Best TWAS P=2.89e-09 · Best GWAS P=9.58e-09 conditioned to 0.457
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | POLR2L | 0.09 | 0.09 | enet | 16 | 0.10 | 4.6e-12 | -3.8 | -5.3 | 1.4e-07 | 0.63 | 0.87 | 0.10 | FALSE |
2 | GTEx | Artery Coronary | AP006621.6 | 0.26 | 0.11 | enet | 20 | 0.12 | 5.3e-05 | 4.3 | 5.8 | 7.2e-09 | -0.82 | 0.02 | 0.96 | FALSE |
3 | GTEx | Brain Frontal Cortex BA9 | PIDD | 0.32 | 0.15 | lasso | 2 | 0.11 | 6.9e-04 | -5.4 | 5.6 | 2.6e-08 | -0.95 | 0.02 | 0.84 | FALSE |
4 | GTEx | Brain Frontal Cortex BA9 | AP006621.5 | 0.18 | 0.03 | lasso | 6 | 0.04 | 2.6e-02 | -5.4 | 5.9 | 2.9e-09 | -0.92 | 0.03 | 0.72 | TRUE |
5 | GTEx | Brain Hippocampus | AP006621.5 | 0.26 | 0.22 | enet | 20 | 0.15 | 2.1e-04 | 4.3 | 5.4 | 7.9e-08 | -0.60 | 0.12 | 0.22 | FALSE |
6 | GTEx | Brain Hypothalamus | PNPLA2 | 0.23 | -0.01 | lasso | 9 | 0.00 | 4.0e-01 | -5.4 | -5.6 | 2.0e-08 | 0.93 | 0.04 | 0.36 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | PIDD | 0.14 | 0.05 | enet | 13 | 0.04 | 2.8e-04 | 4.7 | 5.4 | 6.1e-08 | -0.80 | 0.01 | 0.97 | FALSE |
8 | GTEx | Heart Left Ventricle | AP006621.6 | 0.23 | 0.11 | lasso | 5 | 0.11 | 1.4e-06 | 4.9 | 5.2 | 1.9e-07 | -0.80 | 0.09 | 0.90 | FALSE |
9 | GTEx | Muscle Skeletal | AP006621.6 | 0.15 | 0.12 | enet | 10 | 0.14 | 1.6e-13 | 4.3 | 5.4 | 5.8e-08 | -0.80 | 0.35 | 0.64 | FALSE |
10 | GTEx | Pancreas | EFCAB4A | 0.23 | 0.19 | enet | 8 | 0.16 | 4.1e-07 | -5.7 | 5.8 | 6.9e-09 | -0.97 | 0.00 | 1.00 | FALSE |
11 | GTEx | Pancreas | AP006621.8 | 0.28 | 0.10 | lasso | 6 | 0.14 | 2.5e-06 | -5.4 | 5.4 | 5.1e-08 | -0.85 | 0.01 | 0.99 | FALSE |
12 | GTEx | Testis | POLR2L | 0.16 | 0.03 | enet | 10 | 0.03 | 1.9e-02 | -5.0 | -5.4 | 5.5e-08 | 0.75 | 0.04 | 0.91 | FALSE |
13 | METSIM | Adipose | AP006621.5 | 0.24 | 0.19 | enet | 34 | 0.20 | 1.5e-28 | 4.7 | 5.1 | 2.7e-07 | -0.80 | 0.33 | 0.67 | FALSE |
14 | ROSMAP | Brain Pre-frontal Cortex | AP006621.5 | 0.37 | 0.38 | lasso | 4 | 0.41 | 3.1e-57 | 4.7 | 5.2 | 1.9e-07 | -0.72 | 0.36 | 0.63 | FALSE |
15 | YFS | Blood | POLR2L | 0.26 | 0.19 | bslmm | 383 | 0.30 | 2.4e-98 | -3.8 | 5.3 | 1.0e-07 | -0.49 | 0.94 | 0.04 | FALSE |
16 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CHID1 | 0.06 | 0.05 | blup | 67 | 0.03 | 2.0e-02 | 3.4 | -5.1 | 2.7e-07 | 0.65 | 0.04 | 0.25 | FALSE |
17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CEND1 | 0.04 | 0.03 | lasso | 3 | 0.02 | 9.6e-04 | -5.4 | 5.2 | 1.9e-07 | -0.91 | 0.01 | 0.97 | FALSE |
18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CEND1 | 0.06 | 0.02 | enet | 9 | 0.04 | 7.7e-06 | -4.3 | 5.4 | 7.8e-08 | -0.63 | 0.12 | 0.73 | FALSE |
19 | The Cancer Genome Atlas | Lung Adenocarcinoma | TSPAN4 | 0.09 | 0.04 | enet | 9 | 0.03 | 1.9e-04 | 3.6 | 5.9 | 4.0e-09 | -0.60 | 0.18 | 0.63 | FALSE |
20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CEND1 | 0.05 | 0.00 | blup | 52 | 0.02 | 1.1e-02 | -3.2 | 5.1 | 3.1e-07 | -0.80 | 0.04 | 0.41 | FALSE |
21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CEND1 | 0.02 | 0.01 | blup | 52 | 0.01 | 2.8e-02 | 4.3 | 5.4 | 8.8e-08 | -0.79 | 0.04 | 0.55 | FALSE |