TWAS hub - PLXND1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1050	0.0340	4.6e-07	0.029	0.052	0.042	0.057	0.053	1.6e-04	6.5e-07	6.8e-06	1.8e-07	4.4e-07
2	GTEx	Artery Aorta	0.1240	0.0600	6.0e-03	0.011	NA	0.002	NA	0.006	7.3e-02	NA	2.5e-01	NA	1.5e-01
3	GTEx	Cells Transformed fibroblasts	0.1710	0.0570	4.4e-04	0.047	NA	0.019	NA	0.035	2.0e-04	NA	1.4e-02	NA	1.2e-03
4	GTEx	Nerve Tibial	0.1230	0.0507	8.7e-04	0.030	NA	0.055	NA	0.030	3.4e-03	NA	9.9e-05	NA	3.1e-03
5	TCGA	Cervical Squamous Cell Carcinoma	0.2430	0.1180	5.1e-03	0.002	0.049	0.021	NA	0.006	2.5e-01	2.0e-03	3.1e-02	NA	1.5e-01
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0589	0.0321	6.8e-04	0.013	0.027	0.032	NA	0.024	1.0e-02	4.5e-04	1.4e-04	NA	8.3e-04
7	TCGA	Brain Lower Grade Glioma	0.0822	0.0333	1.3e-08	0.063	0.081	0.072	NA	0.075	1.0e-07	1.8e-09	1.5e-08	NA	7.1e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Waist Hip Ratio (WHR)	13.5	60.6	158.8	8.7	12.6	4.5	7.6	0.1	-9.6	-4.5
Hip circumference	4.5	19.6	53.3	-4.2	-7.3	-0.3	-5.0	0.3	6.0	2.3
Medication: Metformin	3.8	5.4	13.2	0.7	2.5	-0.5	0.1	-2.4	-3.4	-3.6
Glaucoma (self-reported)	3.8	4.5	11.7	3.4	1.2	-0.2	3.1	0.3	-0.1	3.0
Eye problems/disorders: Glaucoma	3.8	4.5	10.4	3.2	1.2	0.1	3.1	1.3	1.1	2.8
Diabetes diagnosed by doctor	3.3	5.4	12.6	0.8	2.7	0.0	-0.0	-2.4	-3.5	-3.4
Type 2 Diabetes (T2D) (2012)	3.1	3.6	7.8	-0.6	2.5	-0.0	0.0	-2.2	-2.8	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	8.3	2.4	-0.3	1.2	2.3	2.9	1.6	1.0
Breast cancer (self-reported)	2.5	3.0	8.7	-0.2	-1.4	-1.6	1.8	0.9	3.0	2.0
Coronary Artery Disease (CAD)	2.2	2.6	5.8	1.1	2.0	0.3	-1.0	-1.4	-2.4	-2.1
Hand grip strength (left)	2.2	5.7	15.1	1.7	0.1	1.4	3.9	2.1	2.2	3.2
Pack years adult smoking proportion	2.2	3.4	7.3	1.3	2.7	2.7	-0.6	-0.4	-1.8	-2.0
Basal cell carcinoma (self-reported)	2.2	2.6	6.0	-0.3	2.5	0.1	0.2	-1.3	-2.2	-2.3
Diabetes (self-reported)	2.1	3.2	8.5	0.4	2.0	-0.2	-0.2	-1.2	-2.9	-2.9
Worry too long after embarrassment	2.1	3.6	7.4	2.7	-0.2	1.3	2.2	2.6	1.0	1.8
Body Mass Index (BMI) (2010)	2.0	2.8	6.1	-1.1	0.4	-1.5	-2.1	-2.5	-0.7	-2.2
Type 2 Diabetes (T2D) (2018)	2.0	3.7	10.8	0.8	2.7	-0.5	0.5	-1.7	-3.3	-1.9
Diabetes (mother)	2.0	2.6	6.2	1.8	2.5	1.1	0.5	-0.8	-2.1	-1.6
Past tobacco smoking	2.0	3.6	13.9	-3.7	-1.1	-1.3	-2.4	-1.0	0.8	-0.8
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	7.1	2.7	1.8	0.1	2.6	1.6	-1.4	0.6
Hypertension (Self-reported)	2.0	5.5	13.9	-1.0	1.2	-0.0	-2.7	-2.2	-3.1	-3.7
Ever smoked	2.0	3.5	10.9	3.3	2.2	0.9	2.2	0.2	-1.7	0.6
Age at First Birth	1.9	2.7	6.7	-2.6	-0.7	1.6	-0.4	2.4	1.8	0.3
Headache pain in last month	1.9	3.2	7.2	-0.7	1.2	-1.1	-1.9	-2.7	-2.3	-1.7
Illnesses of siblings: Diabetes	1.9	2.3	7.0	-0.5	0.9	2.6	-1.7	0.7	-0.3	-2.2
Average weekly red wine intake	1.9	2.8	6.4	-1.6	-1.3	1.8	-1.6	2.5	1.2	1.3
Irritability	1.9	3.2	5.0	2.2	2.0	2.2	1.7	0.6	-1.9	-1.2
Medication: Simvastatin	1.8	2.7	5.4	1.4	1.8	2.3	0.1	0.9	-2.2	-1.6
Medication: Amlodipine	1.8	2.6	8.4	0.4	1.0	0.8	0.1	-1.4	-2.4	-2.9
Smoking status: Previous	1.8	2.7	11.0	3.3	0.4	0.6	1.9	1.7	-0.1	1.0
