Best TWAS P=1.84e-14 · Best GWAS P=6.97e-15 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | LINC00674 | 0.12 | 0.13 | enet | 6 | 0.14 | 9.9e-12 | 5.6 | 5.9 | 3.3e-09 | 0.79 | 0.96 | 0.04 | FALSE |
2 | GTEx | Adipose Subcutaneous | SH3GL1P3 | 0.08 | 0.06 | lasso | 5 | 0.04 | 2.5e-04 | 5.6 | 5.3 | 1.2e-07 | 0.80 | 0.06 | 0.90 | FALSE |
3 | GTEx | Brain Cerebellum | BPTF | 0.22 | -0.01 | lasso | 10 | -0.01 | 6.9e-01 | 5.8 | -7.2 | 7.7e-13 | -0.85 | 0.03 | 0.49 | FALSE |
4 | GTEx | Brain Cortex | C17orf58 | 0.34 | 0.09 | lasso | 6 | 0.13 | 2.4e-04 | 7.6 | 7.2 | 6.5e-13 | 0.95 | 0.03 | 0.95 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | LINC00674 | 0.30 | 0.31 | enet | 10 | 0.32 | 1.5e-24 | 5.6 | 6.5 | 5.9e-11 | 0.86 | 1.00 | 0.00 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | LRRC37A16P | 0.50 | 0.46 | lasso | 8 | 0.47 | 1.1e-38 | 5.6 | 6.0 | 2.5e-09 | 0.84 | 1.00 | 0.00 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | SH3GL1P3 | 0.26 | 0.31 | lasso | 7 | 0.31 | 1.5e-23 | 5.6 | 6.5 | 8.8e-11 | 0.90 | 1.00 | 0.00 | FALSE |
8 | GTEx | Colon Sigmoid | LINC00674 | 0.42 | 0.09 | lasso | 8 | 0.12 | 5.5e-05 | 6.4 | 5.8 | 6.5e-09 | 0.80 | 0.15 | 0.66 | FALSE |
9 | GTEx | Esophagus Muscularis | LINC00674 | 0.11 | 0.04 | lasso | 6 | 0.07 | 7.9e-05 | 3.8 | 5.8 | 7.9e-09 | 0.77 | 0.18 | 0.79 | FALSE |
10 | GTEx | Heart Atrial Appendage | LINC00674 | 0.14 | 0.08 | lasso | 17 | 0.09 | 1.1e-04 | 3.8 | 5.8 | 6.1e-09 | 0.73 | 0.05 | 0.88 | FALSE |
11 | GTEx | Lung | LINC00674 | 0.14 | 0.03 | enet | 22 | 0.08 | 2.1e-06 | 7.3 | 5.9 | 3.0e-09 | 0.80 | 0.14 | 0.86 | FALSE |
12 | GTEx | Nerve Tibial | LRRC37A16P | 0.09 | 0.08 | lasso | 4 | 0.06 | 2.7e-05 | 5.7 | 5.8 | 5.9e-09 | 0.84 | 0.11 | 0.77 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | BPTF | 0.10 | 0.01 | enet | 14 | 0.03 | 2.7e-03 | 5.4 | -5.6 | 2.2e-08 | -0.69 | 0.05 | 0.80 | FALSE |
14 | GTEx | Spleen | C17orf58 | 0.30 | -0.01 | lasso | 8 | -0.01 | 4.6e-01 | 4.0 | 5.8 | 6.3e-09 | 0.81 | 0.03 | 0.35 | FALSE |
15 | GTEx | Stomach | RP11-147L13.8 | 0.23 | -0.01 | enet | 9 | 0.01 | 8.1e-02 | 2.9 | 5.2 | 1.8e-07 | 0.57 | 0.04 | 0.18 | FALSE |
16 | YFS | Blood | KPNA2 | 0.01 | 0.01 | blup | 312 | 0.01 | 2.8e-04 | 6.4 | -7.6 | 4.2e-14 | -0.86 | 0.05 | 0.93 | FALSE |
17 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf58 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.8e-02 | 7.7 | 7.7 | 1.8e-14 | 1.00 | 0.00 | 0.76 | TRUE |