Hub : Genes

TFR2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Caudate basal ganglia 0.1430 0.0590 0.00360 0.001 NA 0.005 NA 0.001 2.9e-01 NA 2.3e-01 NA 2.9e-01
2 GTEx Skin Sun Exposed Lower leg 0.1120 0.0440 0.00096 0.067 NA 0.063 NA 0.063 3.3e-06 NA 6.2e-06 NA 5.9e-06
3 GTEx Stomach 0.0970 0.0410 0.00170 0.035 NA 0.039 NA 0.067 8.6e-03 NA 5.7e-03 NA 4.1e-04
4 TCGA Breast Invasive Carcinoma 0.0165 0.0087 0.00022 0.011 0.016 0.014 NA 0.013 2.1e-03 0.00025 5.0e-04 NA 9.8e-04
5 TCGA Colon Adenocarcinoma 0.1120 0.0550 0.00150 0.059 0.039 0.023 NA 0.040 2.7e-04 0.00260 1.7e-02 NA 2.2e-03
6 TCGA Liver Hepatocellular Carcinoma 0.0760 0.0400 0.00570 0.025 0.056 0.019 NA 0.030 2.2e-02 0.00130 4.2e-02 NA 1.4e-02
7 TCGA Ovarian Serous Cystadenocarcinoma 0.0410 0.0260 0.00470 0.010 0.015 0.000 NA 0.000 6.2e-02 0.03000 3.3e-01 NA 3.2e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.9 1.4 2.4 -0.5 0.8 -1.5 1.3 1.5 1.5 0.4
Bipolar Disorder or Schizophrenia 3.6 8.8 14.3 -3.0 1.4 -3.7 3.1 3.8 3.6 0.5
Depressed Affect (Nagel 2018) 0.5 1.0 1.7 -0.6 1.2 -1.3 1.2 1.1 0.0 0.9
Depression (Nagel 2018) 1.6 2.4 4.8 -2.2 -0.1 -1.5 1.1 2.2 1.9 -0.6
Intelligence (Savage-Jansen 2018) 0.6 1.9 4.6 -1.4 -1.1 1.2 -1.5 -2.1 -1.4 -0.3
Neuroticism (Nagel 2018) 0.3 0.8 2.0 -1.0 -0.1 -0.7 0.4 1.4 1.3 -0.7
Schizophrenia (2018) 4.1 8.4 13.4 -3.5 1.1 -3.5 3.0 3.7 3.4 0.4
Schizophrenia vs Biploar Disorder 2.6 3.5 10.3 -1.5 -1.4 -0.9 0.4 2.5 3.2 -1.7
Worry (Nagel 2018) 0.4 0.9 2.5 -0.8 -0.9 0.1 0.0 1.1 1.6 -1.2
Alzheimer’s Disease (in mother) 1.2 1.4 2.7 0.2 -0.9 1.5 -1.2 -1.6 -1.6 -0.5
Alzheimer’s Disease (in father) 1.0 1.1 3.2 1.2 -0.4 1.2 -0.7 -1.0 -1.8 -0.1
Alzheimer’s Disease (including proxy) 1.7 2.5 8.7 1.0 -0.5 1.5 -1.0 -2.0 -2.9 0.2
Crohns Disease (2017) 3.5 7.7 12.6 -3.1 1.6 -3.3 2.9 3.5 3.1 0.4
Irritable Bowel Disease (IBD) 5.7 13.6 23.1 -3.6 3.4 -4.8 4.2 4.2 3.0 1.9
Ulcerative Colitis (UC) 5.5 10.4 19.6 -2.6 3.9 -4.4 3.6 3.0 1.2 2.8
Major Depression (MDD) 1.5 1.8 3.6 -0.6 1.4 -1.9 1.4 1.9 0.7 0.9
Reaction Time 3.7 7.1 16.3 -3.5 -0.2 -2.6 1.7 4.0 3.3 -0.7
Verbal and Numeric Reasoning (VNR) 0.5 1.3 5.3 -2.3 -1.0 0.3 -1.0 -1.1 -0.0 -0.7
Breast Cancer 1.9 4.6 15.9 -4.0 -2.2 -0.5 -1.5 0.9 1.8 -2.3
Ovarian Cancer 1.9 2.6 4.8 0.1 -1.4 2.1 -2.1 -2.2 -1.1 -1.0
Prostate Cancer 0.4 0.6 0.9 0.9 -0.8 0.4 0.5 0.9 1.0 -0.7
Age at First Birth 2.5 3.6 12.2 0.2 1.6 0.1 -0.1 -2.5 -3.5 2.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.6 -1.3 -0.1 -1.2 0.0 0.0 0.0 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 2.8 4.5 9.9 -2.9 -0.3 -1.7 1.2 2.8 3.1 -1.1
Mean Putamen Volume 1.4 1.6 4.7 -2.2 -0.9 -0.4 -0.5 0.8 1.7 -1.3
Fasting Glucose 0.7 0.8 2.3 1.5 0.6 0.4 -0.4 -0.8 -1.3 0.8
HbA1C 1.0 1.1 2.3 0.4 -0.9 0.2 -0.9 1.1 1.4 -1.5
HDL Cholesterol 0.0 0.1 0.3 -0.2 -0.5 -0.2 0.0 0.0 0.0 0.0
LDL Cholesterol 0.4 0.7 1.8 -1.1 1.2 -1.3 0.0 0.0 0.0 0.0
Lupus 0.4 0.6 2.2 1.5 -0.5 0.7 -0.9 -0.1 0.2 -0.4
Neuroticism (2016) 1.3 1.9 4.1 -0.3 1.0 -1.7 1.9 2.0 1.2 0.4
Primary Biliary Cirrhosis 0.3 0.4 0.7 -0.8 0.5 -0.3 -0.4 -0.7 -0.6 0.7
Rheumatoid Arthritis 1.1 1.6 3.6 0.9 1.6 -0.7 0.7 -0.1 -1.8 1.9
Schizophrenia (2014) 4.8 10.5 19.7 -3.5 0.8 -3.6 3.3 4.4 4.2 -0.1
