TWAS hub - MST1R

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0270	0.0170	2.0e-03	0.047	0.020	0.026	0.024	0.033	1.9e-06	1.7e-03	3.5e-04	0.00058	6.0e-05
2	GTEx	Artery Tibial	0.0619	0.0337	2.2e-03	0.015	NA	0.008	NA	0.017	2.1e-02	NA	6.7e-02	NA	1.5e-02
3	GTEx	Brain Cerebellar Hemisphere	0.3030	0.1180	1.2e-04	0.080	NA	0.097	NA	0.069	4.4e-03	NA	1.8e-03	NA	7.6e-03
4	GTEx	Brain Cerebellum	0.1930	0.0730	5.8e-07	0.240	NA	0.197	NA	0.196	1.0e-07	NA	1.8e-06	NA	1.9e-06
5	GTEx	Cells Transformed fibroblasts	0.0540	0.0270	8.5e-04	0.039	NA	0.038	NA	0.042	6.0e-04	NA	6.9e-04	NA	3.8e-04
6	GTEx	Esophagus Gastroesophageal Junction	0.1770	0.1430	4.7e-03	0.019	NA	0.045	NA	0.064	6.5e-02	NA	9.6e-03	NA	2.4e-03
7	GTEx	Esophagus Muscularis	0.0450	0.0220	1.7e-03	0.005	NA	0.003	NA	0.053	1.6e-01	NA	1.9e-01	NA	3.6e-04
8	GTEx	Heart Atrial Appendage	0.0800	0.0390	9.7e-04	0.004	NA	0.031	NA	0.018	2.0e-01	NA	1.5e-02	NA	4.9e-02
9	GTEx	Lung	0.0583	0.0326	1.4e-03	0.044	NA	0.037	NA	0.037	2.5e-04	NA	7.8e-04	NA	7.5e-04
10	GTEx	Skin Not Sun Exposed Suprapubic	0.0520	0.0290	5.3e-03	0.072	NA	0.053	NA	0.021	8.9e-05	NA	7.0e-04	NA	2.3e-02
11	GTEx	Skin Sun Exposed Lower leg	0.0560	0.0300	2.1e-03	0.071	NA	0.042	NA	0.060	1.7e-06	NA	1.9e-04	NA	1.1e-05
12	GTEx	Small Intestine Terminal Ileum	0.1960	0.0980	1.2e-03	0.054	NA	0.060	NA	0.097	2.4e-02	NA	1.9e-02	NA	3.6e-03
13	GTEx	Thyroid	0.0570	0.0250	8.4e-05	0.056	NA	0.047	NA	0.044	4.2e-05	NA	1.7e-04	NA	2.7e-04
14	METSIM	Adipose	0.0251	0.0150	1.3e-03	0.015	0.016	0.008	0.014	0.015	2.1e-03	1.7e-03	1.9e-02	0.00340	2.1e-03
15	ROSMAP	Brain Pre-frontal Cortex	0.0217	0.0128	1.5e-03	0.004	0.006	0.005	-0.002	-0.001	8.3e-02	4.5e-02	5.7e-02	0.63000	3.9e-01
16	TCGA	Kidney Renal Clear Cell Carcinoma	0.0321	0.0186	1.7e-05	0.038	0.048	0.045	NA	0.044	3.7e-05	4.0e-06	8.0e-06	NA	8.7e-06
17	TCGA	Brain Lower Grade Glioma	0.0828	0.0372	2.0e-09	0.069	0.061	0.089	NA	0.027	3.0e-08	1.7e-07	2.6e-10	NA	4.2e-04
18	TCGA	Thyroid Carcinoma	0.0280	0.0180	8.7e-04	0.014	0.033	0.018	NA	0.017	1.3e-02	3.1e-04	5.8e-03	NA	8.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Qualifications: College or University degree	43.4	136.7	176.9	-8.7	-13.3	-11.0	-13.2	-8.6	-11.9	-11.9	-12.0	-11.9	-11.3	-11.8	-11.9	-11.6	-12.5	-12.7	-12.6	-9.6	-12.6
Qualifications: A levels/AS levels or equivalent	38.3	84.9	112.4	-5.0	-10.6	-9.2	-10.4	-7.4	-9.0	-9.0	-8.5	-9.6	-9.3	-9.5	-8.7	-9.7	-9.4	-10.3	-9.8	-9.1	-9.8
Age at First Birth	36.7	53.4	66.5	-5.7	-7.3	-5.9	-8.2	-6.2	-6.2	-8.1	-6.8	-7.6	-7.2	-7.5	-7.3	-7.9	-7.8	-8.2	-7.8	-7.4	-7.7
Age at last live birth	34.3	49.7	62.7	-5.3	-7.3	-5.1	-7.9	-5.7	-5.9	-7.4	-6.6	-7.5	-7.3	-7.5	-7.5	-7.3	-7.7	-7.9	-7.8	-6.5	-7.7
Body mass index (BMI)	33.8	143.9	179.6	8.0	11.7	11.2	13.4	10.5	12.4	11.8	10.1	13.0	12.6	12.6	11.8	12.5	12.1	13.1	12.8	12.4	12.7
Leg fat mass (left)	31.9	124.6	158.8	7.7	11.1	11.0	12.6	10.6	11.9	10.1	8.8	12.2	11.9	11.7	10.6	11.8	10.8	11.9	11.7	11.7	11.7
Leg fat mass (right)	31.4	121.9	156.2	7.9	10.9	10.9	12.5	10.5	11.7	10.1	8.7	12.0	11.7	11.5	10.5	11.7	10.7	11.8	11.5	11.5	11.6
Age at first live birth	31.2	55.4	69.1	-5.8	-7.5	-5.4	-8.2	-5.8	-6.5	-7.5	-6.9	-8.0	-7.6	-8.1	-7.8	-7.9	-8.2	-8.3	-8.3	-7.1	-8.2
Intelligence (Savage-Jansen 2018)	30.6	94.0	130.0	-5.9	-11.0	-9.8	-11.4	-7.8	-10.1	-9.7	-9.2	-9.7	-9.6	-9.2	-9.0	-10.0	-9.8	-11.0	-10.2	-9.7	-10.0
BMI	29.9	173.2	210.2	7.8	12.8	12.7	14.5	11.2	13.7	12.8	11.1	14.5	13.9	14.1	13.0	13.7	12.9	14.4	14.1	13.9	14.0
Leg fat percentage (right)	28.1	101.7	132.2	8.2	10.4	10.4	11.5	9.7	11.5	9.3	7.5	10.8	10.4	10.5	9.4	10.4	9.1	10.5	10.3	10.4	10.3
Leg fat percentage (left)	28.1	101.7	134.6	7.7	10.4	10.5	11.4	9.7	11.6	9.1	7.4	10.9	10.5	10.6	9.3	10.5	9.0	10.5	10.3	10.7	10.3
Arm fat mass (right)	27.0	111.4	141.6	7.1	10.4	10.6	11.9	9.8	11.3	9.7	8.3	11.5	11.2	11.0	10.1	11.2	10.1	11.2	11.1	11.1	11.2
Arm fat mass (left)	26.7	109.8	141.6	7.0	10.2	10.6	11.9	9.8	11.0	9.6	8.3	11.4	11.1	10.9	10.0	11.2	10.1	11.1	11.0	11.1	11.1
Whole body fat mass	25.4	106.2	139.2	7.3	10.2	10.8	11.8	10.0	11.2	9.0	7.7	11.2	11.0	10.7	9.6	11.0	9.7	10.8	10.7	10.9	10.8
Fluid intelligence score	24.0	49.8	63.8	-4.9	-7.2	-6.9	-8.0	-6.4	-6.8	-7.5	-6.2	-7.3	-7.2	-6.9	-6.7	-7.8	-6.6	-7.9	-7.3	-7.5	-7.2
Taking other prescription medications	23.7	36.6	49.1	5.5	5.5	4.2	7.0	6.3	5.6	5.1	5.4	6.6	6.5	6.2	5.7	6.9	6.7	6.7	6.4	5.4	6.4
Overall health rating	23.5	50.4	67.8	7.3	6.9	5.4	8.2	6.9	6.7	7.4	6.3	7.2	7.2	6.9	7.3	7.5	7.4	8.0	7.5	5.7	7.5
Verbal and Numeric Reasoning (VNR)	22.1	53.0	72.0	-4.5	-8.0	-7.2	-8.5	-5.8	-6.9	-7.9	-7.1	-7.3	-7.1	-6.9	-6.8	-7.8	-7.1	-8.3	-7.8	-7.4	-7.6
Qualifications: None of the above	22.1	47.4	59.4	6.0	7.4	5.4	7.4	4.8	6.6	7.6	7.6	6.9	6.5	6.9	7.5	6.8	7.6	7.7	7.5	5.3	7.5
Weight	22.1	108.5	136.9	6.2	9.7	9.5	11.7	9.8	10.3	8.9	8.5	11.7	11.5	11.0	9.9	11.4	10.9	11.4	11.2	10.9	11.2
Wheeze or whistling in the chest in last year	22.1	39.4	52.9	4.8	5.7	5.8	7.3	6.9	6.0	5.6	4.6	7.0	6.9	6.2	5.8	6.9	6.1	7.0	6.6	6.5	6.5
Arm fat percentage (left)	21.1	84.0	110.0	6.8	9.4	10.3	10.5	8.7	10.1	8.5	6.6	9.8	9.4	9.6	8.5	9.5	8.0	9.3	9.3	10.1	9.4
Arm fat percentage (right)	20.7	81.7	106.4	6.8	9.2	9.9	10.3	8.5	10.0	8.5	6.7	9.6	9.3	9.4	8.5	9.4	7.9	9.3	9.2	9.7	9.3
Body fat percentage	20.3	80.1	109.5	7.1	9.3	10.5	10.3	9.1	10.4	7.7	5.8	9.6	9.3	9.4	7.9	9.3	7.5	8.9	8.9	9.8	9.0
Waist circumference	20.2	74.1	93.7	6.0	8.0	8.1	9.5	8.7	8.4	7.5	6.4	9.7	9.5	9.4	8.2	9.6	8.4	8.9	9.1	9.3	9.2
Number of treatments/medications taken	20.1	36.2	46.7	5.2	5.4	4.7	6.8	6.2	6.4	5.6	4.8	6.5	6.4	5.9	5.9	6.8	6.1	6.8	6.4	5.4	6.4
