Hub : Traits :

Leg pain on walking

15 significantly associated models · 5 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49030828 50800146 5 2 9.3e-09 2.1e-07 0.67 99 IP6K1 RNF123

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 13.86 2 2 4.4 0 1 IP6K1 RNF123
Intelligence (Savage-Jansen 2018) 32.40 2 2 4.4 0 1 IP6K1 RNF123
Neuroticism (Nagel 2018) 3.85 2 0 0.0 0 1 IP6K1 RNF123
Crohns Disease (2017) 21.87 2 2 4.4 0 1 IP6K1 RNF123
Irritable Bowel Disease (IBD) 30.69 2 2 4.4 0 1 IP6K1 RNF123
Ulcerative Colitis (UC) 25.18 2 2 4.4 0 1 IP6K1 RNF123
Reaction Time 4.16 1 0 0.0 0 1 RNF123
Verbal and Numeric Reasoning (VNR) 24.67 2 2 4.4 0 1 IP6K1 RNF123
Breast Cancer 4.39 2 0 0.0 0 1 IP6K1 RNF123
Prostate Cancer 8.78 2 0 0.0 0 1 IP6K1 RNF123
Age at First Birth 41.38 2 2 4.4 0 1 IP6K1 RNF123
Body Mass Index (BMI) (2010) 4.47 1 0 0.0 0 1 RNF123
Coronary Artery Disease (CAD) 8.99 1 0 0.0 0 1 RNF123
Crohns Disease (2012) 22.53 2 1 2.2 0 1 IP6K1 RNF123
HDL Cholesterol 4.19 1 0 0.0 0 1 RNF123
Ulcerative Colitis 27.46 2 2 4.4 0 1 IP6K1 RNF123
Blood Eosinophil Count 0.95 1 0 0.0 0 1 RNF123
Blood Red Count 2.33 1 1 2.2 0 1 RNF123
Blood White Count 6.07 2 2 4.4 0 1 IP6K1 RNF123
Heel T-Score 5.53 1 1 2.2 0 1 RNF123
BMI 23.74 2 2 4.4 0 1 IP6K1 RNF123
Height 1.09 2 1 2.2 0 1 IP6K1 RNF123
Systolic Blood Pressure 3.80 1 1 2.2 0 1 RNF123
Smoking Status 4.32 1 0 0.0 0 1 IP6K1
Cardiovascular Disease 3.13 1 0 0.0 0 1 RNF123
Type 2 Diabetes (T2D) (2018) 10.06 1 1 2.2 0 1 RNF123
Lung FVC 3.41 2 0 0.0 0 1 IP6K1 RNF123
Neuroticism 6.32 2 0 0.0 0 1 IP6K1 RNF123
Chronotype (morning person) 4.68 1 0 0.0 0 1 IP6K1
Number of treatments/medications taken 15.80 2 1 2.2 0 1 IP6K1 RNF123
Ever had hysterectomy (womb removed) 6.89 1 0 0.0 0 1 IP6K1
Systolic blood pressure, automated reading 5.54 2 0 0.0 0 1 IP6K1 RNF123
Medication: Co-codamol 15.06 2 0 0.0 0 1 IP6K1 RNF123
Medication: Metformin 4.88 1 0 0.0 0 1 RNF123
Impedance of leg (right) 5.55 2 1 2.2 0 1 IP6K1 RNF123
Leg fat-free mass (left) 8.07 2 2 4.4 0 1 IP6K1 RNF123
Trunk fat percentage 13.53 2 1 2.2 0 1 IP6K1 RNF123
Maternal smoking around birth 9.27 1 0 0.0 0 1 RNF123
Fed-up feelings 17.46 2 2 4.4 0 1 IP6K1 RNF123
Frequency of unenthusiasm / disinterest in last 2 weeks 6.25 1 0 0.0 0 1 RNF123
Taking other prescription medications 18.86 2 1 2.2 0 1 IP6K1 RNF123
Age when periods started (menarche) 10.15 1 1 2.2 0 1 IP6K1
Bilateral oophorectomy (both ovaries removed) 7.03 1 0 0.0 0 1 RNF123
Heel bone mineral density (BMD) T-score, automated (left) 8.98 1 1 2.2 0 1 RNF123
Qualifications: CSEs or equivalent 13.82 2 0 0.0 0 1 IP6K1 RNF123
Body mass index (BMI) 28.79 2 2 4.4 0 1 IP6K1 RNF123
Impedance of leg (left) 5.84 2 2 4.4 0 1 IP6K1 RNF123
Leg predicted mass (left) 8.02 2 2 4.4 0 1 IP6K1 RNF123
Trunk fat mass 15.80 2 2 4.4 0 1 IP6K1 RNF123
Waist circumference 15.54 2 1 2.2 0 1 IP6K1 RNF123
Frequency of tenseness / restlessness in last 2 weeks 9.21 1 0 0.0 0 1 IP6K1
Forced vital capacity (FVC) 3.82 2 0 0.0 0 1 IP6K1 RNF123
Heel bone mineral density (BMD) T-score, automated (right) 7.61 1 1 2.2 0 1 RNF123
Ever unenthusiastic/disinterested for a whole week 5.81 1 0 0.0 0 1 IP6K1
Qualifications: None of the above 20.05 2 2 4.4 0 1 IP6K1 RNF123
Financial difficulties in last 2 years 5.08 1 0 0.0 0 1 RNF123
Heart attack 7.70 1 0 0.0 0 1 RNF123
