Best TWAS P=1.93e-13 · Best GWAS P=3.49e-15 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | MAP2K5 | 0.14 | 0.18 | lasso | 4 | 0.18 | 1.0e-14 | -5.6 | 5.7 | 1.4e-08 | -0.66 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Visceral Omentum | MAP2K5 | 0.07 | 0.08 | lasso | 3 | 0.05 | 1.0e-03 | -5.8 | 6.1 | 7.8e-10 | -0.65 | 0.08 | 0.87 | FALSE |
3 | GTEx | Artery Aorta | MAP2K5 | 0.06 | 0.05 | enet | 6 | 0.05 | 7.7e-04 | -5.6 | 6.1 | 1.3e-09 | -0.65 | 0.35 | 0.46 | FALSE |
4 | GTEx | Artery Tibial | MAP2K5 | 0.15 | 0.18 | lasso | 3 | 0.18 | 6.3e-14 | -5.6 | 5.7 | 9.5e-09 | -0.66 | 1.00 | 0.00 | FALSE |
5 | GTEx | Brain Hippocampus | IQCH-AS1 | 0.20 | 0.08 | enet | 11 | 0.05 | 2.2e-02 | 4.3 | -5.9 | 3.3e-09 | 0.74 | 0.13 | 0.28 | FALSE |
6 | GTEx | Breast Mammary Tissue | MAP2K5 | 0.14 | 0.07 | lasso | 5 | 0.09 | 2.8e-05 | -7.1 | 6.3 | 3.1e-10 | -0.62 | 0.07 | 0.93 | FALSE |
7 | GTEx | Esophagus Muscularis | MAP2K5 | 0.24 | 0.14 | lasso | 4 | 0.13 | 2.1e-08 | -5.6 | 5.7 | 1.5e-08 | -0.65 | 0.99 | 0.00 | FALSE |
8 | GTEx | Heart Atrial Appendage | MAP2K5 | 0.16 | 0.08 | lasso | 5 | 0.16 | 1.3e-07 | -5.5 | 6.5 | 1.1e-10 | -0.80 | 0.09 | 0.91 | FALSE |
9 | GTEx | Heart Left Ventricle | MAP2K5 | 0.10 | 0.10 | lasso | 3 | 0.10 | 9.4e-06 | -5.6 | 5.7 | 1.0e-08 | -0.66 | 0.67 | 0.26 | FALSE |
10 | GTEx | Lung | MAP2K5 | 0.12 | 0.09 | enet | 11 | 0.07 | 3.6e-06 | -5.5 | 5.3 | 8.8e-08 | -0.60 | 0.93 | 0.04 | FALSE |
11 | GTEx | Muscle Skeletal | MAP2K5 | 0.08 | 0.03 | lasso | 6 | 0.05 | 1.9e-05 | 5.5 | 7.0 | 1.9e-12 | -0.91 | 0.01 | 0.99 | FALSE |
12 | GTEx | Nerve Tibial | MAP2K5 | 0.19 | 0.21 | lasso | 2 | 0.20 | 3.3e-14 | -5.6 | 5.6 | 1.9e-08 | -0.66 | 0.99 | 0.01 | FALSE |
13 | GTEx | Ovary | MAP2K5 | 0.19 | 0.24 | lasso | 3 | 0.21 | 8.3e-06 | -5.6 | 5.7 | 1.2e-08 | -0.65 | 0.14 | 0.68 | FALSE |
14 | GTEx | Skin Sun Exposed Lower leg | MAP2K5 | 0.13 | 0.06 | lasso | 4 | 0.09 | 4.4e-08 | 4.5 | 5.7 | 9.1e-09 | -0.73 | 0.85 | 0.14 | FALSE |
15 | GTEx | Thyroid | MAP2K5 | 0.11 | 0.16 | lasso | 4 | 0.15 | 9.6e-12 | -5.6 | 6.0 | 2.4e-09 | -0.68 | 0.95 | 0.05 | FALSE |
16 | GTEx | Whole Blood | MAP2K5 | 0.09 | 0.06 | lasso | 6 | 0.06 | 8.1e-06 | -5.6 | 6.1 | 9.4e-10 | -0.64 | 0.71 | 0.16 | FALSE |
17 | METSIM | Adipose | MAP2K5 | 0.07 | 0.05 | enet | 19 | 0.06 | 2.8e-09 | -7.0 | 6.4 | 1.3e-10 | -0.60 | 0.09 | 0.91 | FALSE |
18 | NTR | Blood | MAP2K5 | 0.02 | 0.00 | enet | 13 | 0.01 | 5.7e-04 | -5.7 | 5.3 | 1.0e-07 | -0.60 | 0.42 | 0.50 | FALSE |
19 | YFS | Blood | MAP2K5 | 0.05 | 0.07 | lasso | 4 | 0.07 | 1.2e-21 | -5.6 | 5.5 | 4.8e-08 | -0.63 | 1.00 | 0.00 | FALSE |
