TWAS hub - POLD3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1760	0.082	0.0086	-0.006	NA	0.001	NA	-0.006	0.8600	NA	0.290	NA	0.8500
2	TCGA	Breast Invasive Carcinoma	0.0175	0.010	0.0039	0.010	0.011	0.007	NA	0.011	0.0032	0.0023	0.012	NA	0.0018
3	TCGA	Thyroid Carcinoma	0.0290	0.016	0.0091	0.004	0.014	0.007	NA	0.004	0.1200	0.0130	0.064	NA	0.1100

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hand grip strength (right)	21.7	59.1	86.6	-7.1	-9.3	-6.4
Hand grip strength (left)	16.4	43.2	62.9	-6.3	-7.9	-5.2
Sitting height	7.3	51.9	76.2	-5.8	-8.7	-6.8
Falls in the last year	6.5	8.8	13.4	1.1	3.5	3.7
Fractured/broken bones in last 5 years	5.2	6.7	10.4	-0.6	3.2	3.1
Waist Hip Ratio (WHR)	4.8	21.6	35.3	3.0	5.9	4.5
Friendships satisfaction	4.3	5.3	6.5	2.5	2.2	2.1
Frequency of tiredness / lethargy in last 2 weeks	4.0	6.4	18.0	4.2	1.1	-0.1
Birth weight	3.8	8.3	13.9	-1.0	-3.1	-3.7
Overall health rating	3.8	8.1	14.6	3.8	2.8	1.3
Height	3.7	71.3	92.7	-5.9	-9.6	-9.3
Pulse wave Arterial Stiffness index	3.4	4.0	8.9	1.0	-1.4	-3.0
Long-standing illness, disability or infirmity	3.3	5.1	7.0	2.6	2.0	2.1
Ever depressed for a whole week	3.3	4.1	6.2	1.4	2.5	2.0
Number of children fathered	3.2	3.6	5.2	-0.9	-2.3	-2.2
Standing height	3.1	31.0	40.8	-3.8	-6.4	-6.2
Eye problems/disorders: Diabetes related eye disease	3.0	3.3	4.7	2.2	2.0	1.2
Pulse wave peak to peak time	3.0	3.5	7.2	-1.4	1.1	2.7
Heart disease (mother)	3.0	3.7	4.9	-2.2	-1.7	-1.8
Family relationship satisfaction	2.9	3.5	5.4	1.0	2.0	2.3
LDL Cholesterol	2.7	4.2	4.9	-1.8	-2.2	-2.1
Commuting to job workplace: Public transport	2.7	3.3	5.7	0.1	2.0	2.4
Crohns Disease (2012)	2.6	4.2	7.8	-2.8	-1.9	-1.1
Shortness of breath walking on level ground	2.6	3.1	8.3	2.9	0.8	0.6
Hip circumference	2.5	10.6	15.5	-2.4	-3.9	-3.3
Arm fat-free mass (right)	2.5	12.6	19.1	-2.5	-4.4	-3.5
Trunk fat-free mass	2.4	13.9	20.0	-2.7	-4.5	-3.8
Arm predicted mass (right)	2.4	12.4	19.4	-2.5	-4.4	-3.4
Multivitamins +/- minerals	2.3	3.0	6.3	0.4	1.6	2.5
Trunk predicted mass	2.3	13.3	19.3	-2.6	-4.4	-3.7
Comparative body size at age 10	2.3	6.4	9.0	-3.0	-2.5	-1.9
Alcohol drinker status: Never	2.3	2.8	4.2	-0.9	-2.1	-1.8
Arm predicted mass (left)	2.3	11.6	17.4	-2.7	-4.2	-3.2
HbA1C	2.2	2.5	6.2	2.5	-0.0	-1.1
Depression (self-reported)	2.2	2.6	5.0	2.2	1.5	0.7
Pain type(s) experienced in last month: Hip pain	2.2	2.8	4.9	-0.5	-2.2	-1.8
Ever had prostate specific antigen (PSA) test	2.2	2.5	4.5	-0.4	-2.1	-1.7
Coronary Artery Disease (CAD)	2.1	2.5	2.7	-1.4	1.7	1.6
Alcohol usually taken with meals	2.1	3.3	4.6	-2.1	-1.8	-1.5
Weight	2.1	10.5	14.7	-2.2	-3.8	-3.5
Exposure to tobacco smoke outside home	2.1	2.9	4.2	1.0	2.0	1.9
Health satisfaction	2.1	2.8	3.7	1.7	1.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.5	5.6	-2.4	-2.3	-1.6