Medication: Lisinopril	1.8	2.4	4.8	-2.2	-2.0	-0.4	-1.4	2.0	1.2	-0.3
Pack years of smoking	1.8	2.7	6.2	0.9	2.3	2.5	-0.8	-0.2	-1.5	-2.0
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	4.9	-1.4	0.9	-0.7	-1.4	-0.7	-1.6	-2.2
High blood pressure	1.7	4.8	14.6	-1.1	0.9	0.5	-2.7	-1.5	-2.6	-3.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	5.5	-0.3	-2.3	-1.4	0.1	1.0	1.1	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	5.5	0.6	0.4	0.3	-1.3	-0.4	-2.4	-2.1
Tinnitus: Yes, now most or all of the time	1.7	1.9	3.2	1.3	-1.3	1.0	1.3	1.7	1.2	1.8
Supplements: Zinc	1.6	1.7	3.7	-1.5	0.1	-1.8	-1.3	-1.0	0.0	-1.9
Pulse wave reflection index	1.6	2.0	5.7	0.3	-2.4	0.9	0.8	0.7	2.0	1.3
Age at last live birth	1.6	2.4	4.6	-0.7	1.2	-0.3	-1.5	-2.0	-2.1	-1.9
Medication for cholesterol	1.6	2.5	5.8	0.6	-0.6	-0.6	2.1	1.2	2.2	2.4
Osteoporosis (self-reported)	1.6	1.9	6.6	0.1	-2.6	0.3	-0.4	1.9	1.4	1.0
Ever taken oral contraceptive pill	1.6	1.8	5.7	1.0	1.4	1.6	0.1	-0.9	-2.4	-0.6
Fasting Glucose	1.5	1.8	6.4	-0.0	-1.1	-0.6	-0.9	-1.2	-1.6	-2.5
Lupus	1.5	2.3	4.7	-1.8	-1.6	-1.8	0.0	0.4	2.2	1.6
Angina	1.5	2.0	4.1	1.1	1.6	1.0	-0.5	-1.3	-1.7	-2.0
Financial difficulties in last 2 years	1.5	2.0	8.5	0.7	-0.6	1.3	0.6	2.9	1.7	0.5
Pulse wave Arterial Stiffness index	1.5	1.7	4.5	1.7	-0.5	2.0	2.1	0.4	0.4	-0.0
Ever highly irritable/argumentative for 2 days	1.5	1.8	6.2	2.5	1.1	1.0	1.6	-0.9	-0.8	0.3
Fractured/broken bones in last 5 years	1.5	1.9	5.6	-0.4	-2.4	-0.2	-0.6	2.2	1.5	0.4
Diastolic blood pressure, automated reading	1.5	4.7	8.4	-2.6	-2.7	1.5	-2.9	1.1	2.7	-0.0
Prostate Cancer	1.4	2.0	5.3	-1.8	-1.9	-2.3	-0.8	-0.6	0.8	0.7
Height	1.4	26.7	74.5	-3.5	-8.6	1.5	-4.0	3.1	5.9	6.1
Severe depression (siblings)	1.4	1.5	3.1	1.7	1.5	0.2	1.8	-0.1	-0.9	1.2
Alcohol usually taken with meals	1.4	2.2	7.6	-1.6	-1.5	0.9	-2.8	0.7	1.2	-0.1
Had menopause	1.4	1.7	3.3	-0.8	1.1	-0.9	-1.2	-1.3	-1.6	-1.8
Pain all over the body in last month	1.4	1.5	6.5	0.7	-0.0	0.2	1.3	2.5	1.2	0.6
Impedance of arm (left)	1.4	6.3	20.2	-1.1	-4.5	-2.4	-0.9	-0.4	1.2	3.8
Pulse wave peak to peak time	1.4	1.7	5.3	-1.8	0.2	-1.8	-2.3	-0.0	-0.2	0.3
Leg pain on walking	1.4	1.7	6.0	1.7	0.7	0.5	2.5	1.4	0.2	0.3
Mineral and other dietary supplements	1.4	1.9	4.2	-0.3	0.6	-1.9	-1.4	-2.1	-1.5	-0.6
Alcohol drinker status: Never	1.4	1.7	4.1	1.1	-0.3	1.9	1.2	2.0	1.1	-0.2
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.4	-1.2	-1.9	0.2	-1.4	0.1	1.6	1.3
Vascular/heart problems diagnosed by doctor	1.4	3.9	12.5	0.8	-1.0	-0.5	2.2	1.2	2.5	3.5
Alcohol drinker status: Previous	1.4	1.5	4.7	2.2	1.4	-0.1	1.2	0.4	-1.6	0.0
Current tobacco smoking	1.3	2.2	4.9	0.6	1.7	-0.0	-0.9	-2.2	-1.9	-1.7
Impedance of arm (right)	1.3	6.2	21.8	-1.2	-4.7	-2.1	-1.2	0.0	1.3	3.5
Angina (self-reported)	1.3	1.7	3.8	1.0	1.5	1.1	-0.5	-1.2	-1.5	-2.0
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.0	-0.6	-2.0	0.2	0.7	1.0	1.6	1.6
Supplements: Vitamin C	1.3	1.5	3.6	-1.0	-0.0	1.9	-1.1	1.6	0.8	-1.3
Long-standing illness, disability or infirmity	1.3	2.0	7.2	2.7	-0.2	1.5	1.5	1.3	-0.4	-0.1
