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chr17:73,059,836-75,146,266

Best TWAS P=3.18e-10 · Best GWAS P=1.23e-08 conditioned to 0.0156

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TRIM47	0.15	0.12	enet	13	0.14	2.8e-17	4.4	-5.2	1.7e-07	-0.61	0.02	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TRIM65	0.21	0.17	lasso	5	0.21	5.2e-25	5.1	5.4	5.3e-08	0.65	0.11	0.89	FALSE
3	GTEx	Adipose Subcutaneous	RNF157	0.20	0.06	enet	14	0.10	1.0e-08	-4.5	5.2	2.4e-07	0.11	0.78	0.19	FALSE
4	GTEx	Adipose Subcutaneous	MRPL38	0.08	0.07	lasso	4	0.06	9.3e-06	5.4	-5.4	6.6e-08	-0.76	0.02	0.97	FALSE
5	GTEx	Adipose Subcutaneous	RNF157-AS1	0.24	0.11	enet	33	0.11	2.0e-09	2.9	5.3	1.4e-07	0.21	0.98	0.01	FALSE
6	GTEx	Brain Cerebellum	TRIM47	0.30	0.17	lasso	2	0.17	1.1e-05	5.6	-5.3	1.4e-07	-0.60	0.03	0.94	FALSE
7	GTEx	Brain Hypothalamus	TRIM65	0.26	0.09	lasso	7	0.12	9.7e-04	3.8	5.7	1.5e-08	0.81	0.03	0.69	FALSE
8	GTEx	Cells Transformed fibroblasts	TRIM65	0.18	0.13	lasso	8	0.12	4.0e-09	5.6	5.5	3.4e-08	0.58	0.02	0.98	FALSE
9	GTEx	Liver	GALK1	0.35	0.16	lasso	9	0.24	2.6e-07	4.5	5.7	1.4e-08	0.86	0.02	0.96	FALSE
10	GTEx	Lung	UNC13D	0.12	0.09	enet	15	0.10	3.4e-08	5.5	5.3	1.5e-07	0.69	0.02	0.98	FALSE
11	GTEx	Lung	RP11-552F3.10	0.12	0.02	lasso	2	0.03	4.4e-03	5.5	-6.3	3.2e-10	-0.60	0.03	0.38	TRUE
12	GTEx	Muscle Skeletal	FBF1	0.07	0.02	lasso	4	0.02	8.0e-03	5.5	5.3	1.1e-07	0.64	0.03	0.95	FALSE
13	GTEx	Nerve Tibial	TRIM65	0.25	0.10	lasso	6	0.16	8.7e-12	5.0	5.6	2.3e-08	0.64	0.03	0.97	FALSE
14	GTEx	Skin Sun Exposed Lower leg	TRIM47	0.09	0.03	lasso	3	0.03	1.5e-03	5.4	-5.3	1.0e-07	-0.70	0.03	0.96	FALSE
15	GTEx	Skin Sun Exposed Lower leg	MRPL38	0.18	0.10	lasso	6	0.09	4.8e-08	5.3	-5.6	2.4e-08	-0.66	0.06	0.94	FALSE
16	GTEx	Thyroid	WBP2	0.07	0.06	lasso	2	0.06	4.1e-05	5.0	5.4	6.4e-08	0.87	0.03	0.95	FALSE
17	GTEx	Vagina	UBE2O	0.48	-0.01	enet	59	0.04	3.8e-02	-2.7	5.6	2.7e-08	0.28	0.05	0.19	FALSE
18	YFS	Blood	GALK1	0.05	0.04	enet	26	0.04	2.4e-13	5.6	-5.7	1.3e-08	-0.77	0.01	0.98	FALSE
19	The Cancer Genome Atlas	Glioblastoma Multiforme	TRIM65	0.08	0.02	enet	7	0.04	1.9e-02	5.3	5.8	5.8e-09	0.69	0.01	0.68	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIM65	0.07	0.07	lasso	3	0.09	5.7e-10	5.2	5.5	4.7e-08	0.64	0.05	0.95	FALSE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM47	0.04	0.01	blup	30	0.03	2.7e-04	5.5	-5.2	2.5e-07	-0.51	0.01	0.70	FALSE
22	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C17orf106	0.12	0.04	blup	46	0.03	1.5e-02	3.5	-5.1	2.9e-07	-0.46	0.03	0.10	FALSE
23	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C17orf106	0.22	0.14	blup	45	0.13	6.9e-06	3.5	-5.3	1.3e-07	-0.49	0.07	0.30	FALSE
24	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FBF1	0.08	0.05	blup	41	0.04	1.1e-02	4.4	5.5	4.5e-08	0.68	0.02	0.78	FALSE
25	The Cancer Genome Atlas	Stomach Adenocarcinoma	MRPL38	0.04	0.01	blup	29	0.03	5.0e-03	5.1	-6.0	2.5e-09	-0.67	0.02	0.61	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM47	0.06	0.06	blup	30	0.06	1.6e-06	5.5	-5.5	4.6e-08	-0.60	0.01	0.99	FALSE