Hub : Genes

WBP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0490	0.025	0.0160	0.005	0.019	-0.001	0.025	0.000	0.06500	0.002	5.0e-01	0.00048	3.6e-01
2	GTEx	Adipose Subcutaneous	0.0870	0.039	0.0095	-0.002	NA	0.003	NA	0.000	0.51000	NA	1.8e-01	NA	3.5e-01
3	GTEx	Thyroid	0.0720	0.033	0.0044	0.065	NA	0.050	NA	0.056	0.00001	NA	9.7e-05	NA	4.1e-05
4	YFS	Blood	0.0145	0.008	0.0210	0.009	0.002	0.014	0.004	0.009	0.00054	0.067	2.0e-05	0.01200	3.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.6	1.5	-0.0	0.2	0.9	1.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.7	-0.0	0.6	-0.2
Depressed Affect (Nagel 2018)	2.0	4.2	6.8	-1.1	-2.6	-2.3	1.9
Depression (Nagel 2018)	0.7	1.1	2.5	-1.6	-0.4	-0.3	1.3
Intelligence (Savage-Jansen 2018)	1.2	3.7	7.6	0.6	2.8	2.6	-0.5
Neuroticism (Nagel 2018)	0.8	1.9	4.2	-0.1	-2.0	-1.5	1.1
Schizophrenia (2018)	0.3	0.6	1.4	-0.9	-0.2	0.0	-1.2
Schizophrenia vs Biploar Disorder	0.5	0.7	1.1	-0.9	0.5	-0.7	-1.0
Worry (Nagel 2018)	1.5	3.1	7.3	0.2	-2.7	-2.3	0.4
Alzheimer’s Disease (in mother)	0.7	0.9	2.8	-1.7	-0.1	0.5	0.6
Alzheimer’s Disease (in father)	0.4	0.4	1.7	0.1	-0.1	1.3	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	-1.0	-0.4	0.8	0.8
Crohns Disease (2017)	1.0	2.2	5.5	-0.0	-1.0	-2.3	1.5
Irritable Bowel Disease (IBD)	1.2	3.0	5.3	1.9	-1.6	-2.3	0.1
Ulcerative Colitis (UC)	1.6	3.0	6.2	2.5	-1.7	-1.2	-1.4
Major Depression (MDD)	0.5	0.6	1.7	0.1	-1.3	-0.7	0.3
Reaction Time	1.0	1.9	4.8	0.8	2.2	1.5	-0.1
Verbal and Numeric Reasoning (VNR)	1.3	3.1	8.2	1.1	2.9	1.8	0.3
Breast Cancer	1.1	2.6	5.1	1.4	-1.8	-2.2	0.5
Ovarian Cancer	0.5	0.6	1.3	0.9	0.4	0.3	-1.1
Prostate Cancer	2.0	2.8	4.8	0.1	-1.9	-1.7	2.2
Age at First Birth	0.7	1.0	2.2	-1.5	-0.7	-1.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.4	1.9	4.4	-0.5	1.6	2.1	-0.8
Coronary Artery Disease (CAD)	3.7	4.4	11.3	-1.8	-0.2	-1.7	3.4
Crohns Disease (2012)	1.4	2.3	4.8	-0.2	-0.4	-2.0	2.2
Mean Putamen Volume	0.6	0.7	1.8	-0.3	-1.3	-1.0	0.0
Fasting Glucose	0.4	0.5	0.6	0.5	-0.8	-0.8	0.6
HbA1C	0.4	0.5	0.9	-1.0	0.4	-0.3	0.9
HDL Cholesterol	1.5	2.5	4.9	-0.4	1.6	2.2	-1.6
LDL Cholesterol	2.7	4.2	9.5	0.2	-2.2	-3.1	1.7
Lupus	0.2	0.4	0.9	-0.9	0.7	0.3	-0.2
Neuroticism (2016)	0.4	0.6	1.1	0.3	-0.6	-0.9	1.1
Primary Biliary Cirrhosis	1.0	1.4	2.9	-0.7	-0.4	-1.4	1.7
Rheumatoid Arthritis	1.4	1.9	3.9	0.6	0.8	2.0	-1.7
Schizophrenia (2014)	0.1	0.3	0.7	-0.8	0.3	0.2	-0.5
Triglycerides	0.8	1.3	1.9	1.2	-0.8	-1.4	1.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.0	1.0	0.2	-0.4	0.5
Ulcerative Colitis	0.8	1.2	3.1	1.8	-0.8	-0.9	-0.5
Blood Eosinophil Count	2.3	17.8	45.0	1.1	-4.0	-6.7	3.1
