TWAS hub - ARPC1A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.1110	0.0420	0.00012	0.034	NA	0.055	NA	0.055	0.0013	NA	4.8e-05	NA	4.6e-05
2	METSIM	Adipose	0.0247	0.0127	0.00210	0.017	0.016	0.010	0.015	0.012	0.0012	0.0016	1.0e-02	0.002	6.0e-03
3	ROSMAP	Brain Pre-frontal Cortex	0.0206	0.0123	0.01500	0.005	0.003	0.002	0.004	0.001	0.0710	0.1100	1.7e-01	0.092	2.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Ever smoked	12.3	21.5	27.8	-4.7	-5.3	3.8
Supplements: Fish oil (including cod liver oil)	11.0	14.4	20.5	2.4	4.1	-4.5
Past tobacco smoking	9.5	17.5	23.1	3.9	4.8	-3.7
Smoking Status	9.4	22.5	28.5	-4.6	-5.3	4.2
Pulse rate, automated reading	9.4	30.4	44.9	-3.9	-6.7	5.6
Mineral and other dietary supplements	9.2	12.4	20.3	-2.0	-3.6	4.5
Alcohol drinker status: Never	7.8	9.3	15.4	2.7	3.9	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	7.0	9.1	17.8	-4.2	-3.0	0.7
BMI	6.9	40.0	50.8	-6.3	-7.1	5.4
Handedness (chirality/laterality): Left-handed	6.8	8.1	10.6	-2.9	-3.3	2.3
Pack years of smoking	6.7	9.9	12.7	-3.2	-3.6	2.6
Supplements: Calcium	6.6	7.3	7.9	2.8	2.8	-2.5
Father’s age at death	6.5	8.7	11.4	3.2	3.4	-2.2
Hayfever/allergic rhinitis (self-reported)	6.3	8.3	17.8	0.3	2.7	-4.2
Body mass index (BMI)	6.1	25.8	36.0	-4.8	-6.0	4.3
Supplements: Glucosamine	6.0	7.8	10.0	2.3	2.8	-3.2
Waist circumference	6.0	22.1	29.1	-4.0	-5.4	4.6
Leg fat percentage (left)	5.9	21.3	33.5	-4.4	-5.8	3.3
Pack years adult smoking proportion	5.8	8.8	12.2	-2.9	-3.5	2.4
Leg fat mass (left)	5.7	22.3	31.1	-4.6	-5.6	3.8
Pulse rate	5.6	9.5	13.4	-3.1	-3.7	2.4
Leg fat percentage (right)	5.4	19.7	31.9	-4.1	-5.6	3.3
Leg fat mass (right)	5.4	20.9	29.7	-4.4	-5.4	3.7
Maternal smoking around birth	5.3	7.6	15.2	-3.9	-2.7	0.5
Smoking status: Previous	5.2	7.7	8.9	-2.8	-3.0	2.5
Arm fat mass (right)	5.1	20.9	28.5	-4.6	-5.3	3.6
Mother’s age at death	5.0	6.3	9.7	2.4	3.1	-1.8
Ever had prostate specific antigen (PSA) test	5.0	5.7	7.0	1.9	2.6	-2.6
Arm fat mass (left)	4.9	20.0	27.3	-4.4	-5.2	3.7
Type 2 Diabetes (T2D) (2018)	4.8	9.1	13.5	-3.2	-3.7	1.9
Age at First Birth	4.7	6.9	8.2	2.4	2.9	-2.6
Arm fat percentage (left)	4.7	18.6	25.6	-4.4	-5.1	3.3
Arm fat percentage (right)	4.6	18.1	24.2	-4.4	-4.9	3.3
Whole body fat mass	4.5	18.7	26.0	-4.4	-5.1	3.3
Alcohol intake versus 10 years previously	4.4	6.6	10.5	-3.2	-2.7	1.5
Heart disease (siblings)	4.4	5.5	6.9	-1.9	-2.5	2.6
Medication: Aspirin	4.3	5.6	7.0	-1.9	-2.6	2.5
Diabetes (self-reported)	4.2	6.4	9.5	-2.9	-3.1	1.3
Average weekly beer plus cider intake	4.1	6.0	12.3	-1.9	-3.5	1.4
Body fat percentage	4.0	15.8	23.0	-4.1	-4.8	2.8
Chronotype (morning person)	3.9	9.1	10.8	2.8	3.3	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	3.8	5.1	9.3	-1.5	-1.9	3.0
Age at first live birth	3.8	6.7	13.6	3.7	2.5	-0.4
