Hub : Traits :

Leg pain on walking

15 significantly associated models · 5 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	49030828	50800146	5	2	9.3e-09	2.1e-07	0.67	99	IP6K1 RNF123

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Qualifications: College or University degree	43.56	2	2	4.4	1	IP6K1 RNF123
Age at First Birth	41.38	2	2	4.4	1	IP6K1 RNF123
Qualifications: A levels/AS levels or equivalent	37.19	2	2	4.4	1	IP6K1 RNF123
Age at last live birth	32.72	2	2	4.4	1	IP6K1 RNF123
Intelligence (Savage-Jansen 2018)	32.40	2	2	4.4	1	IP6K1 RNF123
Age at first live birth	32.07	2	2	4.4	1	IP6K1 RNF123
Irritable Bowel Disease (IBD)	30.69	2	2	4.4	1	IP6K1 RNF123
Body mass index (BMI)	28.79	2	2	4.4	1	IP6K1 RNF123
Ulcerative Colitis	27.46	2	2	4.4	1	IP6K1 RNF123
Leg fat mass (left)	26.77	2	2	4.4	1	IP6K1 RNF123
Leg fat mass (right)	26.18	2	2	4.4	1	IP6K1 RNF123
Leg fat percentage (left)	25.53	2	2	4.4	1	IP6K1 RNF123
Leg fat percentage (right)	25.33	2	2	4.4	1	IP6K1 RNF123
Ulcerative Colitis (UC)	25.18	2	2	4.4	1	IP6K1 RNF123
Verbal and Numeric Reasoning (VNR)	24.67	2	2	4.4	1	IP6K1 RNF123
BMI	23.74	2	2	4.4	1	IP6K1 RNF123
Overall health rating	22.80	2	2	4.4	1	IP6K1 RNF123
Crohns Disease (2012)	22.53	2	1	2.2	1	IP6K1 RNF123
Arm fat mass (right)	22.22	2	2	4.4	1	IP6K1 RNF123
Arm fat mass (left)	21.88	2	2	4.4	1	IP6K1 RNF123
Crohns Disease (2017)	21.87	2	2	4.4	1	IP6K1 RNF123
Whole body fat mass	20.97	2	2	4.4	1	IP6K1 RNF123
Alcohol intake versus 10 years previously	20.86	2	1	2.2	1	IP6K1 RNF123
Fluid intelligence score	20.78	2	1	2.2	1	IP6K1 RNF123
Qualifications: None of the above	20.05	2	2	4.4	1	IP6K1 RNF123
Taking other prescription medications	18.86	2	1	2.2	1	IP6K1 RNF123
Miserableness	18.34	2	2	4.4	1	IP6K1 RNF123
Arm fat percentage (left)	18.29	2	2	4.4	1	IP6K1 RNF123
Arm fat percentage (right)	18.26	2	2	4.4	1	IP6K1 RNF123
Body fat percentage	17.96	2	2	4.4	1	IP6K1 RNF123
Fed-up feelings	17.46	2	2	4.4	1	IP6K1 RNF123
Impedance of arm (left)	16.71	2	2	4.4	1	IP6K1 RNF123
Weight	16.65	2	2	4.4	1	IP6K1 RNF123
Impedance of arm (right)	15.94	2	2	4.4	1	IP6K1 RNF123
Ever highly irritable/argumentative for 2 days	15.93	2	0	0.0	1	IP6K1 RNF123
Number of treatments/medications taken	15.80	2	1	2.2	1	IP6K1 RNF123
Trunk fat mass	15.80	2	2	4.4	1	IP6K1 RNF123
Mood swings	15.66	2	1	2.2	1	IP6K1 RNF123
Waist circumference	15.54	2	1	2.2	1	IP6K1 RNF123
Wheeze or whistling in the chest in last year	15.54	2	1	2.2	1	IP6K1 RNF123
Medication: Co-codamol	15.06	2	0	0.0	1	IP6K1 RNF123
Pain experienced in last month	15.01	2	1	2.2	1	IP6K1 RNF123
Average weekly beer plus cider intake	14.46	2	0	0.0	1	IP6K1 RNF123
Depressed Affect (Nagel 2018)	13.86	2	2	4.4	1	IP6K1 RNF123
Qualifications: CSEs or equivalent	13.82	2	0	0.0	1	IP6K1 RNF123
Trunk fat percentage	13.53	2	1	2.2	1	IP6K1 RNF123
Alcohol intake frequency.	12.55	2	1	2.2	1	IP6K1 RNF123
Impedance of whole body	12.44	2	2	4.4	1	IP6K1 RNF123
Qualifications: nursing, teaching	12.40	2	1	2.2	1	IP6K1 RNF123
Knee pain experienced in last month	11.94	2	0	0.0	1	IP6K1 RNF123
Diastolic blood pressure, automated reading	11.77	2	1	2.2	1	IP6K1 RNF123
Arm predicted mass (left)	11.74	2	2	4.4	1	IP6K1 RNF123
Arm fat-free mass (left)	11.53	2	2	4.4	1	IP6K1 RNF123
Age started oral contraceptive pill	11.51	1	0	0.0	1	RNF123
