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chr16:86,671-2,954,916

Best TWAS P=2.2e-14 · Best GWAS P=1.32e-13 conditioned to 0.00533

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	C16orf79	0.05	0.01	lasso	4	0.02	1.5e-03	5.8	-7.6	2.2e-14	-0.69	0.02	0.87	TRUE
5	GTEx	Brain Cerebellar Hemisphere	CCDC78	0.21	0.12	enet	12	0.12	6.2e-04	-4.4	-6.8	9.5e-12	0.00	0.13	0.45	TRUE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC100134368	0.03	0.00	enet	5	0.01	2.8e-02	-4.4	-6.8	1.2e-11	-0.02	0.01	0.57	TRUE
55	The Cancer Genome Atlas	Thyroid Carcinoma	SLC9A3R2	0.06	0.03	lasso	5	0.03	3.7e-04	-5.3	6.3	2.8e-10	0.00	0.24	0.05	TRUE
21	GTEx	Thyroid	BRICD5	0.16	0.10	lasso	3	0.09	3.6e-07	7.4	-7.4	1.2e-13	-0.91	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	CASKIN1	0.02	0.00	blup	38	0.01	4.5e-02	5.8	-7.3	4.0e-13	-0.33	0.03	0.06	FALSE
23	METSIM	Adipose	BRICD5	0.07	0.04	enet	19	0.04	8.5e-07	4.7	-7.0	3.3e-12	-0.67	0.29	0.70	FALSE
7	GTEx	Breast Mammary Tissue	BRICD5	0.16	0.08	lasso	5	0.02	3.4e-02	5.8	-6.9	4.4e-12	-0.96	0.01	0.98	FALSE
32	YFS	Blood	MLST8	0.12	0.06	bslmm	326	0.06	4.3e-20	-5.6	6.9	6.5e-12	0.45	0.99	0.01	FALSE
10	GTEx	Esophagus Mucosa	BRICD5	0.17	0.06	enet	9	0.11	1.3e-07	-5.6	-6.8	9.5e-12	-0.74	0.04	0.95	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	MLST8	0.09	0.07	enet	8	0.09	9.9e-09	6.0	6.7	2.8e-11	0.38	0.38	0.62	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	MLST8	0.22	0.18	lasso	6	0.18	7.1e-23	6.1	6.6	3.4e-11	0.32	0.82	0.18	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC100134368	0.05	0.00	blup	48	0.04	2.5e-05	-5.3	-6.6	4.7e-11	-0.01	0.02	0.83	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	MLST8	0.07	0.07	enet	6	0.08	1.2e-09	-5.6	6.5	1.0e-10	0.49	0.48	0.52	FALSE
19	GTEx	Testis	BRICD5	0.26	0.29	enet	12	0.21	1.3e-09	5.3	-6.3	2.5e-10	-0.61	0.96	0.04	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	AXIN1	0.03	0.01	blup	88	0.01	7.7e-03	-5.9	6.3	3.8e-10	0.00	0.01	0.78	FALSE
3	GTEx	Adipose Visceral Omentum	BRICD5	0.12	0.01	lasso	4	0.03	8.7e-03	-4.9	-6.2	6.6e-10	-0.57	0.05	0.62	FALSE
34	YFS	Blood	PGP	0.17	0.14	lasso	3	0.14	9.2e-42	-6.1	-6.1	9.3e-10	-0.65	0.92	0.08	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	LOC100134368	0.06	0.05	blup	47	0.07	3.9e-07	2.9	-6.0	1.7e-09	0.01	0.41	0.45	FALSE
9	GTEx	Breast Mammary Tissue (Female)	BRICD5	0.06	0.00	enet	4	0.03	3.5e-02	7.4	-6.0	2.0e-09	-0.88	0.02	0.34	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	PGP	0.04	0.03	lasso	5	0.02	1.3e-03	-4.9	-6.0	2.0e-09	-0.69	0.06	0.87	FALSE
12	GTEx	Nerve Tibial	BRICD5	0.21	0.18	enet	21	0.18	8.8e-13	7.4	-5.9	2.8e-09	-0.89	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC100134368	0.05	0.00	enet	12	0.03	2.5e-04	3.3	-5.9	3.9e-09	0.06	0.01	0.09	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MLST8	0.04	0.04	lasso	3	0.03	7.6e-05	5.7	5.9	4.2e-09	0.54	0.33	0.22	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	RAB11FIP3	0.15	0.06	lasso	9	0.09	1.9e-05	5.2	-5.9	4.7e-09	-0.01	0.39	0.58	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	SLC9A3R2	0.16	0.11	lasso	6	0.12	6.3e-15	-6.2	5.8	5.3e-09	-0.03	0.89	0.11	FALSE