Triglycerides 0.4 0.6 2.3 -1.5 0.3 -1.4 0.0 0.0 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.8 0.9 0.6 -0.6 0.0 0.0 0.0 0.0
Ulcerative Colitis 2.8 4.1 7.0 -2.3 1.7 -2.6 2.0 2.6 1.6 0.6
Blood Eosinophil Count 1.1 8.7 22.6 0.2 1.4 -2.8 3.5 4.8 4.1 0.0
Blood Platelet Count 9.8 113.6 249.6 15.8 11.6 0.9 6.3 -5.6 -12.4 13.6
Blood Red Count 55.4 535.3 1253.2 -11.0 -26.3 3.0 -9.6 21.7 35.4 -33.3
Blood White Count 1.1 8.2 25.9 2.0 -0.0 -1.6 2.2 5.1 4.2 -1.6
Heel T-Score 1.1 9.1 41.1 -6.4 -2.4 -1.6 -1.6 1.9 1.1 -2.6
BMI 0.6 3.7 11.4 0.2 -0.5 -1.4 1.1 3.4 3.0 -1.4
Height 0.5 9.1 23.4 -2.6 -1.7 2.9 -4.4 -4.8 -1.2 -1.1
Waist Hip Ratio (WHR) 0.7 3.1 8.6 0.3 -0.4 1.9 -1.7 -2.9 -2.5 0.2
Systolic Blood Pressure 2.1 10.3 23.3 4.8 -0.5 3.8 -2.5 -4.2 -3.2 0.3
Smoking Status 1.2 2.9 6.7 1.0 1.7 -1.7 2.6 2.2 0.5 1.3
Allergy or Eczema 0.8 2.2 4.5 0.6 -2.1 1.7 -1.9 -0.3 0.7 -1.7
Cardiovascular Disease 0.7 2.3 3.5 -1.8 0.6 -1.8 1.6 1.9 1.9 -0.1
Hypothyroidism (self reported) 3.9 9.0 16.9 1.9 -1.3 3.3 -4.1 -3.8 -3.9 -0.3
Respiratory disease 0.1 0.1 0.3 -0.6 -0.0 -0.3 -0.2 0.1 0.3 0.6
Type 2 Diabetes (T2D) (2018) 0.8 1.4 4.0 1.4 -0.9 1.0 -2.0 -1.0 -0.9 -0.7
Lung FEV1/FVC ratio 0.7 3.4 8.8 2.7 1.7 0.2 1.2 -1.2 -3.0 1.6
Lung FVC 0.6 3.1 5.5 -0.5 2.3 -2.2 2.2 1.3 1.1 2.0
Neuroticism 0.5 1.2 3.6 -0.6 0.2 -1.0 1.0 1.9 1.4 -0.3
Chronotype (morning person) 0.1 0.2 1.4 -1.2 0.1 -0.3 -0.2 -0.0 -0.0 0.0
Hair Pigment 0.5 15.1 37.2 6.1 -1.0 3.9 -3.4 -4.4 -4.5 0.6
Tanning 0.1 1.1 3.1 1.7 -0.7 1.4 -1.1 -0.8 -0.1 -0.5
Hand grip strength (left) 1.9 5.1 29.1 -5.4 0.5 -2.2 0.6 0.0 0.9 0.5
Number of treatments/medications taken 0.0 0.1 0.3 0.6 0.0 0.0 0.1 0.3 0.1 0.0
Average weekly spirits intake 0.3 0.4 1.5 1.2 0.7 -0.2 0.5 0.2 -0.2 0.8
Sensitivity / hurt feelings 0.9 1.5 4.7 2.2 -0.6 1.5 -1.0 -0.8 -0.9 -0.6
Frequency of depressed mood in last 2 weeks 0.9 1.3 4.1 -2.0 -0.0 -1.1 0.7 1.6 1.0 -0.2
Hearing difficulty/problems: Yes 0.5 0.7 1.7 -0.5 0.9 -0.6 0.6 -0.3 -1.3 1.2
Relative age of first facial hair 0.1 0.2 0.4 -0.2 -0.4 0.4 -0.7 -0.4 -0.4 -0.4
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 4.0 -0.4 1.6 -1.2 0.9 -0.1 -1.5 2.0
Ever used hormone-replacement therapy (HRT) 0.8 1.0 5.5 2.3 0.4 0.4 0.7 0.3 -0.8 0.5
Ever had hysterectomy (womb removed) 0.3 0.3 1.0 1.0 0.4 0.1 -0.1 0.2 -0.7 0.6
Systolic blood pressure, automated reading 1.8 5.3 11.4 3.2 0.6 2.1 -0.3 -2.8 -3.4 1.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.4 0.6 0.4 0.1 -0.0 -1.1 -1.6 0.8
Angina 0.3 0.3 0.8 0.7 0.0 0.6 -0.9 -0.6 -0.1 -0.4
Medication for hormone replacement therapy 0.4 0.5 1.0 1.0 -0.5 0.9 -0.8 -0.3 0.3 -0.7
Vitamin and mineral supplements 0.3 0.3 1.1 -0.7 -0.6 0.6 -0.3 0.1 0.2 -1.0
Supplements: Zinc 1.4 1.6 3.0 -0.6 -1.7 0.6 -1.7 0.0 1.2 -1.7
Medication: Co-codamol 0.4 0.5 1.0 1.0 -0.6 0.8 -0.6 -0.1 0.5 -0.8
Medication: Metformin 1.8 2.5 5.3 1.3 2.3 -1.1 0.8 -0.4 -1.9 2.3
Diabetes (father) 0.6 0.8 1.6 1.3 -0.8 1.0 -1.1 -0.6 -0.7 -0.1
Diabetes (mother) 0.7 1.0 5.4 2.3 -0.1 0.7 -0.2 -0.2 -0.8 0.1
Severe depression (siblings) 1.0 1.2 3.6 -1.9 -0.5 -1.0 0.3 0.9 1.4 -0.6
Pack years adult smoking proportion 0.2 0.3 1.1 -0.4 0.1 -0.6 0.1 0.7 1.0 -0.3
Impedance of leg (right) 0.5 2.5 15.4 -3.9 -0.6 -0.7 0.2 0.1 0.9 -0.4