Blood Platelet Count	0.9	10.2	21.1	4.6	0.3	-2.7	3.5
Blood Red Count	0.5	4.6	6.8	2.1	1.4	2.3	-2.6
Blood White Count	1.0	7.7	20.3	1.3	-2.5	-4.5	1.5
Heel T-Score	0.6	4.4	8.2	-2.5	-2.9	-1.5	1.1
BMI	1.3	7.4	20.5	-0.9	2.4	4.5	-1.6
Height	0.5	9.7	22.5	3.2	0.3	2.5	-4.7
Waist Hip Ratio (WHR)	1.7	7.5	11.9	2.8	-3.5	-3.1	1.0
Systolic Blood Pressure	3.0	14.8	29.2	1.7	-3.7	-5.4	3.7
Smoking Status	0.5	1.2	2.1	-1.5	-1.2	0.1	-1.1
Allergy or Eczema	1.2	3.1	7.6	-1.7	2.8	0.9	1.0
Cardiovascular Disease	4.6	15.1	30.1	1.9	-3.8	-5.5	3.5
Hypothyroidism (self reported)	1.7	3.8	5.2	-2.3	-0.7	2.1	-2.3
Respiratory disease	3.9	8.6	14.0	-2.7	3.4	3.7	-1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	-0.8	-0.4	-1.2	0.1
Lung FEV1/FVC ratio	0.6	3.0	8.7	0.8	-0.7	-1.5	3.0
Lung FVC	1.2	6.0	17.7	-4.2	0.3	2.2	-1.0
Neuroticism	1.7	4.2	6.7	-0.7	-2.6	-2.4	2.0
Chronotype (morning person)	1.0	2.4	7.4	2.7	-0.5	-1.3	0.4
Hair Pigment	0.2	5.9	13.6	3.7	-1.4	-2.9	0.3
Tanning	0.1	1.8	3.2	-1.1	1.8	1.7	0.3
Hand grip strength (left)	0.6	1.5	5.0	2.2	0.1	-1.0	-0.1
Number of treatments/medications taken	0.3	0.6	1.0	-0.8	-0.1	-1.0	0.9
Average weekly spirits intake	0.9	1.1	3.2	1.0	0.4	0.2	-1.8
Sensitivity / hurt feelings	0.9	1.5	4.2	0.1	-1.0	-0.9	2.1
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.4	-0.5	-0.7	-0.6	1.2
Hearing difficulty/problems: Yes	1.1	1.7	4.5	2.1	1.2	0.9	0.1
Relative age of first facial hair	0.5	1.0	2.1	-0.4	-1.4	-1.2	-0.3
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.7	-0.7	0.9	1.6	-1.7
Ever used hormone-replacement therapy (HRT)	2.8	3.5	6.3	-1.9	-1.5	-2.5	1.4
Ever had hysterectomy (womb removed)	0.9	1.0	3.8	-1.9	0.3	0.1	0.5
Systolic blood pressure, automated reading	2.2	6.5	12.5	-0.1	-3.3	-3.5	1.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.8	-0.1	0.2	-0.1	-0.9
Angina	0.2	0.3	1.2	-1.1	-0.1	-0.1	-0.1
Medication for hormone replacement therapy	1.0	1.2	2.9	-0.4	-0.8	-1.7	1.0
Vitamin and mineral supplements	1.0	1.3	4.0	-0.8	-0.2	-0.7	2.0
Supplements: Zinc	0.1	0.1	0.2	-0.5	0.1	0.4	-0.1
Medication: Co-codamol	1.3	1.5	2.7	-1.6	-1.3	-0.6	-1.1
Medication: Metformin	0.3	0.4	0.6	-0.4	0.7	-0.8	0.5
Diabetes (father)	0.3	0.4	0.8	-0.8	-0.2	-0.9	0.1
Diabetes (mother)	1.7	2.2	8.3	2.9	0.1	-0.3	-0.5
Severe depression (siblings)	2.0	2.3	3.8	0.1	1.6	2.0	-1.6
Pack years adult smoking proportion	0.9	1.3	3.6	-0.8	-0.8	0.8	-1.9
Impedance of leg (right)	0.4	2.0	5.4	0.6	-2.3	-1.5	0.3
Leg fat-free mass (left)	1.2	6.3	12.5	0.8	2.5	3.5	-2.4
Trunk fat percentage	1.9	7.4	21.1	-1.3	2.0	4.6	-1.7
Hand grip strength (right)	0.5	1.5	5.5	2.3	0.2	-0.4	-0.4