Medication: Gliclazide	1.3	1.4	3.8	1.5	1.4	0.4	1.9	0.6	-0.9	-0.8
Miserableness	1.3	2.3	6.8	2.1	1.6	1.1	0.3	-0.3	-2.6	-1.0
Medication: Blood pressure	1.3	2.4	5.5	-2.0	-0.2	0.2	-2.1	-1.4	-0.9	-2.3
Illnesses of father: High blood pressure	1.3	1.6	4.1	-0.9	-1.2	0.1	-2.0	-1.5	-0.8	-1.5
Smoking Status	1.2	3.0	9.4	3.1	1.9	1.6	1.0	0.9	-1.5	-0.9
Trunk fat percentage	1.2	4.6	15.1	-1.6	-3.9	0.4	-2.5	0.1	2.6	1.1
Hair/balding pattern: Pattern 2	1.2	1.5	3.3	-1.8	0.7	-0.7	-1.5	0.2	-1.0	-1.8
Alcohol intake versus 10 years previously	1.2	1.7	3.2	-0.3	1.7	0.7	-0.6	-1.8	-1.5	-1.7
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.8	0.0	-1.9	-0.1	0.5	1.0	1.7	1.6
Leg fat percentage (right)	1.2	4.5	9.3	-3.0	-2.0	0.8	-3.0	-0.1	1.8	-2.4
Qualifications: College or University degree	1.2	3.8	15.3	-3.9	-0.9	-1.1	-2.9	-1.0	0.1	-0.2
Illnesses of father: Heart disease	1.2	1.7	3.6	-0.9	-0.7	-1.2	-1.9	-0.9	-1.1	-1.9
Commuting to job workplace: Walk	1.2	1.2	4.0	1.6	2.0	1.0	0.6	-0.7	-0.1	-0.6
Illnesses of father: None of the above (group 1)	1.2	1.5	3.6	1.3	-0.3	-0.3	1.9	0.7	1.4	1.6
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.0	0.2	0.0	2.0	1.7	1.6	1.2	0.6
Medication: Atorvastatin	1.2	1.4	3.6	1.2	1.9	-0.2	1.5	0.4	-1.6	-0.1
Cholesterol lowering medication	1.2	1.7	4.2	1.5	1.3	1.1	0.5	-0.1	-2.1	-1.5
Alzheimer’s Disease (in father)	1.1	1.2	4.6	1.2	0.8	-0.9	-0.1	-0.8	-0.3	2.1
Happiness	1.1	1.3	3.6	1.9	-0.0	1.0	1.9	0.9	-0.2	0.6
Medication: Cholesterol lowering	1.1	1.8	4.5	1.4	2.0	1.2	0.4	-0.2	-2.1	-0.7
Lung cancer (father)	1.1	1.3	3.5	-0.3	0.4	0.6	-1.3	-1.9	-1.4	-1.3
High blood pressure (siblings)	1.1	1.6	4.1	-0.2	-0.7	0.6	-2.0	-0.8	-1.4	-1.8
Mouth/teeth dental problems: Loose teeth	1.1	1.3	5.0	-0.0	1.4	0.5	-0.6	0.3	-1.3	-2.2
Neck or shoulder pain in last month	1.1	1.6	8.2	1.4	-0.2	0.5	-0.0	2.9	0.7	0.1
Medication: Allopurinol	1.1	1.4	3.5	-1.1	-0.6	1.9	-1.6	0.7	1.0	-0.8
Intelligence (Savage-Jansen 2018)	1.0	3.2	7.0	-0.7	-2.2	1.0	-0.8	2.2	2.6	1.9
Blood White Count	1.0	7.0	28.4	0.5	3.4	1.7	0.9	0.4	-2.4	-5.3
Heel T-Score	1.0	8.2	18.1	-4.3	-4.0	-1.6	-1.3	-0.9	3.4	2.6
Cardiovascular Disease	1.0	3.3	8.5	0.6	2.3	0.6	0.1	-1.3	-2.9	-2.7
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.7	1.7	-0.5	0.6	1.4	1.9	0.6	0.4
Relative age of first facial hair	1.0	2.1	8.2	0.5	0.2	-2.9	-0.2	-1.7	-1.6	0.6
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.8	1.4	1.4	-1.0	1.7	-0.8	-1.0	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.0	0.9	1.6	-0.6	1.7	-0.1	-1.2	0.0
Depression (self-reported)	1.0	1.2	4.4	0.9	0.9	2.1	1.1	1.1	0.1	-0.2
Loud music exposure frequency	1.0	1.1	5.2	0.7	-0.0	1.2	0.3	2.3	0.8	0.1
Pulse rate, automated reading	1.0	3.3	7.5	1.7	2.7	-0.3	0.9	-1.6	-2.7	-1.5
Mother’s age at death	1.0	1.3	2.2	0.1	-1.2	-1.5	1.1	1.4	1.4	0.3
Leg fat percentage (left)	1.0	3.7	7.1	-2.5	-1.7	1.4	-2.7	0.2	1.8	-2.0
Number of operations (self-reported)	1.0	1.5	3.6	1.4	1.7	1.2	0.3	0.5	-0.3	-1.9
Neuroticism (Nagel 2018)	0.9	2.0	6.3	2.5	0.3	0.5	2.0	1.7	-0.9	-0.0