Leg fat-free mass (left) 0.2 1.0 1.9 0.9 -0.8 0.4 -1.2 0.5 1.4 -1.3
Trunk fat percentage 0.5 2.1 4.3 -1.6 0.2 -1.7 1.3 2.1 1.9 -0.3
Hand grip strength (right) 3.0 8.1 35.2 -5.9 0.2 -2.9 1.4 2.0 2.6 -0.2
Townsend deprivation index at recruitment 1.0 1.4 3.6 -1.1 0.4 -1.0 0.9 1.7 1.9 -0.6
Current tobacco smoking 0.9 1.5 3.6 0.3 0.7 -1.3 1.9 1.9 1.0 0.4
Average weekly fortified wine intake 1.1 1.2 2.8 0.5 -1.3 1.2 -1.7 -1.2 -0.3 -1.1
Maternal smoking around birth 0.2 0.2 0.4 0.3 0.5 -0.4 0.0 0.6 0.7 -0.5
Fed-up feelings 1.6 3.0 5.8 1.1 1.8 -1.8 2.4 2.2 0.7 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 2.9 3.8 7.9 -2.2 1.2 -2.3 2.3 2.8 1.3 0.7
Relative age voice broke 1.0 1.5 2.9 -1.1 0.7 -1.4 1.7 1.7 0.6 0.6
Taking other prescription medications 0.5 0.7 1.8 0.3 -1.2 0.9 -1.4 -0.4 -0.3 -0.8
Age when periods started (menarche) 0.7 1.8 3.3 -1.1 1.8 -1.8 1.2 0.4 -0.2 1.7
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 4.5 2.1 0.3 0.4 0.5 0.6 -0.5 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 7.8 -2.8 -0.4 -1.1 0.2 1.2 0.4 -0.6
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.0 1.2 -1.4 1.3 -0.8 -0.1 0.2 -1.1
Qualifications: CSEs or equivalent 0.7 1.0 1.8 0.3 1.3 -1.0 1.3 1.0 0.2 1.1
Serious illness, injury or assault to yourself 1.8 2.1 6.6 0.7 -1.0 -0.4 -0.0 2.4 2.6 -1.1
High blood pressure 0.2 0.7 1.3 -0.5 0.8 -0.9 1.0 0.8 1.1 0.0
Hayfever, allergic rhinitis or eczema 1.5 3.2 7.1 1.1 -2.7 2.1 -2.0 -0.1 0.9 -2.2
Multivitamins +/- minerals 0.3 0.4 1.0 0.9 0.4 0.1 -0.1 -0.7 -0.7 1.0
Stomach or abdominal pain in last month 5.3 6.6 14.5 1.5 -3.2 3.0 -3.8 -1.8 -0.4 -2.7
Supplements: Glucosamine 2.0 2.5 5.3 1.0 -0.9 1.6 -2.3 -2.2 -1.8 -0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 1.9 1.4 -0.1 0.2 0.2 0.0 -0.1 -0.2
Medication: Atenolol 0.9 1.1 1.9 1.1 1.2 0.2 -0.0 -1.4 -1.2 1.1
Medication: Levothyroxine sodium 2.5 4.2 11.4 1.3 -0.6 2.0 -2.3 -2.5 -3.4 0.4
Sitting height 0.8 5.9 15.1 -0.4 -2.4 2.8 -3.9 -2.9 -0.8 -1.9
Chronic bronchitis/emphysema (father) 1.5 1.8 4.5 -0.5 0.7 -1.5 1.7 2.1 1.3 0.5
High blood pressure (mother) 0.1 0.1 0.7 0.8 0.4 0.1 0.1 0.0 0.1 0.3
Body mass index (BMI) 0.7 3.0 8.1 0.7 1.1 -1.9 2.2 2.9 1.4 0.4
Impedance of leg (left) 0.6 3.1 16.6 -4.1 0.6 -1.6 1.2 0.1 0.4 0.8
Leg predicted mass (left) 0.2 1.0 2.1 0.8 -0.8 0.4 -1.1 0.6 1.4 -1.3
Trunk fat mass 0.4 1.9 3.7 -1.4 0.4 -1.7 1.1 1.9 1.8 -0.2
Waist circumference 0.1 0.3 0.5 0.4 0.7 -0.6 0.7 0.6 -0.2 0.4
Number of incorrect matches in round 3.9 6.5 13.2 -3.6 1.6 -3.5 2.5 2.9 1.6 0.7
Past tobacco smoking 0.2 0.4 1.9 -1.4 -0.5 0.1 -0.2 -0.3 0.6 -0.5
Alcohol usually taken with meals 1.6 2.7 5.3 0.1 -2.2 1.6 -2.3 -0.8 0.7 -2.2
Nervous feelings 0.8 1.5 2.9 0.8 -1.7 1.5 -1.5 -0.3 0.6 -1.5
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 9.3 -3.1 -0.6 -1.0 0.3 1.8 1.5 -1.0
Hearing difficulty/problems with background noise 0.3 0.4 1.9 -1.4 -0.2 -0.5 -0.2 0.5 0.7 -0.2
Hair/balding pattern: Pattern 2 0.5 0.6 3.5 -1.9 -0.5 -0.2 -0.2 -0.4 0.6 -0.4
Had menopause 0.7 0.9 1.8 1.0 0.9 -0.3 1.3 0.0 -1.0 1.3
Had other major operations 4.6 5.7 15.0 3.9 -1.6 3.0 -2.6 -1.8 -0.7 -1.5