Impedance of arm (right)	20.1	93.8	141.6	-4.8	-8.4	-5.3	-10.2	-7.0	-8.4	-10.6	-10.1	-10.7	-10.4	-10.0	-10.8	-9.9	-11.9	-11.7	-11.0	-8.7	-10.8
Impedance of arm (left)	19.9	92.1	136.9	-5.1	-8.4	-5.1	-10.1	-6.9	-8.4	-10.7	-10.0	-10.5	-10.2	-9.8	-10.7	-9.8	-11.7	-11.7	-10.9	-8.4	-10.7
Trunk fat mass	19.6	84.2	110.2	6.5	9.0	10.1	10.5	9.3	10.2	7.7	6.4	10.0	9.8	9.6	8.2	9.9	8.3	9.3	9.4	10.1	9.5
Miserableness	19.3	33.4	46.7	5.2	5.7	3.6	6.6	5.4	4.7	6.6	6.1	6.0	5.8	5.9	6.3	5.7	6.1	6.8	6.1	4.3	6.1
Average weekly beer plus cider intake	19.0	27.5	40.1	4.0	5.0	4.0	5.8	4.0	4.2	5.2	6.3	5.3	5.2	5.4	5.8	5.7	6.0	5.6	5.9	3.9	5.8
Irritable Bowel Disease (IBD)	18.9	44.9	89.5	-4.9	-9.5	-8.2	-8.2	-5.2	-7.8	-7.3	-6.0	-5.6	-5.3	-5.9	-6.1	-5.7	-6.4	-7.0	-6.8	-5.9	-6.9
Alcohol intake versus 10 years previously	18.6	27.8	39.0	4.4	5.9	5.4	6.2	5.6	3.8	4.5	4.3	5.7	5.8	5.5	4.9	5.6	5.3	5.3	5.4	5.3	5.5
Ever highly irritable/argumentative for 2 days	18.2	21.8	29.2	4.3	3.9	3.1	5.4	4.4	4.0	5.3	4.5	5.1	5.0	4.8	5.4	4.6	4.9	5.1	5.1	3.4	5.1
Ulcerative Colitis (UC)	17.4	32.6	53.6	-4.4	-7.3	-5.7	-6.7	-3.9	-6.1	-6.6	-6.1	-4.8	-4.8	-5.3	-5.9	-4.8	-6.1	-6.3	-6.2	-4.2	-6.2
Medication: Co-codamol	16.9	19.6	28.6	4.3	4.4	3.3	4.7	3.4	4.2	5.3	4.5	4.5	4.3	4.4	5.0	4.4	4.5	4.9	4.8	3.7	4.8
Arm predicted mass (left)	16.6	84.3	114.5	4.7	7.8	6.6	10.1	8.4	8.4	8.2	8.2	10.5	10.4	9.6	9.3	10.1	10.7	10.6	10.3	8.9	10.2
Arm fat-free mass (left)	16.2	82.3	112.4	4.4	7.7	6.5	10.0	8.2	8.2	8.1	8.1	10.3	10.3	9.5	9.2	10.0	10.6	10.5	10.2	8.9	10.1
Impedance of whole body	16.0	81.3	130.0	-4.0	-7.6	-4.7	-9.4	-5.9	-7.4	-10.2	-9.9	-9.9	-9.6	-9.2	-10.2	-9.1	-11.4	-11.1	-10.4	-7.9	-10.1
Leg pain on walking	15.9	19.9	32.3	2.2	5.4	3.5	5.5	3.3	3.4	3.4	4.4	4.8	4.5	4.6	4.0	5.0	5.7	5.0	5.0	4.1	5.0
Trunk fat percentage	15.6	62.4	98.2	6.2	8.2	9.9	9.1	8.4	9.4	6.4	4.7	8.4	8.2	8.2	6.6	8.3	6.2	7.6	7.7	9.0	7.9
Crohns Disease (2012)	15.4	24.9	47.1	-3.5	-6.9	-6.8	-6.0	-4.4	-5.8	-5.0	-3.7	-4.5	-3.8	-4.9	-4.0	-4.8	-4.1	-4.7	-4.9	-5.5	-5.0
Arm predicted mass (right)	15.3	78.3	106.1	4.6	7.5	6.5	9.7	8.1	7.7	7.9	7.9	10.1	10.1	9.2	9.0	9.8	10.3	10.2	9.9	8.7	9.8
Ulcerative Colitis	14.8	21.4	40.7	-3.6	-6.4	-4.6	-5.4	-3.4	-4.9	-5.2	-5.3	-3.5	-3.7	-4.2	-4.7	-4.1	-5.1	-4.9	-4.9	-3.3	-4.9
Mouth/teeth dental problems: Dentures	14.7	24.8	30.9	4.1	4.9	4.7	5.6	4.0	5.1	4.7	4.6	5.4	5.3	5.2	5.4	4.7	5.2	5.6	5.4	4.0	5.4
Arm fat-free mass (right)	14.6	74.9	104.0	4.0	7.3	6.3	9.5	7.9	7.7	7.6	7.7	9.9	9.9	9.0	8.6	9.6	10.2	10.1	9.7	8.7	9.6
Fed-up feelings	14.5	26.4	36.3	5.1	6.0	4.7	6.0	4.3	4.9	6.0	4.5	5.0	4.7	5.3	5.1	4.7	5.1	5.8	5.2	4.1	5.2
Basal metabolic rate	13.7	76.0	102.0	4.4	7.4	6.7	9.7	8.0	7.9	7.6	7.8	9.9	9.9	9.0	8.7	9.7	10.1	9.9	9.7	8.7	9.6
Hip circumference	13.5	58.1	73.3	4.9	7.2	6.9	8.6	6.5	8.2	7.4	6.6	8.3	8.2	7.9	7.9	7.6	8.1	8.4	8.2	7.3	8.2
Alcohol intake frequency.	13.0	30.1	45.3	5.2	5.8	5.2	6.2	6.7	3.7	4.6	3.0	6.2	6.3	5.8	5.3	5.7	5.4	5.2	5.4	6.0	5.7
Qualifications: NVQ or HND or HNC or equivalent	13.0	15.6	24.4	2.7	4.0	4.8	4.5	4.6	4.1	3.3	1.6	4.5	4.5	4.2	3.4	4.1	3.0	3.6	3.9	4.9	4.0
Crohns Disease (2017)	12.9	28.4	62.1	-3.5	-7.9	-7.5	-6.6	-4.9	-6.5	-5.2	-3.8	-4.6	-4.2	-4.5	-4.1	-4.8	-4.4	-5.2	-5.0	-5.6	-5.2
Exposure to tobacco smoke at home	12.9	14.5	23.0	2.7	3.8	2.3	4.0	2.2	3.1	4.6	4.8	3.6	3.4	3.7	4.0	4.5	4.4	4.7	4.3	2.9	4.2
Mood swings	12.9	23.2	33.7	4.1	4.9	3.5	5.7	4.7	3.3	5.3	4.5	5.0	4.9	4.8	4.7	5.3	4.9	5.8	4.9	4.8	4.9
Qualifications: nursing, teaching	12.5	19.5	29.7	-4.0	-5.5	-4.5	-5.0	-3.7	-4.9	-3.8	-3.9	-4.5	-4.1	-4.8	-4.0	-4.5	-4.4	-4.3	-4.5	-4.0	-4.6
Leg fat-free mass (left)	12.3	65.3	84.6	4.0	7.0	6.8	9.0	7.5	7.5	6.9	7.0	9.2	9.2	8.4	7.9	8.9	9.2	9.1	8.9	8.3	8.9
Chronic bronchitis/emphysema (mother)	12.3	14.4	18.8	2.7	3.8	2.5	4.0	3.2	4.1	3.6	4.3	4.0	3.9	3.9	3.9	4.2	4.3	4.0	4.1	3.2	4.1
Pain experienced in last month	12.3	20.5	30.2	-3.8	-5.1	-3.4	-5.1	-3.2	-4.0	-4.4	-4.6	-4.7	-4.3	-4.7	-4.6	-4.5	-5.5	-5.3	-5.1	-3.4	-5.0
Depressed Affect (Nagel 2018)	12.2	25.6	36.6	4.4	5.5	3.4	5.9	4.2	4.7	5.8	5.4	5.0	4.9	4.9	5.3	4.9	5.5	6.0	5.3	3.8	5.2
Leg predicted mass (left)	12.2	64.7	85.0	4.0	6.9	6.6	9.0	7.4	7.4	6.9	7.0	9.2	9.1	8.3	8.0	8.9	9.2	9.0	8.9	8.2	8.8
Diabetes (self-reported)	11.8	18.3	29.3	2.8	3.8	3.8	4.5	5.1	3.8	3.8	2.5	4.9	5.0	4.8	3.9	5.4	3.7	4.2	4.3	5.2	4.4
Exposure to tobacco smoke outside home	11.3	15.1	23.8	3.2	3.5	2.4	4.3	2.8	2.8	4.1	4.6	4.0	3.8	4.1	4.3	4.0	4.9	4.4	4.4	2.9	4.3
Medication: Seretide 50 evohaler	11.0	12.6	20.1	3.5	3.1	3.3	4.1	3.9	3.4	4.5	2.9	3.4	3.6	2.7	3.7	3.9	3.1	3.9	3.5	3.4	3.6
Qualifications: CSEs or equivalent	10.9	14.3	18.3	3.0	4.2	2.8	4.3	2.5	3.7	4.1	4.2	3.6	3.4	3.7	3.7	4.3	4.3	4.1	4.1	3.5	4.0
Whole body water mass	10.8	61.8	90.2	3.5	6.3	5.4	8.6	7.1	6.7	6.9	7.3	9.0	9.0	8.1	8.0	8.8	9.5	9.2	8.9	7.7	8.8
Number of live births	10.7	15.1	18.8	3.9	3.8	3.6	4.1	3.3	3.7	3.3	4.0	4.3	4.1	4.3	4.1	3.8	4.0	3.6	4.2	3.4	4.2
Type 2 Diabetes (T2D) (2018)	10.5	19.6	32.8	3.2	4.2	3.5	4.7	5.0	3.6	3.5	3.2	5.0	4.9	5.0	3.9	5.7	4.4	4.2	4.5	5.3	4.7
Whole body fat-free mass	10.5	60.0	88.2	3.5	6.3	5.3	8.5	6.9	6.7	6.8	7.2	8.9	8.9	8.0	7.8	8.7	9.4	9.0	8.8	7.6	8.7
Schizophrenia vs Biploar Disorder	10.3	13.6	21.6	-4.1	-2.9	-2.4	-3.6	-4.6	-3.7	-3.6	-2.9	-4.1	-4.4	-3.6	-4.6	-3.2	-3.7	-3.7	-4.0	-2.0	-4.0
Leg fat-free mass (right)	10.2	54.5	73.5	3.0	6.3	6.0	8.2	6.7	6.9	6.1	6.5	8.5	8.5	7.6	7.2	8.2	8.6	8.4	8.2	7.7	8.1
Leg predicted mass (right)	10.1	53.9	72.5	3.0	6.2	6.0	8.1	6.7	6.9	6.1	6.4	8.4	8.4	7.6	7.2	8.1	8.5	8.3	8.2	7.6	8.1