Neuroticism (2016)	0.9	1.2	4.1	2.0	-0.5	0.0	1.3	1.3	0.0	1.0
Sensitivity / hurt feelings	0.9	1.5	5.8	1.2	-0.3	1.6	0.5	2.4	0.7	0.2
Vitamin and mineral supplements	0.9	1.2	6.7	0.1	-0.3	-2.6	-0.3	-1.0	-0.5	0.3
Hand grip strength (right)	0.9	2.4	5.3	1.5	0.7	0.7	2.3	0.9	1.4	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.6	1.1	1.5	1.6	0.7	0.9	-0.4	-1.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.7	-1.0	0.2	0.7	-1.6	0.5	-0.2	-1.6
Qualifications: CSEs or equivalent	0.9	1.1	3.5	1.0	1.9	0.7	1.4	1.0	-0.3	0.1
Trunk fat mass	0.9	3.9	10.6	-1.5	-3.3	0.9	-2.7	0.2	2.4	0.9
Number of incorrect matches in round	0.9	1.5	6.0	0.1	-1.1	-2.5	1.6	-0.2	0.8	0.4
Illnesses of siblings	0.9	1.3	2.8	0.6	0.9	-1.1	1.5	-1.3	-0.1	1.7
Noisy workplace	0.9	1.1	2.7	1.2	1.0	1.4	1.6	0.4	-0.1	-0.6
Birth weight	0.9	2.0	4.6	0.8	0.6	2.1	1.3	2.1	0.5	1.3
Body fat percentage	0.9	3.7	11.1	-1.8	-3.3	0.3	-2.6	-0.1	2.2	0.1
Health satisfaction	0.9	1.2	4.4	2.1	0.2	1.0	1.7	-0.1	-0.6	0.3
Loneliness, isolation	0.9	1.2	3.4	1.8	-1.7	0.0	-0.2	0.9	0.5	1.2
Qualifications: nursing, teaching	0.9	1.5	6.4	-2.5	-0.8	0.2	-1.3	-0.1	1.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.6	-0.2	1.3	1.5	-1.6	0.6	-0.1	-1.0
Smoking status: Current	0.9	1.5	3.0	0.5	1.5	0.5	-0.7	-1.7	-1.6	-1.4
High cholesterol (Self-reported)	0.9	1.6	4.8	2.2	1.3	0.7	0.9	0.6	-1.8	0.3
Worry (Nagel 2018)	0.8	1.6	3.8	1.6	-0.1	-0.6	1.9	1.7	0.1	1.3
Primary Biliary Cirrhosis	0.8	1.1	3.1	1.0	-0.3	-1.3	1.3	-0.2	0.1	1.7
Medication for hormone replacement therapy	0.8	0.9	1.8	0.2	0.9	0.6	-1.4	-0.6	-1.4	-1.1
Impedance of leg (right)	0.8	3.9	16.1	-4.0	-1.9	-0.6	-1.6	0.8	0.7	-1.8
Townsend deprivation index at recruitment	0.8	1.2	4.9	2.2	1.1	0.3	1.1	0.7	-0.5	0.2
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.1	-0.6	-0.2	-0.8	-1.3	-1.4	-1.1	-0.6
Medication: Atenolol	0.8	1.0	2.7	0.8	1.1	0.1	-0.0	-0.3	-1.6	-1.6
Neuroticism score	0.8	1.7	5.3	2.3	1.1	0.8	1.4	1.3	-1.2	0.1
Father’s age at death	0.8	1.1	5.2	0.4	2.3	0.9	0.8	0.1	-0.5	0.7
Mouth/teeth dental problems: Dentures	0.8	1.4	2.4	1.5	-1.4	0.4	1.4	1.4	0.8	0.8
Number of children fathered	0.8	0.9	3.6	-0.2	-0.5	0.1	0.6	1.3	1.9	0.3
Mean time to correctly identify matches	0.8	1.6	3.7	-0.6	-1.3	1.4	-1.2	1.9	1.4	0.2
Comparative height size at age 10	0.8	4.6	13.9	0.7	-3.2	0.6	-0.0	1.0	2.4	3.7
Chest pain or discomfort	0.8	1.2	2.6	0.8	1.4	-0.8	-0.2	0.6	-1.4	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.9	1.3	0.1	1.3	1.4	1.1	0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	8.1	0.9	-1.2	-1.2	0.6	-0.2	0.2	2.9
Guilty feelings	0.8	1.2	2.7	1.4	0.6	0.9	1.4	1.6	0.2	0.6
Unable to work because of sickness or disability	0.8	1.0	2.5	1.5	0.6	-0.5	1.6	0.8	-0.1	0.9
Schizophrenia (2018)	0.7	1.5	4.7	-2.2	-0.7	-1.7	-1.2	-0.6	0.8	0.6
Breast Cancer	0.7	1.8	5.6	0.1	2.0	1.0	-0.7	-0.5	-1.0	-2.4
Lung FVC	0.7	3.6	12.4	-2.3	-2.1	0.3	-0.7	1.4	3.5	-0.1
Supplements: Glucosamine	0.7	1.0	3.4	-0.3	-1.0	1.9	-0.7	-0.1	1.3	0.0
Forced vital capacity (FVC)	0.7	2.9	6.0	-1.6	-2.0	1.5	-0.9	1.4	2.4	1.7
Fluid intelligence score	0.7	1.5	4.4	0.0	-2.0	-0.6	-1.2	0.2	0.6	2.1
