[Hub]/) : Traits : Leg pain on walking :

chr3:49,030,828-50,800,146

Best TWAS P=9.35e-09 · Best GWAS P=2.1e-07 conditioned to 0.67

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RNF123 0.14 0.10 blup 324 0.12 4.7e-14 4.8 5.6 2.0e-08 -0.73 0.14 0.86 TRUE
2 GTEx Artery Coronary RBM6 0.14 0.14 enet 23 0.15 1.0e-05 4.8 -5.3 8.9e-08 0.86 0.11 0.88 FALSE
3 GTEx Artery Tibial MST1R 0.06 0.02 lasso 5 0.02 1.5e-02 4.6 5.4 8.1e-08 -0.81 0.08 0.60 FALSE
4 GTEx Artery Tibial IP6K1 0.03 0.00 enet 22 0.01 2.5e-02 4.6 5.7 9.3e-09 -0.62 0.09 0.64 TRUE
5 GTEx Artery Tibial UBA7 0.04 0.03 lasso 4 0.02 7.8e-03 -5.0 -5.2 2.2e-07 0.86 0.07 0.64 FALSE
6 GTEx Brain Cerebellum MST1R 0.19 0.24 enet 22 0.20 1.8e-06 -5.1 5.5 3.7e-08 -0.95 0.06 0.94 FALSE
7 GTEx Breast Mammary Tissue RNF123 0.11 0.07 enet 14 0.02 3.2e-02 4.7 5.4 7.2e-08 -0.67 0.15 0.78 FALSE
8 GTEx Colon Transverse RBM6 0.29 0.33 enet 43 0.36 4.6e-18 -4.6 -5.1 2.8e-07 0.95 0.13 0.87 FALSE
9 GTEx Esophagus Mucosa RBM6 0.18 0.21 enet 18 0.23 3.0e-15 5.1 -5.3 1.1e-07 0.94 0.06 0.94 FALSE
10 GTEx Lung RBM6 0.17 0.20 lasso 6 0.24 4.6e-18 -5.1 -5.2 2.1e-07 0.97 0.08 0.92 FALSE
11 GTEx Spleen RBM6 0.36 0.39 lasso 8 0.40 2.0e-11 -5.2 -5.3 1.0e-07 0.99 0.04 0.95 FALSE
12 GTEx Vagina RBM6 0.24 0.22 enet 27 0.21 1.5e-05 -4.1 -5.3 1.1e-07 0.95 0.07 0.92 FALSE
13 GTEx Whole Blood UBA7 0.03 0.04 lasso 2 0.01 1.5e-02 4.8 -5.3 1.4e-07 0.79 0.11 0.78 FALSE
14 METSIM Adipose MST1R 0.03 0.02 blup 331 0.02 1.7e-03 5.1 5.7 1.3e-08 -0.85 0.06 0.93 FALSE