Exposure to tobacco smoke outside home	11.41	2	0	0.0	1	IP6K1 RNF123
Exposure to tobacco smoke at home	11.17	2	0	0.0	1	IP6K1 RNF123
Hip circumference	11.01	2	2	4.4	1	IP6K1 RNF123
Mouth/teeth dental problems: Dentures	10.98	2	0	0.0	1	IP6K1 RNF123
Chronic bronchitis/emphysema (mother)	10.72	2	0	0.0	1	IP6K1 RNF123
Financial situation satisfaction	10.55	1	0	0.0	1	RNF123
Arm predicted mass (right)	10.35	2	2	4.4	1	IP6K1 RNF123
Osteoarthritis (self-reported)	10.28	2	0	0.0	1	IP6K1 RNF123
Age when periods started (menarche)	10.15	1	1	2.2	1	IP6K1
Type 2 Diabetes (T2D) (2018)	10.06	1	1	2.2	1	RNF123
Arm fat-free mass (right)	10.00	2	2	4.4	1	IP6K1 RNF123
Father's age at death	9.87	2	0	0.0	1	IP6K1 RNF123
Basal metabolic rate	9.36	2	2	4.4	1	IP6K1 RNF123
Diabetes (self-reported)	9.34	1	1	2.2	1	RNF123
Qualifications: NVQ or HND or HNC or equivalent	9.30	1	0	0.0	1	RNF123
Maternal smoking around birth	9.27	1	0	0.0	1	RNF123
Frequency of tenseness / restlessness in last 2 weeks	9.21	1	0	0.0	1	IP6K1
Loneliness, isolation	9.18	2	0	0.0	1	IP6K1 RNF123
Coronary Artery Disease (CAD)	8.99	1	0	0.0	1	RNF123
Heel bone mineral density (BMD) T-score, automated (left)	8.98	1	1	2.2	1	RNF123
Pain all over the body in last month	8.82	1	0	0.0	1	IP6K1
Ever had bowel cancer screening	8.79	1	0	0.0	1	RNF123
Prostate Cancer	8.78	2	0	0.0	1	IP6K1 RNF123
Qualifications: O levels/GCSEs or equivalent	8.61	1	0	0.0	1	RNF123
Number of live births	8.28	1	0	0.0	1	RNF123
Medication for cholesterol, blood pressure or diabetes	8.26	1	0	0.0	1	RNF123
Leg fat-free mass (left)	8.07	2	2	4.4	1	IP6K1 RNF123
Leg predicted mass (left)	8.02	2	2	4.4	1	IP6K1 RNF123
Pulse rate, automated reading	7.91	1	1	2.2	1	RNF123
Frequency of tiredness / lethargy in last 2 weeks	7.85	1	0	0.0	1	IP6K1
Medication: Paracetamol	7.81	1	0	0.0	1	IP6K1
Medication: Omeprazole	7.79	2	0	0.0	1	IP6K1 RNF123
Diabetes diagnosed by doctor	7.74	1	0	0.0	1	RNF123
Heart attack	7.70	1	0	0.0	1	RNF123
Heel bone mineral density (BMD) T-score, automated (right)	7.61	1	1	2.2	1	RNF123
Number of operations (self-reported)	7.56	1	0	0.0	1	IP6K1
Neck or shoulder pain in last month	7.06	1	0	0.0	1	IP6K1
Bilateral oophorectomy (both ovaries removed)	7.03	1	0	0.0	1	RNF123
Medication: Lansoprazole	6.95	1	0	0.0	1	IP6K1
Whole body water mass	6.90	2	2	4.4	1	IP6K1 RNF123
Ever had hysterectomy (womb removed)	6.89	1	0	0.0	1	IP6K1
Shortness of breath walking on level ground	6.87	1	0	0.0	1	IP6K1
Medication: Seretide 50 evohaler	6.87	1	0	0.0	1	RNF123
Number of full sisters	6.87	1	0	0.0	1	RNF123
Guilty feelings	6.85	2	0	0.0	1	IP6K1 RNF123
Whole body fat-free mass	6.69	2	2	4.4	1	IP6K1 RNF123
Leg fat-free mass (right)	6.68	2	1	2.2	1	IP6K1 RNF123
Leg predicted mass (right)	6.57	2	1	2.2	1	IP6K1 RNF123
Heart attack/myocardial infarction (self-reported)	6.53	1	0	0.0	1	RNF123
Breastfed as a baby	6.44	1	0	0.0	1	RNF123
Medication: Paracetamol	6.41	1	0	0.0	1	IP6K1
Average weekly champagne plus white wine intake	6.39	1	0	0.0	1	RNF123
Neuroticism	6.32	2	0	0.0	1	IP6K1 RNF123
Neuroticism score	6.31	2	0	0.0	1	IP6K1 RNF123
Health satisfaction	6.30	1	0	0.0	1	RNF123
Frequency of unenthusiasm / disinterest in last 2 weeks	6.25	1	0	0.0	1	RNF123
Number of children fathered	6.17	1	0	0.0	1	IP6K1
