Best TWAS P=2.37e-10 · Best GWAS P=1.12e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CPSF4 | 0.06 | 0.06 | blup | 313 | 0.07 | 6.6e-09 | -6.4 | -6.0 | 2.3e-09 | 0.90 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CPSF4 | 0.08 | 0.03 | lasso | 4 | 0.03 | 1.8e-03 | -5.3 | -5.4 | 6.5e-08 | 0.77 | 0.22 | 0.46 | FALSE |
| 3 | GTEx | Esophagus Mucosa | GS1-259H13.2 | 0.07 | 0.07 | lasso | 3 | 0.05 | 1.7e-04 | -5.2 | 5.3 | 1.0e-07 | -0.78 | 0.28 | 0.60 | FALSE |
| 4 | GTEx | Lung | ZKSCAN5 | 0.09 | 0.05 | lasso | 2 | 0.03 | 2.7e-03 | -5.3 | 5.2 | 1.5e-07 | -0.75 | 0.33 | 0.26 | FALSE |
| 5 | METSIM | Adipose | ARPC1A | 0.02 | 0.02 | blup | 308 | 0.02 | 1.6e-03 | -4.2 | -5.4 | 6.9e-08 | 0.85 | 0.06 | 0.89 | FALSE |
| 6 | METSIM | Adipose | GS1-259H13.2 | 0.04 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | -5.2 | 5.2 | 1.9e-07 | -0.74 | 0.21 | 0.76 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | GS1-259H13.2 | 0.07 | 0.05 | bslmm | 305 | 0.06 | 6.9e-08 | -5.6 | 5.5 | 4.7e-08 | -0.81 | 0.27 | 0.73 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZKSCAN5 | 0.03 | 0.04 | lasso | 2 | 0.03 | 1.0e-04 | -6.3 | -6.3 | 2.4e-10 | 0.98 | 0.01 | 0.99 | TRUE |