Medication: Ventolin 100micrograms inhaler	10.0	12.8	18.1	4.2	2.8	2.9	4.1	4.2	3.3	3.2	2.6	3.7	3.8	3.2	3.5	4.3	3.7	3.4	3.6	3.4	3.8
Age started oral contraceptive pill	9.9	12.4	17.2	-2.7	-3.7	-3.3	-4.2	-3.4	-3.4	-4.0	-2.8	-3.6	-3.5	-3.5	-3.0	-3.8	-3.6	-3.8	-3.5	-3.9	-3.5
Diabetes diagnosed by doctor	9.8	16.1	26.8	2.4	3.4	3.6	4.2	5.0	3.5	3.3	2.1	4.7	4.8	4.5	3.5	5.1	3.4	3.8	4.0	5.2	4.1
Coronary Artery Disease (CAD)	9.5	11.3	14.9	1.5	3.6	3.7	3.8	2.7	2.9	3.6	2.7	3.7	3.5	3.4	3.1	3.7	3.0	3.6	3.7	3.9	3.7
Qualifications: O levels/GCSEs or equivalent	9.5	15.1	23.9	-1.7	-4.9	-3.9	-4.2	-2.5	-3.9	-3.9	-3.6	-4.0	-3.5	-4.3	-3.4	-3.8	-4.1	-4.6	-4.2	-3.9	-4.1
Ever had bowel cancer screening	9.5	11.2	16.8	-2.6	-3.3	-3.3	-3.9	-3.4	-2.3	-3.1	-3.5	-3.4	-3.4	-3.2	-3.2	-4.1	-3.4	-3.3	-3.4	-3.5	-3.5
Knee pain experienced in last month	9.3	14.5	23.9	2.5	3.5	2.1	4.5	3.1	4.0	3.8	4.0	4.0	4.2	3.4	4.3	3.5	4.9	4.2	4.3	2.5	4.3
Pain all over the body in last month	9.2	9.9	17.0	2.3	3.3	2.2	3.5	2.6	2.1	4.0	3.3	3.1	3.2	3.0	3.7	2.8	3.6	4.1	3.4	2.3	3.4
Impedance of leg (left)	9.1	44.1	73.3	-2.3	-5.3	-3.8	-6.9	-4.0	-5.3	-7.5	-7.5	-7.3	-7.0	-6.8	-7.5	-6.7	-8.6	-8.1	-7.7	-6.1	-7.5
Diastolic blood pressure, automated reading	9.1	28.1	39.6	4.3	6.3	5.1	6.1	5.7	5.8	4.1	4.1	5.4	5.2	5.2	4.0	5.9	5.3	5.4	5.0	6.2	5.2
Blood White Count	8.9	66.0	90.6	5.5	8.3	7.6	8.7	7.8	7.5	6.4	5.2	9.2	8.8	9.5	7.0	9.3	8.0	9.1	8.6	9.2	8.7
Financial situation satisfaction	8.9	11.0	18.2	1.7	3.6	2.3	4.0	3.2	2.6	3.2	3.4	3.5	3.4	3.2	2.8	3.7	3.9	4.3	3.4	3.4	3.3
Osteoarthritis (self-reported)	8.8	11.5	17.5	2.2	3.5	2.6	3.9	3.1	4.2	2.9	2.9	3.7	3.8	3.3	3.5	3.3	3.7	3.7	3.7	2.7	3.6
Number of operations (self-reported)	8.8	13.1	27.2	2.9	2.8	1.0	4.0	2.5	2.2	4.2	5.2	3.6	3.8	3.2	4.8	3.1	4.8	4.2	4.1	1.2	4.0
Prospective memory result	8.6	10.6	17.9	2.5	3.2	3.9	3.8	3.5	4.2	2.1	1.7	3.7	3.6	3.5	2.6	3.4	2.4	3.3	3.2	3.7	3.2
Medication for cholesterol, blood pressure or diabetes	8.6	14.2	21.0	-2.7	-3.8	-4.2	-4.2	-3.4	-4.5	-4.1	-2.3	-3.8	-3.6	-3.8	-3.2	-4.4	-3.3	-3.7	-3.7	-4.6	-3.8
Frequency of tenseness / restlessness in last 2 weeks	8.4	13.0	20.5	4.4	3.5	1.4	4.2	3.9	2.2	3.8	3.6	3.6	3.6	3.5	3.7	3.6	4.3	4.5	3.6	2.3	3.6
Impedance of leg (right)	8.3	40.2	65.4	-1.4	-5.2	-3.8	-6.5	-3.7	-5.4	-7.0	-7.0	-7.0	-6.8	-6.5	-7.0	-6.4	-8.1	-7.8	-7.4	-6.1	-7.1
Trunk fat-free mass	8.2	47.0	77.8	3.0	5.2	3.8	7.4	5.9	5.4	6.0	6.8	7.9	7.9	7.1	7.2	7.7	8.8	8.2	8.0	6.3	7.8
Maternal smoking around birth	8.1	11.7	22.3	1.3	3.8	1.9	3.8	1.9	3.2	2.2	4.3	3.6	3.3	3.9	2.8	3.9	4.7	4.1	3.8	3.1	3.6
Bilateral oophorectomy (both ovaries removed)	8.1	9.4	12.6	2.0	2.8	2.3	3.6	2.8	2.7	3.2	3.4	3.1	3.2	3.2	3.2	3.3	3.5	3.3	3.3	2.6	3.2
Ever unenthusiastic/disinterested for a whole week	8.1	10.0	15.6	3.9	2.2	0.2	3.5	3.1	1.4	3.7	4.0	3.0	3.0	2.9	3.8	3.3	3.8	3.8	3.5	1.3	3.4
Medication: Omeprazole	8.1	9.7	13.6	2.9	2.8	1.9	3.7	3.3	3.3	2.5	3.1	3.3	3.5	2.8	3.4	3.1	3.7	3.4	3.3	2.1	3.3
Trunk predicted mass	8.0	45.6	74.8	2.9	5.1	3.8	7.2	5.8	5.3	6.0	6.7	7.8	7.8	7.0	7.0	7.6	8.7	8.1	7.8	6.3	7.7
Loneliness, isolation	7.7	10.7	14.8	2.8	3.4	2.1	3.8	2.7	3.3	3.4	3.3	3.4	3.3	3.0	3.3	3.2	3.6	3.9	3.6	2.5	3.5
Shortness of breath walking on level ground	7.6	9.0	13.1	1.7	3.0	2.2	3.6	2.8	2.5	2.4	2.5	3.5	3.4	3.2	3.0	3.1	3.4	3.4	3.4	2.7	3.3
Heel bone mineral density (BMD) T-score, automated (left)	7.5	16.9	40.4	2.2	4.8	6.0	4.5	5.1	4.1	2.6	0.6	4.6	4.5	4.3	2.5	4.7	2.4	3.2	3.6	6.4	3.8
Pulse rate, automated reading	7.5	24.1	72.1	3.3	5.2	8.2	5.0	7.6	4.8	0.7	-2.0	5.2	4.8	5.5	0.9	5.6	1.3	2.8	3.2	8.5	3.7
Health satisfaction	7.4	9.6	15.1	2.6	2.8	2.1	3.8	3.6	2.7	2.5	2.8	3.3	3.2	2.9	2.5	3.8	3.2	3.9	3.2	3.1	3.1
Body Mass Index (BMI) (2010)	7.3	10.1	13.0	1.4	2.9	2.7	3.4	2.6	3.2	3.4	3.1	3.6	3.6	3.4	3.4	3.1	3.3	3.3	3.5	3.1	3.5
Average weekly red wine intake	7.2	10.6	15.7	-3.5	-2.9	-2.0	-3.3	-3.4	-2.6	-3.4	-2.9	-3.6	-3.6	-3.8	-4.0	-3.2	-3.0	-3.3	-3.5	-2.3	-3.5
Chest pain or discomfort	7.1	10.2	16.7	2.4	2.6	1.6	3.6	3.2	3.7	3.0	2.6	3.5	3.7	3.0	3.7	2.8	3.7	4.1	3.6	1.6	3.5
Illnesses of siblings: Diabetes	7.1	8.7	12.4	2.9	2.6	1.5	3.4	3.4	2.4	2.4	2.1	3.5	3.5	3.4	3.2	3.0	3.0	3.1	3.2	2.3	3.3
Heel T-Score	6.9	54.8	148.8	4.2	8.3	11.7	7.8	10.1	7.3	3.9	-0.9	8.2	8.1	8.7	3.7	7.5	3.3	5.2	5.5	12.2	5.9
Noisy workplace	6.9	8.5	11.4	3.1	2.9	1.9	3.4	3.0	2.2	2.7	2.6	3.2	3.2	3.2	3.2	2.8	3.2	3.1	3.0	2.1	3.2
HDL Cholesterol	6.8	11.4	22.3	-2.2	-3.0	-2.9	-3.7	-4.7	-3.0	-2.3	-2.2	-4.1	-4.4	-3.5	-3.5	-3.4	-3.1	-2.9	-3.4	-3.7	-3.5
Respiratory disease	6.8	15.2	21.3	3.5	1.9	1.7	4.4	4.5	3.4	3.5	3.8	4.4	4.6	3.4	4.4	4.6	4.4	4.4	4.4	2.9	4.3
Neuroticism score	6.8	14.3	19.3	4.3	3.5	2.0	4.2	4.3	2.7	4.4	3.7	3.9	3.8	3.8	4.0	4.0	3.6	4.3	3.8	3.0	3.9
Prostate Cancer	6.7	9.4	15.3	1.5	3.7	2.2	3.4	2.5	3.5	3.7	3.6	2.7	3.0	2.7	3.2	3.1	3.4	3.9	3.2	1.7	3.1
Ever had hysterectomy (womb removed)	6.5	7.4	12.0	3.3	2.7	2.1	2.9	2.0	2.9	2.7	3.1	2.6	2.6	2.8	3.5	2.2	2.9	2.3	3.0	1.4	3.0
Age when periods started (menarche)	6.5	15.7	40.8	2.8	4.6	1.0	4.4	1.8	2.5	3.6	6.2	3.7	3.5	3.5	4.4	3.0	6.4	4.8	4.6	0.4	4.4
Heel bone mineral density (BMD) T-score, automated (right)	6.5	15.0	36.3	1.6	4.8	6.0	4.1	5.0	4.4	1.3	0.0	4.4	4.2	4.3	1.9	4.3	1.8	2.6	3.2	6.0	3.4
Number of children fathered	6.5	7.4	11.9	2.0	3.0	1.9	3.0	2.2	2.5	2.1	3.1	3.0	2.8	2.9	2.8	2.5	3.4	2.7	3.0	1.9	3.1
Father’s age at death	6.4	8.6	14.3	-1.7	-3.5	-3.1	-3.7	-2.4	-2.2	-3.2	-2.8	-3.0	-2.8	-2.6	-2.4	-3.1	-2.9	-3.8	-3.0	-3.1	-2.9
Number of full sisters	6.3	7.7	13.2	3.6	2.6	0.6	2.8	1.9	1.2	3.0	2.8	3.0	2.5	3.2	3.2	2.9	3.5	2.9	3.1	2.1	3.2