Townsend deprivation index at recruitment	0.3	0.5	1.3	0.4	-1.1	-0.5	-0.4
Current tobacco smoking	0.5	0.8	1.8	-0.6	-1.3	-1.0	-0.4
Average weekly fortified wine intake	1.9	2.3	4.4	0.3	1.7	2.1	-1.3
Maternal smoking around birth	2.2	3.2	5.7	-1.4	1.3	2.4	-1.8
Fed-up feelings	2.0	3.6	6.0	-0.5	-1.9	-2.1	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	-0.2	-0.0	-0.4	1.1
Relative age voice broke	0.3	0.4	1.4	1.2	0.5	-0.1	0.2
Taking other prescription medications	1.2	1.9	3.4	-1.0	1.6	1.8	0.8
Age when periods started (menarche)	0.2	0.5	0.8	-0.6	0.9	0.7	-0.5
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	3.9	-2.0	0.6	1.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.4	-1.5	-1.2	0.6	-0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	-0.8	-0.2	0.4	0.2
Qualifications: CSEs or equivalent	1.0	1.3	2.2	1.1	-1.1	-1.5	-0.8
Serious illness, injury or assault to yourself	1.5	1.8	3.0	1.2	1.7	1.4	-0.9
High blood pressure	3.5	9.8	21.3	2.0	-2.7	-4.6	2.5
Hayfever, allergic rhinitis or eczema	2.7	5.8	12.1	-1.9	3.5	2.6	0.8
Multivitamins +/- minerals	1.3	1.7	3.4	1.4	0.8	0.8	-1.8
Stomach or abdominal pain in last month	0.8	1.0	2.6	-0.0	-1.6	-0.2	1.1
Supplements: Glucosamine	0.7	0.9	1.9	1.4	-0.7	-1.0	-0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.2	0.4	0.4	-0.3
Medication: Atenolol	2.8	3.5	6.2	0.6	-1.8	-2.5	2.1
Medication: Levothyroxine sodium	2.2	3.6	8.6	-2.9	-1.7	0.8	-1.6
Sitting height	0.3	2.0	4.0	1.2	2.0	1.4	-0.7
Chronic bronchitis/emphysema (father)	0.8	0.9	1.9	-1.4	0.7	0.8	0.8
High blood pressure (mother)	2.9	4.0	6.2	0.8	-2.5	-2.1	2.2
Body mass index (BMI)	1.1	4.6	12.6	-0.8	2.1	3.5	-0.9
Impedance of leg (left)	0.7	3.2	6.9	0.4	-2.6	-2.1	1.2
Leg predicted mass (left)	1.2	6.4	12.8	0.8	2.4	3.6	-2.5
Trunk fat mass	1.8	7.8	21.0	-0.7	2.2	4.6	-2.2
Waist circumference	0.8	2.9	8.9	-0.3	0.7	3.0	-1.4
Number of incorrect matches in round	1.7	2.8	7.3	0.6	-1.8	-2.7	0.5
Past tobacco smoking	0.3	0.6	1.4	1.2	-0.4	-0.5	0.8
Alcohol usually taken with meals	1.6	2.5	3.6	-1.8	0.5	-1.9	1.8
Nervous feelings	0.9	1.7	3.4	-0.3	-1.8	-1.8	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.7	-0.7	0.1	-0.9	1.6
Hearing difficulty/problems with background noise	0.3	0.5	1.2	-0.9	0.1	1.1	0.4
Hair/balding pattern: Pattern 2	0.3	0.3	0.5	-0.7	-0.2	-0.4	-0.7
Had menopause	0.3	0.3	0.7	-0.5	-0.2	0.5	-0.8
Had other major operations	0.5	0.6	1.6	-0.9	0.2	-0.2	1.3
Forced vital capacity (FVC)	0.9	3.7	7.3	-1.7	1.4	2.7	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.2	-1.5	-1.8	0.1	-0.8
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	10.7	1.1	0.6	-0.9	3.3
