1.7	0.3	-0.6	0.1	-0.5	-0.4	0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	-1.0	1.0	-0.6	0.2	-0.8	-0.2	0.9
Illnesses of father: Heart disease	0.4	0.6	1.4	-1.0	-1.2	0.5	-0.3	0.1	0.5	-1.1
Eye problems/disorders: Cataract	0.4	0.4	1.2	-0.7	0.5	-0.8	0.0	0.6	1.1	-0.0
Osteoarthritis (self-reported)	0.4	0.5	1.4	0.2	-0.1	0.7	-0.9	-0.9	-1.2	0.2
Medication: Lisinopril	0.4	0.5	1.2	-0.3	-0.8	-0.0	-0.7	0.3	1.1	-1.0
Illnesses of father: High blood pressure	0.4	0.5	2.6	-1.6	-0.0	-0.5	0.5	0.3	-0.1	-0.2
Age started oral contraceptive pill	0.4	0.4	1.4	-1.2	0.0	0.1	0.7	-0.6	-0.8	0.5
Unable to work because of sickness or disability	0.4	0.5	0.9	0.9	0.8	-0.7	0.9	0.8	0.1	0.6
Neuroticism (Nagel 2018)	0.3	0.8	2.0	-1.0	-0.1	-0.7	0.4	1.4	1.3	-0.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	-1.3	-0.1	-1.2	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.3	0.4	0.7	-0.8	0.5	-0.3	-0.4	-0.7	-0.6	0.7
Average weekly spirits intake	0.3	0.4	1.5	1.2	0.7	-0.2	0.5	0.2	-0.2	0.8
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	1.0	0.4	0.1	-0.1	0.2	-0.7	0.6
Angina	0.3	0.3	0.8	0.7	0.0	0.6	-0.9	-0.6	-0.1	-0.4
Vitamin and mineral supplements	0.3	0.3	1.1	-0.7	-0.6	0.6	-0.3	0.1	0.2	-1.0
Multivitamins +/- minerals	0.3	0.4	1.0	0.9	0.4	0.1	-0.1	-0.7	-0.7	1.0
Hearing difficulty/problems with background noise	0.3	0.4	1.9	-1.4	-0.2	-0.5	-0.2	0.5	0.7	-0.2
Financial difficulties in last 2 years	0.3	0.4	0.9	0.2	-0.9	0.8	-0.8	-0.3	0.3	-0.9
Neuroticism score	0.3	0.7	2.3	-0.2	0.2	-0.8	0.8	1.5	1.0	0.0
Noisy workplace	0.3	0.4	0.9	1.0	-0.7	0.6	-0.5	-0.4	0.0	-0.5
Depression (self-reported)	0.3	0.3	0.8	-0.7	-0.2	-0.6	0.4	0.9	0.3	-0.5
Illnesses of mother	0.3	0.4	0.8	-0.2	-0.9	0.3	-0.6	0.4	0.8	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.3	1.0	0.5	0.7	-0.6	-1.5	-1.2	0.8
Hair/balding pattern: Pattern 4	0.3	0.7	3.5	-1.9	-0.4	-0.5	-0.0	0.6	0.6	-0.6
Exposure to tobacco smoke outside home	0.3	0.4	2.3	1.5	-0.2	0.3	0.1	0.4	0.6	-0.2
Neck or shoulder pain in last month	0.3	0.4	1.4	1.0	0.4	-0.3	0.6	1.2	-0.0	0.3
Medication: Aspirin	0.3	0.4	1.4	-0.2	-0.2	0.5	-0.6	-0.7	-1.2	0.1
Mood swings	0.3	0.5	1.2	1.1	0.6	0.5	-0.3	-0.5	-1.1	0.5
Long-standing illness, disability or infirmity	0.3	0.4	1.0	0.1	-0.3	0.7	-1.0	-0.8	-0.9	-0.1
Medication: Gliclazide	0.3	0.4	0.7	0.4	0.8	-0.8	0.4	0.4	-0.6	0.8
Wears glasses or contact lenses	0.3	0.4	1.8	-1.4	-0.6	-0.1	0.0	0.2	0.2	-0.7
Irritability	0.3	0.5	1.5	0.4	0.2	-0.6	0.1	1.1	1.2	-0.2