Forced vital capacity (FVC) 0.1 0.5 1.8 -1.3 0.6 -0.7 -0.2 -0.2 0.6 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 8.7 -3.0 0.1 -1.5 0.4 1.5 0.9 -0.5
Ever unenthusiastic/disinterested for a whole week 0.0 0.1 0.3 0.2 0.1 0.2 0.3 0.0 -0.5 0.0
Qualifications: None of the above 0.7 1.4 4.2 2.1 1.4 -0.2 1.4 0.3 -0.5 1.1
Financial difficulties in last 2 years 0.3 0.4 0.9 0.2 -0.9 0.8 -0.8 -0.3 0.3 -0.9
Mouth/teeth dental problems 0.1 0.2 1.0 1.0 -0.4 0.4 -0.4 -0.2 0.3 -0.1
Heart attack 0.4 0.5 1.9 0.7 -0.3 0.7 -1.4 -0.8 -0.1 -0.5
Allergy 1.7 3.8 7.7 -1.5 2.8 -2.5 2.6 0.5 -0.2 2.0
Pain all over the body in last month 0.6 0.7 1.5 -0.7 1.0 -1.2 0.7 0.8 0.7 0.5
Diabetes (self-reported) 0.7 1.1 2.8 1.6 0.8 0.2 -0.7 -0.9 -1.7 0.7
Hayfever/allergic rhinitis (self-reported) 2.6 3.4 8.4 2.9 -0.8 2.1 -1.8 -2.2 -1.6 -0.0
Medication: Ramipril 0.9 1.1 2.3 0.5 1.5 -1.4 1.0 0.4 -0.3 1.5
Medication: Simvastatin 1.4 2.0 4.6 -0.6 2.1 -1.6 1.6 0.4 -0.7 1.8
Fluid intelligence score 1.3 2.6 15.4 -3.9 0.3 -1.4 0.9 0.1 0.1 0.4
Illnesses of siblings 1.0 1.5 6.2 2.5 -1.0 1.1 -0.8 -0.3 0.6 -0.9
Neuroticism score 0.3 0.7 2.3 -0.2 0.2 -0.8 0.8 1.5 1.0 0.0
Weight 0.2 0.8 2.0 -0.3 0.1 -1.0 0.5 1.4 1.4 -0.3
Impedance of arm (right) 1.0 4.8 9.4 -1.9 -2.6 2.2 -3.1 -1.8 0.4 -2.3
Arm fat percentage (right) 0.4 1.7 5.3 -0.2 0.6 -1.5 1.5 2.3 1.4 0.0
Trunk fat-free mass 0.0 0.1 0.2 0.4 0.2 -0.2 -0.4 -0.0 0.3 0.0
Hip circumference 0.1 0.6 1.8 -0.1 -0.2 -0.6 0.3 1.4 1.2 -0.6
Time employed in main current job 1.5 1.7 3.5 -1.9 0.4 -1.3 1.0 1.7 1.7 -0.2
Alcohol intake versus 10 years previously 0.5 0.7 2.3 1.5 0.5 0.1 0.6 -0.0 -1.0 1.1
Father’s age at death 1.3 1.8 3.8 1.7 -1.5 1.9 -0.8 -1.0 -0.7 -1.0
Worrier / anxious feelings 1.2 2.2 5.4 -2.3 -0.3 -1.2 0.9 2.1 1.8 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.6 -0.6 -0.2 -0.5 0.0 0.8 0.0 0.2
Falls in the last year 2.1 2.8 5.9 -0.1 2.4 -2.1 2.0 1.2 -0.5 1.9
Hair/balding pattern: Pattern 3 3.4 5.1 8.8 2.0 -1.8 3.0 -2.7 -2.7 -1.7 -1.4
Number of live births 0.5 0.8 1.4 -0.5 1.1 -1.0 1.0 0.4 -0.5 1.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 1.3 0.6 0.3 0.6 -0.7 -1.2 -0.8 0.5
Pulse rate 18.2 30.7 48.9 -4.6 4.3 -6.8 7.0 6.7 5.4 2.1
Happiness 1.0 1.2 2.0 -1.3 -1.4 -0.1 -0.3 0.8 1.3 -1.4
Noisy workplace 0.3 0.4 0.9 1.0 -0.7 0.6 -0.5 -0.4 0.0 -0.5
Qualifications: A levels/AS levels or equivalent 1.0 2.2 6.1 -1.3 -0.7 1.1 -1.9 -2.5 -1.6 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 1.9 0.2 -1.2 1.1 -1.4 -0.7 -0.5 -1.3
Mouth/teeth dental problems: Dentures 0.8 1.3 4.0 2.0 0.9 0.6 0.1 -1.0 -1.6 0.8
Asthma 0.1 0.2 0.6 -0.2 -0.5 0.1 -0.7 0.2 0.8 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 3.1 -0.4 -1.4 1.4 -1.7 -1.6 -1.1 -0.9
Medication: Cholesterol lowering 0.9 1.4 4.6 0.2 2.1 -1.2 1.1 0.2 -0.2 1.5
Depression (self-reported) 0.3 0.3 0.8 -0.7 -0.2 -0.6 0.4 0.9 0.3 -0.5
Medication: Lansoprazole 1.6 1.8 3.6 -0.3 1.3 -1.9 1.7 1.8 0.8 0.7
Prospective memory result 1.3 1.6 4.5 0.6 0.6 -1.1 2.1 1.9 0.6 0.7
Lung cancer (father) 4.0 4.7 11.0 1.4 3.3 -1.9 2.7 0.5 -0.9 2.9
Illnesses of mother 0.3 0.4 0.8 -0.2 -0.9 0.3 -0.6 0.4 0.8 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.3 1.0 0.5 0.7 -0.6 -1.5 -1.2 0.8
Pulse wave Arterial Stiffness index 1.5 1.8 4.5 -1.0 -1.1 -0.4 0.3 1.5 2.1 -1.7