14	GTEx	Nerve Tibial	ARHGDIG	0.13	0.07	lasso	2	0.07	8.0e-06	-6.0	5.8	6.5e-09	-0.02	0.01	0.95	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SLC9A3R2	0.15	0.09	enet	7	0.10	7.8e-12	-5.3	5.8	6.9e-09	0.02	0.96	0.04	FALSE
18	GTEx	Testis	AXIN1	0.36	0.29	lasso	3	0.28	4.3e-13	-6.0	-5.8	7.9e-09	0.01	0.01	0.99	FALSE
15	GTEx	Pancreas	NARFL	0.24	0.21	lasso	4	0.16	3.6e-07	4.8	5.8	8.7e-09	-0.05	0.71	0.23	FALSE
47	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LOC100134368	0.08	0.07	blup	48	0.06	1.9e-03	2.9	-5.7	9.6e-09	-0.01	0.05	0.15	FALSE
46	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MLST8	0.09	0.05	blup	38	0.04	8.7e-03	-6.0	5.7	1.2e-08	0.66	0.04	0.58	FALSE
13	GTEx	Nerve Tibial	PDIA2	0.12	0.01	enet	13	0.06	4.4e-05	-4.8	5.6	2.1e-08	0.01	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM8A	0.03	0.01	blup	52	0.02	3.4e-03	3.3	5.6	2.5e-08	0.01	0.04	0.07	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	PDIA2	0.15	0.07	lasso	8	0.10	5.2e-13	-4.0	-5.5	2.9e-08	0.00	0.07	0.93	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	RAB11FIP3	0.05	0.01	enet	7	0.02	4.2e-03	5.2	5.5	3.4e-08	-0.01	0.04	0.22	FALSE
4	GTEx	Artery Tibial	BRICD5	0.28	0.21	lasso	3	0.27	1.8e-21	7.4	-5.5	4.2e-08	-0.88	0.00	1.00	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	MRPL28	0.17	0.10	lasso	5	0.12	1.1e-15	3.2	5.4	5.2e-08	0.02	0.97	0.03	FALSE
20	GTEx	Thyroid	MLST8	0.10	0.06	lasso	5	0.06	2.2e-05	-5.6	5.4	5.9e-08	0.56	0.55	0.36	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM173A	0.06	0.05	enet	11	0.04	1.9e-05	4.1	5.4	6.5e-08	0.03	0.33	0.51	FALSE
22	GTEx	Whole Blood	NME4	0.12	0.03	lasso	5	0.04	3.0e-04	2.9	5.3	9.0e-08	-0.02	0.03	0.95	FALSE
42	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MLST8	0.10	0.02	blup	37	0.06	7.3e-04	-5.7	5.3	9.3e-08	0.49	0.03	0.20	FALSE
11	GTEx	Nerve Tibial	AXIN1	0.11	0.09	lasso	2	0.06	3.9e-05	-6.0	5.3	1.1e-07	-0.01	0.02	0.98	FALSE
6	GTEx	Brain Putamen basal ganglia	DECR2	0.14	0.01	enet	8	0.06	1.9e-02	4.9	5.3	1.2e-07	-0.01	0.14	0.26	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	CASKIN1	0.06	0.02	blup	38	0.04	1.5e-04	-7.4	-5.3	1.2e-07	0.21	0.01	0.96	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MLST8	0.11	0.08	enet	5	0.11	1.0e-06	-5.6	5.3	1.3e-07	0.52	0.44	0.13	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RHBDL1	0.12	0.01	enet	6	0.02	1.0e-01	4.8	5.3	1.4e-07	-0.02	0.04	0.41	FALSE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC100134368	0.04	0.01	enet	6	0.03	2.4e-04	3.5	-5.3	1.4e-07	0.06	0.02	0.38	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	BRICD5	0.19	0.05	enet	36	0.06	4.5e-08	6.0	-5.2	1.5e-07	-0.30	0.59	0.41	FALSE
30	YFS	Blood	FAM173A	0.12	0.07	lasso	6	0.10	2.0e-29	5.1	5.2	1.6e-07	0.01	0.67	0.33	FALSE
31	YFS	Blood	METRN	0.05	0.06	lasso	2	0.06	2.0e-18	5.1	5.2	1.7e-07	0.00	0.64	0.36	FALSE
16	GTEx	Pituitary	BRICD5	0.22	0.15	lasso	3	0.14	2.0e-04	-4.9	-5.2	2.3e-07	-0.56	0.08	0.32	FALSE
33	YFS	Blood	NARFL	0.16	0.19	lasso	3	0.19	1.1e-60	4.9	5.2	2.5e-07	-0.01	0.81	0.19	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	DECR2	0.19	0.19	blup	366	0.17	7.8e-22	3.9	5.1	3.0e-07	0.02	0.97	0.03	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	METRN	0.02	0.02	lasso	1	0.02	2.0e-04	5.1	5.1	3.1e-07	0.01	0.00	0.96	FALSE