Qualifications: None of the above	0.1	0.2	0.4	0.5	0.3	0.4	-0.6
Financial difficulties in last 2 years	1.2	1.6	3.0	0.2	1.7	1.7	0.7
Mouth/teeth dental problems	1.2	1.9	6.0	1.1	-0.3	0.2	-2.4
Heart attack	1.7	2.2	4.0	-0.7	-1.2	-2.0	1.7
Allergy	3.6	8.3	13.0	2.9	-3.3	-3.6	1.0
Pain all over the body in last month	1.8	1.9	4.7	-2.2	-1.0	0.0	-1.4
Diabetes (self-reported)	0.2	0.3	0.8	-0.4	0.9	-0.2	-0.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.5	-0.2	1.6	1.0	0.2
Medication: Ramipril	0.6	0.8	2.0	-0.9	-0.1	-0.4	1.4
Medication: Simvastatin	4.5	6.7	18.3	0.4	-2.3	-4.3	1.7
Fluid intelligence score	0.8	1.6	4.3	1.0	2.1	1.1	0.1
Illnesses of siblings	3.2	4.5	11.3	1.5	0.1	2.1	-3.4
Neuroticism score	1.9	3.9	6.5	0.1	-2.1	-2.5	2.1
Weight	1.2	5.7	14.4	0.1	2.0	3.8	-2.1
Impedance of arm (right)	0.3	1.4	3.3	-1.8	-0.6	1.2	-0.7
Arm fat percentage (right)	2.0	7.7	22.0	-1.8	2.0	4.7	-1.3
Trunk fat-free mass	0.4	2.6	4.2	2.0	0.7	1.2	-2.0
Hip circumference	2.7	11.7	29.2	-1.5	2.9	5.4	-2.7
Time employed in main current job	1.1	1.3	2.6	-0.2	-1.5	0.3	-1.6
Alcohol intake versus 10 years previously	4.3	6.4	12.6	-0.7	-3.0	-3.5	1.9
Father’s age at death	1.3	1.7	3.0	-1.7	1.6	1.0	-0.4
Worrier / anxious feelings	2.0	3.7	8.3	0.8	-2.3	-2.9	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.1	-1.2	0.5	0.2	2.0
Falls in the last year	0.6	0.8	2.3	-0.6	1.5	0.7	0.4
Hair/balding pattern: Pattern 3	0.7	1.0	2.8	0.4	1.0	0.4	1.7
Number of live births	1.2	1.7	2.9	-1.7	1.3	1.1	-1.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.7	-0.9	1.5	2.4	-0.9
Pulse rate	1.5	2.5	5.6	0.9	0.1	-2.4	1.9
Happiness	1.6	1.9	5.5	-1.2	-0.7	-0.4	2.4
Noisy workplace	0.3	0.3	0.9	-0.6	-0.4	-0.9	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	0.1	0.6	0.6	0.6
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.5	4.3	-1.2	2.0	2.1	-0.0
Mouth/teeth dental problems: Dentures	0.4	0.7	2.3	-0.2	0.2	0.8	1.5
Asthma	4.7	9.2	17.2	-1.6	4.2	4.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	5.4	-0.7	-0.5	-0.9	2.3
Medication: Cholesterol lowering	2.1	3.3	9.1	0.9	-0.9	-3.0	1.5
Depression (self-reported)	0.3	0.4	0.9	-0.5	-0.5	-0.5	0.9
Medication: Lansoprazole	0.3	0.4	0.6	0.7	0.5	0.5	-0.8
Prospective memory result	1.7	2.1	4.1	1.4	-1.3	-2.0	-0.7
Lung cancer (father)	1.2	1.4	4.1	-0.4	-2.0	-0.8	-0.9
Illnesses of mother	1.2	1.4	4.8	-0.5	-0.1	0.9	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	7.4	-1.1	1.6	2.7	-0.5
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.7	0.1	-0.8	-0.5
Impedance of arm (left)	0.3	1.4	2.7	-1.6	-0.2	1.5	-0.9
Arm fat mass (right)	1.7	6.9	19.4	-0.6	2.3	4.4	-1.5
Trunk predicted mass	0.5	2.6	4.4	2.1	0.6	1.2	-2.0