Blood White Count	6.07	2	2	4.4	1	IP6K1 RNF123
Noisy workplace	6.06	1	0	0.0	1	IP6K1
Forced expiratory volume in 1-second (FEV1), Best measure	5.93	2	0	0.0	1	IP6K1 RNF123
Impedance of leg (left)	5.84	2	2	4.4	1	IP6K1 RNF123
Ever unenthusiastic/disinterested for a whole week	5.81	1	0	0.0	1	IP6K1
Basal cell carcinoma (self-reported)	5.80	1	0	0.0	1	RNF123
Medication: Blood pressure	5.70	1	0	0.0	1	RNF123
Impedance of leg (right)	5.55	2	1	2.2	1	IP6K1 RNF123
Systolic blood pressure, automated reading	5.54	2	0	0.0	1	IP6K1 RNF123
Heel T-Score	5.53	1	1	2.2	1	RNF123
Medication: Ventolin 100micrograms inhaler	5.32	1	0	0.0	1	RNF123
Forced vital capacity (FVC), Best measure	5.23	2	0	0.0	1	IP6K1 RNF123
Prospective memory result	5.22	1	0	0.0	1	RNF123
Financial difficulties in last 2 years	5.08	1	0	0.0	1	RNF123
Number of full brothers	5.02	1	0	0.0	1	IP6K1
Medication: Cholesterol lowering	4.91	1	0	0.0	1	RNF123
Trunk fat-free mass	4.90	2	1	2.2	1	IP6K1 RNF123
Medication: Metformin	4.88	1	0	0.0	1	RNF123
Mean time to correctly identify matches	4.75	1	0	0.0	1	RNF123
Trunk predicted mass	4.74	2	1	2.2	1	IP6K1 RNF123
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.73	1	0	0.0	1	IP6K1
Chronotype (morning person)	4.68	1	0	0.0	1	IP6K1
Ever depressed for a whole week	4.66	1	0	0.0	1	IP6K1
Chest pain or discomfort	4.57	1	0	0.0	1	IP6K1
Forced expiratory volume in 1-second (FEV1)	4.51	2	0	0.0	1	IP6K1 RNF123
Body Mass Index (BMI) (2010)	4.47	1	0	0.0	1	RNF123
Breast Cancer	4.39	2	0	0.0	1	IP6K1 RNF123
Number of self-reported non-cancer illnesses	4.39	1	0	0.0	1	IP6K1
Seen doctor (GP) for nerves, anxiety, tension or depression	4.34	1	0	0.0	1	IP6K1
Medication for pain relief, constipation, heartburn	4.33	1	0	0.0	1	IP6K1
Smoking Status	4.32	1	0	0.0	1	IP6K1
HDL Cholesterol	4.19	1	0	0.0	1	RNF123
Reaction Time	4.16	1	0	0.0	1	RNF123
Neuroticism (Nagel 2018)	3.85	2	0	0.0	1	IP6K1 RNF123
Forced vital capacity (FVC)	3.82	2	0	0.0	1	IP6K1 RNF123
Systolic Blood Pressure	3.80	1	1	2.2	1	RNF123
Worry too long after embarrassment	3.45	1	0	0.0	1	IP6K1
Lung FVC	3.41	2	0	0.0	1	IP6K1 RNF123
Cardiovascular Disease	3.13	1	0	0.0	1	RNF123
Vascular/heart problems diagnosed by doctor	2.35	1	0	0.0	1	RNF123
Blood Red Count	2.33	1	1	2.2	1	RNF123
Comparative height size at age 10	2.27	2	0	0.0	1	IP6K1 RNF123
Height	1.09	2	1	2.2	1	IP6K1 RNF123
Blood Eosinophil Count	0.95	1	0	0.0	1	RNF123
Standing height	0.95	2	0	0.0	1	IP6K1 RNF123

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.4
GTEx	Heart Left Ventricle	1	0.065	1.4
GTEx	Liver	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Coronary	1	0.085	1.3
GTEx	Artery Tibial	3	0.080	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	1	0.050	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	1	0.051	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	1	0.048	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	1	0.030	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Lung	1	0.035	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Spleen	1	0.071	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Vagina	1	0.157	1.3
GTEx	Whole Blood	1	0.050	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
METSIM	Adipose	1	0.022	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.1