Shortness of breath walking on level ground	3.8	4.5	8.2	-2.9	-2.0	-1.1
Blood White Count	3.7	27.4	50.3	-7.1	-5.6	1.0
Had other major operations	3.7	4.5	7.5	-2.2	-2.7	0.9
Medication: Simvastatin	3.7	5.5	7.3	-2.0	-2.7	2.3
Allergy or Eczema	3.6	9.5	19.7	0.9	2.8	-4.4
Average weekly spirits intake	3.6	4.4	6.6	-2.6	-2.1	1.4
Mean time to correctly identify matches	3.6	6.9	10.4	-2.0	-2.5	3.2
Fractured/broken bones in last 5 years	3.6	4.7	8.8	1.7	3.0	-1.5
Depression (Nagel 2018)	3.5	5.2	9.0	-1.7	-1.9	3.0
Relative age voice broke	3.5	5.3	7.5	2.7	2.7	-1.1
Hayfever, allergic rhinitis or eczema	3.5	7.5	16.4	0.9	2.3	-4.0
Medication: Aspirin	3.5	4.6	6.7	-1.3	-2.3	2.6
Commuting to job workplace: Walk	3.4	3.6	5.6	2.3	2.4	0.4
Schizophrenia vs Biploar Disorder	3.3	4.3	6.1	1.5	2.5	-2.1
Vitamin and mineral supplements	3.3	4.4	6.7	0.1	-2.6	2.6
Wheeze or whistling in the chest in last year	3.3	5.8	8.7	-3.0	-2.5	1.5
Current tobacco smoking	3.2	5.3	7.8	-2.2	-2.8	1.8
Prospective memory result	3.2	4.0	5.9	-2.4	-0.6	-2.4
Bipolar Disorder (2018)	3.1	4.9	7.2	-1.9	-1.9	2.7
Number of full sisters	3.1	3.8	5.0	-1.6	-2.2	2.0
Overall health rating	3.1	6.6	8.4	-2.9	-2.7	2.0
Rheumatoid Arthritis	3.0	4.1	5.8	1.3	2.4	-2.2
Reaction Time	2.9	5.6	8.6	-1.6	-2.3	2.9
HbA1C	2.9	3.2	6.4	0.6	2.5	-1.7
Trunk fat percentage	2.9	11.6	16.7	-3.6	-4.1	2.3
Trunk fat mass	2.9	12.6	17.1	-3.7	-4.1	2.6
Chest pain or discomfort	2.9	4.2	5.1	-1.8	-2.2	2.1
Diastolic blood pressure, automated reading	2.9	8.9	18.0	-2.6	-4.2	1.4
Medication: Metformin	2.8	4.0	5.0	-2.1	-2.2	1.6
Medication: Blood pressure	2.8	4.9	6.5	-1.9	-2.2	2.5
Diabetes diagnosed by doctor	2.8	4.6	7.3	-1.9	-2.7	1.7
Medication for cholesterol, blood pressure or diabetes	2.7	4.5	5.3	1.9	2.1	-2.3
Pulse wave peak to peak time	2.7	3.2	6.0	1.8	2.4	-0.7
Vascular/heart problems diagnosed by doctor	2.7	7.4	10.4	2.5	3.2	-2.4
Chronic bronchitis/emphysema (mother)	2.6	3.0	8.0	-2.8	-1.0	0.0
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.1	4.8	-2.0	-2.2	0.8
Leg pain on walking	2.6	3.2	5.4	-2.3	-1.9	0.8
Smoking status: Current	2.6	4.2	6.9	-1.9	-2.6	1.4
Multivitamins +/- minerals	2.5	3.2	6.2	-0.1	1.8	-2.5
Illnesses of siblings	2.5	3.5	5.7	0.5	2.4	-2.1
Hip circumference	2.5	10.9	13.4	-3.3	-3.7	2.9
Cardiovascular Disease	2.4	7.8	10.8	-2.0	-3.3	3.0
Hand grip strength (left)	2.4	6.4	8.9	3.0	3.0	-1.2
Weight	2.4	11.6	15.5	-3.5	-3.9	2.7
Myopia	2.4	3.5	5.6	1.4	1.7	-2.4
Happiness	2.3	2.7	6.1	-2.5	-1.4	0.1
Loud music exposure frequency	2.3	2.5	3.5	-1.9	-1.7	1.0
Medication for pain relief, constipation, heartburn	2.3	3.9	5.6	1.5	2.4	-1.9
Type 2 Diabetes (T2D) (2012)	2.2	2.6	7.5	0.2	0.4	-2.7
Townsend deprivation index at recruitment	2.2	3.2	4.0	-1.9	-1.3	2.0
