Best TWAS P=2.43e-09 · Best GWAS P=6.25e-09 conditioned to 0.167
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | MTCH2 | 0.03 | 0.00 | bslmm | 299 | 0.00 | 1.1e-01 | 1.5 | -5.6 | 1.8e-08 | -0.33 | 0.08 | 0.47 | FALSE |
2 | GTEx | Brain Cortex | C1QTNF4 | 0.26 | 0.04 | lasso | 8 | 0.02 | 1.2e-01 | 5.4 | 5.5 | 4.3e-08 | 0.70 | 0.04 | 0.25 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | FNBP4 | 0.11 | 0.05 | lasso | 8 | 0.08 | 1.6e-06 | 5.5 | -5.5 | 4.8e-08 | -0.65 | 0.06 | 0.94 | FALSE |
4 | GTEx | Esophagus Muscularis | C1QTNF4 | 0.10 | 0.05 | enet | 23 | 0.06 | 1.4e-04 | -4.9 | 5.4 | 8.1e-08 | 0.42 | 0.21 | 0.75 | FALSE |
5 | GTEx | Heart Atrial Appendage | C1QTNF4 | 0.26 | 0.14 | lasso | 9 | 0.17 | 3.9e-08 | -4.8 | 5.2 | 2.2e-07 | 0.53 | 0.39 | 0.60 | FALSE |
6 | GTEx | Liver | C1QTNF4 | 0.25 | 0.14 | enet | 16 | 0.20 | 2.3e-06 | -4.8 | 5.2 | 2.4e-07 | 0.76 | 0.18 | 0.68 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | C1QTNF4 | 0.25 | 0.22 | lasso | 12 | 0.23 | 4.2e-19 | -4.8 | 5.7 | 1.5e-08 | 0.58 | 0.47 | 0.53 | FALSE |
8 | GTEx | Spleen | C1QTNF4 | 0.31 | 0.28 | enet | 29 | 0.34 | 1.8e-09 | -5.2 | 5.9 | 4.3e-09 | 0.58 | 0.16 | 0.83 | FALSE |
9 | GTEx | Testis | C1QTNF4 | 0.14 | 0.12 | lasso | 4 | 0.11 | 1.6e-05 | 5.5 | 5.3 | 1.2e-07 | 0.72 | 0.05 | 0.94 | FALSE |
10 | GTEx | Whole Blood | C1QTNF4 | 0.09 | 0.05 | lasso | 3 | 0.03 | 1.4e-03 | -5.2 | 5.2 | 2.4e-07 | 0.42 | 0.21 | 0.68 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | FNBP4 | 0.04 | 0.04 | lasso | 3 | 0.04 | 8.2e-06 | 5.5 | -6.0 | 2.4e-09 | -0.85 | 0.05 | 0.95 | TRUE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | NUP160 | 0.05 | 0.05 | blup | 44 | 0.05 | 7.7e-04 | 5.5 | -5.7 | 1.5e-08 | -0.65 | 0.02 | 0.82 | FALSE |
13 | The Cancer Genome Atlas | Lung Adenocarcinoma | C1QTNF4 | 0.03 | 0.02 | blup | 15 | 0.02 | 1.3e-03 | -4.8 | 5.4 | 8.1e-08 | 0.59 | 0.03 | 0.75 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUP160 | 0.03 | 0.02 | enet | 7 | 0.02 | 6.3e-03 | -5.2 | -5.6 | 1.9e-08 | -0.61 | 0.04 | 0.57 | FALSE |