Guilty feelings	6.3	9.5	22.2	3.5	2.9	2.0	3.2	1.8	1.9	4.7	4.4	2.6	2.4	2.6	3.6	3.0	3.2	3.6	3.2	1.9	3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	6.1	8.2	12.8	3.6	3.1	2.0	3.5	3.1	1.9	3.1	2.7	2.8	2.6	2.8	2.6	3.2	2.9	3.1	2.8	2.4	2.8
Chronic bronchitis/emphysema (father)	6.1	7.2	14.8	3.8	1.8	1.3	2.7	2.8	2.7	2.7	2.8	2.8	2.8	2.9	3.3	2.2	2.5	2.8	2.9	1.3	2.9
Number of full brothers	6.0	7.6	14.8	2.2	1.9	0.7	2.9	1.9	2.2	3.9	3.7	2.7	2.8	2.4	3.8	2.4	3.3	3.4	3.0	1.1	3.0
Ever depressed for a whole week	6.0	7.5	16.2	3.8	1.8	-0.6	2.7	2.0	1.2	4.0	3.9	2.2	2.3	2.2	3.5	2.5	3.5	3.2	2.8	0.7	2.8
Neck or shoulder pain in last month	5.9	8.3	17.1	2.1	3.1	1.4	3.4	2.3	2.5	2.6	3.4	3.0	2.9	2.8	2.9	2.7	4.1	3.6	3.2	1.5	3.1
Neuroticism	5.8	14.0	19.7	4.1	3.5	1.7	4.3	4.2	3.1	4.4	3.8	3.6	3.7	3.3	4.1	3.9	3.7	4.4	3.8	2.8	3.8
Medication: Metformin	5.8	8.2	15.4	1.8	2.6	2.6	2.9	3.2	2.6	2.4	1.6	3.4	3.3	3.4	2.3	3.5	2.5	2.8	2.8	3.9	2.8
Asthma (self-reported)	5.8	11.5	16.8	3.1	1.8	2.0	3.9	4.0	2.6	3.2	3.4	3.6	4.1	2.8	4.0	3.9	3.7	3.6	3.7	2.5	3.7
Number of self-reported non-cancer illnesses	5.8	10.1	14.2	3.1	2.5	1.2	3.6	3.6	3.3	2.2	2.8	3.5	3.6	3.0	3.2	3.7	3.7	3.8	3.6	2.2	3.5
Basal cell carcinoma (self-reported)	5.8	6.8	10.7	-2.4	-2.8	-2.3	-2.9	-2.2	-1.7	-3.3	-2.6	-2.5	-2.5	-2.6	-3.0	-2.8	-2.5	-2.7	-2.7	-2.4	-2.8
Major Depression (MDD)	5.7	6.9	12.6	2.2	2.2	1.2	3.0	2.3	1.6	3.2	2.3	2.8	2.5	2.8	2.5	2.9	2.9	3.5	2.9	2.8	2.9
Breastfed as a baby	5.7	7.1	13.4	-2.2	-2.7	-2.4	-2.8	-2.9	-3.7	-2.4	-0.9	-2.9	-2.8	-3.1	-2.2	-3.1	-1.6	-2.6	-2.6	-3.1	-2.6
Long-standing illness, disability or infirmity	5.7	8.7	14.0	2.1	1.7	1.2	3.1	3.4	2.3	2.1	2.5	3.6	3.7	3.1	3.2	3.6	3.4	3.4	3.3	2.6	3.3
Asthma	5.5	10.9	16.2	2.9	1.7	2.0	3.8	4.0	2.4	3.1	3.2	3.5	4.0	2.7	3.9	3.9	3.6	3.6	3.7	2.4	3.6
Average weekly champagne plus white wine intake	5.5	7.5	11.8	-1.4	-3.4	-2.7	-3.1	-2.2	-3.1	-2.0	-2.4	-2.9	-2.8	-2.8	-2.4	-3.1	-2.9	-2.8	-2.9	-2.9	-3.0
Medication: Blood pressure	5.2	9.2	14.5	2.6	2.9	2.7	3.5	2.9	3.8	3.5	2.0	3.0	3.0	2.5	2.8	3.6	3.0	3.1	2.9	3.3	3.0
Medication: Atenolol	5.1	6.4	8.7	3.0	2.9	2.4	2.9	2.8	2.8	1.8	1.7	2.8	2.7	2.4	2.3	2.4	2.5	2.5	2.5	2.2	2.6
Alcohol usually taken with meals	5.1	8.2	11.8	-1.2	-2.8	-2.4	-3.0	-2.1	-2.4	-3.3	-2.5	-3.0	-2.9	-3.3	-3.1	-3.1	-3.0	-3.4	-3.2	-2.8	-3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	5.1	7.8	14.4	3.8	2.1	1.0	3.1	2.8	2.2	3.1	2.8	2.9	2.9	2.7	3.3	2.5	2.9	3.3	3.0	1.4	3.0
Smoking Status	5.0	12.1	33.5	1.9	2.8	0.8	3.6	0.7	3.1	4.2	5.8	3.0	2.6	3.1	4.0	2.9	5.3	4.4	4.1	1.1	3.9
Tinnitus: Yes, but not now, but have in the past	5.0	5.3	8.3	1.3	2.7	2.8	2.9	2.6	2.9	2.1	1.6	2.4	2.5	2.1	2.0	2.0	2.0	2.5	2.2	2.1	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	5.0	16.0	28.1	-3.0	-4.6	-4.3	-4.3	-1.9	-4.5	-5.3	-3.4	-3.8	-3.1	-4.4	-3.7	-3.9	-3.3	-5.0	-4.3	-3.7	-4.1
Commuting to job workplace: Car/motor vehicle	5.0	5.8	10.1	2.9	2.3	1.0	2.6	1.4	2.0	2.8	3.2	2.4	2.2	2.2	3.0	1.9	3.1	2.4	2.7	1.1	2.8
Medication: Omeprazole (e.g. Zanprol)	5.0	6.0	8.7	2.6	2.0	1.3	3.0	2.8	2.5	2.1	2.0	2.7	2.8	2.4	2.8	2.3	2.8	2.7	2.6	1.5	2.6
Mean time to correctly identify matches	4.9	9.4	18.6	-1.2	-3.5	-3.8	-3.4	-3.6	-3.2	-2.5	-1.4	-3.2	-3.1	-3.2	-2.0	-3.5	-2.5	-2.8	-2.9	-4.3	-3.0
Commuting to job workplace: Walk	4.8	5.1	11.7	-2.0	-2.1	-1.1	-2.4	-1.6	-2.3	-2.3	-3.4	-2.1	-2.2	-1.9	-2.8	-2.2	-2.9	-2.2	-2.5	-0.9	-2.5
Forced vital capacity (FVC), Best measure	4.6	16.9	25.4	-3.8	-4.9	-4.1	-4.4	-2.3	-4.9	-5.0	-3.7	-3.9	-3.3	-4.7	-4.0	-3.9	-3.3	-4.7	-4.3	-3.6	-4.2
Financial difficulties in last 2 years	4.5	6.1	9.6	1.7	3.1	2.6	2.8	2.5	2.8	2.1	1.6	2.7	2.5	2.9	2.1	2.2	2.0	2.8	2.4	2.5	2.5
Medication: Lansoprazole	4.5	5.2	7.6	2.4	2.5	2.3	2.7	2.8	2.2	1.9	1.5	2.3	2.4	2.4	2.1	2.1	2.2	2.1	2.2	2.1	2.2
Medication: Paracetamol	4.5	7.0	13.7	2.1	2.5	1.0	3.3	1.6	2.3	3.3	3.6	2.2	2.3	1.9	3.0	2.4	3.5	3.7	3.0	0.4	2.9
Current tobacco smoking	4.4	7.2	11.9	1.5	2.5	1.7	3.1	1.6	1.8	2.5	3.2	2.8	2.6	2.8	2.9	2.7	3.5	3.4	3.2	1.9	3.2
Mother’s age at death	4.4	5.5	10.1	-1.4	-2.1	-1.2	-2.6	-1.1	-2.0	-2.5	-2.7	-2.4	-2.3	-2.3	-2.4	-2.6	-3.1	-3.2	-2.7	-1.8	-2.5
Mouth/teeth dental problems	4.3	6.6	11.0	-3.3	-2.0	-1.8	-2.6	-2.1	-2.5	-2.3	-2.4	-2.8	-2.6	-2.8	-3.0	-2.5	-2.7	-2.5	-3.0	-1.8	-2.9
Heart attack	4.3	5.5	8.1	1.5	2.7	1.9	2.7	1.6	1.7	2.8	1.7	2.4	2.2	2.4	2.2	2.5	2.7	2.6	2.5	2.7	2.5
Neuroticism (Nagel 2018)	4.2	9.8	15.2	3.9	2.6	1.2	3.5	3.7	2.7	3.8	3.4	3.0	3.2	2.8	3.7	3.1	3.0	3.7	3.1	1.9	3.1
Pain type(s) experienced in last month: Hip pain	4.2	5.3	11.0	1.4	2.3	1.3	2.5	1.6	1.4	1.6	2.7	2.5	2.5	2.5	2.4	2.6	3.3	2.5	2.8	1.6	2.6
Chronotype (morning person)	4.1	9.5	24.7	-2.8	-2.9	-0.1	-3.3	-1.7	-2.8	-2.1	-5.0	-2.9	-2.7	-2.7	-3.9	-2.7	-4.2	-3.2	-3.9	0.7	-3.8
Medication: Cholesterol lowering	4.1	6.4	14.2	0.9	2.7	3.2	2.7	1.8	3.8	2.9	1.4	2.5	2.2	2.6	1.8	2.8	2.1	2.4	2.4	3.3	2.5
Had major operations	4.1	4.8	11.7	2.1	1.7	0.2	2.1	1.7	1.3	3.2	3.4	1.9	2.0	1.7	2.9	1.8	2.8	2.8	2.3	0.3	2.3
Average weekly spirits intake	4.0	4.9	13.9	1.5	3.2	3.7	2.8	1.6	2.2	2.2	1.8	2.1	2.0	2.0	1.9	1.7	1.3	2.3	2.2	1.8	2.2
Forced expiratory volume in 1-second (FEV1)	4.0	13.6	25.0	-2.4	-4.3	-4.0	-4.0	-1.2	-3.9	-5.0	-3.7	-3.4	-2.7	-3.9	-3.2	-3.5	-3.2	-5.0	-3.9	-3.4	-3.7
Lung cancer (father)	4.0	4.7	8.4	2.1	2.6	1.6	2.7	1.9	1.8	1.6	2.3	2.2	2.1	2.5	1.7	2.0	2.9	2.4	2.1	1.8	2.1
Smoking status: Current	4.0	6.3	10.1	1.3	2.5	1.7	3.0	1.8	1.6	2.1	2.9	2.7	2.5	2.7	2.6	2.6	3.1	3.2	3.0	2.0	2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.0	8.5	14.4	-2.2	-2.5	-1.7	-3.1	-1.2	-3.4	-3.5	-3.6	-2.6	-2.4	-2.9	-3.2	-3.3	-3.2	-3.8	-3.4	-1.6	-3.2