Impedance of arm (left) 1.0 4.6 8.6 -2.2 -2.5 2.0 -2.9 -1.9 0.4 -2.1
Arm fat mass (right) 0.4 1.6 4.1 0.1 0.9 -1.5 1.4 2.0 1.4 0.2
Trunk predicted mass 0.0 0.1 0.1 0.4 0.3 -0.2 -0.4 -0.0 0.3 0.1
Standing height 0.5 5.3 13.2 -2.1 -2.0 2.0 -3.6 -2.9 0.1 -1.6
Length of working week for main job 0.7 0.7 1.4 -0.6 1.1 -1.2 0.9 0.4 -0.1 1.1
Exposure to tobacco smoke at home 0.9 1.0 5.9 2.4 0.0 0.8 -0.4 -0.4 -0.2 -0.3
Breastfed as a baby 2.6 3.2 6.5 1.3 -1.9 2.5 -2.1 -1.8 -0.6 -1.7
Tense / ‘highly strung’ 0.7 1.2 3.1 -1.3 -0.4 -0.7 0.2 1.4 1.8 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 1.4 -1.2 -0.2 -0.1 -0.1 0.1 -0.3 -0.1
Hair/balding pattern: Pattern 4 0.3 0.7 3.5 -1.9 -0.4 -0.5 -0.0 0.6 0.6 -0.6
Birth weight of first child 0.4 0.8 3.4 -1.9 0.8 -0.8 0.6 -0.1 -0.5 0.6
Peak expiratory flow (PEF) 0.5 1.2 2.7 0.3 -0.6 1.1 -1.4 -1.6 -1.5 -0.2
Pulse wave reflection index 1.2 1.5 3.5 -1.0 -1.9 0.8 -1.2 0.4 0.4 -1.9
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.0 0.2 0.9 -0.7 0.7 1.0 0.1 0.6
Loud music exposure frequency 0.2 0.3 0.6 0.5 -0.7 0.1 -0.3 0.3 0.8 -0.7
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.9 -0.0 -0.5 0.6 -1.0 -0.8 -0.4 -0.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.1 -0.8 -0.8 0.8 -0.9 -0.6 -1.1 -0.2
Blood clot in the leg (DVT) 2.6 3.3 9.1 3.0 0.5 1.3 -1.0 -1.6 -2.7 1.3
Medication: Paracetamol 0.6 1.0 2.1 0.6 -1.4 0.9 -1.0 0.0 0.9 -1.4
Headache pain in last month 0.2 0.3 1.2 0.1 -0.0 0.4 -0.5 -0.7 -1.1 0.5
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 3.6 0.1 -1.9 1.3 -0.8 -0.3 -0.3 -1.3
Glaucoma (self-reported) 1.1 1.3 3.8 -0.5 -1.3 0.7 -0.6 0.8 1.3 -1.9
Gout (self-reported) 0.1 0.1 0.5 0.7 -0.1 0.2 0.1 -0.5 -0.2 0.3
Hypothyroidism/myxoedema (self-reported) 4.1 8.1 15.7 2.2 -1.3 3.2 -4.0 -3.4 -3.5 -0.5
Medication: Amlodipine 1.8 2.6 5.1 -1.2 1.7 -2.1 2.3 1.6 0.9 1.0
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.4 -0.1 0.6 -0.4 0.0 0.1 0.4 0.4
Birth weight 0.2 0.5 1.5 -0.8 0.4 -0.6 0.6 0.7 1.2 -0.1
Chronic bronchitis/emphysema (mother) 2.1 2.5 6.0 -1.4 0.3 -1.7 1.4 2.1 2.4 -0.4
High blood pressure (siblings) 1.0 1.4 4.0 -1.7 0.6 -0.0 -0.1 -1.3 -2.0 1.0
Forced vital capacity (FVC), Best measure 0.1 0.4 0.9 -0.5 0.8 -0.1 -0.3 -0.8 -0.2 0.9
Body fat percentage 0.9 3.6 7.7 -1.6 0.7 -2.3 2.0 2.8 2.1 0.1
Leg fat percentage (right) 1.9 6.9 14.0 -2.4 1.2 -3.3 3.2 3.7 2.5 0.4
Arm fat-free mass (right) 0.1 0.7 1.6 -0.2 0.7 -1.3 0.8 1.1 0.9 0.4
Exposure to tobacco smoke outside home 0.3 0.4 2.3 1.5 -0.2 0.3 0.1 0.4 0.6 -0.2
Comparative body size at age 10 0.9 2.4 9.9 -3.1 1.3 -1.9 0.8 0.3 -0.6 0.7
Number of full brothers 0.1 0.2 0.3 0.0 0.4 -0.1 0.5 0.4 -0.5 0.5
Worry too long after embarrassment 1.0 1.7 4.2 -1.6 -0.4 -1.0 0.6 1.7 2.0 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.3 -1.1 0.3 -0.6 0.5 0.3 -0.0 0.3
Wheeze or whistling in the chest in last year 1.4 2.5 6.8 -0.9 -0.2 -1.4 0.8 2.6 2.6 -0.6
Number of children fathered 1.8 2.0 7.3 2.7 -0.2 1.6 -1.0 -1.4 -1.2 0.0
Reason for reducing amount of alcohol drunk: Health precaution 2.7 3.1 7.3 -2.7 -2.1 0.3 -1.2 0.2 1.8 -2.2
Age at first live birth 2.3 4.0 8.6 -1.0 -1.9 2.0 -2.9 -2.6 -1.4 -1.4
