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chr17:44,788,310-47,688,526

Best TWAS P=4.91e-12 · Best GWAS P=9.3e-12 conditioned to 0.000192

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	GTEx	Heart Atrial Appendage	CDK5RAP3	0.13	0.00	enet	18	0.04	5.1e-03	3.66	-6.9	4.9e-12	-0.42	0.09	0.05	TRUE
25	YFS	Blood	UBE2Z	0.06	0.03	enet	19	0.06	1.5e-18	2.48	5.6	2.6e-08	0.10	0.68	0.06	TRUE
17	GTEx	Muscle Skeletal	AC003665.1	0.05	0.03	enet	8	0.03	1.4e-03	5.58	6.6	5.0e-11	0.63	0.12	0.73	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	CDK5RAP3	0.21	0.09	lasso	6	0.07	1.2e-03	-4.22	-6.2	6.6e-10	-0.30	0.09	0.50	FALSE
6	GTEx	Artery Aorta	RP11-6N17.10	0.20	0.07	enet	24	0.14	3.5e-08	-4.22	-6.1	1.1e-09	-0.43	0.47	0.16	FALSE
9	GTEx	Brain Cerebellar Hemisphere	CDK5RAP3	0.22	0.10	lasso	6	0.09	2.6e-03	4.83	-6.1	1.3e-09	-0.74	0.07	0.46	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	CDK5RAP3	0.21	0.04	lasso	4	0.02	7.2e-02	5.70	-5.9	4.1e-09	-0.78	0.07	0.44	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDK5RAP3	0.06	0.00	blup	62	0.03	1.0e-03	-2.72	-5.8	6.3e-09	-0.35	0.01	0.70	FALSE
20	GTEx	Stomach	RP11-6N17.9	0.13	0.02	lasso	6	0.04	8.0e-03	5.51	-5.8	6.9e-09	-0.70	0.10	0.74	FALSE
21	GTEx	Testis	RP11-6N17.4	0.14	0.02	lasso	10	0.02	4.8e-02	5.67	5.7	1.3e-08	0.78	0.15	0.71	FALSE
8	GTEx	Brain Cerebellar Hemisphere	SNX11	0.25	0.19	enet	38	0.22	2.0e-06	3.24	-5.7	1.5e-08	-0.52	0.21	0.09	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	CBX1	0.03	0.04	lasso	4	0.04	3.7e-05	5.72	-5.6	1.7e-08	-0.84	0.04	0.95	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CDK5RAP3	0.15	0.12	bslmm	392	0.14	3.6e-16	5.46	-5.6	2.0e-08	-0.78	0.63	0.37	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDK5RAP3	0.05	0.03	lasso	2	0.02	1.8e-05	5.51	-5.6	2.2e-08	-0.76	0.00	1.00	FALSE
10	GTEx	Brain Cerebellar Hemisphere	RP11-6N17.10	0.21	0.16	lasso	5	0.13	3.8e-04	4.83	-5.5	3.7e-08	-0.73	0.08	0.50	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	RP11-6N17.9	0.18	0.14	lasso	3	0.09	4.9e-04	-4.22	-5.5	4.2e-08	-0.49	0.03	0.72	FALSE
18	GTEx	Pancreas	CDK5RAP3	0.11	-0.01	lasso	4	0.02	5.1e-02	4.83	-5.5	4.4e-08	-0.48	0.09	0.19	FALSE
3	GTEx	Adipose Visceral Omentum	MRPL45P2	0.24	0.00	enet	24	0.01	1.2e-01	4.83	-5.4	5.6e-08	-0.40	0.04	0.30	FALSE
2	GTEx	Adipose Subcutaneous	RP11-6N17.9	0.10	0.05	enet	14	0.05	6.8e-05	-4.18	-5.4	6.0e-08	-0.42	0.46	0.07	FALSE
24	GTEx	Thyroid	RP11-6N17.10	0.19	0.12	lasso	5	0.13	3.0e-10	-4.22	-5.3	1.1e-07	-0.47	1.00	0.00	FALSE
22	GTEx	Thyroid	CDK5RAP3	0.21	0.14	lasso	5	0.18	1.6e-13	-4.22	-5.3	1.2e-07	-0.51	1.00	0.00	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	RP11-6N17.9	0.47	0.05	lasso	17	0.11	8.3e-04	5.03	-5.3	1.3e-07	-0.65	0.10	0.44	FALSE
19	GTEx	Pancreas	EFCAB13	0.27	0.12	enet	15	0.11	2.4e-05	-4.54	-5.3	1.4e-07	-0.03	0.05	0.81	FALSE
13	GTEx	Cells Transformed fibroblasts	RP11-6N17.9	0.14	0.04	enet	17	0.08	2.3e-06	-4.22	-5.3	1.5e-07	-0.39	0.96	0.02	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNX11	0.07	0.07	blup	53	0.08	1.4e-09	3.45	-5.2	1.7e-07	-0.58	0.94	0.05	FALSE
5	GTEx	Artery Aorta	RP11-6N17.9	0.23	0.12	enet	19	0.19	9.5e-11	-4.22	-5.2	1.8e-07	-0.42	0.99	0.01	FALSE
7	GTEx	Brain Caudate basal ganglia	RP11-6N17.9	0.45	-0.01	enet	28	0.16	3.3e-05	-0.19	-5.2	2.1e-07	-0.48	0.06	0.16	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-6N17.9	0.13	0.04	enet	16	0.05	8.4e-04	-2.07	-5.2	2.5e-07	-0.47	0.25	0.34	FALSE
23	GTEx	Thyroid	RP11-6N17.9	0.22	0.14	lasso	5	0.14	5.2e-11	-4.22	-5.2	2.6e-07	-0.44	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CBX1	0.03	0.01	lasso	3	0.01	8.7e-03	5.70	-5.1	2.8e-07	-0.80	0.02	0.52	FALSE