Whole body water mass	2.1	11.8	16.6	-2.5	-4.1	-3.5
Arm fat-free mass (left)	2.1	10.7	16.8	-2.4	-4.1	-3.1
Alzheimer’s Disease (in mother)	2.0	2.4	6.0	-2.4	0.4	1.0
Alzheimer’s Disease (including proxy)	2.0	2.8	7.0	-2.6	-1.0	-0.8
Medication: Co-codamol	2.0	2.3	4.5	-0.1	2.1	1.6
Headache pain in last month	2.0	3.5	3.6	1.9	1.8	1.9
Whole body fat-free mass	2.0	11.6	16.6	-2.4	-4.1	-3.5
Basal metabolic rate	1.9	10.5	14.7	-2.3	-3.8	-3.4
Worrier / anxious feelings	1.8	3.5	6.0	1.4	2.4	1.6
Had major operations	1.8	2.1	3.2	0.7	1.6	1.8
Bipolar Disorder (2011)	1.7	1.7	4.6	2.1	0.5	0.4
Hypothyroidism (self reported)	1.7	4.0	8.4	-0.3	1.8	2.9
Leg pain on walking	1.7	2.1	4.5	2.1	1.3	0.6
Smoking status: Previous	1.7	2.5	6.6	-2.6	0.2	0.9
Osteoporosis (self-reported)	1.7	2.1	3.4	1.6	1.9	0.7
Average weekly champagne plus white wine intake	1.7	2.3	3.8	-1.9	1.4	1.2
Breast Cancer	1.6	3.9	5.5	0.8	2.4	2.4
Average weekly fortified wine intake	1.6	1.8	5.2	-2.3	-0.5	-0.3
Chronic bronchitis/emphysema (father)	1.6	1.9	3.4	0.7	-1.3	-1.9
Pain all over the body in last month	1.6	1.7	2.6	-0.4	-1.6	-1.5
Length of working week for main job	1.6	1.8	4.1	-0.4	1.1	2.0
Eye problems/disorders: Glaucoma	1.6	1.9	2.8	1.7	1.3	1.0
Risk taking	1.6	2.3	3.7	-1.9	-1.7	-0.6
Leg fat mass (left)	1.6	6.1	9.5	-1.4	-3.1	-2.6
Leg fat-free mass (left)	1.5	7.7	10.1	-1.7	-3.2	-3.2
Leg predicted mass (left)	1.5	8.1	10.6	-1.8	-3.3	-3.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	6.1	2.5	0.3	-0.8
Loud music exposure frequency	1.5	1.6	4.7	2.2	0.4	-0.1
Leg fat mass (right)	1.5	6.0	9.2	-1.5	-3.0	-2.5
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.5	-1.9	-1.1	-0.5
Osteoarthritis (self-reported)	1.5	2.0	3.2	0.7	1.8	1.5
Leg predicted mass (right)	1.5	7.7	10.9	-1.4	-3.2	-3.3
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.6	1.6	1.2	0.9
Average weekly spirits intake	1.4	1.8	3.1	0.7	1.8	1.4
Trunk fat mass	1.4	5.9	7.1	-1.9	-2.7	-2.7
Forced vital capacity (FVC)	1.4	5.3	10.4	-0.9	-2.1	-3.2
Alcohol intake versus 10 years previously	1.4	2.1	3.2	-0.1	-1.8	-1.7
Leg fat-free mass (right)	1.4	7.7	11.0	-1.3	-3.2	-3.3
Handedness (chirality/laterality): Left-handed	1.4	1.6	2.8	-1.0	1.7	1.0
Financial situation satisfaction	1.4	1.8	3.1	0.1	1.8	1.5
Crohns Disease (2017)	1.3	2.9	5.0	-1.8	-2.2	-0.8
Lupus	1.3	1.9	3.8	1.0	1.0	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	2.4	1.1	1.5	1.2
Ever highly irritable/argumentative for 2 days	1.3	1.6	1.9	1.2	1.2	1.4
Ever had bowel cancer screening	1.3	1.5	2.0	1.4	-0.9	-1.4
Age started oral contraceptive pill	1.3	1.7	2.2	1.5	1.3	1.0
Heart disease (siblings)	1.3	1.6	2.2	-1.2	-1.1	-1.5
Pack years adult smoking proportion	1.2	1.8	3.8	1.0	1.9	0.8