Standing height	0.4	4.1	8.1	2.6	0.1	1.1	-2.9
Length of working week for main job	0.5	0.6	1.7	-0.1	1.3	0.5	0.6
Exposure to tobacco smoke at home	0.7	0.8	2.4	0.5	-1.5	-0.4	0.5
Breastfed as a baby	0.1	0.1	0.2	0.4	0.5	0.1	-0.2
Tense / ‘highly strung’	0.1	0.1	0.3	-0.5	-0.4	0.1	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.5	0.0	0.1	-0.5
Hair/balding pattern: Pattern 4	3.0	7.4	13.1	1.9	-3.4	-3.6	1.1
Birth weight of first child	0.7	1.3	3.3	1.8	0.4	-1.0	0.8
Peak expiratory flow (PEF)	0.6	1.4	3.9	-0.9	1.0	2.0	0.1
Pulse wave reflection index	0.7	0.8	2.6	0.4	-0.3	0.7	-1.6
Ever highly irritable/argumentative for 2 days	2.6	3.2	4.4	-0.1	2.1	2.1	2.0
Loud music exposure frequency	1.4	1.6	3.1	-0.5	-1.0	-1.4	1.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.0	1.0	0.6	1.0	-0.2
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.3	-1.8	0.4	-0.0	1.5
Blood clot in the leg (DVT)	2.5	3.2	8.0	-2.8	-1.0	0.2	-1.9
Medication: Paracetamol	0.8	1.3	3.2	0.9	-1.8	-0.7	0.8
Headache pain in last month	1.3	2.2	4.6	2.1	1.2	-0.4	1.7
Medication for cholesterol, blood pressure or diabetes	2.7	4.4	12.6	-1.0	2.0	3.5	-0.6
Glaucoma (self-reported)	1.2	1.4	3.2	0.5	-0.6	-1.8	1.3
Gout (self-reported)	0.6	0.9	1.5	-0.6	-1.1	-0.5	-1.2
Hypothyroidism/myxoedema (self-reported)	2.0	3.8	5.8	-2.3	-1.1	1.8	-2.4
Medication: Amlodipine	6.3	8.8	15.4	-1.8	-2.5	-3.9	3.2
Medication: Ventolin 100micrograms inhaler	1.3	1.7	2.8	-0.5	1.7	1.4	-1.4
Birth weight	0.6	1.3	2.6	1.5	-0.0	0.4	-1.6
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.7	1.3	0.8	1.0	-0.3
High blood pressure (siblings)	3.9	5.6	11.7	-1.6	-1.3	-2.5	3.4
Forced vital capacity (FVC), Best measure	0.9	3.5	7.3	-1.9	1.6	2.7	-0.7
Body fat percentage	1.8	6.9	19.8	-1.3	1.9	4.5	-1.7
Leg fat percentage (right)	1.3	4.6	13.8	-0.8	1.3	3.7	-1.6
Arm fat-free mass (right)	0.7	3.3	4.2	2.0	1.4	1.9	-2.0
Exposure to tobacco smoke outside home	0.2	0.3	1.0	-0.0	0.2	-0.1	1.0
Comparative body size at age 10	0.7	1.9	4.3	-2.1	-0.7	-1.7	-0.1
Number of full brothers	1.9	2.4	3.8	1.6	1.9	1.5	1.0
Worry too long after embarrassment	0.4	0.6	0.9	0.3	0.8	0.9	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.4	0.1	-0.1	0.8
Wheeze or whistling in the chest in last year	1.5	2.6	4.0	-2.0	1.3	2.0	-1.0
Number of children fathered	1.1	1.3	3.0	-1.1	0.4	1.7	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	4.7	0.0	-2.2	-2.0	-0.4
Age at first live birth	0.1	0.3	0.7	0.8	0.6	0.1	-0.0
Pulse wave peak to peak time	0.3	0.3	0.6	-0.6	0.0	0.8	0.6
Health satisfaction	0.9	1.1	2.3	-1.3	-0.7	1.5	0.2
