Best TWAS P=4.7e-15 · Best GWAS P=8.4e-18 conditioned to 0.0215
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC100507032 | 0.08 | 0.06 | enet | 14 | 0.08 | 4.6e-10 | 6.6 | -7.8 | 4.7e-15 | -0.69 | 0.98 | 0.02 | TRUE |
| 2 | GTEx | Artery Aorta | PLXND1 | 0.12 | 0.01 | lasso | 3 | 0.01 | 1.5e-01 | 8.1 | -7.3 | 2.9e-13 | -0.84 | 0.04 | 0.38 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-723O4.9 | 0.12 | 0.04 | lasso | 5 | 0.06 | 3.4e-05 | 2.5 | 5.5 | 3.8e-08 | 0.09 | 0.08 | 0.86 | FALSE |
| 4 | GTEx | Brain Cortex | COPG1 | 0.24 | 0.00 | enet | 57 | 0.03 | 5.3e-02 | -6.2 | -6.1 | 9.0e-10 | -0.31 | 0.04 | 0.26 | FALSE |
| 5 | GTEx | Colon Transverse | RPL32P3 | 0.19 | 0.00 | lasso | 7 | 0.00 | 4.8e-01 | 4.3 | -6.8 | 1.3e-11 | -0.56 | 0.04 | 0.29 | TRUE |
| 6 | GTEx | Whole Blood | FAM86HP | 0.07 | 0.00 | enet | 40 | 0.01 | 1.8e-02 | -1.9 | -5.1 | 2.7e-07 | -0.21 | 0.16 | 0.03 | FALSE |
| 7 | YFS | Blood | H1FX | 0.02 | 0.01 | lasso | 3 | 0.01 | 1.4e-03 | -6.2 | 6.5 | 7.9e-11 | 0.15 | 0.17 | 0.07 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | H1FX | 0.02 | 0.02 | lasso | 5 | 0.03 | 6.5e-07 | 4.5 | 6.6 | 3.8e-11 | 0.05 | 0.10 | 0.87 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PLXND1 | 0.06 | 0.01 | enet | 9 | 0.03 | 1.4e-04 | 4.3 | 6.0 | 2.4e-09 | 0.77 | 0.02 | 0.74 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | H1FX | 0.02 | 0.00 | blup | 36 | 0.00 | 5.1e-01 | -6.7 | 6.7 | 1.8e-11 | 0.06 | 0.00 | 0.67 | TRUE |
| 11 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPL32P3 | 0.07 | 0.00 | blup | 35 | 0.01 | 6.4e-03 | -2.8 | -5.4 | 5.1e-08 | -0.24 | 0.00 | 0.06 | FALSE |