Medication: Paracetamol	3.9	6.5	14.2	2.2	2.4	1.0	3.0	1.3	2.7	3.0	3.8	2.1	2.1	1.8	3.0	2.2	3.3	3.5	2.9	0.1	2.7
Friendships satisfaction	3.8	4.7	6.5	-1.6	-2.0	-2.2	-2.2	-1.6	-2.5	-1.6	-1.9	-2.5	-2.4	-2.3	-2.3	-2.3	-2.4	-1.8	-2.4	-2.2	-2.5
Blood Eosinophil Count	3.7	28.6	47.4	4.2	3.7	4.9	5.3	6.9	4.0	2.2	4.7	6.4	6.7	6.0	5.2	6.8	5.4	4.3	5.9	5.4	6.0
Forced vital capacity (FVC)	3.6	13.9	20.9	-3.6	-4.5	-3.7	-3.9	-1.8	-4.3	-4.6	-3.7	-3.6	-2.9	-4.2	-3.5	-3.5	-3.1	-4.4	-3.9	-3.1	-3.7
High blood pressure (siblings)	3.6	5.2	8.8	3.0	1.4	1.2	2.2	3.0	2.0	2.9	1.5	2.4	2.5	2.1	2.8	2.2	2.1	2.3	2.3	1.7	2.4
Reaction Time	3.5	6.6	13.1	-0.1	-3.4	-3.5	-2.9	-2.8	-3.4	-1.8	-1.1	-2.5	-2.5	-2.5	-1.3	-2.8	-2.3	-2.3	-2.4	-3.6	-2.4
Relative age of first facial hair	3.5	7.3	21.6	1.4	1.3	-1.0	2.4	1.7	0.2	2.8	4.7	2.8	2.9	2.3	3.6	2.5	4.0	3.1	3.3	0.4	3.2
Diabetes (mother)	3.5	4.5	9.9	1.3	1.8	2.3	2.0	2.4	2.3	2.4	1.3	2.2	2.2	2.1	1.7	2.7	1.3	2.1	1.9	3.1	2.0
Medication: Ibuprofen (e.g. Nurofen)	3.5	4.5	7.4	1.7	2.3	1.2	2.4	1.8	2.7	2.1	2.3	2.1	2.1	1.9	2.2	2.0	2.6	2.3	2.2	1.4	2.3
Medication for pain relief, constipation, heartburn	3.5	5.9	10.4	-2.4	-1.9	-1.1	-2.9	-1.9	-3.2	-2.6	-2.9	-2.3	-2.3	-1.9	-2.6	-2.4	-2.9	-3.2	-2.6	-0.9	-2.5
Illnesses of siblings	3.4	4.8	9.2	-3.0	-1.3	-0.8	-2.3	-2.9	-2.5	-3.0	-0.9	-2.2	-2.3	-1.8	-2.5	-2.2	-1.8	-2.4	-2.0	-1.8	-2.1
Commuting to job workplace: Public transport	3.4	4.0	6.6	-2.2	-1.7	-0.5	-2.3	-1.6	-1.3	-2.6	-2.4	-1.9	-1.9	-1.4	-2.2	-2.3	-2.6	-2.2	-2.1	-1.5	-2.1
Heart attack/myocardial infarction (self-reported)	3.4	4.4	6.7	1.4	2.4	1.7	2.5	1.4	1.6	2.6	1.4	2.1	1.9	2.1	1.9	2.3	2.5	2.4	2.2	2.4	2.2
Lung FVC	3.3	16.8	24.6	-3.9	-5.0	-3.9	-4.4	-2.7	-4.4	-4.5	-4.0	-3.9	-3.3	-4.5	-3.5	-4.6	-3.6	-4.9	-4.4	-3.2	-4.3
Commuting to job workplace: Cycle	3.3	3.9	6.7	-2.6	-2.0	-1.2	-2.1	-0.8	-2.4	-2.5	-1.9	-1.9	-1.5	-2.0	-2.3	-1.7	-1.9	-2.0	-2.4	-1.1	-2.3
Frequency of depressed mood in last 2 weeks	3.2	4.5	9.5	3.1	1.9	0.6	2.4	2.5	0.9	2.3	2.2	2.2	2.2	2.2	2.6	1.9	1.9	2.3	2.2	0.9	2.3
Ever used hormone-replacement therapy (HRT)	3.2	4.1	6.8	0.9	1.8	1.2	2.0	1.6	1.9	1.5	2.1	2.6	2.6	2.4	2.5	1.9	2.4	2.1	2.4	1.1	2.4
Medication: Gliclazide	3.2	3.6	6.5	2.5	1.0	1.2	1.9	2.3	0.9	1.8	1.3	2.1	2.3	1.9	2.0	2.5	1.5	1.9	1.8	2.3	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.1	3.6	6.0	1.1	2.1	1.4	2.2	1.5	2.4	0.5	2.4	2.0	1.9	1.8	1.5	2.4	2.5	2.2	2.1	1.2	2.0
Hand grip strength (right)	3.0	8.1	13.4	1.3	3.6	3.2	3.2	2.4	2.1	2.5	2.2	3.1	3.0	2.9	2.4	2.9	3.7	3.1	2.9	3.0	3.0
Hair/balding pattern: Pattern 2	3.0	3.8	6.4	2.1	0.3	-0.2	2.0	2.4	0.2	1.8	2.0	2.2	2.4	1.6	2.4	2.5	2.4	2.0	2.0	1.5	2.1
Neuroticism (2016)	2.9	4.2	7.5	2.5	2.5	1.4	2.6	2.5	1.4	2.7	1.7	1.7	1.9	1.7	2.0	2.0	1.6	2.5	1.9	1.5	1.9
Breast Cancer	2.7	6.6	12.7	-1.5	-3.6	-2.4	-3.0	-1.5	-1.5	-2.2	-3.0	-2.5	-1.9	-2.9	-1.8	-3.0	-2.9	-3.2	-2.8	-2.4	-2.7
Systolic blood pressure, automated reading	2.7	7.8	14.6	1.2	3.8	2.1	3.0	1.3	3.6	2.7	3.1	2.4	2.0	2.7	1.8	3.1	3.3	3.6	2.7	3.2	2.6
Had other major operations	2.7	3.3	8.1	1.0	0.8	-0.8	1.9	1.4	-0.1	1.2	2.6	2.1	2.1	1.7	2.4	1.6	2.9	2.0	2.4	0.3	2.2
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	5.5	-0.7	-2.1	-0.7	-1.6	-0.6	-0.9	-2.4	-1.9	-1.8	-1.6	-1.8	-2.2	-2.0	-2.3	-2.1	-2.2	-1.2	-2.2
Back pain experienced in last month	2.7	3.9	7.2	1.9	2.7	1.8	2.4	1.2	1.3	1.6	2.0	2.0	1.7	2.2	1.6	2.1	2.2	2.4	2.2	1.7	2.1
Primary Biliary Cirrhosis	2.6	3.7	6.4	-1.1	-1.5	-2.0	-2.3	-2.5	-2.1	-1.8	-1.3	-2.2	-2.2	-1.7	-1.6	-2.0	-1.5	-2.2	-1.8	-2.4	-1.8
Peak expiratory flow (PEF)	2.6	6.0	12.0	-1.5	-2.5	-3.2	-2.5	-1.0	-2.5	-3.5	-2.4	-2.3	-1.9	-2.6	-2.4	-2.7	-1.5	-2.8	-2.7	-2.3	-2.6
Medication: Ibuprofen	2.6	3.1	5.7	1.0	1.8	0.7	2.1	1.1	2.1	2.3	2.3	1.5	1.5	1.3	1.9	1.6	2.4	2.1	1.9	1.0	1.8
Supplements: Calcium	2.6	2.9	4.9	-1.9	-1.6	-2.0	-1.9	-2.2	-2.0	-1.1	-1.1	-1.7	-1.7	-1.6	-1.4	-2.1	-1.2	-1.3	-1.4	-2.2	-1.5
Mouth/teeth dental problems: Bleeding gums	2.5	3.3	9.0	0.4	-1.9	-3.0	-2.0	-2.0	-2.5	-1.2	-0.3	-2.0	-2.2	-1.6	-1.3	-1.3	-0.9	-1.8	-1.6	-2.4	-1.6
Cholesterol lowering medication	2.5	3.6	5.9	1.9	1.3	1.6	1.9	2.4	1.8	1.2	0.7	2.4	2.4	2.4	1.7	2.1	1.5	1.9	1.9	2.4	1.9
Alcohol drinker status: Previous	2.5	2.9	7.8	0.0	1.5	1.2	1.8	0.6	0.2	2.8	2.3	1.4	1.4	1.5	2.0	1.7	2.1	2.4	1.8	1.6	1.7
Vitamin and mineral supplements	2.4	3.2	8.3	1.7	1.5	2.6	1.8	2.2	1.4	1.3	-0.1	2.1	2.1	2.1	1.6	1.8	0.8	1.3	1.5	2.9	1.6
Diabetes (father)	2.4	3.0	7.8	1.7	1.4	1.3	1.6	2.8	2.3	0.9	0.9	2.1	2.2	2.1	2.1	1.4	1.4	1.0	1.6	1.1	1.8
Pack years adult smoking proportion	2.4	3.7	9.7	0.6	1.8	1.1	2.3	1.4	1.9	2.3	1.4	1.9	1.7	1.9	1.5	1.8	2.5	3.1	2.0	1.9	1.9
Illnesses of mother	2.4	3.0	6.0	-2.3	-1.4	-1.4	-1.7	-2.1	-1.9	-1.9	-0.8	-1.7	-1.6	-1.7	-1.3	-2.3	-1.3	-1.4	-1.4	-2.5	-1.5
Medication for cholesterol	2.4	3.6	5.3	-1.3	-2.2	-1.9	-2.0	-2.1	-2.3	-0.9	-1.1	-2.2	-2.2	-2.1	-1.5	-2.2	-1.8	-1.9	-2.0	-2.1	-2.0
Gout (self-reported)	2.3	3.2	6.0	2.5	1.7	2.0	1.8	2.2	2.2	1.5	0.5	1.8	1.7	1.9	1.3	2.1	1.0	1.4	1.5	2.3	1.6
Medication: Ramipril	2.2	2.8	5.5	1.2	1.0	0.1	1.7	1.3	1.7	2.2	1.7	1.6	1.4	1.4	1.8	2.4	2.2	2.1	1.9	1.5	1.8
Hair/balding pattern: Pattern 3	2.2	3.3	5.4	-1.7	-0.4	0.0	-1.9	-2.3	-0.5	-1.7	-1.7	-2.0	-2.2	-1.9	-2.1	-2.3	-2.3	-1.8	-1.9	-1.7	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	5.3	0.8	1.4	0.6	1.8	1.4	1.6	1.7	1.6	1.6	1.7	1.4	1.7	1.7	1.8	2.3	1.9	1.2	1.8
Worrier / anxious feelings	2.1	3.9	12.9	2.5	1.6	1.5	2.0	3.6	1.5	2.1	0.6	2.1	2.4	1.7	1.9	2.1	0.7	2.0	1.6	2.2	1.7