Shortness of breath walking on level ground	1.5	1.8	2.5	-1.5	1.5	1.6	0.5
Qualifications: College or University degree	0.2	0.7	2.4	-0.4	-1.6	-0.3	-0.5
Eye problems/disorders: None of the above	1.2	1.4	3.1	0.5	1.8	1.4	-0.5
Mouth/teeth dental problems: Loose teeth	2.1	2.5	5.8	-2.4	-1.6	-1.2	0.6
Emphysema/chronic bronchitis	1.1	1.2	3.6	0.2	0.5	0.9	-1.9
Medication for pain relief, constipation, heartburn	1.6	2.7	9.8	0.2	0.4	1.0	-3.1
Neck or shoulder pain in last month	1.3	1.9	4.2	0.1	-1.0	-2.1	1.5
Medication: Blood pressure	2.5	4.4	10.9	1.5	-1.8	-3.3	1.0
Angina (self-reported)	0.2	0.3	1.3	-1.1	0.1	0.1	-0.1
Migraine (self-reported)	3.1	3.8	10.6	3.3	1.5	1.1	-1.0
Medication: Ibuprofen	1.5	1.7	4.9	-1.3	-0.6	-0.2	2.2
Medication: Allopurinol	0.4	0.5	1.2	0.9	-0.5	-0.2	-1.1
Medication: Omeprazole	0.7	0.8	1.9	-1.0	-0.4	0.6	1.4
Medication: Seretide 50 evohaler	1.2	1.4	2.1	-1.2	1.4	1.4	0.1
Mean time to correctly identify matches	0.5	1.0	2.5	0.7	1.6	0.7	0.8
Heart disease (mother)	2.2	2.7	4.1	1.8	1.8	0.4	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.4	0.5	1.1	1.6	-1.4
Whole body fat mass	1.6	6.6	18.2	-0.6	2.0	4.3	-1.9
Leg fat mass (right)	1.7	6.6	18.4	-0.4	1.9	4.3	-2.0
Arm predicted mass (right)	0.8	3.9	4.3	2.0	1.8	2.1	-2.0
Pulse rate, automated reading	1.2	3.8	6.6	2.6	-0.7	-2.4	1.5
Alcohol intake frequency.	0.7	1.7	3.5	1.3	-0.2	-1.2	1.9
Comparative height size at age 10	0.2	1.3	2.5	1.4	0.3	0.7	-1.6
Number of full sisters	2.7	3.2	9.4	-0.4	1.1	3.1	-1.4
Suffer from ‘nerves’	3.1	4.9	8.4	0.7	-2.9	-2.9	1.6
Overall health rating	1.2	2.6	3.9	-0.7	-1.5	-1.9	2.0
Chest pain or discomfort	0.1	0.2	0.3	-0.2	-0.3	0.6	0.4
Had major operations	0.3	0.3	0.6	0.3	-0.4	-0.7	0.6
Age at last live birth	0.3	0.5	0.6	-0.5	0.8	0.7	-0.8
Family relationship satisfaction	1.9	2.4	3.3	-1.7	-1.8	-1.5	1.0
Leg pain on walking	2.7	3.3	5.4	-1.0	-1.8	-2.0	2.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.6	-0.1	1.4	0.1	1.6
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.7	-0.8	-0.6	0.5	-0.7
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.8	0.3	-1.4	-1.2	0.1
Medication: Aspirin	0.8	1.0	1.6	-1.2	-0.4	-1.3	0.9
Supplements: Vitamin C	0.5	0.5	1.1	0.9	0.5	1.1	-0.2
Knee pain experienced in last month	2.5	3.8	6.1	-1.1	-1.8	-2.5	2.2
Hypertension (Self-reported)	3.8	10.5	22.4	1.4	-3.2	-4.7	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.5	1.0	0.9	1.2	-0.0
Illnesses of father: Heart disease	1.3	1.9	3.9	0.4	0.1	-2.0	1.9
Illnesses of siblings: Diabetes	1.2	1.5	3.9	-1.2	0.4	-0.7	2.0
Smoking status: Previous	0.3	0.4	1.4	-0.6	-0.0	0.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	3.8	2.0	0.7	1.3	-1.5