Ever depressed for a whole week	0.3	0.3	1.4	1.2	0.4	0.5	-0.4	-0.5	-0.4	-0.0
Commuting to job workplace: Cycle	0.3	0.3	1.5	-1.2	-0.1	-0.1	0.1	-0.1	-0.8	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.6	0.5	-0.8	1.0	-1.0	-1.0	-1.3	-0.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	0.4	-0.3	0.5	-1.2	-0.8	-0.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.8	0.9	0.6	-0.6	0.0	0.0	0.0	0.0
Pack years adult smoking proportion	0.2	0.3	1.1	-0.4	0.1	-0.6	0.1	0.7	1.0	-0.3
Leg fat-free mass (left)	0.2	1.0	1.9	0.9	-0.8	0.4	-1.2	0.5	1.4	-1.3
Maternal smoking around birth	0.2	0.2	0.4	0.3	0.5	-0.4	0.0	0.6	0.7	-0.5
High blood pressure	0.2	0.7	1.3	-0.5	0.8	-0.9	1.0	0.8	1.1	0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.9	1.4	-0.1	0.2	0.2	0.0	-0.1	-0.2
Leg predicted mass (left)	0.2	1.0	2.1	0.8	-0.8	0.4	-1.1	0.6	1.4	-1.3
Past tobacco smoking	0.2	0.4	1.9	-1.4	-0.5	0.1	-0.2	-0.3	0.6	-0.5
Weight	0.2	0.8	2.0	-0.3	0.1	-1.0	0.5	1.4	1.4	-0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.3	0.6	0.3	0.6	-0.7	-1.2	-0.8	0.5
Loud music exposure frequency	0.2	0.3	0.6	0.5	-0.7	0.1	-0.3	0.3	0.8	-0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.9	-0.0	-0.5	0.6	-1.0	-0.8	-0.4	-0.3
Headache pain in last month	0.2	0.3	1.2	0.1	-0.0	0.4	-0.5	-0.7	-1.1	0.5
Birth weight	0.2	0.5	1.5	-0.8	0.4	-0.6	0.6	0.7	1.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.3	-1.1	0.3	-0.6	0.5	0.3	-0.0	0.3
Migraine (self-reported)	0.2	0.2	0.7	-0.8	-0.6	0.1	-0.4	0.0	-0.2	-0.5
Arm predicted mass (right)	0.2	1.0	2.2	-0.5	0.9	-1.5	0.9	1.2	1.2	0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	0.5	-0.8	0.5	-0.2	-0.2	0.1	-0.7
Illnesses of siblings: Diabetes	0.2	0.2	1.2	0.2	-0.1	-0.1	-0.0	1.1	0.3	-0.3
Back pain experienced in last month	0.2	0.2	1.0	0.6	0.1	-0.1	0.4	1.0	0.4	-0.2
Number of self-reported non-cancer illnesses	0.2	0.3	1.3	-0.1	0.1	0.4	-0.6	-0.6	-1.2	0.4
Arm fat-free mass (left)	0.2	0.9	1.9	-0.2	0.9	-1.4	1.0	1.2	0.9	0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.7	0.5	0.4	-0.4	0.8	0.4	-0.3	0.7
Supplements: Calcium	0.2	0.2	0.4	-0.0	0.4	-0.6	0.6	0.5	-0.4	0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.7	0.0	0.7	0.0	-0.7	-0.3	-0.2
Respiratory disease	0.1	0.1	0.3	-0.6	-0.0	-0.3	-0.2	0.1	0.3	0.6
Chronotype (morning person)	0.1	0.2	1.4	-1.2	0.1	-0.3	-0.2	-0.0	-0.0	0.0
Tanning	0.1	1.1	3.1	1.7	-0.7	1.4	-1.1	-0.8	-0.1	-0.5
Relative age of first facial hair	0.1	0.2	0.4	-0.2	-0.4	0.4	-0.7	-0.4	-0.4	-0.4
High blood pressure (mother)	0.1	0.1	0.7	0.8	0.4	0.1	0.1	0.0	0.1	0.3
