Best TWAS P=4.35e-08 · Best GWAS P=5.86e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | ADAMTSL4 | 0.17 | 0.14 | lasso | 4 | 0.10 | 3.7e-06 | 5.4 | -5.4 | 6.2e-08 | -0.99 | 0 | 1.00 | FALSE |
2 | GTEx | Artery Aorta | RP11-54A4.2 | 0.12 | 0.13 | lasso | 2 | 0.11 | 7.7e-07 | 5.4 | -5.4 | 5.8e-08 | -1.00 | 0 | 1.00 | FALSE |
3 | GTEx | Artery Tibial | ADAMTSL4 | 0.10 | 0.06 | lasso | 4 | 0.08 | 6.4e-07 | 5.2 | -5.2 | 2.2e-07 | -0.90 | 0 | 1.00 | FALSE |
4 | GTEx | Artery Tibial | RP11-54A4.2 | 0.10 | 0.07 | lasso | 4 | 0.09 | 1.3e-07 | 5.2 | -5.2 | 1.9e-07 | -0.86 | 0 | 0.99 | FALSE |
5 | GTEx | Esophagus Mucosa | ECM1 | 0.14 | 0.10 | lasso | 10 | 0.12 | 2.2e-08 | 5.4 | -5.3 | 1.0e-07 | -0.94 | 0 | 1.00 | FALSE |
6 | GTEx | Esophagus Mucosa | ADAMTSL4 | 0.40 | 0.40 | lasso | 5 | 0.41 | 5.8e-29 | 5.4 | -5.5 | 4.3e-08 | -0.99 | 0 | 1.00 | TRUE |
7 | GTEx | Esophagus Mucosa | RP11-54A4.2 | 0.35 | 0.33 | enet | 15 | 0.34 | 1.6e-23 | 5.4 | -5.3 | 1.1e-07 | -0.96 | 0 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ADAMTSL4 | 0.11 | 0.07 | lasso | 4 | 0.07 | 1.2e-08 | 5.4 | -5.3 | 1.3e-07 | -0.97 | 0 | 1.00 | FALSE |