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	1.9	0.9	1.3	1.4
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	4.6	-0.2	1.6	2.2
Forced vital capacity (FVC), Best measure	1.2	4.5	9.2	-0.8	-2.0	-3.0
Whole body fat mass	1.2	5.0	6.6	-1.7	-2.6	-2.4
Medication: Atorvastatin	1.2	1.5	2.6	0.3	1.6	1.3
Illnesses of father: High blood pressure	1.2	1.5	3.1	0.5	1.0	1.8
Basal cell carcinoma (self-reported)	1.2	1.5	3.6	-1.9	-0.0	0.9
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.5	1.9	0.1	-0.5
Happiness	1.1	1.4	2.3	0.4	1.5	1.2
Asthma	1.1	2.1	3.5	1.9	1.2	1.1
Medication: Lansoprazole	1.1	1.2	2.2	0.5	1.1	1.5
Glaucoma (self-reported)	1.1	1.3	2.9	1.7	0.8	0.6
Emphysema/chronic bronchitis	1.1	1.3	1.5	-1.1	-1.2	-1.1
Medication: Seretide 50 evohaler	1.1	1.3	3.8	1.9	0.2	0.3
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.2	-1.0	-1.5	-0.9
Illnesses of father: Heart disease	1.1	1.6	3.7	-0.0	-1.9	-1.0
Asthma (self-reported)	1.1	2.1	3.4	1.8	1.3	1.1
Medication: Bendroflumethiazide	1.1	1.7	3.2	1.8	0.3	-1.4
Unable to work because of sickness or disability	1.1	1.4	2.2	0.4	1.4	1.5
Alcohol drinker status: Previous	1.1	1.2	2.4	1.6	1.0	0.3
Schizophrenia (2018)	1.0	2.0	3.8	0.9	-1.1	-2.0
Relative age of first facial hair	1.0	2.0	4.0	0.8	1.1	2.0
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.3	0.8	1.0	1.5
Fed-up feelings	1.0	1.8	3.0	1.7	1.3	0.8
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	1.9	1.4	1.2	0.3
Hair/balding pattern: Pattern 2	1.0	1.3	1.8	1.3	1.3	0.5
Number of live births	1.0	1.4	2.7	1.6	1.0	0.8
Breastfed as a baby	1.0	1.3	3.1	-1.8	-0.3	-0.8
Irritable Bowel Disease (IBD)	0.9	2.1	4.0	-1.0	-2.0	-1.1
Major Depression (MDD)	0.9	1.1	2.0	1.4	1.1	0.4
Reaction Time	0.9	1.6	4.1	2.0	-0.3	-0.8
Taking other prescription medications	0.9	1.4	4.1	2.0	0.3	-0.2
Medication: Levothyroxine sodium	0.9	1.5	2.5	-1.0	1.0	1.6
Past tobacco smoking	0.9	1.7	4.1	2.0	-0.3	-1.0
Father’s age at death	0.9	1.3	1.7	0.6	1.3	1.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.9	-1.7	-0.4	-0.6
Wheeze or whistling in the chest in last year	0.9	1.7	3.3	1.8	1.1	0.6
Qualifications: College or University degree	0.9	2.9	4.7	-0.6	2.2	1.9
Commuting to job workplace: Walk	0.9	1.0	1.6	0.9	1.3	0.7
Miserableness	0.9	1.5	3.3	0.6	-1.0	-1.8
Pack years of smoking	0.9	1.3	2.6	1.1	1.6	0.4
Alzheimer’s Disease (in father)	0.8	0.9	1.7	-0.7	-0.7	-1.3
Mean Putamen Volume	0.8	0.9	1.0	0.9	0.9	1.0
Smoking Status	0.8	2.0	2.9	-0.6	1.7	1.7
Medication: Atenolol	0.8	1.0	1.7	1.0	1.3	0.5
Time employed in main current job	0.8	0.9	1.5	0.6	0.9	1.2
Noisy workplace	0.8	1.0	2.2	1.5	-0.9	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.0	-0.4	1.4	0.8
Eye problems/disorders: None of the above	0.8	0.9	2.2	-1.5	0.2	0.6