Waist circumference	0.1	0.3	0.5	0.4	0.7	-0.6	0.7	0.6	-0.2	0.4
Forced vital capacity (FVC)	0.1	0.5	1.8	-1.3	0.6	-0.7	-0.2	-0.2	0.6	0.7
Mouth/teeth dental problems	0.1	0.2	1.0	1.0	-0.4	0.4	-0.4	-0.2	0.3	-0.1
Hip circumference	0.1	0.6	1.8	-0.1	-0.2	-0.6	0.3	1.4	1.2	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.6	-0.2	-0.5	0.0	0.8	0.0	0.2
Asthma	0.1	0.2	0.6	-0.2	-0.5	0.1	-0.7	0.2	0.8	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	1.4	-1.2	-0.2	-0.1	-0.1	0.1	-0.3	-0.1
Gout (self-reported)	0.1	0.1	0.5	0.7	-0.1	0.2	0.1	-0.5	-0.2	0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.1	0.6	-0.4	0.0	0.1	0.4	0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	0.9	-0.5	0.8	-0.1	-0.3	-0.8	-0.2	0.9
Arm fat-free mass (right)	0.1	0.7	1.6	-0.2	0.7	-1.3	0.8	1.1	0.9	0.4
Number of full brothers	0.1	0.2	0.3	0.0	0.4	-0.1	0.5	0.4	-0.5	0.5
Health satisfaction	0.1	0.1	0.3	0.6	-0.4	0.2	-0.2	0.1	-0.5	0.1
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.3	-0.4	0.4	0.2	0.2	-0.0	-0.2
Supplements: Vitamin C	0.1	0.1	0.5	-0.4	0.2	-0.7	0.1	0.3	0.0	0.4
Leg fat-free mass (right)	0.1	0.6	1.8	1.4	-0.3	0.5	-1.1	-0.0	0.7	-0.6
Commuting to job workplace: Walk	0.1	0.1	0.4	0.5	-0.2	0.4	-0.6	-0.5	-0.1	0.1
Asthma (self-reported)	0.1	0.2	0.8	-0.2	-0.1	-0.3	-0.4	0.4	0.9	-0.1
Medication: Aspirin	0.1	0.1	0.7	-0.4	0.1	0.2	-0.2	-0.3	-0.8	0.1
Leg predicted mass (right)	0.1	0.6	1.8	1.4	-0.3	0.5	-1.1	0.0	0.8	-0.7
Pain experienced in last month	0.1	0.1	0.3	-0.5	-0.5	0.2	-0.4	-0.3	0.4	-0.3
Pack years of smoking	0.1	0.2	0.4	-0.1	0.5	-0.6	0.3	0.6	0.6	0.1
Arm predicted mass (left)	0.1	0.6	1.2	-0.1	0.6	-1.1	0.7	1.1	1.1	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.1	0.3	-0.2	-0.5	-0.2	0.0	0.0	0.0	0.0
Number of treatments/medications taken	0.0	0.1	0.3	0.6	0.0	0.0	0.1	0.3	0.1	0.0
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.3	0.2	0.1	0.2	0.3	0.0	-0.5	0.0
Trunk fat-free mass	0.0	0.1	0.2	0.4	0.2	-0.2	-0.4	-0.0	0.3	0.0
Trunk predicted mass	0.0	0.1	0.1	0.4	0.3	-0.2	-0.4	-0.0	0.3	0.1
Number of full sisters	0.0	0.0	0.1	-0.3	0.2	-0.0	-0.3	0.2	0.2	-0.2
Whole body fat-free mass	0.0	0.2	0.6	0.5	-0.0	-0.1	-0.5	0.3	0.8	-0.3
Whole body water mass	0.0	0.2	0.6	0.5	0.0	-0.2	-0.5	0.4	0.8	-0.3
Medication: Bendroflumethiazide	0.0	0.1	0.3	-0.6	0.1	-0.2	0.0	-0.3	0.0	0.0
Basal metabolic rate	0.0	0.3	1.0	0.3	0.2	-0.5	-0.1	0.7	1.0	-0.2
Myopia	0.0	0.1	0.1	-0.3	0.3	-0.2	-0.2	0.1	0.3	0.0

Hub : Genes

TFR2

Models

Trait associations