High blood pressure	2.2	6.1	8.9	-2.2	-3.0	2.1
Pulse wave Arterial Stiffness index	2.2	2.6	4.8	-1.6	-2.2	0.5
Exposure to tobacco smoke outside home	2.2	2.9	6.8	-1.1	-0.8	2.6
Heart disease (mother)	2.2	2.6	4.0	-0.9	-1.8	2.0
Crohns Disease (2017)	2.1	4.5	7.3	2.7	1.2	2.2
Irritable Bowel Disease (IBD)	2.1	5.1	10.4	3.2	1.4	1.7
Impedance of arm (left)	2.1	9.6	14.0	2.2	3.1	-3.7
Mouth/teeth dental problems: Loose teeth	2.1	2.5	3.5	-1.5	-1.3	1.9
Hypertension (Self-reported)	2.1	5.9	7.9	-2.3	-2.8	2.1
Hearing difficulty/problems with background noise	2.0	3.3	4.6	-1.7	-2.2	1.5
Birth weight of first child	2.0	3.6	10.2	3.2	0.7	0.0
Age at last live birth	2.0	2.9	6.5	2.6	1.4	0.4
Medication: Lisinopril	2.0	2.5	3.3	-1.8	-1.8	1.0
Impedance of whole body	2.0	10.3	14.9	2.6	3.0	-3.9
Financial difficulties in last 2 years	1.9	2.6	3.5	-1.9	-1.3	1.6
Fluid intelligence score	1.9	4.0	6.4	2.5	0.7	2.2
Medication: Amlodipine	1.9	2.7	4.8	-1.6	-2.2	0.9
Hearing aid user	1.9	2.1	4.7	0.4	1.2	-2.2
Commuting to job workplace: Public transport	1.9	2.2	6.4	-2.5	-0.3	-0.5
Worry (Nagel 2018)	1.8	3.9	4.6	1.8	2.0	-2.1
Blood Platelet Count	1.8	20.7	42.4	-1.0	-4.3	6.5
Medication: Cholesterol lowering	1.8	2.8	4.1	-1.6	-2.0	1.3
Health satisfaction	1.8	2.3	4.3	-2.1	-1.6	-0.1
Emphysema/chronic bronchitis	1.8	2.1	2.7	-1.5	-1.1	1.7
Bipolar Disorder (2011)	1.7	1.6	2.7	-0.5	-1.6	1.4
Stomach or abdominal pain in last month	1.7	2.1	5.8	-2.4	-0.6	-0.1
Sitting height	1.7	11.8	19.2	3.0	4.4	-2.7
Nervous feelings	1.7	3.2	4.6	1.3	1.9	-2.1
Allergy	1.7	3.8	6.2	-0.4	-2.2	2.5
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	4.3	-0.9	-1.3	2.1
Gout (self-reported)	1.7	2.3	3.6	-1.1	-1.5	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.5	2.1	1.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	5.2	2.2	0.7	2.3
Medication: Paracetamol	1.7	2.6	2.9	-1.7	-1.4	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.8	7.9	-1.5	-2.8	1.0
Impedance of arm (right)	1.6	7.5	11.8	1.9	2.7	-3.4
Alcohol intake frequency.	1.6	3.7	6.6	1.8	2.6	-1.2
Family relationship satisfaction	1.6	1.9	2.4	-1.6	-1.3	1.3
Medication: Blood pressure	1.6	3.1	5.9	-1.4	-2.4	1.2
Blood Red Count	1.5	14.4	26.7	-2.8	-5.2	-2.9
Waist Hip Ratio (WHR)	1.5	6.7	9.5	-1.7	-2.7	3.1
Diabetes (mother)	1.5	1.9	3.8	-1.3	-2.0	0.0
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.6	0.6	1.1	-1.9
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.5	-1.9	-1.4	-0.0
Medication: Atorvastatin	1.5	1.9	4.9	-0.5	0.7	-2.2
Bipolar Disorder or Schizophrenia	1.4	3.4	5.2	-1.5	-1.6	2.3
Impedance of leg (right)	1.4	6.6	8.9	2.6	2.0	-3.0
Hand grip strength (right)	1.4	3.8	4.6	2.0	2.1	-1.7
Number of live births	1.4	1.9	4.6	-1.0	-2.1	0.4
Depression (self-reported)	1.4	1.6	2.8	-1.4	0.4	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	3.8	-1.9	-1.4	0.7