Pain all over the body in last month 8.82 1 0 0.0 0 1 IP6K1
Diabetes (self-reported) 9.34 1 1 2.2 0 1 RNF123
Fluid intelligence score 20.78 2 1 2.2 0 1 IP6K1 RNF123
Neuroticism score 6.31 2 0 0.0 0 1 IP6K1 RNF123
Weight 16.65 2 2 4.4 0 1 IP6K1 RNF123
Impedance of arm (right) 15.94 2 2 4.4 0 1 IP6K1 RNF123
Arm fat percentage (right) 18.26 2 2 4.4 0 1 IP6K1 RNF123
Trunk fat-free mass 4.90 2 1 2.2 0 1 IP6K1 RNF123
Hip circumference 11.01 2 2 4.4 0 1 IP6K1 RNF123
Alcohol intake versus 10 years previously 20.86 2 1 2.2 0 1 IP6K1 RNF123
Father's age at death 9.87 2 0 0.0 0 1 IP6K1 RNF123
Frequency of tiredness / lethargy in last 2 weeks 7.85 1 0 0.0 0 1 IP6K1
Number of live births 8.28 1 0 0.0 0 1 RNF123
Forced expiratory volume in 1-second (FEV1) 4.51 2 0 0.0 0 1 IP6K1 RNF123
Noisy workplace 6.06 1 0 0.0 0 1 IP6K1
Qualifications: A levels/AS levels or equivalent 37.19 2 2 4.4 0 1 IP6K1 RNF123
Mouth/teeth dental problems: Dentures 10.98 2 0 0.0 0 1 IP6K1 RNF123
Medication: Cholesterol lowering 4.91 1 0 0.0 0 1 RNF123
Medication: Lansoprazole 6.95 1 0 0.0 0 1 IP6K1
Prospective memory result 5.22 1 0 0.0 0 1 RNF123
Forced expiratory volume in 1-second (FEV1), Best measure 5.93 2 0 0.0 0 1 IP6K1 RNF123
Impedance of arm (left) 16.71 2 2 4.4 0 1 IP6K1 RNF123
Arm fat mass (right) 22.22 2 2 4.4 0 1 IP6K1 RNF123
Trunk predicted mass 4.74 2 1 2.2 0 1 IP6K1 RNF123
Standing height 0.95 2 0 0.0 0 1 IP6K1 RNF123
Exposure to tobacco smoke at home 11.17 2 0 0.0 0 1 IP6K1 RNF123
Breastfed as a baby 6.44 1 0 0.0 0 1 RNF123
Seen doctor (GP) for nerves, anxiety, tension or depression 4.34 1 0 0.0 0 1 IP6K1
Ever highly irritable/argumentative for 2 days 15.93 2 0 0.0 0 1 IP6K1 RNF123
Qualifications: O levels/GCSEs or equivalent 8.61 1 0 0.0 0 1 RNF123
Medication: Paracetamol 6.41 1 0 0.0 0 1 IP6K1
Medication for cholesterol, blood pressure or diabetes 8.26 1 0 0.0 0 1 RNF123
Medication: Ventolin 100micrograms inhaler 5.32 1 0 0.0 0 1 RNF123
Chronic bronchitis/emphysema (mother) 10.72 2 0 0.0 0 1 IP6K1 RNF123
Forced vital capacity (FVC), Best measure 5.23 2 0 0.0 0 1 IP6K1 RNF123
Body fat percentage 17.96 2 2 4.4 0 1 IP6K1 RNF123
Leg fat percentage (right) 25.33 2 2 4.4 0 1 IP6K1 RNF123
Arm fat-free mass (right) 10.00 2 2 4.4 0 1 IP6K1 RNF123
Exposure to tobacco smoke outside home 11.41 2 0 0.0 0 1 IP6K1 RNF123
Number of full brothers 5.02 1 0 0.0 0 1 IP6K1
Worry too long after embarrassment 3.45 1 0 0.0 0 1 IP6K1
Wheeze or whistling in the chest in last year 15.54 2 1 2.2 0 1 IP6K1 RNF123
Number of children fathered 6.17 1 0 0.0 0 1 IP6K1
Age at first live birth 32.07 2 2 4.4 0 1 IP6K1 RNF123
Health satisfaction 6.30 1 0 0.0 0 1 RNF123
Shortness of breath walking on level ground 6.87 1 0 0.0 0 1 IP6K1
Qualifications: College or University degree 43.56 2 2 4.4 0 1 IP6K1 RNF123
Medication for pain relief, constipation, heartburn 4.33 1 0 0.0 0 1 IP6K1
Neck or shoulder pain in last month 7.06 1 0 0.0 0 1 IP6K1
Medication: Blood pressure 5.70 1 0 0.0 0 1 RNF123
Medication: Omeprazole 7.79 2 0 0.0 0 1 IP6K1 RNF123
Medication: Seretide 50 evohaler 6.87 1 0 0.0 0 1 RNF123
Mean time to correctly identify matches 4.75 1 0 0.0 0 1 RNF123
Whole body fat mass 20.97 2 2 4.4 0 1 IP6K1 RNF123
Leg fat mass (right) 26.18 2 2 4.4 0 1 IP6K1 RNF123
Arm predicted mass (right) 10.35 2 2 4.4 0 1 IP6K1 RNF123