Pulse wave peak to peak time 1.8 2.1 5.3 1.0 1.1 0.5 -0.4 -1.8 -2.3 1.8
Health satisfaction 0.1 0.1 0.3 0.6 -0.4 0.2 -0.2 0.1 -0.5 0.1
Shortness of breath walking on level ground 0.7 0.8 1.4 0.3 1.1 -1.0 1.2 1.0 0.2 1.1
Qualifications: College or University degree 1.2 3.8 9.9 -3.1 -2.1 0.7 -2.7 -1.6 -0.2 -1.4
Eye problems/disorders: None of the above 0.1 0.1 0.2 0.3 -0.4 0.4 0.2 0.2 -0.0 -0.2
Mouth/teeth dental problems: Loose teeth 1.8 2.1 5.1 -2.3 0.8 -2.0 1.0 1.5 1.1 0.6
Emphysema/chronic bronchitis 0.6 0.6 1.5 1.0 -0.3 1.2 -0.9 -0.9 -0.6 0.0
Medication for pain relief, constipation, heartburn 0.8 1.3 2.4 -0.2 1.4 -1.4 1.6 1.3 0.9 0.8
Neck or shoulder pain in last month 0.3 0.4 1.4 1.0 0.4 -0.3 0.6 1.2 -0.0 0.3
Medication: Blood pressure 0.4 0.7 1.8 -0.4 1.4 -1.1 0.3 0.4 1.2 0.4
Angina (self-reported) 0.4 0.5 0.9 0.9 -0.0 0.8 -0.9 -0.9 -0.3 -0.3
Migraine (self-reported) 0.2 0.2 0.7 -0.8 -0.6 0.1 -0.4 0.0 -0.2 -0.5
Medication: Ibuprofen 0.8 1.0 1.9 -0.6 -1.3 0.9 -1.4 -1.0 -0.4 -0.9
Medication: Allopurinol 0.4 0.5 1.0 1.0 0.8 -0.3 0.6 -0.2 -0.4 1.0
Medication: Omeprazole 1.9 2.2 3.7 1.8 -1.5 1.9 -1.8 -1.1 -0.6 -1.3
Medication: Seretide 50 evohaler 0.4 0.4 1.9 0.6 -0.1 -0.2 0.1 0.9 1.4 -0.2
Mean time to correctly identify matches 2.5 4.7 10.8 -2.9 0.2 -2.2 1.8 3.3 2.3 -0.2
Heart disease (mother) 0.6 0.7 4.6 -2.1 -0.1 -0.5 -0.1 0.1 0.0 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.5 0.4 0.6 -0.3 0.8 -0.2 -1.0 1.2
Whole body fat mass 0.7 2.8 6.8 -1.0 0.7 -2.0 1.6 2.6 2.2 -0.1
Leg fat mass (right) 1.2 4.5 9.5 -1.4 1.3 -2.8 2.4 3.1 2.1 0.4
Arm predicted mass (right) 0.2 1.0 2.2 -0.5 0.9 -1.5 0.9 1.2 1.2 0.4
Pulse rate, automated reading 30.8 99.4 163.8 -9.6 8.4 -12.6 12.8 11.2 7.6 5.3
Alcohol intake frequency. 1.4 3.2 18.1 4.3 0.6 1.3 0.4 -0.5 -1.2 0.8
Comparative height size at age 10 0.4 2.3 6.2 1.3 -0.2 1.7 -2.0 -2.5 -1.1 0.1
Number of full sisters 0.0 0.0 0.1 -0.3 0.2 -0.0 -0.3 0.2 0.2 -0.2
Suffer from ‘nerves’ 0.7 1.2 3.4 0.2 0.0 -0.8 1.1 1.8 1.6 -0.1
Overall health rating 1.0 2.1 4.0 -0.1 1.8 -1.6 2.0 1.7 -0.2 1.5
Chest pain or discomfort 0.8 1.2 2.8 -0.0 -1.0 0.4 -0.5 1.1 1.6 -1.7
Had major operations 0.5 0.6 2.0 -0.2 -0.3 -0.5 -0.1 1.3 1.4 -0.7
Age at last live birth 0.4 0.6 3.0 -1.7 0.3 -0.6 0.1 -0.5 -0.4 0.4
Family relationship satisfaction 2.0 2.5 5.3 -2.3 -0.1 -1.8 1.2 2.0 1.7 -0.4
Leg pain on walking 0.6 0.7 2.1 1.4 -0.9 0.9 -0.9 0.1 -0.5 -0.3
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 3.1 1.5 1.3 -1.0 1.8 1.0 -0.2 1.4
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.7 0.5 -0.8 0.5 -0.2 -0.2 0.1 -0.7
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.0 -1.0 1.0 -0.6 0.2 -0.8 -0.2 0.9
Medication: Aspirin 0.3 0.4 1.4 -0.2 -0.2 0.5 -0.6 -0.7 -1.2 0.1
Supplements: Vitamin C 0.1 0.1 0.5 -0.4 0.2 -0.7 0.1 0.3 0.0 0.4
Knee pain experienced in last month 0.6 0.9 4.2 2.0 0.6 0.6 -0.3 -0.5 -1.0 0.3
Hypertension (Self-reported) 0.5 1.4 2.6 -1.0 0.8 -1.4 1.2 1.4 1.6 0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.3 5.3 2.1 0.6 1.1 -0.5 -1.9 -2.3 1.0
Illnesses of father: Heart disease 0.4 0.6 1.4 -1.0 -1.2 0.5 -0.3 0.1 0.5 -1.1
Illnesses of siblings: Diabetes 0.2 0.2 1.2 0.2 -0.1 -0.1 -0.0 1.1 0.3 -0.3
