Best TWAS P=4.91e-12 · Best GWAS P=9.3e-12 conditioned to 0.000192
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CDK5RAP3 | 0.15 | 0.12 | bslmm | 392 | 0.14 | 3.6e-16 | 5.46 | -5.6 | 2.0e-08 | -0.78 | 0.63 | 0.37 | FALSE |
2 | GTEx | Adipose Subcutaneous | RP11-6N17.9 | 0.10 | 0.05 | enet | 14 | 0.05 | 6.8e-05 | -4.18 | -5.4 | 6.0e-08 | -0.42 | 0.46 | 0.07 | FALSE |
3 | GTEx | Adipose Visceral Omentum | MRPL45P2 | 0.24 | 0.00 | enet | 24 | 0.01 | 1.2e-01 | 4.83 | -5.4 | 5.6e-08 | -0.40 | 0.04 | 0.30 | FALSE |
4 | GTEx | Adipose Visceral Omentum | RP11-6N17.9 | 0.13 | 0.04 | enet | 16 | 0.05 | 8.4e-04 | -2.07 | -5.2 | 2.5e-07 | -0.47 | 0.25 | 0.34 | FALSE |
5 | GTEx | Artery Aorta | RP11-6N17.9 | 0.23 | 0.12 | enet | 19 | 0.19 | 9.5e-11 | -4.22 | -5.2 | 1.8e-07 | -0.42 | 0.99 | 0.01 | FALSE |
6 | GTEx | Artery Aorta | RP11-6N17.10 | 0.20 | 0.07 | enet | 24 | 0.14 | 3.5e-08 | -4.22 | -6.1 | 1.1e-09 | -0.43 | 0.47 | 0.16 | FALSE |
7 | GTEx | Brain Caudate basal ganglia | RP11-6N17.9 | 0.45 | -0.01 | enet | 28 | 0.16 | 3.3e-05 | -0.19 | -5.2 | 2.1e-07 | -0.48 | 0.06 | 0.16 | FALSE |
8 | GTEx | Brain Cerebellar Hemisphere | SNX11 | 0.25 | 0.19 | enet | 38 | 0.22 | 2.0e-06 | 3.24 | -5.7 | 1.5e-08 | -0.52 | 0.21 | 0.09 | FALSE |
9 | GTEx | Brain Cerebellar Hemisphere | CDK5RAP3 | 0.22 | 0.10 | lasso | 6 | 0.09 | 2.6e-03 | 4.83 | -6.1 | 1.3e-09 | -0.74 | 0.07 | 0.46 | FALSE |
10 | GTEx | Brain Cerebellar Hemisphere | RP11-6N17.10 | 0.21 | 0.16 | lasso | 5 | 0.13 | 3.8e-04 | 4.83 | -5.5 | 3.7e-08 | -0.73 | 0.08 | 0.50 | FALSE |
11 | GTEx | Brain Nucleus accumbens basal ganglia | CDK5RAP3 | 0.21 | 0.04 | lasso | 4 | 0.02 | 7.2e-02 | 5.70 | -5.9 | 4.1e-09 | -0.78 | 0.07 | 0.44 | FALSE |
12 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-6N17.9 | 0.47 | 0.05 | lasso | 17 | 0.11 | 8.3e-04 | 5.03 | -5.3 | 1.3e-07 | -0.65 | 0.10 | 0.44 | FALSE |
13 | GTEx | Cells Transformed fibroblasts | RP11-6N17.9 | 0.14 | 0.04 | enet | 17 | 0.08 | 2.3e-06 | -4.22 | -5.3 | 1.5e-07 | -0.39 | 0.96 | 0.02 | FALSE |
14 | GTEx | Esophagus Gastroesophageal Junction | CDK5RAP3 | 0.21 | 0.09 | lasso | 6 | 0.07 | 1.2e-03 | -4.22 | -6.2 | 6.6e-10 | -0.30 | 0.09 | 0.50 | FALSE |