Arm fat percentage (right)	0.7	2.6	9.8	-0.6	-3.1	-0.4	-2.0	-0.7	1.7	0.6
Worrier / anxious feelings	0.7	1.4	5.4	2.3	0.2	0.6	1.1	1.4	-0.6	0.2
Length of working week for main job	0.7	0.7	2.1	-0.5	0.0	-1.4	-0.8	-0.7	-0.5	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.8	1.5	1.2	-0.0	1.7	1.1	0.1	-0.1
Hair/balding pattern: Pattern 4	0.7	1.7	4.2	1.8	1.2	2.1	0.3	-0.4	-1.3	-0.9
Shortness of breath walking on level ground	0.7	0.8	2.5	0.2	0.7	1.6	0.6	0.1	-0.5	-1.4
Whole body fat mass	0.7	2.9	7.7	-1.1	-2.8	0.8	-2.5	0.1	2.1	0.4
Leg fat mass (right)	0.7	2.7	6.5	-1.9	-1.9	0.8	-2.5	0.1	1.9	-1.2
Number of full sisters	0.7	0.9	2.5	0.8	0.3	0.5	-0.2	-1.5	-1.6	-0.7
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.2	-1.5	-1.1	-0.4	-1.4	-0.4	0.6	-0.1
Mood swings	0.7	1.3	3.9	1.7	0.8	0.0	-0.3	-0.9	-2.0	-0.8
Arm fat mass (left)	0.7	2.7	7.0	-0.7	-2.6	0.5	-2.4	-0.1	2.2	0.7
Hearing aid user	0.7	0.8	3.0	-0.2	1.3	-0.6	0.2	-0.2	-0.7	-1.7
Commuting to job workplace: Cycle	0.7	0.8	3.5	-0.5	-0.2	-1.9	-0.6	-0.3	-1.1	0.2
Impedance of whole body	0.7	3.7	13.2	-2.2	-3.6	-1.0	-0.7	0.6	1.4	1.9
Depressed Affect (Nagel 2018)	0.6	1.3	4.0	2.0	0.4	0.8	0.4	-0.1	-1.8	-0.8
Alzheimer’s Disease (including proxy)	0.6	0.8	2.3	1.5	0.7	-0.9	-0.3	-0.5	-1.4	0.3
Reaction Time	0.6	1.1	5.0	0.5	0.1	1.3	-0.3	2.2	0.7	0.1
LDL Cholesterol	0.6	1.0	2.9	1.7	0.9	-0.5	1.1	0.4	-1.0	0.9
Rheumatoid Arthritis	0.6	0.8	2.8	-0.1	0.9	-1.7	0.1	-1.0	-0.8	0.4
Schizophrenia (2014)	0.6	1.4	5.2	-2.3	-0.6	-1.3	-1.1	-0.7	0.6	0.7
Triglycerides	0.6	1.0	4.8	0.2	0.4	-0.6	-0.4	-0.8	-0.7	-2.2
Blood Red Count	0.6	5.7	17.3	-3.1	-4.2	0.2	-3.0	1.1	1.6	-0.2
Neuroticism	0.6	1.5	4.4	1.4	0.5	1.4	1.1	2.1	-0.7	0.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.5	-0.7	-1.2	-0.4	-0.9	0.2	0.9	-1.1
Medication: Co-codamol	0.6	0.6	2.1	-0.1	-0.3	1.1	0.0	1.5	1.0	0.2
Maternal smoking around birth	0.6	0.8	4.2	2.1	0.3	1.0	0.4	-0.0	-0.3	0.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.5	0.7	1.0	1.2	1.2	-0.4	0.1	0.7
Impedance of leg (left)	0.6	3.2	12.9	-3.6	-1.6	0.6	-1.1	1.5	1.0	-1.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.2	1.4	-0.3	-0.2	1.5	-0.1	-0.3	1.0
Falls in the last year	0.6	0.8	1.8	-1.3	-1.1	-0.9	-0.9	0.3	-0.5	-0.9
Number of live births	0.6	0.9	1.9	-0.4	1.1	-0.8	-0.6	-1.4	-1.0	-1.1
Illnesses of mother	0.6	0.7	2.7	0.7	1.6	-0.3	1.0	-0.4	-0.1	0.8
Arm fat mass (right)	0.6	2.5	7.0	-0.7	-2.6	0.2	-2.4	-0.4	1.9	0.4
Standing height	0.6	6.2	15.4	-1.8	-3.2	1.1	-2.1	1.6	2.5	3.9
Breastfed as a baby	0.6	0.7	2.1	-0.6	-0.0	-0.2	-0.9	-1.4	-0.4	-1.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.8	-0.2	1.0	-0.5	0.2	-0.7	-1.7	-0.8
Blood clot in the leg (DVT)	0.6	0.8	2.7	1.6	1.1	0.5	0.5	0.4	-0.9	-0.5
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.7	-0.2	-0.6	0.8	-1.3	-0.5	-1.1	-0.4
Forced vital capacity (FVC), Best measure	0.6	2.2	5.8	-1.3	-1.7	0.1	-0.3	0.5	2.4	2.2
Exposure to tobacco smoke outside home	0.6	0.8	2.4	0.8	0.8	0.3	0.3	0.9	-1.0	-1.6
Comparative body size at age 10	0.6	1.6	5.0	-0.2	-0.2	1.7	-0.8	1.0	1.2	-2.2
