Best TWAS P=3.9e-11 · Best GWAS P=5.16e-15 conditioned to 0.0102
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ADAMTSL3 | 0.10 | 0.04 | lasso | 4 | 0.04 | 8.7e-06 | -6.513 | -5.2 | 1.9e-07 | 0.67 | 0.07 | 0.73 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | LOC388152 | 0.14 | 0.14 | enet | 20 | 0.18 | 6.7e-22 | 3.700 | -5.7 | 1.4e-08 | 0.38 | 1.00 | 0.00 | FALSE |
3 | GTEx | Adipose Subcutaneous | AC103965.1 | 0.24 | 0.14 | lasso | 6 | 0.15 | 2.6e-12 | 3.733 | -5.2 | 1.6e-07 | 0.30 | 1.00 | 0.00 | FALSE |
4 | GTEx | Adipose Visceral Omentum | GOLGA6L3 | 0.23 | 0.05 | lasso | 5 | 0.07 | 2.2e-04 | -6.342 | -5.8 | 6.1e-09 | 0.29 | 0.00 | 1.00 | FALSE |
5 | GTEx | Artery Tibial | SCAND2P | 0.12 | 0.05 | enet | 16 | 0.08 | 8.7e-07 | -3.159 | -5.9 | 2.9e-09 | 0.37 | 0.35 | 0.49 | TRUE |
6 | GTEx | Brain Cerebellum | AC103965.1 | 0.13 | 0.02 | enet | 21 | 0.01 | 2.1e-01 | 3.727 | -5.4 | 5.1e-08 | 0.37 | 0.12 | 0.14 | FALSE |
7 | GTEx | Brain Cortex | GOLGA6L4 | 0.42 | 0.21 | lasso | 7 | 0.28 | 2.8e-08 | -6.120 | -6.6 | 3.9e-11 | 0.56 | 0.30 | 0.56 | TRUE |
8 | GTEx | Brain Nucleus accumbens basal ganglia | GOLGA6L4 | 0.21 | 0.04 | lasso | 5 | 0.09 | 2.3e-03 | -6.746 | -6.1 | 8.8e-10 | 0.55 | 0.05 | 0.28 | FALSE |
9 | GTEx | Breast Mammary Tissue | GOLGA6L3 | 0.28 | 0.16 | lasso | 7 | 0.21 | 3.5e-11 | -6.342 | -5.5 | 4.9e-08 | 0.25 | 0.00 | 1.00 | FALSE |
10 | GTEx | Breast Mammary Tissue (Male) | GOLGA6L4 | 0.23 | 0.07 | lasso | 2 | 0.12 | 8.3e-04 | -6.120 | -5.9 | 3.6e-09 | 0.41 | 0.08 | 0.18 | FALSE |
11 | GTEx | Breast Mammary Tissue (Male) | AC103965.1 | 0.24 | 0.14 | lasso | 4 | 0.11 | 1.4e-03 | 3.530 | -5.1 | 2.9e-07 | 0.42 | 0.09 | 0.46 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | AC103965.1 | 0.15 | 0.09 | lasso | 7 | 0.11 | 1.3e-08 | 3.733 | -5.4 | 7.9e-08 | 0.38 | 0.99 | 0.00 | FALSE |
13 | GTEx | Colon Transverse | GOLGA6L3 | 0.18 | 0.17 | lasso | 4 | 0.14 | 2.2e-07 | -6.342 | -5.7 | 1.4e-08 | 0.22 | 0.00 | 1.00 | FALSE |
14 | GTEx | Colon Transverse | AC103965.1 | 0.15 | 0.07 | enet | 33 | 0.06 | 7.1e-04 | -6.138 | -6.5 | 1.0e-10 | 0.35 | 0.19 | 0.08 | FALSE |
15 | GTEx | Colon Transverse | CSPG4P11 | 0.10 | 0.10 | lasso | 4 | 0.08 | 1.2e-04 | -6.138 | -6.0 | 1.6e-09 | 0.25 | 0.25 | 0.03 | FALSE |
16 | GTEx | Esophagus Mucosa | AC103965.1 | 0.20 | 0.19 | enet | 47 | 0.16 | 8.4e-11 | 3.660 | -5.2 | 2.5e-07 | 0.34 | 1.00 | 0.00 | FALSE |
17 | GTEx | Esophagus Mucosa | RP11-182J1.16 | 0.20 | 0.05 | lasso | 5 | 0.10 | 1.8e-07 | 3.683 | -5.6 | 2.3e-08 | 0.27 | 0.90 | 0.00 | FALSE |
18 | GTEx | Esophagus Mucosa | CSPG4P11 | 0.21 | 0.01 | enet | 28 | 0.08 | 3.7e-06 | -6.138 | -6.1 | 1.1e-09 | 0.38 | 0.88 | 0.01 | FALSE |
19 | GTEx | Esophagus Muscularis | UBE2Q2P1 | 0.34 | 0.03 | lasso | 7 | 0.15 | 1.9e-09 | 2.506 | 5.2 | 1.7e-07 | -0.25 | 0.06 | 0.88 | FALSE |
20 | GTEx | Lung | AC103965.1 | 0.20 | 0.14 | lasso | 4 | 0.16 | 1.8e-12 | 3.660 | -5.2 | 2.2e-07 | 0.32 | 1.00 | 0.00 | FALSE |
21 | GTEx | Pancreas | RP11-182J1.16 | 0.08 | -0.01 | enet | 11 | -0.01 | 7.9e-01 | -6.138 | -6.2 | 7.2e-10 | 0.45 | 0.05 | 0.11 | FALSE |
22 | GTEx | Prostate | RP11-182J1.16 | 0.24 | 0.06 | enet | 27 | 0.08 | 6.2e-03 | 0.095 | -5.7 | 1.4e-08 | 0.37 | 0.08 | 0.12 | FALSE |
23 | GTEx | Prostate | CSPG4P11 | 0.34 | 0.07 | enet | 13 | 0.18 | 2.3e-05 | -2.019 | -6.1 | 1.3e-09 | 0.24 | 0.17 | 0.16 | FALSE |
24 | GTEx | Skin Sun Exposed Lower leg | ZSCAN2 | 0.08 | 0.02 | enet | 13 | 0.03 | 1.4e-03 | -6.095 | 5.3 | 1.4e-07 | -0.20 | 0.04 | 0.91 | FALSE |
25 | GTEx | Skin Sun Exposed Lower leg | AC103965.1 | 0.33 | 0.17 | enet | 24 | 0.23 | 4.8e-19 | 3.660 | -6.1 | 7.9e-10 | 0.39 | 1.00 | 0.00 | FALSE |
26 | GTEx | Small Intestine Terminal Ileum | RP11-182J1.14 | 0.26 | 0.01 | enet | 27 | 0.12 | 1.3e-03 | -6.332 | 5.7 | 1.2e-08 | -0.42 | 0.05 | 0.20 | FALSE |
27 | GTEx | Spleen | GOLGA6L4 | 0.55 | 0.20 | enet | 19 | 0.40 | 2.6e-11 | -6.378 | -6.3 | 3.4e-10 | 0.36 | 0.89 | 0.01 | FALSE |
28 | GTEx | Whole Blood | GOLGA6L4 | 0.12 | 0.08 | enet | 16 | 0.11 | 2.1e-10 | -4.346 | -6.0 | 1.6e-09 | 0.39 | 0.99 | 0.01 | FALSE |