Whole body fat-free mass	0.6	3.5	5.1	1.6	1.4	2.1	-2.3
Leg fat-free mass (right)	0.9	4.8	9.5	0.6	2.2	3.1	-2.1
Arm fat percentage (left)	2.2	8.8	24.6	-1.6	2.4	5.0	-1.6
Average weekly red wine intake	1.6	2.3	4.0	-1.6	2.0	0.5	-1.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	0.0	-1.0	-0.4	0.6
Mood swings	1.0	1.8	3.3	0.5	-1.3	-1.4	1.8
Loneliness, isolation	4.1	5.7	10.3	-0.1	-2.7	-3.2	2.3
Long-standing illness, disability or infirmity	1.7	2.6	6.4	-0.7	2.5	1.9	-0.3
Ever had bowel cancer screening	2.8	3.3	8.6	-0.8	-2.9	-1.9	-0.5
Diabetes diagnosed by doctor	0.2	0.3	0.6	-0.2	0.7	-0.7	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.2	-1.5	0.7	0.5	0.5
Friendships satisfaction	0.6	0.7	1.7	-0.9	-1.3	-0.5	0.1
Qualifications: nursing, teaching	0.5	0.8	2.6	-0.7	0.3	1.6	-0.3
Commuting to job workplace: Walk	1.7	1.8	5.6	0.1	-0.7	-2.4	1.1
Eye problems/disorders: Cataract	1.1	1.2	2.1	-0.8	-1.1	-1.5	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.7	0.7	1.3	0.1	1.1
Medication for cholesterol	4.4	6.6	12.6	1.2	2.7	3.5	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	-0.8	0.0	-0.4	0.8
Back pain experienced in last month	0.2	0.3	0.8	0.5	0.1	-0.2	0.9
Mineral and other dietary supplements	1.4	1.9	3.6	-0.3	1.4	1.9	1.4
Breast cancer (self-reported)	3.7	4.5	8.9	2.8	3.0	0.9	-0.4
Asthma (self-reported)	5.5	10.9	20.5	-1.4	4.5	4.5	-0.8
Osteoporosis (self-reported)	2.2	2.7	3.6	1.9	1.9	1.8	0.7
Osteoarthritis (self-reported)	1.9	2.5	6.5	0.3	-2.5	-1.8	0.0
Medication: Aspirin	0.7	1.0	1.5	-1.2	-0.1	-1.0	1.2
Medication: Gliclazide	0.6	0.7	1.3	0.1	1.1	-1.2	0.1
Illnesses of father: None of the above (group 1)	1.2	1.5	4.0	0.3	-0.2	1.3	-2.0
Smoking status: Current	0.7	1.0	2.5	-0.6	-1.6	-1.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.9	8.9	-0.1	2.5	3.0	-0.4
Whole body water mass	0.6	3.3	4.4	1.6	1.4	2.0	-2.1
Leg predicted mass (right)	0.9	4.9	9.7	0.7	2.2	3.1	-2.1
Arm fat mass (left)	1.9	7.8	21.9	-0.6	2.5	4.7	-1.6
Number of self-reported non-cancer illnesses	0.8	1.4	3.1	-0.5	-0.6	-1.8	1.4
Average weekly champagne plus white wine intake	1.5	2.0	3.8	-0.1	-2.0	-1.3	-1.7
Miserableness	0.7	1.3	2.6	-0.9	-0.5	-1.6	1.2
Guilty feelings	0.3	0.4	0.7	0.7	-0.1	0.4	0.9
Wears glasses or contact lenses	0.6	0.7	1.4	-0.1	-1.0	-1.2	-0.4
Ever taken oral contraceptive pill	0.4	0.5	1.7	0.1	0.5	0.0	-1.3
Hearing aid user	0.8	0.9	2.5	0.1	1.6	1.0	0.1
Mother’s age at death	0.6	0.8	2.0	-0.2	-0.9	0.4	-1.4
Financial situation satisfaction	1.6	2.0	5.0	-1.2	0.3	1.2	2.2
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.8	0.8	0.7	1.4	-1.7