Suffer from ‘nerves’	1.4	2.2	2.5	1.6	1.2	-1.6
Ulcerative Colitis (UC)	1.3	2.4	6.4	2.5	1.0	0.1
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.7	-1.7	-1.0	1.3
Medication: Co-codamol	1.3	1.5	2.1	-1.5	-1.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.1	6.9	-1.0	-2.6	1.1
Medication: Levothyroxine sodium	1.3	2.2	4.3	2.1	1.1	-1.1
Impedance of leg (left)	1.3	6.2	8.2	2.5	2.0	-2.9
Guilty feelings	1.3	1.9	3.3	-1.6	-1.8	-0.1
Age started oral contraceptive pill	1.3	1.6	4.3	0.4	0.6	-2.1
Ulcerative Colitis	1.2	1.8	3.3	1.8	1.0	-1.0
Diabetes (father)	1.2	1.5	1.7	1.3	1.3	-1.0
Medication: Atenolol	1.2	1.5	3.9	-0.2	-0.7	2.0
Medication: Ramipril	1.2	1.6	3.1	1.1	0.7	1.8
Medication: Paracetamol	1.2	1.9	2.9	-1.7	-1.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.7	1.9	0.7	-0.3
Pain type(s) experienced in last month: Hip pain	1.2	1.6	3.7	-0.4	-1.9	0.9
Medication: Bendroflumethiazide	1.2	1.8	2.6	-0.3	-1.6	1.6
Peak expiratory flow (PEF)	1.1	2.6	3.2	1.7	1.8	-1.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	2.5	-1.6	-1.6	-0.7
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	3.1	1.8	1.2	-1.4
Medication: Ibuprofen	1.1	1.4	2.4	-1.0	-0.9	1.6
Had major operations	1.1	1.3	2.7	0.6	0.9	-1.6
Eye problems/disorders: Cataract	1.1	1.3	2.9	0.6	-0.7	1.7
Ovarian Cancer	1.0	1.3	2.1	-0.9	-1.5	1.0
HDL Cholesterol	1.0	1.7	2.8	0.9	1.7	-1.2
Height	1.0	18.9	29.3	3.4	5.4	-4.0
Systolic blood pressure, automated reading	1.0	3.0	5.8	-1.4	-2.4	-1.1
Fed-up feelings	1.0	1.8	2.6	-1.6	-1.5	0.7
Leg predicted mass (left)	1.0	5.1	5.6	-2.3	-2.1	2.4
Hair/balding pattern: Pattern 2	1.0	1.3	3.5	-0.4	0.4	-1.9
Noisy workplace	1.0	1.3	2.9	-0.3	-0.9	1.7
Hair/balding pattern: Pattern 4	1.0	2.5	6.5	2.5	0.0	1.1
Financial situation satisfaction	1.0	1.3	3.3	-0.5	-0.5	1.8
Eye problems/disorders: Glaucoma	1.0	1.1	1.9	0.5	-1.4	1.1
Risk taking	1.0	1.5	3.6	-0.9	-0.1	1.9
Ever depressed for a whole week	1.0	1.3	2.4	-1.6	-1.1	-0.4
Crohns Disease (2012)	0.9	1.5	3.9	2.0	0.7	0.4
Triglycerides	0.9	1.4	2.3	-0.1	-1.5	1.4
Relative age of first facial hair	0.9	1.9	3.3	-0.1	1.6	-1.8
Leg fat-free mass (left)	0.9	5.0	5.4	-2.3	-2.1	2.3
Falls in the last year	0.9	1.3	1.9	1.1	1.4	-0.8
Mouth/teeth dental problems: Dentures	0.9	1.6	4.7	-2.2	-0.0	-0.2
Standing height	0.9	8.5	12.6	2.3	3.5	-2.8
Migraine (self-reported)	0.9	1.1	2.1	0.9	0.6	-1.5
Medication: Allopurinol	0.9	1.2	2.5	-1.0	-0.4	1.6
Medication: Seretide 50 evohaler	0.9	1.0	1.6	-1.3	1.1	0.5
Supplements: Vitamin C	0.9	1.1	1.4	1.0	1.2	-1.0
Loneliness, isolation	0.9	1.2	3.1	-1.8	-0.4	0.7
Ever had bowel cancer screening	0.9	1.1	2.4	1.5	0.9	0.1
Basal metabolic rate	0.9	4.9	5.2	-2.1	-2.2	2.3
Arm predicted mass (left)	0.9	4.7	5.4	-2.0	-2.3	2.2