Smoking status: Previous 0.6 0.9 2.1 1.4 0.0 0.9 -1.0 -0.9 -1.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 3.6 1.1 1.3 0.3 0.0 -1.6 -1.9 1.8
Whole body fat-free mass 0.0 0.2 0.6 0.5 -0.0 -0.1 -0.5 0.3 0.8 -0.3
Leg fat-free mass (right) 0.1 0.6 1.8 1.4 -0.3 0.5 -1.1 -0.0 0.7 -0.6
Arm fat percentage (left) 0.5 1.9 5.6 -0.3 0.6 -1.6 1.5 2.4 1.6 -0.0
Average weekly red wine intake 0.5 0.7 2.2 -0.7 -0.0 0.5 -0.5 -1.4 -1.5 0.2
Handedness (chirality/laterality): Left-handed 2.9 3.4 5.9 -2.1 1.9 -2.4 2.3 0.9 -0.4 1.9
Mood swings 0.3 0.5 1.2 1.1 0.6 0.5 -0.3 -0.5 -1.1 0.5
Loneliness, isolation 1.2 1.6 4.7 -1.0 0.4 -1.4 1.7 2.2 0.7 0.3
Long-standing illness, disability or infirmity 0.3 0.4 1.0 0.1 -0.3 0.7 -1.0 -0.8 -0.9 -0.1
Ever had bowel cancer screening 2.4 2.8 5.8 -1.4 0.8 -2.3 2.0 2.4 0.6 1.1
Diabetes diagnosed by doctor 0.7 1.2 3.1 1.5 0.5 0.3 -0.9 -1.0 -1.8 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.5 0.5 -0.7 0.7 -1.2 -0.1 0.2 -0.9
Friendships satisfaction 1.9 2.4 5.5 -2.3 -0.0 -1.9 1.4 2.1 1.2 0.0
Qualifications: nursing, teaching 0.5 0.7 2.6 -1.6 -0.4 0.2 -1.1 -0.9 -0.4 0.1
Commuting to job workplace: Walk 0.1 0.1 0.4 0.5 -0.2 0.4 -0.6 -0.5 -0.1 0.1
Eye problems/disorders: Cataract 0.4 0.4 1.2 -0.7 0.5 -0.8 0.0 0.6 1.1 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.7 1.0 3.4 -1.8 -1.1 0.0 -0.4 0.4 0.8 -1.4
Medication for cholesterol 1.1 1.6 4.2 1.0 -1.2 1.4 -2.0 -1.4 -0.4 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.3 3.8 7.2 -1.5 2.3 -2.7 2.4 1.7 0.9 1.6
Back pain experienced in last month 0.2 0.2 1.0 0.6 0.1 -0.1 0.4 1.0 0.4 -0.2
Mineral and other dietary supplements 1.7 2.2 4.9 -1.7 -0.0 -1.0 0.8 2.2 2.2 -1.1
Breast cancer (self-reported) 1.5 1.8 8.2 2.9 1.4 -0.2 0.9 0.3 -0.2 1.4
Asthma (self-reported) 0.1 0.2 0.8 -0.2 -0.1 -0.3 -0.4 0.4 0.9 -0.1
Osteoporosis (self-reported) 1.7 2.1 4.0 0.8 1.5 -1.6 2.0 1.6 0.4 1.5
Osteoarthritis (self-reported) 0.4 0.5 1.4 0.2 -0.1 0.7 -0.9 -0.9 -1.2 0.2
Medication: Aspirin 0.1 0.1 0.7 -0.4 0.1 0.2 -0.2 -0.3 -0.8 0.1
Medication: Gliclazide 0.3 0.4 0.7 0.4 0.8 -0.8 0.4 0.4 -0.6 0.8
Illnesses of father: None of the above (group 1) 0.7 0.9 4.8 2.2 0.8 0.2 0.1 -0.4 -0.3 0.7
Smoking status: Current 1.0 1.6 3.9 0.2 0.7 -1.3 2.0 2.0 1.0 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.7 -0.0 1.6 -0.5 0.6 -0.7 -0.9 1.6
Whole body water mass 0.0 0.2 0.6 0.5 0.0 -0.2 -0.5 0.4 0.8 -0.3
Leg predicted mass (right) 0.1 0.6 1.8 1.4 -0.3 0.5 -1.1 0.0 0.8 -0.7
Arm fat mass (left) 0.5 2.0 5.2 -0.2 0.9 -1.8 1.6 2.3 1.5 0.3
Number of self-reported non-cancer illnesses 0.2 0.3 1.3 -0.1 0.1 0.4 -0.6 -0.6 -1.2 0.4
Average weekly champagne plus white wine intake 3.3 4.6 9.7 -0.5 -2.6 2.4 -3.1 -2.0 -0.0 -2.3
Miserableness 1.0 1.8 3.1 -1.5 1.0 -1.8 1.7 1.7 0.3 0.8
Guilty feelings 1.5 2.2 5.2 -2.3 -0.8 -1.1 0.6 1.8 1.8 -1.2
Wears glasses or contact lenses 0.3 0.4 1.8 -1.4 -0.6 -0.1 0.0 0.2 0.2 -0.7
Ever taken oral contraceptive pill 1.0 1.1 2.2 0.0 -1.2 1.3 -1.5 -1.1 -1.0 -0.6
Hearing aid user 1.5 1.7 4.0 0.4 1.1 -1.5 1.7 2.0 1.1 0.6
Mother’s age at death 1.3 1.6 3.0 0.5 -1.4 1.7 -1.7 -1.3 -0.9 -0.7
Financial situation satisfaction 1.7 2.1 3.9 1.1 2.0 -1.3 2.0 0.7 -0.7 1.9
