TWAS
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Models
Genes
Traits
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Traits
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Hand grip strength (right)
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chr15:74,942,759-76,350,952
Best TWAS P=2.37e-08 · Best GWAS P=3.83e-07 conditioned to 1
75M
75.2M
75.4M
75.6M
75.8M
76M
76.2M
76.4M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Esophageal Carcinoma
SNUPN
0.18
0.11
lasso
5
0.07
2.6e-03
5.0
5.6
2.4e-08
0.96
0.00
0.89
TRUE
2
GTEx
Adrenal Gland
MAN2C1
0.20
0.24
lasso
6
0.21
4.3e-08
5.0
5.5
4.7e-08
0.98
0.02
0.98
FALSE
3
GTEx
Brain Caudate basal ganglia
MAN2C1
0.23
0.24
enet
20
0.22
7.9e-07
5.1
5.4
5.4e-08
0.89
0.02
0.97
FALSE
1
GTEx
Adipose Subcutaneous
NEIL1
0.05
0.03
lasso
5
0.02
1.6e-02
4.8
5.1
2.9e-07
0.98
0.03
0.96
FALSE