Number of full brothers	0.6	0.8	3.4	1.8	1.0	-0.3	0.8	0.6	-0.3	0.2
Age at first live birth	0.6	1.1	4.3	-1.6	-0.6	0.4	-2.1	-0.2	-0.1	-0.6
Medication for pain relief, constipation, heartburn	0.6	1.1	2.6	-1.4	-0.6	0.3	0.3	1.2	1.6	0.9
Medication: Blood pressure	0.6	1.0	4.8	-0.2	-0.4	0.1	-1.1	-0.1	-0.9	-2.2
Suffer from ‘nerves’	0.6	0.9	2.1	0.7	0.3	-0.6	0.9	1.4	0.4	1.5
Had major operations	0.6	0.7	1.4	0.1	-0.1	1.2	-1.1	0.7	0.8	-1.0
Arm fat percentage (left)	0.6	2.4	8.8	-0.5	-3.0	-0.4	-2.0	-0.9	1.7	0.6
Medication: Bendroflumethiazide	0.6	1.0	4.2	-0.9	-2.0	-0.7	-0.1	-0.4	1.1	-0.1
Average weekly beer plus cider intake	0.6	0.8	3.3	0.8	0.2	-1.8	1.0	-0.8	-0.4	-0.0
Leg fat mass (left)	0.6	2.3	4.9	-1.6	-1.7	1.2	-2.2	0.4	1.9	-0.9
Depression (Nagel 2018)	0.5	0.8	1.5	1.0	0.2	1.2	1.2	1.0	0.2	-0.7
Major Depression (MDD)	0.5	0.6	3.4	0.3	-0.3	-0.3	0.2	1.8	0.5	0.6
Blood Eosinophil Count	0.5	4.2	15.3	-1.4	-1.8	-3.9	-1.8	-1.3	-1.7	-0.9
Lung FEV1/FVC ratio	0.5	2.5	6.9	2.2	2.6	0.1	1.1	-0.5	-2.1	0.3
Hearing difficulty/problems: Yes	0.5	0.8	2.8	-0.7	0.1	1.1	-0.8	1.7	0.3	-0.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.4	1.6	-0.4	-0.3	0.6	0.2	-1.1	0.0
Systolic blood pressure, automated reading	0.5	1.6	5.6	-0.8	-2.4	0.5	-0.3	0.8	2.0	0.2
Diabetes (father)	0.5	0.6	1.8	0.7	0.9	0.7	-0.3	-0.2	-1.4	-0.7
Average weekly fortified wine intake	0.5	0.6	1.8	-0.5	-0.4	-1.3	0.1	1.1	0.3	0.7
High blood pressure (mother)	0.5	0.6	2.8	-0.1	-1.7	0.3	-0.3	0.6	1.0	0.2
Heart attack	0.5	0.6	1.8	1.3	0.8	1.0	0.4	-0.1	-0.7	0.5
Medication: Ramipril	0.5	0.6	3.3	0.3	0.1	0.6	-0.3	0.6	-0.6	-1.8
Weight	0.5	2.7	5.5	-1.0	-2.2	1.3	-2.3	0.4	2.3	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.3	1.5	-0.2	-0.8	-0.2	0.9	-1.1	-0.6
Pulse rate	0.5	0.9	2.5	0.7	1.1	0.2	0.5	-0.8	-1.6	-0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.1	-1.0	-0.3	-1.1	-1.4	-1.4	-0.7	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.4	-0.1	0.3	-0.7	-1.2	-1.1	-1.0	-0.5
Prospective memory result	0.5	0.6	1.8	1.0	0.5	0.3	1.3	-0.4	-0.7	-0.8
Tense / ‘highly strung’	0.5	0.8	1.9	1.2	-0.5	-1.1	0.9	0.1	-1.4	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	-0.6	0.5	-0.6	-1.0	-1.3	-0.5	-0.6
Migraine (self-reported)	0.5	0.7	1.7	-1.3	-0.2	-0.3	-0.8	-0.7	0.4	-1.3
Medication: Ibuprofen	0.5	0.6	1.6	-0.3	0.2	-0.8	-1.3	-1.1	-0.8	-0.3
Overall health rating	0.5	1.1	3.5	1.9	1.0	1.4	0.6	0.4	-0.5	-0.7
Family relationship satisfaction	0.5	0.6	1.6	1.3	-0.9	1.0	0.2	0.9	0.0	-0.1
Number of self-reported non-cancer illnesses	0.5	0.8	4.1	2.0	-0.3	-0.1	0.6	-0.5	-1.0	0.2
Average weekly champagne plus white wine intake	0.5	0.7	1.6	-0.6	0.5	0.4	-0.6	-1.3	-1.0	-1.1
Wears glasses or contact lenses	0.5	0.6	3.0	0.8	-0.5	0.4	-0.4	-0.2	-0.2	-1.7
Financial situation satisfaction	0.5	0.6	1.2	1.1	-0.9	0.5	0.4	0.8	1.0	0.5
Myopia	0.5	0.8	2.8	0.5	-0.9	0.1	-0.5	-0.6	-1.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.5	1.6	0.9	0.3	0.5	0.3	-0.6	-0.2
Heart disease (siblings)	0.5	0.6	1.4	-0.7	-0.9	0.5	-1.2	0.9	0.2	-0.6