Tinnitus: Yes, now most or all of the time 1.0 1.1 3.6 0.4 -0.0 1.0 -1.0 -1.9 -1.4 0.3
Commuting to job workplace: Public transport 0.6 0.7 1.3 0.5 -1.0 1.1 -1.1 -0.9 -0.2 -0.6
Eye problems/disorders: Glaucoma 1.0 1.2 3.2 0.1 -1.3 1.0 -0.4 0.9 1.2 -1.8
Medication: Blood pressure 0.6 1.1 2.9 -1.7 0.3 -1.3 1.1 1.1 0.7 -0.0
Pain type(s) experienced in last month: Hip pain 0.8 1.0 1.9 0.9 -0.9 1.4 -1.0 -1.1 -0.9 -0.5
Supplements: Fish oil (including cod liver oil) 3.7 4.9 9.7 2.8 1.9 0.1 0.5 -1.9 -3.1 3.0
High cholesterol (Self-reported) 1.0 1.7 3.5 -1.9 1.2 -1.6 1.6 1.1 0.8 0.4
Medication: Bendroflumethiazide 0.0 0.1 0.3 -0.6 0.1 -0.2 0.0 -0.3 0.0 0.0
Medication: Paracetamol 0.6 1.0 1.9 1.2 -1.0 0.5 -0.4 0.8 1.4 -1.2
Medication: Lisinopril 0.4 0.5 1.2 -0.3 -0.8 -0.0 -0.7 0.3 1.1 -1.0
Medication: Atorvastatin 3.5 4.3 7.6 -1.9 2.3 -2.7 2.8 1.5 0.8 1.8
Illnesses of father: High blood pressure 0.4 0.5 2.6 -1.6 -0.0 -0.5 0.5 0.3 -0.1 -0.2
Alcohol drinker status: Never 1.8 2.2 4.5 1.2 -1.0 2.0 -1.6 -2.1 -1.3 -0.3
Ever smoked 0.6 1.1 5.3 2.3 0.6 0.3 0.2 -0.2 -1.1 0.8
Basal metabolic rate 0.0 0.3 1.0 0.3 0.2 -0.5 -0.1 0.7 1.0 -0.2
Leg fat percentage (left) 2.2 7.8 14.0 -2.2 1.8 -3.6 3.7 3.7 2.1 1.0
Arm fat-free mass (left) 0.2 0.9 1.9 -0.2 0.9 -1.4 1.0 1.2 0.9 0.5
Number of operations (self-reported) 1.0 1.4 3.1 0.9 -1.1 0.8 -1.6 0.6 1.1 -1.8
Average weekly beer plus cider intake 0.6 0.8 1.7 -0.7 0.7 -1.1 1.3 0.9 0.9 0.5
Irritability 0.3 0.5 1.5 0.4 0.2 -0.6 0.1 1.1 1.2 -0.2
Risk taking 2.2 3.3 9.5 -3.1 -1.0 -1.5 0.3 2.3 2.1 -0.8
Ever had prostate specific antigen (PSA) test 0.7 0.8 3.6 -1.9 -0.1 -1.0 0.6 0.6 0.3 0.4
Fractured/broken bones in last 5 years 0.2 0.3 0.7 0.5 0.4 -0.4 0.8 0.4 -0.3 0.7
Age started oral contraceptive pill 0.4 0.4 1.4 -1.2 0.0 0.1 0.7 -0.6 -0.8 0.5
Diastolic blood pressure, automated reading 2.8 8.7 19.4 -2.5 0.3 -2.4 3.4 4.1 4.4 -1.0
Ever depressed for a whole week 0.3 0.3 1.4 1.2 0.4 0.5 -0.4 -0.5 -0.4 -0.0
Unable to work because of sickness or disability 0.4 0.5 0.9 0.9 0.8 -0.7 0.9 0.8 0.1 0.6
Commuting to job workplace: Cycle 0.3 0.3 1.5 -1.2 -0.1 -0.1 0.1 -0.1 -0.8 0.5
Myopia 0.0 0.1 0.1 -0.3 0.3 -0.2 -0.2 0.1 0.3 0.0
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.6 0.5 -0.8 1.0 -1.0 -1.0 -1.3 -0.0
Cholesterol lowering medication 6.8 9.9 17.8 -3.4 3.1 -4.2 4.2 2.6 0.7 2.3
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 4.5 2.1 -0.9 1.6 -1.2 -0.9 -0.9 -0.8
Pain experienced in last month 0.1 0.1 0.3 -0.5 -0.5 0.2 -0.4 -0.3 0.4 -0.3
Supplements: Calcium 0.2 0.2 0.4 -0.0 0.4 -0.6 0.6 0.5 -0.4 0.6
Basal cell carcinoma (self-reported) 0.2 0.2 0.5 0.7 0.0 0.7 0.0 -0.7 -0.3 -0.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.5 0.4 -0.3 0.5 -1.2 -0.8 -0.1 -0.4
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 7.6 2.8 0.4 1.2 -1.1 -1.4 -2.4 1.1
Heart disease (siblings) 0.6 0.8 3.0 -1.7 0.3 -0.9 0.7 0.7 0.8 0.1
Alcohol drinker status: Previous 0.5 0.5 1.0 0.8 0.8 0.0 0.9 0.0 -0.8 1.0
Pack years of smoking 0.1 0.2 0.4 -0.1 0.5 -0.6 0.3 0.6 0.6 0.1
Impedance of whole body 0.5 2.5 10.3 -3.2 -1.5 0.7 -1.3 -1.1 0.6 -1.1
Leg fat mass (left) 1.2 4.8 9.5 -1.3 1.6 -2.9 2.7 3.1 1.9 0.8
Arm predicted mass (left) 0.1 0.6 1.2 -0.1 0.6 -1.1 0.7 1.1 1.1 0.2