Comparative body size at age 10	2.1	5.8	17.3	1.0	1.6	0.9	2.3	0.0	1.6	3.2	4.2	2.1	2.0	2.3	3.1	2.2	3.6	2.7	2.8	1.3	2.7
Depression (Nagel 2018)	2.0	2.9	7.5	2.7	1.8	0.4	1.8	2.1	1.2	2.0	1.8	1.6	1.5	1.7	1.9	1.6	1.6	1.8	1.7	0.6	1.8
Bipolar Disorder (2011)	2.0	2.0	8.4	-0.3	-1.4	-2.9	-1.1	-2.2	-1.7	0.3	1.6	-1.2	-1.1	-1.3	0.3	-1.0	0.4	-0.7	-0.6	-2.5	-0.7
Birth weight of first child	2.0	3.7	12.0	-1.6	-2.4	-2.4	-1.7	-2.2	-3.5	-1.8	-0.5	-1.9	-1.9	-2.0	-1.9	-1.7	-0.6	-1.5	-1.7	-1.7	-1.9
Pulse wave reflection index	2.0	2.5	11.0	0.4	0.2	-0.7	1.1	-0.2	1.2	2.1	3.3	1.2	1.3	0.9	2.3	1.1	2.5	1.9	1.7	-0.3	1.6
Schizophrenia (2014)	1.9	4.2	12.8	-0.8	-1.8	-3.6	-1.6	-3.1	-2.9	-1.0	0.6	-2.4	-2.5	-2.0	-1.4	-1.7	-0.5	-1.7	-1.6	-2.6	-1.7
Cardiovascular Disease	1.9	6.2	13.3	2.4	2.7	2.2	2.8	2.5	3.6	2.4	1.4	2.3	2.2	2.2	1.9	3.0	2.2	2.5	2.2	3.0	2.3
Pulse rate	1.9	3.3	13.9	0.8	1.8	3.7	1.2	2.9	1.7	-1.2	-2.3	1.4	1.3	1.6	-0.9	1.6	-1.1	-0.1	0.2	3.3	0.5
Tense / ‘highly strung’	1.9	3.1	6.9	2.5	1.3	0.1	2.1	2.6	1.5	1.5	1.8	1.8	1.9	1.4	1.7	1.7	1.8	2.2	1.6	1.0	1.6
Mouth/teeth dental problems: Loose teeth	1.9	2.3	6.0	2.4	1.2	1.6	1.7	1.9	1.3	0.9	0.4	1.7	1.4	1.8	1.0	1.6	1.6	1.1	1.3	1.7	1.4
Breast cancer (self-reported)	1.9	2.3	4.8	0.0	1.8	1.4	1.6	0.7	0.8	1.2	1.8	1.6	1.7	1.9	1.7	1.0	2.2	1.9	1.7	0.9	1.6
Risk taking	1.9	2.8	5.4	-1.0	1.7	0.9	1.7	1.1	0.5	0.8	1.7	2.0	2.1	1.8	1.6	1.6	2.3	2.1	2.0	1.6	1.9
Bipolar Disorder (2018)	1.8	2.9	11.6	1.8	0.5	-1.1	1.4	0.6	-0.1	2.1	3.4	1.3	1.5	0.7	2.5	1.2	2.6	1.7	1.8	-0.5	1.7
Schizophrenia (2018)	1.8	3.7	10.0	-0.6	-1.7	-3.2	-1.6	-2.8	-2.2	-1.2	-0.0	-2.3	-2.3	-2.0	-1.3	-2.0	-0.8	-1.8	-1.7	-2.5	-1.8
Lupus	1.8	2.7	7.5	-0.8	1.3	-0.3	1.5	0.9	1.4	0.1	2.3	1.9	2.1	1.6	2.0	1.2	2.7	1.6	2.1	0.1	2.0
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	7.0	-1.6	-2.1	-2.6	-1.7	-1.8	-1.6	-1.7	-0.8	-1.3	-1.3	-1.3	-1.1	-1.1	-0.8	-0.9	-0.9	-2.1	-1.1
Comparative height size at age 10	1.7	9.1	19.4	-3.3	-3.4	-2.1	-3.2	-1.8	-3.6	-4.4	-3.3	-2.7	-2.5	-2.9	-3.6	-2.3	-2.9	-3.1	-3.1	-2.1	-3.0
Vascular/heart problems diagnosed by doctor	1.7	4.7	11.4	-1.4	-2.0	-1.3	-2.4	-2.2	-3.4	-2.3	-1.3	-2.1	-2.0	-1.7	-1.6	-2.6	-2.3	-2.5	-2.0	-2.6	-2.0
Angina	1.6	2.2	4.5	0.8	1.2	2.1	1.6	1.6	1.6	1.6	-0.3	1.8	1.6	1.6	1.2	1.3	0.4	1.5	1.4	2.1	1.5
Medication for hormone replacement therapy	1.6	1.8	4.0	0.4	1.7	1.0	1.5	0.6	0.5	0.8	1.7	1.4	1.5	1.3	1.5	1.3	2.0	1.3	1.6	0.5	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	4.5	2.1	0.9	0.0	1.7	2.0	-0.2	1.4	1.5	1.6	1.6	1.2	1.7	1.1	1.6	2.0	1.5	0.3	1.4
Pulse wave peak to peak time	1.6	1.9	4.5	-1.1	-1.4	-1.0	-1.4	-1.0	-2.1	-0.9	-1.9	-1.4	-1.4	-1.4	-1.3	-1.2	-1.6	-1.5	-1.5	-0.7	-1.4
Medication: Bendroflumethiazide	1.6	2.4	4.5	1.1	1.2	1.7	1.7	2.1	2.0	1.4	-0.9	1.7	1.7	1.5	0.9	1.6	1.2	1.6	1.3	2.1	1.4
Worry (Nagel 2018)	1.5	3.2	14.0	2.8	1.0	0.7	1.9	3.7	1.1	1.6	0.7	1.9	2.3	1.3	1.9	1.8	0.8	1.6	1.3	1.5	1.5
Falls in the last year	1.5	2.1	3.8	-0.3	0.3	0.0	1.2	0.9	1.1	1.6	1.9	1.6	1.8	1.1	1.9	1.6	1.9	1.8	1.8	1.0	1.7
Wears glasses or contact lenses	1.5	1.7	2.7	1.7	1.3	1.4	1.2	0.7	1.5	1.3	1.6	1.3	1.1	1.4	1.4	1.4	1.3	1.1	1.3	0.8	1.3
Pack years of smoking	1.5	2.3	6.8	0.1	1.3	0.6	1.7	0.8	1.6	1.9	1.1	1.5	1.3	1.4	1.2	1.4	2.1	2.6	1.6	1.4	1.5
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	7.2	-0.4	0.4	1.2	1.1	2.7	1.3	0.3	-0.4	1.5	1.9	1.2	0.7	1.4	0.2	1.1	0.8	1.9	0.9
Average weekly fortified wine intake	1.4	1.6	2.6	0.4	1.4	1.3	1.2	1.1	1.0	1.3	0.9	1.5	1.4	1.3	1.2	1.2	1.1	1.6	1.6	1.3	1.5
Medication: Simvastatin	1.4	2.1	6.2	1.0	1.0	1.8	1.4	1.5	1.9	1.5	-0.2	1.6	1.5	1.6	0.9	1.8	0.8	1.2	1.2	2.5	1.2
Happiness	1.4	1.8	6.3	0.5	-1.5	-2.5	-1.1	-0.7	-2.2	-0.8	-0.3	-1.5	-1.5	-1.3	-1.1	-0.9	-0.9	-0.9	-1.3	-1.5	-1.3
Pulse wave Arterial Stiffness index	1.4	1.7	3.9	0.8	1.3	1.0	1.3	1.1	2.0	0.7	1.6	1.4	1.4	1.3	1.1	1.2	1.5	1.4	1.4	0.8	1.3
Worry too long after embarrassment	1.4	2.3	6.3	-0.7	-2.2	-1.9	-2.1	-0.6	-2.5	-0.6	-1.1	-1.5	-1.5	-1.1	-1.2	-0.9	-2.2	-1.5	-1.5	-0.7	-1.5
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	4.5	0.2	0.9	0.7	1.2	1.5	1.3	1.1	1.0	2.1	2.1	1.9	2.1	1.5	1.2	1.2	2.0	1.5	2.0
Medication: Atorvastatin	1.4	1.8	3.8	0.8	1.6	1.2	1.0	1.2	1.8	0.8	0.9	1.6	1.5	1.9	1.4	1.1	1.1	1.1	1.4	1.1	1.5
Fractured/broken bones in last 5 years	1.4	1.8	4.3	-2.0	-1.6	-2.1	-1.2	-1.6	-1.6	-1.0	-0.2	-1.3	-1.2	-1.5	-0.7	-1.1	-0.4	-0.8	-0.8	-1.9	-0.9
Systolic Blood Pressure	1.3	6.5	13.8	1.8	3.7	2.0	2.9	1.8	3.5	2.0	2.5	2.0	1.7	2.0	1.2	3.5	3.0	2.8	2.2	3.2	2.2
Stomach or abdominal pain in last month	1.3	1.6	3.5	1.9	1.5	0.6	1.5	1.1	0.9	1.4	1.0	1.1	1.0	1.4	1.3	1.1	1.3	1.6	1.4	0.3	1.4
Past tobacco smoking	1.3	2.4	16.4	-0.2	-0.8	0.7	-0.9	1.9	-1.1	-2.1	-4.0	-0.3	0.2	-0.8	-1.4	-0.3	-2.6	-1.6	-1.4	1.1	-1.1
Angina (self-reported)	1.3	1.7	4.2	0.7	1.0	1.9	1.4	1.2	1.3	1.5	-0.5	1.5	1.3	1.4	1.0	1.2	0.2	1.3	1.2	2.0	1.2
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	3.2	0.4	1.3	0.5	1.4	1.6	1.4	0.1	0.9	1.7	1.8	1.7	1.2	1.0	1.7	1.4	1.4	0.3	1.4
Fasting Glucose	1.2	1.4	5.9	0.6	1.9	2.4	1.4	0.7	1.5	1.8	0.6	0.7	0.6	0.8	0.6	0.9	0.3	1.1	0.7	1.8	0.7
Blood Red Count	1.2	11.8	30.1	2.4	3.9	5.5	3.3	5.5	5.4	0.6	-0.5	3.1	3.1	3.0	1.0	4.3	0.7	1.7	2.0	5.4	2.4
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	5.2	2.0	0.7	-1.6	1.3	-0.1	-0.1	1.6	2.1	0.6	0.5	0.6	1.8	0.3	2.3	2.0	1.5	-1.7	1.3
Blood clot in the leg (DVT)	1.2	1.6	2.9	0.7	1.3	0.5	1.4	1.6	1.2	-0.0	1.0	1.6	1.7	1.6	1.2	1.0	1.7	1.2	1.4	0.2	1.4
Smoking status: Previous	1.2	1.8	11.1	0.1	0.6	-0.1	0.8	-1.7	1.4	2.1	3.3	0.2	-0.2	0.6	1.1	0.4	2.1	1.2	1.2	-0.7	1.0