Schizophrenia vs Biploar Disorder	0.4	0.5	2.1	-0.2	0.8	-0.4	-0.2	-0.7	0.3	1.5
Alzheimer’s Disease (in mother)	0.4	0.4	1.8	0.1	-1.3	-0.4	-0.5	0.7	-0.1	-0.7
Ovarian Cancer	0.4	0.6	3.0	0.3	0.4	1.7	0.2	0.3	0.0	-0.9
HDL Cholesterol	0.4	0.7	1.5	0.3	-0.3	1.0	0.9	0.8	0.9	1.2
Fed-up feelings	0.4	0.8	2.6	1.6	-0.1	0.1	0.5	-0.8	-1.3	0.1
Relative age voice broke	0.4	0.6	1.2	0.9	-0.7	-1.1	0.2	-0.6	-0.8	0.6
Taking other prescription medications	0.4	0.7	1.4	0.8	0.1	1.0	-0.5	-0.5	-1.2	-1.0
Serious illness, injury or assault to yourself	0.4	0.4	1.4	0.7	1.2	-0.2	0.3	-0.1	-1.0	0.2
Hayfever, allergic rhinitis or eczema	0.4	1.0	2.6	-0.8	-1.6	-0.8	-0.5	0.1	0.8	1.4
Multivitamins +/- minerals	0.4	0.5	2.1	-0.2	0.9	1.5	0.6	-0.4	-0.1	0.2
Stomach or abdominal pain in last month	0.4	0.5	1.4	0.2	0.8	0.1	-0.4	-0.1	-1.1	-1.2
Sitting height	0.4	2.5	7.9	-2.4	-1.4	-0.1	-2.8	-0.7	0.3	1.3
Qualifications: None of the above	0.4	0.9	3.6	1.2	-0.4	0.2	1.9	0.1	0.9	0.1
Hair/balding pattern: Pattern 3	0.4	0.5	2.4	0.3	-0.8	-1.6	-0.1	-0.8	0.1	0.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	3.1	-0.6	-1.3	1.1	-0.3	1.2	1.6	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.8	-0.4	-1.2	-0.0	0.2	0.4	1.5	2.2
Birth weight of first child	0.4	0.7	1.7	-1.0	0.5	1.3	-0.5	1.1	0.7	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.1	0.0	-0.4	-0.7	0.5	-0.1	1.2	1.4
Gout (self-reported)	0.4	0.6	1.8	-0.6	-0.5	1.4	-0.9	0.1	0.8	-0.3
Eye problems/disorders: None of the above	0.4	0.5	2.1	-0.8	-0.5	1.4	-0.1	0.4	-0.1	-0.5
Emphysema/chronic bronchitis	0.4	0.5	2.1	0.6	-0.1	-0.7	-0.2	-0.5	-0.1	1.5
Medication: Omeprazole	0.4	0.5	1.8	1.3	0.5	0.5	-0.2	-0.4	-1.0	-0.4
Alcohol intake frequency.	0.4	1.0	3.6	-0.8	0.4	0.6	-1.1	-0.7	-0.5	-1.9
Medication: Aspirin	0.4	0.5	2.0	1.4	0.4	0.5	0.4	-0.1	-0.8	-0.5
Ever had bowel cancer screening	0.4	0.5	1.9	0.2	-0.8	1.4	0.4	0.1	0.6	0.5
Friendships satisfaction	0.4	0.5	1.3	0.8	-1.1	0.1	-0.1	0.6	-0.1	0.9
Risk taking	0.4	0.6	2.4	-0.3	0.7	0.1	-0.1	1.0	-0.4	-1.5
Ever depressed for a whole week	0.4	0.5	1.9	1.4	0.6	0.4	0.6	0.4	-0.4	0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.2	1.0	0.2	0.3	-0.5	-0.0	-1.1	-0.9
Supplements: Calcium	0.4	0.4	1.5	-1.1	-0.1	-0.5	-0.1	1.2	0.3	-0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	1.3	0.7	0.9	0.5	-0.2	-0.5	0.5
Bipolar Disorder (2018)	0.3	0.5	1.3	-0.5	-0.4	1.1	0.7	0.6	0.4	-1.1
Bipolar Disorder or Schizophrenia	0.3	0.8	3.7	-1.9	-0.8	-0.6	-0.5	-0.1	0.9	-0.2
Crohns Disease (2017)	0.3	0.7	2.3	0.2	1.5	0.2	1.1	-0.4	-1.1	0.3
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.9	-0.4	-1.4	-0.8	-1.1	-0.4	0.2	0.6
HbA1C	0.3	0.3	1.2	0.2	-0.2	0.2	0.4	1.1	0.4	0.7
BMI	0.3	1.8	6.4	-0.2	-0.7	0.8	-2.5	-0.7	0.6	-2.0
Respiratory disease	0.3	0.7	1.7	0.7	1.1	-0.1	1.3	0.5	0.4	1.1
Chronotype (morning person)	0.3	0.6	1.4	-0.4	-0.6	1.1	-0.7	-0.2	-1.2	-0.8
Number of treatments/medications taken	0.3	0.5	1.8	1.3	-0.7	-0.0	-0.1	-1.0	-0.3	-0.3
Average weekly spirits intake	0.3	0.4	0.8	-0.9	-0.7	-0.6	-0.2	0.4	-0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.2	-0.2	-0.8	-0.7	-0.2	-1.1	0.8	0.9