Intelligence (Savage-Jansen 2018)	0.8	2.3	5.3	1.0	-0.8	2.3
Body Mass Index (BMI) (2010)	0.8	1.0	2.7	-0.6	-0.3	1.6
Hypothyroidism (self reported)	0.8	1.9	3.3	1.8	1.2	-1.0
High blood pressure (mother)	0.8	1.1	2.6	0.7	0.1	-1.6
Pain all over the body in last month	0.8	0.9	1.7	-1.3	-0.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.8	-1.7	-1.0	0.1
Medication: Lansoprazole	0.8	0.9	1.1	1.0	1.0	-0.9
Forced vital capacity (FVC), Best measure	0.8	2.8	4.1	2.0	2.0	0.6
Number of full brothers	0.8	1.0	1.6	-1.1	-1.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.3	1.5	0.5	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.6	0.7	1.2	-0.9
Leg fat-free mass (right)	0.8	4.0	5.1	-2.0	-1.7	2.2
Average weekly red wine intake	0.8	1.2	1.9	-1.1	-1.4	0.8
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	1.8	1.3	1.3	-0.4
Medication for cholesterol	0.8	1.1	2.6	0.1	1.6	-0.9
Leg predicted mass (right)	0.8	4.2	5.3	-2.1	-1.8	2.3
Average weekly champagne plus white wine intake	0.8	1.2	2.3	-0.6	-0.9	1.5
Arm fat-free mass (left)	0.8	4.2	4.8	-1.8	-2.1	2.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.3	-0.7	-0.7	-1.1
Taking other prescription medications	0.7	1.1	2.3	-0.1	1.0	-1.5
Number of incorrect matches in round	0.7	1.2	2.0	1.4	0.9	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	4.4	2.1	1.4	0.4
Arm fat-free mass (right)	0.7	3.5	4.2	-1.6	-1.9	2.0
Arm predicted mass (right)	0.7	3.6	4.8	-1.6	-1.9	2.2
Illnesses of siblings: Diabetes	0.7	0.9	2.5	0.2	0.2	-1.6
Mood swings	0.7	1.2	2.6	-1.6	-1.0	-0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.2	1.0	-0.3	1.8
Prostate Cancer	0.6	0.8	1.4	1.0	0.3	1.2
Fasting Glucose	0.6	0.7	1.7	-1.3	0.6	-0.4
Heel T-Score	0.6	4.5	9.1	-1.6	-3.0	-1.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.8	0.4	-0.6	1.3
Angina	0.6	0.8	1.8	-1.3	-0.3	0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	-1.1	-0.6	-0.8
Hair/balding pattern: Pattern 3	0.6	0.8	1.4	1.0	1.2	-0.0
Breastfed as a baby	0.6	0.7	1.3	0.0	-0.9	1.1
Pulse wave reflection index	0.6	0.8	2.1	1.4	0.3	0.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.3	-1.1	-1.0	0.2
Number of children fathered	0.6	0.6	1.0	-0.8	-0.5	1.0
Number of self-reported non-cancer illnesses	0.6	1.0	1.9	-1.4	-0.5	-0.9
Miserableness	0.6	1.0	1.5	-1.2	-1.2	0.4
Wears glasses or contact lenses	0.6	0.7	1.6	0.8	0.0	-1.3
Commuting to job workplace: Cycle	0.6	0.8	1.9	-0.2	-0.6	1.4
Alzheimer’s Disease (including proxy)	0.5	0.8	1.6	1.3	0.8	-0.0
LDL Cholesterol	0.5	0.7	1.6	-0.8	0.2	-1.3
Primary Biliary Cirrhosis	0.5	0.8	1.9	-0.4	0.4	-1.4
Age when periods started (menarche)	0.5	1.1	2.2	0.9	0.6	1.5
Glaucoma (self-reported)	0.5	0.5	0.9	0.9	-0.9	0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.7	-0.2	-1.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.7	1.3	0.9	0.7