Suffer from ‘nerves’	0.8	1.3	3.6	1.9	0.4	-0.3
Eye problems/disorders: Cataract	0.8	0.9	1.7	1.3	-0.8	-0.7
Hearing aid user	0.8	0.9	1.3	1.1	1.0	0.6
Number of operations (self-reported)	0.8	1.2	1.4	1.2	1.1	1.1
Pain experienced in last month	0.8	1.3	2.5	0.5	1.6	1.1
Fasting Glucose	0.7	0.9	1.5	1.2	0.2	1.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.7	0.6	-0.9	-1.3
Diabetes (mother)	0.7	0.9	1.4	-0.8	1.2	0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.9	1.4	-0.0	0.5
Serious illness, injury or assault to yourself	0.7	0.8	2.4	1.5	0.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.2	-1.5	-0.5	-0.3
Exposure to tobacco smoke at home	0.7	0.8	1.1	0.9	-0.6	-1.0
Alcohol intake frequency.	0.7	1.7	4.7	2.2	0.1	-0.7
Comparative height size at age 10	0.7	3.7	6.7	-0.6	-2.0	-2.6
Diabetes diagnosed by doctor	0.7	1.1	1.7	-0.0	1.3	1.3
Ever taken oral contraceptive pill	0.7	0.8	2.3	-1.5	-0.3	-0.2
Leg fat percentage (left)	0.7	2.5	4.5	-0.5	-2.1	-1.7
Depressed Affect (Nagel 2018)	0.6	1.2	3.1	1.8	-0.1	-0.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.9	-0.1	1.4	1.2
Townsend deprivation index at recruitment	0.6	0.8	1.5	1.2	1.0	-0.1
High blood pressure	0.6	1.8	3.8	2.0	1.2	-0.3
Financial difficulties in last 2 years	0.6	0.8	1.5	-1.2	0.8	0.4
Medication: Simvastatin	0.6	0.9	1.8	-1.3	-0.4	-0.8
Neuroticism score	0.6	1.3	2.4	1.6	1.1	0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.5	-1.6	0.9	1.0
Birth weight of first child	0.6	1.0	1.5	1.1	-0.6	-1.2
Gout (self-reported)	0.6	0.9	1.2	-0.8	1.1	0.9
Leg fat percentage (right)	0.6	2.2	3.8	-0.8	-1.9	-1.4
Pulse rate, automated reading	0.6	1.8	4.1	2.0	1.0	0.6
Hypertension (Self-reported)	0.6	1.7	3.5	1.9	1.2	-0.4
Arm fat mass (left)	0.6	2.4	2.9	-1.2	-1.7	-1.7
Ever smoked	0.6	1.1	2.1	-1.4	0.7	0.8
Ulcerative Colitis (UC)	0.5	1.0	1.6	0.3	-1.3	-1.1
Schizophrenia (2014)	0.5	1.0	1.7	1.1	-0.4	-1.3
Blood Eosinophil Count	0.5	3.7	5.3	1.6	2.3	1.8
Blood White Count	0.5	4.0	4.9	2.2	2.2	1.6
Respiratory disease	0.5	1.2	2.3	1.5	1.0	0.4
Sensitivity / hurt feelings	0.5	0.8	2.4	1.6	-0.0	0.2
Supplements: Zinc	0.5	0.5	0.8	0.4	0.8	0.9
Diabetes (father)	0.5	0.6	0.9	-1.0	0.8	0.6
Trunk fat percentage	0.5	2.0	2.6	-1.2	-1.4	-1.6
Hearing difficulty/problems with background noise	0.5	0.7	2.0	-1.4	-0.5	0.1
Heart attack	0.5	0.7	1.8	-1.3	0.3	-0.4
Diabetes (self-reported)	0.5	0.8	1.2	-0.2	1.0	1.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	-0.3	-0.4	-1.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.7	-0.7	-1.0	-1.9
Mouth/teeth dental problems: Dentures	0.5	0.9	1.3	0.3	1.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.4	-0.8	-1.0	-1.8
Arm fat mass (right)	0.5	1.9	2.2	-1.1	-1.5	-1.5
Peak expiratory flow (PEF)	0.5	1.1	2.3	-1.5	-0.6	-0.8