20 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IQCH | 0.06 | 0.05 | blup | 112 | 0.06 | 5.2e-12 | -3.6 | 5.7 | 9.8e-09 | -0.65 | 0.96 | 0.04 | FALSE |
21 | The Cancer Genome Atlas | Glioblastoma Multiforme | IQCH | 0.19 | 0.14 | enet | 21 | 0.12 | 2.4e-04 | -5.2 | 6.2 | 5.5e-10 | -0.66 | 0.05 | 0.91 | FALSE |
22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IQCH | 0.06 | 0.04 | blup | 111 | 0.03 | 1.0e-04 | -5.2 | 5.6 | 2.6e-08 | -0.67 | 0.06 | 0.88 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IQCH | 0.12 | 0.10 | enet | 22 | 0.12 | 4.0e-13 | -5.1 | 5.6 | 1.8e-08 | -0.61 | 0.65 | 0.35 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAP2K5 | 0.03 | 0.03 | blup | 142 | 0.02 | 1.6e-03 | -5.7 | 6.0 | 1.6e-09 | -0.53 | 0.10 | 0.85 | TRUE |
25 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IQCH | 0.05 | 0.04 | blup | 111 | 0.04 | 7.7e-06 | -5.2 | 5.8 | 8.1e-09 | -0.69 | 0.07 | 0.92 | FALSE |
26 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | IQCH | 0.10 | 0.01 | blup | 111 | 0.03 | 1.4e-02 | 5.1 | 6.5 | 9.1e-11 | -0.72 | 0.02 | 0.70 | TRUE |
27 | The Cancer Genome Atlas | Lung Adenocarcinoma | IQCH | 0.04 | 0.02 | enet | 8 | 0.01 | 1.6e-02 | -6.4 | 7.4 | 1.9e-13 | -0.71 | 0.01 | 0.95 | TRUE |
28 | The Cancer Genome Atlas | Lung Adenocarcinoma | MAP2K5 | 0.04 | 0.04 | lasso | 3 | 0.03 | 8.7e-05 | -5.6 | 5.8 | 6.2e-09 | -0.66 | 0.15 | 0.81 | FALSE |
29 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IQCH | 0.04 | 0.02 | enet | 6 | 0.03 | 1.6e-04 | -5.8 | 6.5 | 8.4e-11 | -0.63 | 0.11 | 0.77 | TRUE |
30 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | IQCH | 0.11 | 0.10 | blup | 112 | 0.10 | 2.3e-07 | -6.3 | 6.1 | 1.3e-09 | -0.71 | 0.00 | 1.00 | FALSE |
31 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IQCH | 0.35 | 0.04 | blup | 112 | 0.12 | 1.5e-05 | -5.2 | 6.4 | 2.0e-10 | -0.57 | 0.34 | 0.30 | FALSE |
32 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IQCH | 0.19 | 0.07 | blup | 111 | 0.16 | 7.4e-17 | -3.3 | 5.7 | 1.0e-08 | -0.70 | 0.03 | 0.97 | FALSE |
33 | The Cancer Genome Atlas | Stomach Adenocarcinoma | IQCH | 0.08 | 0.03 | blup | 111 | 0.04 | 9.2e-04 | -5.2 | 5.7 | 1.3e-08 | -0.62 | 0.07 | 0.35 | FALSE |
34 | The Cancer Genome Atlas | Thyroid Carcinoma | IQCH | 0.15 | 0.17 | enet | 19 | 0.17 | 1.3e-16 | -5.1 | 6.0 | 1.6e-09 | -0.67 | 0.21 | 0.79 | FALSE |
35 | The Cancer Genome Atlas | Thyroid Carcinoma | MAP2K5 | 0.10 | 0.06 | lasso | 5 | 0.04 | 6.1e-05 | -5.7 | 5.7 | 1.1e-08 | -0.64 | 0.68 | 0.28 | FALSE |