Whole body fat-free mass	0.5	2.8	3.6	-1.6	-1.5	1.9
Long-standing illness, disability or infirmity	0.5	0.8	1.6	0.3	1.3	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.5	-0.2	-1.2	0.4
Whole body water mass	0.5	3.0	4.0	-1.6	-1.6	2.0
Depressed Affect (Nagel 2018)	0.4	0.8	1.6	-1.2	-0.8	0.3
Alzheimer’s Disease (in father)	0.4	0.4	0.7	0.8	-0.1	0.7
Lung FVC	0.4	2.2	2.8	1.2	1.7	1.5
Severe depression (siblings)	0.4	0.4	0.8	-0.7	-0.9	0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.6	-0.1	-0.8	-0.7
Qualifications: CSEs or equivalent	0.4	0.6	1.3	-0.5	-1.1	0.4
Had menopause	0.4	0.6	1.4	0.0	0.5	-1.2
Forced vital capacity (FVC)	0.4	1.5	2.8	1.7	0.9	1.0
Worrier / anxious feelings	0.4	0.7	2.0	1.4	0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.6	1.9	0.5	0.6
Illnesses of mother	0.4	0.5	0.9	0.7	0.9	-0.2
Exposure to tobacco smoke at home	0.4	0.4	1.1	0.4	1.0	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	0.9	0.3	0.8
Blood clot in the leg (DVT)	0.4	0.6	1.0	-0.2	0.9	1.0
Neck or shoulder pain in last month	0.4	0.6	1.5	-0.5	0.1	-1.2
Angina (self-reported)	0.4	0.5	1.1	-1.1	-0.1	0.6
Irritability	0.4	0.7	1.5	-1.2	-0.7	0.4
Cholesterol lowering medication	0.4	0.6	1.5	-0.4	-1.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	-0.2	1.0	0.7
Alcohol drinker status: Previous	0.4	0.5	1.0	-0.1	-1.0	0.6
Schizophrenia (2014)	0.3	0.7	1.3	-0.7	-1.2	0.4
Respiratory disease	0.3	0.7	1.5	-0.4	1.2	-0.7
Number of treatments/medications taken	0.3	0.6	1.0	-0.9	-1.0	-0.2
Sensitivity / hurt feelings	0.3	0.5	1.5	0.2	0.2	-1.2
Supplements: Zinc	0.3	0.3	0.5	0.3	0.5	0.7
Qualifications: None of the above	0.3	0.6	1.4	-0.2	-0.6	1.2
Mouth/teeth dental problems	0.3	0.5	0.9	1.0	-0.3	-0.6
Heart attack	0.3	0.4	1.1	-0.2	-0.1	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	0.1	0.7	-0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	0.3	-0.3	1.0
High blood pressure (siblings)	0.3	0.4	0.7	-0.2	-0.8	0.7
Worry too long after embarrassment	0.3	0.4	1.1	1.0	0.2	-0.4
Eye problems/disorders: None of the above	0.3	0.4	0.5	-0.7	0.2	-0.7
Illnesses of father: Heart disease	0.3	0.5	1.0	-0.6	-0.3	-1.0
Back pain experienced in last month	0.3	0.4	0.9	0.9	-0.6	0.1
High cholesterol (Self-reported)	0.3	0.5	1.0	-0.4	-0.7	-1.0
Number of operations (self-reported)	0.3	0.5	0.9	-0.5	-0.6	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	0.7	0.8	0.3
Major Depression (MDD)	0.2	0.3	0.7	-0.0	-0.9	0.4
Breast Cancer	0.2	0.5	1.2	1.1	0.2	0.5
Blood Eosinophil Count	0.2	1.9	4.2	-0.5	1.1	-2.1
Systolic Blood Pressure	0.2	1.0	2.2	-0.0	-1.5	-0.9
Lung FEV1/FVC ratio	0.2	1.2	2.6	1.6	-1.0	-0.1
Neuroticism	0.2	0.5	0.8	0.4	0.9	-0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.5	-0.8	0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	-0.3	0.5	-0.5