Pulse rate, automated reading 7.91 1 1 2.2 0 1 RNF123
Alcohol intake frequency. 12.55 2 1 2.2 0 1 IP6K1 RNF123
Comparative height size at age 10 2.27 2 0 0.0 0 1 IP6K1 RNF123
Number of full sisters 6.87 1 0 0.0 0 1 RNF123
Overall health rating 22.80 2 2 4.4 0 1 IP6K1 RNF123
Chest pain or discomfort 4.57 1 0 0.0 0 1 IP6K1
Age at last live birth 32.72 2 2 4.4 0 1 IP6K1 RNF123
Qualifications: NVQ or HND or HNC or equivalent 9.30 1 0 0.0 0 1 RNF123
Knee pain experienced in last month 11.94 2 0 0.0 0 1 IP6K1 RNF123
Whole body fat-free mass 6.69 2 2 4.4 0 1 IP6K1 RNF123
Leg fat-free mass (right) 6.68 2 1 2.2 0 1 IP6K1 RNF123
Arm fat percentage (left) 18.29 2 2 4.4 0 1 IP6K1 RNF123
Mood swings 15.66 2 1 2.2 0 1 IP6K1 RNF123
Loneliness, isolation 9.18 2 0 0.0 0 1 IP6K1 RNF123
Ever had bowel cancer screening 8.79 1 0 0.0 0 1 RNF123
Diabetes diagnosed by doctor 7.74 1 0 0.0 0 1 RNF123
Qualifications: nursing, teaching 12.40 2 1 2.2 0 1 IP6K1 RNF123
Osteoarthritis (self-reported) 10.28 2 0 0.0 0 1 IP6K1 RNF123
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.73 1 0 0.0 0 1 IP6K1
Whole body water mass 6.90 2 2 4.4 0 1 IP6K1 RNF123
Leg predicted mass (right) 6.57 2 1 2.2 0 1 IP6K1 RNF123
Arm fat mass (left) 21.88 2 2 4.4 0 1 IP6K1 RNF123
Number of self-reported non-cancer illnesses 4.39 1 0 0.0 0 1 IP6K1
Average weekly champagne plus white wine intake 6.39 1 0 0.0 0 1 RNF123
Miserableness 18.34 2 2 4.4 0 1 IP6K1 RNF123
Guilty feelings 6.85 2 0 0.0 0 1 IP6K1 RNF123
Financial situation satisfaction 10.55 1 0 0.0 0 1 RNF123
Medication: Paracetamol 7.81 1 0 0.0 0 1 IP6K1
Basal metabolic rate 9.36 2 2 4.4 0 1 IP6K1 RNF123
Leg fat percentage (left) 25.53 2 2 4.4 0 1 IP6K1 RNF123
Arm fat-free mass (left) 11.53 2 2 4.4 0 1 IP6K1 RNF123
Number of operations (self-reported) 7.56 1 0 0.0 0 1 IP6K1
Average weekly beer plus cider intake 14.46 2 0 0.0 0 1 IP6K1 RNF123
Age started oral contraceptive pill 11.51 1 0 0.0 0 1 RNF123
Diastolic blood pressure, automated reading 11.77 2 1 2.2 0 1 IP6K1 RNF123
Ever depressed for a whole week 4.66 1 0 0.0 0 1 IP6K1
Vascular/heart problems diagnosed by doctor 2.35 1 0 0.0 0 1 RNF123
Pain experienced in last month 15.01 2 1 2.2 0 1 IP6K1 RNF123
Basal cell carcinoma (self-reported) 5.80 1 0 0.0 0 1 RNF123
Heart attack/myocardial infarction (self-reported) 6.53 1 0 0.0 0 1 RNF123
Impedance of whole body 12.44 2 2 4.4 0 1 IP6K1 RNF123
Leg fat mass (left) 26.77 2 2 4.4 0 1 IP6K1 RNF123
Arm predicted mass (left) 11.74 2 2 4.4 0 1 IP6K1 RNF123

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 1 0.085 1.3
GTEx Artery Tibial 3 0.080 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 1 0.050 1.3
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 1 0.051 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.4
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 1 0.048 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 1 0.030 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 1 0.065 1.4
GTEx Liver 0 0.000 1.4
GTEx Lung 1 0.035 1.3
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 1 0.071 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.3
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 1 0.157 1.3
GTEx Whole Blood 1 0.050 1.3
METSIM Adipose 1 0.022 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 1 0.019 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4