Unable to work because of sickness or disability	1.2	1.6	4.1	1.9	0.6	0.2	1.5	2.0	1.2	1.6	0.7	1.2	1.4	1.0	1.6	0.9	1.1	1.5	1.1	0.7	1.1
Myopia	1.2	1.7	4.4	0.9	-1.6	-1.2	-1.4	-0.9	-1.6	0.3	-0.7	-1.3	-1.1	-1.2	0.3	-2.0	-1.4	-1.8	-1.0	-2.1	-0.9
Alzheimer’s Disease (including proxy)	1.1	1.7	3.4	0.9	1.1	0.9	1.6	1.9	1.2	0.4	1.2	1.5	1.7	1.3	1.0	1.2	1.8	1.2	1.1	1.3	1.1
HbA1C	1.1	1.2	5.9	-1.9	0.5	-0.2	-1.3	0.1	0.0	-2.4	-1.6	-0.6	-0.5	-0.3	-1.6	-0.0	-0.9	-1.1	-1.0	0.2	-1.0
Hand grip strength (left)	1.1	2.8	6.9	0.0	2.4	2.6	1.9	1.4	1.4	1.7	0.8	1.8	1.7	1.6	1.0	1.3	2.0	1.8	1.5	2.1	1.5
Townsend deprivation index at recruitment	1.1	1.5	3.4	1.3	1.8	0.7	1.4	0.3	1.1	1.1	0.4	1.3	0.8	1.8	0.8	1.0	1.6	1.4	1.3	1.3	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.2	0.8	0.8	0.7	1.3	1.5	0.3	0.6	1.2	1.0	0.9	1.3	0.1	1.4	1.3	1.6	0.8	1.8	0.7
Alzheimer’s Disease (in mother)	1.0	1.2	2.8	0.7	0.8	0.4	1.2	1.3	0.6	0.1	1.3	1.3	1.2	1.3	0.8	1.4	1.7	1.1	1.1	1.1	1.1
Multivitamins +/- minerals	1.0	1.3	5.4	-1.4	-0.5	-1.6	-1.1	-1.9	-0.8	-0.6	0.6	-1.2	-1.3	-1.2	-0.6	-1.3	-0.1	-0.5	-0.6	-2.3	-0.7
Medication: Allopurinol	1.0	1.4	3.2	1.5	1.1	1.6	1.2	1.8	1.1	1.0	0.3	1.1	1.2	1.1	0.8	1.5	0.4	0.9	0.8	1.8	0.9
Ever taken oral contraceptive pill	1.0	1.2	5.5	0.1	1.1	0.0	1.0	0.0	-0.1	2.3	1.6	0.7	0.6	0.8	1.2	0.7	1.7	1.3	1.1	0.4	1.0
Medication: Lisinopril	1.0	1.2	6.6	0.5	1.0	0.7	1.0	1.6	2.6	0.5	0.2	1.2	1.4	0.8	0.8	1.1	0.9	0.9	0.7	1.1	0.8
Ever smoked	1.0	1.7	10.9	0.1	0.5	-1.0	0.6	-1.7	0.1	1.7	3.3	0.1	-0.4	0.6	1.2	-0.2	2.1	1.3	1.1	-1.5	0.9
High blood pressure	0.9	2.4	8.7	0.8	1.4	0.6	1.6	1.6	3.0	1.4	0.8	1.5	1.5	1.1	1.0	1.8	1.8	1.8	1.4	1.8	1.4
Allergy	0.9	2.1	5.4	-1.4	0.1	-0.3	-1.8	-2.3	-1.4	-0.9	-1.9	-1.3	-1.7	-0.4	-1.6	-1.7	-1.7	-1.6	-1.6	-0.4	-1.5
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.0	-1.5	-0.8	-0.6	-1.4	-0.6	-1.7	-0.4	-1.1	-1.0	-0.9	-0.9	-1.2	-0.5	-1.4	-0.8	-1.1	0.0	-1.1
Irritability	0.9	1.6	4.6	1.4	0.5	-1.3	1.1	1.1	0.3	1.7	1.7	0.9	1.0	0.8	1.6	1.0	1.7	2.1	1.1	-0.1	1.0
Supplements: Zinc	0.8	0.9	2.7	-1.7	-1.3	-1.4	-1.0	-1.3	-0.6	-0.1	-0.3	-1.0	-1.1	-1.1	-0.8	-0.4	-0.5	-0.3	-0.6	-0.8	-0.8
Relative age voice broke	0.8	1.3	5.8	0.6	-0.6	-2.4	0.0	-0.3	-1.6	0.3	2.0	0.3	0.4	0.0	1.2	-0.3	1.7	0.8	0.7	-1.8	0.6
Supplements: Glucosamine	0.8	1.0	2.8	-1.7	-0.1	-0.6	-1.0	-1.4	-0.8	-1.3	-0.8	-1.0	-1.0	-0.8	-1.2	-1.3	-0.6	-0.9	-0.8	-1.1	-0.8
Medication: Amlodipine	0.8	1.1	2.7	0.6	0.9	1.5	1.1	1.0	1.5	1.5	0.1	1.0	1.0	0.8	0.6	1.0	0.5	1.0	0.7	1.6	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.7	0.2	-0.4	-0.7	-1.0	-1.2	-1.2	-0.7	-0.5	-1.3	-1.3	-0.8	-1.1	-0.9	-1.1	-1.2	-1.1	-0.5	-1.1
Family relationship satisfaction	0.8	1.0	2.7	0.1	0.7	-0.2	1.1	0.6	-0.1	1.1	1.5	0.9	0.9	0.9	0.9	1.3	1.3	1.6	1.2	0.7	1.1
Supplements: Vitamin C	0.8	1.0	3.0	-1.7	-0.6	-0.7	-0.9	-1.4	-1.0	-0.5	0.0	-1.3	-1.3	-1.2	-1.1	-0.6	-0.7	-0.7	-0.8	-1.0	-0.9
Bipolar Disorder or Schizophrenia	0.7	1.8	9.8	0.7	-1.1	-3.1	-0.4	-1.7	-1.7	0.4	2.1	-0.9	-0.8	-1.0	0.5	-0.8	1.0	-0.3	-0.2	-2.3	-0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.7	0.1	1.1	0.8	0.7	1.3	1.1	-0.6	0.1	1.0	0.8	1.0	0.1	1.2	0.9	0.7	0.8	1.2	0.8
Loud music exposure frequency	0.7	0.8	3.3	0.8	-1.3	-1.8	-0.9	0.1	-0.6	-0.7	-0.9	-0.8	-0.7	-0.8	-0.5	-0.5	-0.7	-0.9	-0.8	-1.1	-0.7
Eye problems/disorders: Glaucoma	0.7	0.8	3.6	0.2	0.4	0.5	0.5	1.7	0.5	0.1	-0.9	1.2	1.3	1.2	0.2	0.8	-0.5	0.7	0.5	1.9	0.5
Mean Putamen Volume	0.6	0.7	3.8	-0.1	-1.1	-0.8	-0.8	-0.5	0.1	-0.6	-0.2	-0.9	-0.7	-0.9	-0.2	-1.0	-1.0	-1.1	-0.6	-1.9	-0.6
Hypothyroidism (self reported)	0.6	1.4	2.9	1.1	0.9	-0.2	1.0	1.1	1.1	1.7	1.1	1.2	1.2	1.1	1.6	1.3	1.3	1.5	1.3	0.9	1.3
Lung FEV1/FVC ratio	0.6	2.8	11.2	3.0	-0.6	-1.6	-1.5	0.4	-1.0	-3.3	-0.5	-0.7	-0.5	-0.2	-0.4	-1.8	-1.3	-3.2	-1.4	-2.2	-1.0
Severe depression (siblings)	0.6	0.6	4.3	0.1	-1.4	-2.1	-0.7	0.1	-1.2	-0.5	0.2	-0.3	-0.1	-0.9	0.2	-0.3	-0.2	-0.5	-0.2	-1.4	-0.1
Medication: Levothyroxine sodium	0.6	1.0	2.3	1.0	0.6	-0.6	0.8	0.2	1.4	1.1	1.5	0.8	0.8	0.6	1.3	1.2	1.3	1.2	1.1	0.2	1.0
Had menopause	0.6	0.8	2.6	-0.9	-1.4	-1.6	-1.2	-0.9	-1.2	-1.4	-0.5	-0.2	-0.0	-0.3	0.0	-0.8	-0.3	-0.9	-0.3	-1.1	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.5	-1.2	-0.3	-1.6	-0.3	-1.4	-1.2	0.9	1.4	-0.1	-0.2	-0.2	0.6	-0.3	1.1	0.7	0.5	-0.8	0.2
Depression (self-reported)	0.6	0.7	3.8	2.0	-0.1	-1.1	0.6	0.4	0.0	0.7	1.0	0.2	0.4	0.0	1.2	-0.6	0.8	0.4	0.5	-1.4	0.5
Glaucoma (self-reported)	0.6	0.7	3.5	-0.5	-0.7	-0.2	-0.9	0.4	0.0	-0.8	-1.9	-0.1	-0.1	0.1	-0.8	-0.6	-1.7	-0.7	-0.8	0.7	-0.8
Birth weight	0.6	1.4	2.7	-0.2	-1.1	-1.3	-1.0	-1.3	-1.6	-1.2	-0.2	-1.3	-1.3	-1.4	-1.1	-1.5	-0.3	-1.1	-1.2	-1.6	-1.2
Eye problems/disorders: None of the above	0.6	0.6	3.3	-0.2	-0.5	-0.1	-0.6	-1.8	-0.5	0.3	0.0	-1.1	-1.3	-1.0	-0.5	-1.1	-0.1	-0.7	-0.7	-0.7	-0.7
Hypertension (Self-reported)	0.6	1.7	7.1	0.6	1.0	0.3	1.4	1.4	2.7	1.2	0.5	1.2	1.2	0.9	0.8	1.6	1.4	1.6	1.1	1.5	1.1
Eye problems/disorders: Cataract	0.6	0.7	2.0	-0.2	-0.4	-1.3	-0.9	-0.6	-1.3	-0.9	-0.2	-0.8	-0.9	-0.8	-0.6	-0.5	-0.4	-0.8	-0.7	-1.4	-0.7
Mineral and other dietary supplements	0.6	0.8	3.2	1.8	0.2	1.1	1.1	1.6	1.1	0.3	0.4	0.8	1.0	0.5	0.8	1.1	0.1	0.5	0.5	1.0	0.6
Hearing aid user	0.6	0.7	1.7	0.9	0.6	0.6	0.6	0.7	1.0	0.4	0.6	1.0	0.9	1.3	0.8	0.9	0.6	0.5	0.8	1.0	0.9
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.6	-1.6	-0.0	-0.2	-1.0	-1.0	0.1	-0.3	-1.4	-0.8	-0.9	-0.7	-1.1	-1.0	-0.7	-0.8	-0.9	-0.2	-0.9
Tanning	0.5	6.4	10.4	1.1	2.9	3.2	2.6	1.9	3.0	3.0	1.4	2.7	2.5	2.7	2.4	2.5	2.0	2.3	2.6	3.0	2.6
Sensitivity / hurt feelings	0.5	0.9	5.6	2.4	-0.7	-1.1	0.4	1.3	-0.0	0.8	0.7	0.6	0.8	0.6	1.2	1.0	0.5	0.4	0.7	-0.3	0.7