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	0.4	0.3	-0.7
Serious illness, injury or assault to yourself	0.2	0.3	0.9	-0.9	0.0	0.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.1	0.7	-0.3
Alcohol usually taken with meals	0.2	0.3	0.8	-0.5	0.0	-0.9
Neuroticism score	0.2	0.5	1.0	-1.0	-0.3	-0.6
Trunk fat-free mass	0.2	1.0	1.8	-0.8	-0.8	1.4
Time employed in main current job	0.2	0.2	0.5	0.2	-0.2	0.7
Asthma	0.2	0.3	0.5	0.1	0.7	0.6
Lung cancer (father)	0.2	0.3	0.6	0.2	0.8	-0.4
Trunk predicted mass	0.2	1.0	1.8	-0.8	-0.8	1.3
Tense / ‘highly strung’	0.2	0.4	0.6	-0.5	-0.5	-0.8
Comparative body size at age 10	0.2	0.6	1.1	0.5	1.0	0.6
Medication: Omeprazole	0.2	0.2	0.4	0.3	0.4	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.3	-0.6	-0.6	0.4
Friendships satisfaction	0.2	0.2	0.6	0.3	0.1	0.7
Qualifications: nursing, teaching	0.2	0.3	0.4	0.2	0.6	-0.6
Breast cancer (self-reported)	0.2	0.2	0.6	-0.8	-0.0	-0.2
Asthma (self-reported)	0.2	0.3	0.8	0.2	0.9	0.4
Medication: Gliclazide	0.2	0.2	0.4	-0.3	-0.3	-0.7
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.7	-0.3	0.4
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.0	0.1	0.8
Illnesses of father: High blood pressure	0.2	0.3	0.8	0.0	0.0	-0.9
Pain experienced in last month	0.2	0.3	0.5	-0.7	-0.5	0.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.9	0.2	0.1	0.9
Neuroticism (Nagel 2018)	0.1	0.1	0.3	0.2	0.3	-0.6
Schizophrenia (2018)	0.1	0.2	0.4	-0.4	-0.5	0.6
Coronary Artery Disease (CAD)	0.1	0.1	0.4	-0.1	0.0	-0.6
Mean Putamen Volume	0.1	0.1	0.2	0.4	-0.2	0.2
Lupus	0.1	0.1	0.3	0.6	-0.3	-0.1
Neuroticism (2016)	0.1	0.1	0.3	-0.4	-0.1	-0.5
Hair Pigment	0.1	1.7	4.6	-2.1	-0.7	0.4
Tanning	0.1	0.7	1.3	0.0	1.2	0.9
Medication for hormone replacement therapy	0.1	0.1	0.1	-0.1	-0.4	0.3
Average weekly fortified wine intake	0.1	0.1	0.2	0.1	0.3	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.4	0.0	-0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.3	-0.3	-0.7
Length of working week for main job	0.1	0.2	0.2	0.5	-0.2	0.5
Headache pain in last month	0.1	0.1	0.2	-0.4	0.4	-0.1
Osteoporosis (self-reported)	0.1	0.1	0.2	0.4	0.4	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.1	-0.4	0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.4	0.2	-0.3
Alzheimer’s Disease (in mother)	0.0	0.1	0.2	-0.1	-0.0	0.4
Birth weight	0.0	0.1	0.1	0.3	-0.2	0.2
Qualifications: College or University degree	0.0	0.1	0.2	-0.4	0.3	-0.2
Comparative height size at age 10	0.0	0.2	0.4	-0.1	0.7	0.1
Knee pain experienced in last month	0.0	0.1	0.2	-0.4	0.1	-0.1
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.0	0.2	-0.2
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.3	0.0	0.2

Hub : Genes

ARPC1A

Models

Trait associations