Body fat percentage	0.5	2.0	2.5	-1.0	-1.6	-1.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.0	0.2	0.9	1.0
Medication: Ibuprofen	0.5	0.6	0.9	-0.9	-0.6	-0.7
Mean time to correctly identify matches	0.5	1.0	1.3	0.9	-1.1	-0.9
Illnesses of siblings: Diabetes	0.5	0.6	1.1	1.1	0.8	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	0.8	-0.9	-0.9	-0.1
Mineral and other dietary supplements	0.5	0.6	1.1	0.0	-0.9	-1.1
Wears glasses or contact lenses	0.5	0.6	1.2	-0.4	-0.7	-1.1
Mother’s age at death	0.5	0.6	1.0	0.3	-1.0	-0.9
Medication: Blood pressure	0.5	1.0	2.3	1.5	0.4	-0.7
Diastolic blood pressure, automated reading	0.5	1.6	2.9	1.3	1.7	0.2
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.8	-1.7	-1.0	0.5
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.6	-1.3	0.2	-0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	1.3	1.0	-0.4	-1.2
Ovarian Cancer	0.4	0.5	1.3	1.2	0.4	-0.2
Prostate Cancer	0.4	0.6	1.1	1.1	0.1	-0.8
Neuroticism (2016)	0.4	0.6	1.0	1.0	0.8	-0.3
Systolic Blood Pressure	0.4	1.8	4.2	0.8	2.0	0.7
Cardiovascular Disease	0.4	1.4	2.7	1.3	1.6	0.0
Lung FEV1/FVC ratio	0.4	2.1	3.2	-0.4	1.8	1.7
Chronotype (morning person)	0.4	0.9	1.5	-1.2	0.0	1.2
Angina	0.4	0.5	1.3	-1.1	0.2	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.3	-1.5	-0.0	0.4
Impedance of arm (right)	0.4	2.0	4.8	0.2	2.2	1.1
Illnesses of mother	0.4	0.5	0.7	0.6	0.7	0.8
Hair/balding pattern: Pattern 4	0.4	0.9	1.4	-1.2	0.6	0.9
Medication: Amlodipine	0.4	0.6	1.7	1.3	0.1	-0.3
Number of full brothers	0.4	0.6	1.6	1.3	0.3	-0.1
Worry too long after embarrassment	0.4	0.6	1.0	1.0	0.9	0.3
Angina (self-reported)	0.4	0.5	1.4	-1.2	-0.2	0.0
Medication: Omeprazole	0.4	0.5	0.6	0.8	-0.7	-0.7
Supplements: Vitamin C	0.4	0.4	0.8	0.5	-0.9	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.5	0.6	0.6	0.7
Mood swings	0.4	0.7	0.8	0.9	0.8	0.8
Medication: Gliclazide	0.4	0.5	0.6	0.5	0.7	0.8
Guilty feelings	0.4	0.5	0.8	0.9	-0.5	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.6	0.8	-0.7	-0.6
Depression (Nagel 2018)	0.3	0.5	1.4	1.2	0.1	-0.4
Age at First Birth	0.3	0.4	0.7	-0.6	-0.5	-0.8
Rheumatoid Arthritis	0.3	0.4	0.6	-0.6	0.5	0.8
Blood Platelet Count	0.3	3.1	3.5	-1.9	-1.7	-1.7
Heel T-Score	0.3	2.8	3.6	1.3	1.9	1.7
Lung FVC	0.3	1.3	2.2	1.5	0.2	-1.3
Neuroticism	0.3	0.7	1.8	1.3	0.4	0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.8	0.9	-0.2	0.4
Ever had hysterectomy (womb removed)	0.3	0.4	0.9	1.0	0.5	0.2
Maternal smoking around birth	0.3	0.4	0.6	0.4	-0.8	-0.6
Qualifications: CSEs or equivalent	0.3	0.4	0.9	0.1	0.6	1.0
Nervous feelings	0.3	0.7	1.4	1.2	-0.4	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	-0.5	-0.6	-0.8
Had menopause	0.3	0.3	0.6	0.4	-0.5	-0.8
Medication: Ramipril	0.3	0.4	1.0	0.3	1.0	0.1
Impedance of arm (left)	0.3	1.5	3.4	0.9	1.9	0.6