15 | GTEx | Esophagus Gastroesophageal Junction | RP11-6N17.9 | 0.18 | 0.14 | lasso | 3 | 0.09 | 4.9e-04 | -4.22 | -5.5 | 4.2e-08 | -0.49 | 0.03 | 0.72 | FALSE |
16 | GTEx | Heart Atrial Appendage | CDK5RAP3 | 0.13 | 0.00 | enet | 18 | 0.04 | 5.1e-03 | 3.66 | -6.9 | 4.9e-12 | -0.42 | 0.09 | 0.05 | TRUE |
17 | GTEx | Muscle Skeletal | AC003665.1 | 0.05 | 0.03 | enet | 8 | 0.03 | 1.4e-03 | 5.58 | 6.6 | 5.0e-11 | 0.63 | 0.12 | 0.73 | FALSE |
18 | GTEx | Pancreas | CDK5RAP3 | 0.11 | -0.01 | lasso | 4 | 0.02 | 5.1e-02 | 4.83 | -5.5 | 4.4e-08 | -0.48 | 0.09 | 0.19 | FALSE |
19 | GTEx | Pancreas | EFCAB13 | 0.27 | 0.12 | enet | 15 | 0.11 | 2.4e-05 | -4.54 | -5.3 | 1.4e-07 | -0.03 | 0.05 | 0.81 | FALSE |
20 | GTEx | Stomach | RP11-6N17.9 | 0.13 | 0.02 | lasso | 6 | 0.04 | 8.0e-03 | 5.51 | -5.8 | 6.9e-09 | -0.70 | 0.10 | 0.74 | FALSE |
21 | GTEx | Testis | RP11-6N17.4 | 0.14 | 0.02 | lasso | 10 | 0.02 | 4.8e-02 | 5.67 | 5.7 | 1.3e-08 | 0.78 | 0.15 | 0.71 | FALSE |
22 | GTEx | Thyroid | CDK5RAP3 | 0.21 | 0.14 | lasso | 5 | 0.18 | 1.6e-13 | -4.22 | -5.3 | 1.2e-07 | -0.51 | 1.00 | 0.00 | FALSE |
23 | GTEx | Thyroid | RP11-6N17.9 | 0.22 | 0.14 | lasso | 5 | 0.14 | 5.2e-11 | -4.22 | -5.2 | 2.6e-07 | -0.44 | 1.00 | 0.00 | FALSE |
24 | GTEx | Thyroid | RP11-6N17.10 | 0.19 | 0.12 | lasso | 5 | 0.13 | 3.0e-10 | -4.22 | -5.3 | 1.1e-07 | -0.47 | 1.00 | 0.00 | FALSE |
25 | YFS | Blood | UBE2Z | 0.06 | 0.03 | enet | 19 | 0.06 | 1.5e-18 | 2.48 | 5.6 | 2.6e-08 | 0.10 | 0.68 | 0.06 | TRUE |
26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDK5RAP3 | 0.05 | 0.03 | lasso | 2 | 0.02 | 1.8e-05 | 5.51 | -5.6 | 2.2e-08 | -0.76 | 0.00 | 1.00 | FALSE |
27 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CBX1 | 0.03 | 0.01 | lasso | 3 | 0.01 | 8.7e-03 | 5.70 | -5.1 | 2.8e-07 | -0.80 | 0.02 | 0.52 | FALSE |
28 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SNX11 | 0.07 | 0.07 | blup | 53 | 0.08 | 1.4e-09 | 3.45 | -5.2 | 1.7e-07 | -0.58 | 0.94 | 0.05 | FALSE |
29 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CBX1 | 0.03 | 0.04 | lasso | 4 | 0.04 | 3.7e-05 | 5.72 | -5.6 | 1.7e-08 | -0.84 | 0.04 | 0.95 | FALSE |
30 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CDK5RAP3 | 0.06 | 0.00 | blup | 62 | 0.03 | 1.0e-03 | -2.72 | -5.8 | 6.3e-09 | -0.35 | 0.01 | 0.70 | FALSE |