Time employed in main current job	0.5	0.6	1.8	-0.1	-0.5	0.1	-0.9	-0.4	-0.1	-0.3	-1.3	-0.6	-0.5	-0.6	-0.4	-1.2	-1.4	-1.0	-1.0	-0.4	-0.9
Standing height	0.5	4.7	21.6	-2.9	-3.0	-2.1	-1.9	-0.1	-2.8	-4.7	-1.8	-1.2	-0.8	-2.0	-2.6	-0.6	-0.8	-2.0	-1.6	-1.8	-1.6
Hair/balding pattern: Pattern 4	0.5	1.2	4.9	-0.1	2.2	1.9	1.3	0.1	1.9	0.5	0.4	0.7	0.4	1.1	-0.3	0.5	1.1	0.7	0.6	1.6	0.6
Headache pain in last month	0.5	0.8	1.8	1.4	0.9	0.3	1.0	0.9	0.2	1.0	1.0	0.8	0.8	0.9	1.1	0.8	1.2	1.0	1.0	0.1	1.0
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.6	0.7	0.4	-0.5	0.7	0.5	1.0	1.2	0.8	0.9	0.9	0.9	1.3	1.2	1.1	1.2	1.1	0.5	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.5	-0.2	-1.4	-1.8	-0.5	-0.1	-1.6	-1.9	0.0	-0.6	-0.3	-1.3	-0.8	-0.6	0.2	-0.9	-0.8	-1.4	-0.8
Medication: Blood pressure	0.5	1.0	3.0	1.0	0.5	0.4	0.9	1.7	1.7	0.4	-0.3	1.1	1.1	0.7	0.4	1.2	0.6	0.9	0.7	1.4	0.8
Height	0.4	8.3	47.9	-2.7	-4.0	-2.7	-2.6	-0.1	-3.7	-6.9	-2.4	-1.4	-1.1	-2.2	-3.7	-0.9	-1.2	-2.8	-2.0	-2.4	-2.0
Waist Hip Ratio (WHR)	0.4	1.7	7.8	1.5	-0.6	0.5	-0.1	2.8	-1.1	-2.3	-1.9	0.5	0.6	0.6	-0.9	1.8	-1.1	-1.3	-0.2	1.2	0.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.3	-0.5	-1.4	-0.5	-0.5	0.2	0.3	-0.9	-0.7	-1.0	-0.7	-1.5	-0.8	-1.0	-1.2	-0.9	-0.9	-0.9	-1.0
Suffer from ‘nerves’	0.4	0.6	3.9	2.0	0.0	0.3	0.6	1.7	-0.2	0.8	-0.1	0.8	0.9	0.3	0.7	0.3	-0.1	0.7	0.3	0.4	0.4
Medication: Aspirin	0.4	0.5	2.6	0.0	0.2	0.7	0.4	1.0	0.6	0.7	-0.5	0.8	0.7	0.7	0.1	1.1	0.2	0.6	0.5	1.6	0.5
Illnesses of father: None of the above (group 1)	0.4	0.4	1.9	0.6	-0.1	-0.1	-0.4	-1.0	-1.4	-1.0	-0.3	-0.6	-0.7	-0.3	-0.5	-0.5	-0.3	-0.8	-0.6	-0.8	-0.6
High cholesterol (Self-reported)	0.4	0.7	3.1	0.3	0.6	1.8	0.2	0.5	1.5	0.1	-1.2	0.5	0.2	0.9	-0.2	0.5	-0.4	-0.0	0.1	1.6	0.2
Alcohol drinker status: Never	0.4	0.4	1.8	1.1	-0.2	0.4	-0.1	1.2	0.1	-0.8	-1.4	0.1	0.1	-0.1	-0.4	-0.1	-0.6	-0.9	-0.5	0.7	-0.3
Heart disease (siblings)	0.4	0.5	1.4	0.5	1.0	0.7	0.8	0.6	1.2	1.0	-0.3	0.8	0.7	0.6	0.4	0.2	0.1	0.9	0.5	0.8	0.5
Alzheimer’s Disease (in father)	0.3	0.3	1.1	0.0	0.4	0.6	0.7	0.7	1.1	0.4	0.5	0.5	0.7	0.1	0.5	0.4	0.4	0.3	0.3	0.6	0.4
Triglycerides	0.3	0.5	1.9	1.4	1.1	1.4	0.1	0.7	0.7	-0.2	-0.6	0.5	0.2	0.8	-0.1	0.4	-0.1	-0.5	0.0	0.9	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.4	-0.1	-0.1	-0.9	-0.2	-0.1	-1.2	-0.5	-0.8	-0.4	-0.3	-0.5	-0.3	-0.7	-0.0	0.3	-0.3	-1.1	-0.4
Nervous feelings	0.3	0.6	4.0	1.8	-0.3	-0.6	0.3	2.0	-0.4	0.2	0.5	0.5	0.8	0.1	0.7	1.1	-0.1	0.2	0.3	0.2	0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.8	-0.1	-0.5	-0.6	-0.3	-0.0	0.2	-1.3	-0.6	-0.7	-0.7	-0.7	-1.1	-0.6	-0.4	-0.6	-0.6	-0.7	-0.6
Emphysema/chronic bronchitis	0.3	0.4	1.1	0.5	-0.1	-0.5	0.4	0.4	1.1	0.5	1.1	0.4	0.4	-0.0	0.6	0.3	1.1	0.8	0.4	-0.5	0.4
Migraine (self-reported)	0.3	0.4	2.6	1.6	-0.1	-0.7	0.5	0.6	0.2	0.1	0.3	0.5	0.6	0.5	0.7	0.7	1.0	0.3	0.5	-0.2	0.6
Heart disease (mother)	0.3	0.3	0.6	0.0	-0.5	-0.3	-0.6	-0.6	-0.6	0.3	-0.5	-0.6	-0.7	-0.7	-0.6	-0.7	-0.6	-0.3	-0.7	-0.5	-0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.8	-0.2	-0.5	0.0	-0.5	-0.6	-0.4	-0.9	-0.4	-0.6	-0.7	-0.3	-0.8	-0.4	-0.8	-0.9	-0.7	-0.3	-0.7
Illnesses of father: Heart disease	0.3	0.4	2.2	-0.7	-0.0	-0.5	0.2	-0.1	-1.0	1.5	0.4	0.3	0.3	0.0	0.5	0.6	0.5	0.6	0.5	0.9	0.5
Osteoporosis (self-reported)	0.3	0.4	1.4	-0.5	-0.8	-1.2	-0.3	-0.9	-0.8	-0.3	0.4	-0.0	0.0	-0.0	0.3	-0.4	0.7	0.4	0.2	-1.1	0.0
Medication: Aspirin	0.3	0.3	1.7	0.3	-0.0	0.5	0.3	0.8	0.4	0.7	-0.5	0.5	0.5	0.5	-0.0	1.1	0.1	0.5	0.4	1.3	0.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.0	0.0	-0.5	0.3	-0.3	-0.0	0.4	-0.1	-0.8	-0.6	-0.3	-1.0	-0.3	-0.6	-0.9	-0.8	-0.6	-0.8	-0.6
Allergy or Eczema	0.2	0.6	1.8	-0.8	-0.9	-0.5	-0.6	-0.2	0.6	-0.5	-0.3	-0.8	-0.6	-1.3	-0.5	-1.1	-0.9	-0.7	-0.7	-0.9	-0.8
Hearing difficulty/problems: Yes	0.2	0.4	0.8	0.1	-0.0	0.8	0.5	0.8	0.7	0.7	0.3	0.8	0.9	0.6	0.7	0.4	-0.1	0.8	0.5	0.7	0.5
Sitting height	0.2	1.4	5.0	-2.2	0.4	2.2	0.7	1.6	0.9	-1.9	-1.0	1.0	1.4	0.5	-0.7	0.7	0.6	0.2	0.3	1.5	0.3
Number of incorrect matches in round	0.2	0.4	2.0	-0.4	0.2	0.4	-0.1	-0.6	-0.2	1.4	-0.2	-0.5	-0.5	-0.8	-0.3	-1.0	-0.3	0.5	-0.6	0.3	-0.7
Hearing difficulty/problems with background noise	0.2	0.3	2.4	-1.5	-0.8	-0.9	-0.5	-0.6	-0.6	-0.4	0.0	0.0	-0.0	0.2	-0.2	-0.3	0.0	0.5	0.1	-0.4	-0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.1	-0.4	0.9	1.0	0.2	0.4	0.3	-0.3	-0.8	0.2	0.3	0.2	-0.2	0.4	-0.3	0.0	0.0	0.7	0.0
LDL Cholesterol	0.1	0.2	1.1	0.2	0.7	1.0	0.1	-0.5	0.2	0.4	-0.2	0.1	-0.2	0.3	-0.5	-0.3	-0.0	-0.3	-0.1	0.6	-0.1
Rheumatoid Arthritis	0.1	0.1	0.7	-0.4	-0.2	-0.4	-0.4	-0.8	0.1	-0.3	-0.4	-0.2	-0.5	0.1	-0.3	-0.1	-0.5	-0.0	0.1	-0.4	0.0
Blood Platelet Count	0.1	1.3	5.4	0.2	-0.4	0.6	-0.0	-0.7	0.4	0.2	-0.1	1.9	1.2	2.3	0.9	1.1	1.6	0.8	1.7	1.0	1.7
Serious illness, injury or assault to yourself	0.1	0.1	0.8	-0.2	-0.5	-0.5	-0.0	0.3	-0.5	0.5	-0.9	-0.1	-0.0	-0.3	-0.1	-0.3	-0.0	0.2	-0.2	0.3	-0.2
High blood pressure (mother)	0.1	0.1	0.6	0.5	-0.6	-0.7	-0.3	0.3	0.0	0.3	-0.8	0.1	-0.0	-0.1	-0.0	0.3	-0.3	-0.3	-0.2	0.5	-0.0
Length of working week for main job	0.1	0.1	0.3	0.3	-0.3	0.1	0.1	-0.3	-0.5	0.4	-0.2	-0.2	-0.4	-0.3	-0.2	0.2	-0.1	-0.1	-0.3	0.5	-0.2
Illnesses of father: High blood pressure	0.1	0.1	0.7	-0.4	-0.0	-0.1	-0.1	0.8	0.8	-0.2	-0.3	-0.2	0.1	-0.3	-0.4	0.3	-0.2	-0.3	-0.3	0.4	-0.2
Ovarian Cancer	0.0	0.1	0.4	-0.6	0.0	0.1	-0.0	0.1	0.2	0.1	-0.3	-0.2	0.1	-0.3	0.0	-0.5	-0.3	0.3	-0.1	-0.1	-0.2
Hair Pigment	0.0	0.9	3.8	-0.4	-0.6	-1.4	0.8	0.1	-0.3	0.4	1.2	0.8	0.9	-0.2	1.1	0.8	1.9	1.0	1.1	-0.2	1.1

Hub : Genes

MST1R

Models

Trait associations