Blood clot in the leg (DVT)	0.3	0.4	0.6	0.8	0.8	0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.5	0.2	0.7	0.7
Medication for pain relief, constipation, heartburn	0.3	0.4	1.0	1.0	0.6	0.0
Medication: Blood pressure	0.3	0.6	1.5	0.1	1.2	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.5	0.2	-0.7	-0.7
Age at last live birth	0.3	0.4	0.7	0.6	0.3	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.8	0.6	-0.9	-0.2
Breast cancer (self-reported)	0.3	0.4	1.0	0.3	-0.3	-1.0
Illnesses of father: None of the above (group 1)	0.3	0.3	0.7	-0.1	0.9	0.5
Smoking status: Current	0.3	0.5	1.0	0.6	1.0	0.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.2	1.1	0.2	-0.1
High cholesterol (Self-reported)	0.3	0.5	1.6	-1.3	0.0	0.1
Myopia	0.3	0.5	0.9	-0.9	-0.2	-0.6
Supplements: Calcium	0.3	0.3	0.6	-0.8	-0.2	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.5	0.7	0.7	0.4
Bipolar Disorder (2018)	0.2	0.4	0.5	0.5	0.7	0.6
Neuroticism (Nagel 2018)	0.2	0.5	0.9	0.9	-0.4	-0.7
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	-0.6	0.6	0.2
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.8	-0.6	-0.0
HDL Cholesterol	0.2	0.4	0.8	-0.9	-0.5	-0.4
Blood Red Count	0.2	2.1	4.8	2.2	1.0	-0.6
Hearing difficulty/problems: Yes	0.2	0.2	0.4	-0.6	0.4	0.4
Severe depression (siblings)	0.2	0.3	0.5	0.0	-0.6	-0.7
Current tobacco smoking	0.2	0.4	1.0	0.4	1.0	0.2
Body mass index (BMI)	0.2	0.7	1.2	-0.6	-1.1	-0.8
Waist circumference	0.2	0.6	0.9	-0.1	-0.9	-1.0
Number of incorrect matches in round	0.2	0.4	1.0	-0.3	-1.0	-0.3
Mouth/teeth dental problems	0.2	0.3	0.6	0.0	-0.8	-0.7
Allergy	0.2	0.5	1.2	-1.1	-0.3	0.3
Fluid intelligence score	0.2	0.4	0.8	-0.9	-0.1	-0.7
Hair/balding pattern: Pattern 3	0.2	0.2	0.4	0.3	0.4	0.6
Medication: Cholesterol lowering	0.2	0.4	0.8	-0.9	-0.4	-0.3
Prospective memory result	0.2	0.3	0.4	0.1	-0.6	-0.7
Lung cancer (father)	0.2	0.3	0.4	0.6	0.7	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	-0.3	-0.7	-0.5
Medication: Paracetamol	0.2	0.3	0.6	-0.8	0.2	-0.5
High blood pressure (siblings)	0.2	0.3	0.5	-0.1	-0.7	-0.6
Age at first live birth	0.2	0.3	0.8	0.1	0.9	0.3
Chest pain or discomfort	0.2	0.2	0.3	0.6	-0.5	-0.4
Medication: Aspirin	0.2	0.3	0.8	-0.9	-0.2	0.0
Knee pain experienced in last month	0.2	0.4	0.5	0.7	0.7	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.2	-0.3	-0.6
Medication for cholesterol	0.2	0.4	0.7	-0.4	-0.5	0.8
Back pain experienced in last month	0.2	0.3	0.8	-0.1	-0.9	0.1
Medication: Aspirin	0.2	0.2	0.6	-0.8	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	0.0	-0.2	-1.1
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	1.0	0.1	-0.3
Medication: Paracetamol	0.2	0.3	0.8	-0.2	0.1	-0.9
Irritability	0.2	0.3	0.3	0.6	0.5	0.5