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.0	-0.5	-0.0	-0.0
Eye problems/disorders: Glaucoma	1.7	2.0	3.9	-0.2	-1.7	-2.0	1.0
Medication: Blood pressure	2.3	4.4	6.6	-1.6	-2.2	-1.9	2.6
Pain type(s) experienced in last month: Hip pain	1.7	2.2	4.6	-0.8	-1.2	-2.1	1.4
Supplements: Fish oil (including cod liver oil)	1.7	2.2	5.0	-0.7	-1.5	-2.2	-1.1
High cholesterol (Self-reported)	7.4	13.1	34.8	1.9	-3.1	-5.9	2.0
Medication: Bendroflumethiazide	1.0	1.5	2.6	1.6	-1.0	-0.9	1.3
Medication: Paracetamol	1.0	1.6	2.5	0.8	-1.6	-0.8	1.6
Medication: Lisinopril	1.1	1.4	3.9	-0.2	-1.2	-2.0	0.4
Medication: Atorvastatin	1.7	2.1	6.5	0.5	-0.7	-2.5	1.1
Illnesses of father: High blood pressure	1.0	1.3	4.1	0.1	-0.1	-0.9	2.0
Alcohol drinker status: Never	1.1	1.3	2.3	-0.7	1.5	1.5	-0.5
Ever smoked	0.4	0.6	1.3	-1.2	0.8	0.6	-0.4
Basal metabolic rate	0.7	4.1	7.1	1.3	1.7	2.7	-2.2
Leg fat percentage (left)	1.0	3.6	11.2	-1.0	1.1	3.3	-1.1
Arm fat-free mass (left)	0.5	2.8	4.3	2.1	1.3	1.7	-1.5
Number of operations (self-reported)	0.3	0.5	0.7	-0.7	-0.2	0.8	0.8
Average weekly beer plus cider intake	0.3	0.4	1.4	-0.1	0.1	0.1	1.2
Irritability	0.5	0.8	2.7	0.3	0.3	0.6	1.7
Risk taking	0.2	0.4	0.6	-0.2	0.7	0.8	-0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	-0.5	0.4	0.6	-0.1
Fractured/broken bones in last 5 years	0.3	0.4	1.1	-0.0	-0.8	0.0	-1.0
Age started oral contraceptive pill	0.5	0.6	1.1	-0.2	-0.9	-0.7	-1.0
Diastolic blood pressure, automated reading	2.1	6.6	15.2	0.2	-3.9	-3.0	1.4
Ever depressed for a whole week	0.3	0.4	0.8	-0.6	-0.1	-0.9	0.5
Unable to work because of sickness or disability	1.6	2.1	5.0	-2.2	-0.3	1.2	-1.3
Commuting to job workplace: Cycle	0.7	0.9	2.1	0.2	0.9	1.4	-0.7
Myopia	0.5	0.7	2.1	0.3	0.7	-0.3	1.5
Vascular/heart problems diagnosed by doctor	2.9	7.9	18.0	-1.4	2.5	4.2	-2.3
Cholesterol lowering medication	3.9	5.8	15.8	0.3	-2.3	-4.0	1.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.9	-0.2	0.2	0.9	1.0
Pain experienced in last month	1.8	2.9	5.7	0.2	1.3	2.4	-2.1
Supplements: Calcium	2.3	2.5	5.9	0.9	1.5	1.0	-2.4
Basal cell carcinoma (self-reported)	0.1	0.2	0.5	0.0	0.7	-0.0	-0.4
Heart attack/myocardial infarction (self-reported)	2.1	2.7	6.1	-0.1	-1.3	-2.5	1.8
Deep venous thrombosis (DVT) (self-reported)	2.3	3.0	8.6	-2.9	-1.0	0.3	-1.6
Heart disease (siblings)	2.3	2.8	7.7	-0.3	0.0	-1.9	2.8
Alcohol drinker status: Previous	0.6	0.7	2.5	1.6	-0.2	-0.1	0.2
Pack years of smoking	1.0	1.5	3.4	-1.1	-0.9	0.7	-1.9
Impedance of whole body	0.1	0.4	1.4	-0.4	-1.2	0.1	-0.3
Leg fat mass (left)	1.5	5.9	16.6	-0.6	1.9	4.1	-1.7
Arm predicted mass (left)	0.5	2.4	3.5	1.9	1.1	1.5	-1.6