Cholesterol lowering medication	0.2	0.2	0.4	-0.6	0.6	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.6	-0.1	0.1	-0.8
Primary Biliary Cirrhosis	0.1	0.2	0.2	0.4	0.5	0.3
Triglycerides	0.1	0.1	0.3	-0.4	-0.5	-0.2
Ulcerative Colitis	0.1	0.1	0.2	-0.2	-0.2	-0.4
Hair Pigment	0.1	3.1	5.5	-0.1	2.3	1.9
Tanning	0.1	0.9	2.0	-0.8	-1.4	-0.2
Number of treatments/medications taken	0.1	0.2	0.6	0.8	0.3	0.1
Medication for hormone replacement therapy	0.1	0.2	0.4	-0.2	0.0	-0.7
Vitamin and mineral supplements	0.1	0.2	0.3	0.3	0.3	-0.6
Impedance of leg (right)	0.1	0.4	1.1	-1.0	0.2	0.4
Relative age voice broke	0.1	0.2	0.3	0.0	-0.6	-0.5
Age when periods started (menarche)	0.1	0.3	0.6	-0.4	-0.4	-0.8
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.5	-0.5	-0.1
High blood pressure (mother)	0.1	0.1	0.2	0.1	0.2	-0.4
Illnesses of siblings	0.1	0.1	0.3	0.0	0.1	0.6
Arm fat percentage (right)	0.1	0.3	0.4	-0.4	-0.4	-0.6
Pulse rate	0.1	0.1	0.3	0.6	-0.2	-0.3
Tense / ‘highly strung’	0.1	0.1	0.3	-0.1	-0.5	-0.4
Pulse wave reflection index	0.1	0.1	0.3	-0.5	0.2	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.7	-0.3	0.0
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.0	-0.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.2	0.3	-0.4	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.4	0.2	-0.4
Neck or shoulder pain in last month	0.1	0.2	0.3	0.5	0.4	-0.4
Migraine (self-reported)	0.1	0.1	0.4	0.0	0.6	-0.2
Medication: Allopurinol	0.1	0.2	0.3	-0.4	0.5	0.4
Arm fat percentage (left)	0.1	0.3	0.5	-0.3	-0.4	-0.7
Average weekly red wine intake	0.1	0.1	0.2	0.4	0.2	0.2
Loneliness, isolation	0.1	0.2	0.4	0.7	0.3	0.1
Qualifications: nursing, teaching	0.1	0.2	0.2	-0.4	0.5	0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	-0.0	0.1	0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.4	0.1	0.1	0.6
Average weekly beer plus cider intake	0.1	0.1	0.1	0.3	0.4	0.1
Commuting to job workplace: Cycle	0.1	0.2	0.3	-0.5	-0.1	0.5
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	0.2	0.5	-0.3
Worry (Nagel 2018)	0.0	0.1	0.1	0.3	-0.1	-0.3
BMI	0.0	0.1	0.1	0.3	-0.4	0.2
Allergy or Eczema	0.0	0.1	0.1	-0.1	0.2	-0.3
Systolic blood pressure, automated reading	0.0	0.1	0.1	-0.3	-0.0	-0.4
Medication: Metformin	0.0	0.0	0.0	-0.0	0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.5	-0.1	0.1
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	0.0	0.2	-0.2
Supplements: Glucosamine	0.0	0.0	0.0	0.0	0.2	0.2
Impedance of leg (left)	0.0	0.1	0.2	-0.4	-0.2	0.1
Had other major operations	0.0	0.0	0.0	0.0	-0.0	0.2
Qualifications: None of the above	0.0	0.0	0.1	0.2	-0.1	-0.2
Number of full sisters	0.0	0.1	0.1	-0.0	0.2	0.3
Medication: Lisinopril	0.0	0.0	0.0	-0.1	0.1	-0.1
Impedance of whole body	0.0	0.2	0.5	0.2	0.7	0.2

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