Chronic bronchitis/emphysema (father)	0.3	0.4	1.1	1.1	-0.2	0.8	0.6	0.5	0.4	0.2
Waist circumference	0.3	1.1	3.1	0.4	0.6	1.8	-1.2	-0.8	-0.3	-1.4
Had other major operations	0.3	0.3	1.4	1.2	-0.3	-0.5	0.5	0.3	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.0	-0.9	-1.0	-0.3	-0.4	-0.3	1.4	1.1
Mouth/teeth dental problems	0.3	0.5	1.3	-0.7	0.1	0.0	-0.3	-0.4	1.1	1.1
Time employed in main current job	0.3	0.4	0.9	0.7	-0.1	0.1	1.0	-0.9	-0.4	-0.6
Exposure to tobacco smoke at home	0.3	0.4	1.7	0.7	-0.2	1.3	0.3	0.0	0.1	-0.6
Peak expiratory flow (PEF)	0.3	0.7	1.3	1.1	1.0	0.8	0.7	0.7	-0.3	1.0
Medication: Seretide 50 evohaler	0.3	0.3	1.2	-0.3	-1.1	-0.1	0.4	0.8	0.3	-0.1
Heart disease (mother)	0.3	0.4	0.7	0.2	-0.8	-0.6	0.3	-0.8	-0.7	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	0.8	-0.2	0.7	0.1	0.7	-0.1	0.7
Leg fat-free mass (right)	0.3	1.4	5.4	1.3	-0.5	1.0	-0.8	-0.1	1.0	2.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.4	0.0	-0.3	0.9	-0.9	1.2	-0.3	-0.3
Back pain experienced in last month	0.3	0.4	1.7	0.5	0.7	0.4	1.3	-0.0	-0.2	-0.4
Medication: Aspirin	0.3	0.4	1.4	1.2	0.3	0.7	0.2	0.1	-0.5	-0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.8	0.3	-0.4	1.3	0.2	0.1	0.6	-0.7
Arm fat-free mass (left)	0.3	1.4	3.8	-0.6	-0.1	1.9	-1.6	0.9	1.4	0.0
Age started oral contraceptive pill	0.3	0.4	1.0	-0.7	-0.6	0.6	0.5	0.6	1.0	-0.4
Pain experienced in last month	0.3	0.4	1.5	-1.0	-0.4	0.5	-0.3	0.3	1.2	0.3
Arm predicted mass (left)	0.3	1.3	3.0	-0.7	-0.5	1.7	-1.7	0.6	1.5	0.0
Irritable Bowel Disease (IBD)	0.2	0.5	1.8	-0.0	1.3	0.4	0.9	0.3	-0.7	-0.5
Ulcerative Colitis (UC)	0.2	0.5	1.6	-0.7	0.1	0.5	0.2	1.3	0.8	-0.2
Bipolar Disorder (2011)	0.2	0.2	0.9	0.0	0.0	0.0	0.0	-0.0	1.0	-0.8
Crohns Disease (2012)	0.2	0.4	0.8	-0.6	0.6	-0.1	0.4	-0.8	-0.9	-0.3
Blood Platelet Count	0.2	2.3	4.4	1.9	2.1	0.5	1.9	1.0	-0.2	-1.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.8	0.5	0.4	0.3	0.5	0.9	0.2	0.1
Leg fat-free mass (left)	0.2	1.1	3.5	0.7	-0.8	0.4	-1.4	-0.5	0.9	1.9
Body mass index (BMI)	0.2	1.0	2.5	-0.2	-0.8	1.1	-1.6	-0.2	1.2	-1.0
Leg predicted mass (left)	0.2	1.1	3.4	0.8	-0.9	0.4	-1.3	-0.4	1.0	1.8
Trunk fat-free mass	0.2	0.9	3.0	-0.5	-0.0	1.5	-1.7	0.4	0.9	0.3
Asthma	0.2	0.4	0.9	0.5	-0.4	-0.6	0.5	-0.7	0.7	0.9
Medication: Lansoprazole	0.2	0.2	0.7	0.3	-0.3	0.7	0.8	0.5	-0.1	-0.2
Trunk predicted mass	0.2	1.0	3.2	-0.5	-0.1	1.5	-1.8	0.4	0.9	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.5	0.3	-1.0	-0.0	0.2	-0.4	-0.2	1.2
Medication: Paracetamol	0.2	0.3	1.6	0.5	-0.1	-0.3	-0.2	-1.2	-0.5	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	2.6	-0.1	-1.6	-0.0	-0.0	0.6	0.4	0.3
Arm fat-free mass (right)	0.2	0.9	2.6	-0.4	0.3	1.6	-1.4	0.5	1.0	0.0
Wheeze or whistling in the chest in last year	0.2	0.4	1.3	0.1	-1.0	-0.7	0.3	1.1	0.1	0.4
Knee pain experienced in last month	0.2	0.3	1.1	0.9	-1.0	-0.4	0.1	-0.1	-0.2	0.4
Whole body fat-free mass	0.2	0.9	2.1	0.2	-0.4	1.2	-1.4	0.3	1.0	1.0
Eye problems/disorders: Cataract	0.2	0.3	1.1	-0.2	-0.2	-1.0	-0.4	0.1	0.4	0.7
Osteoarthritis (self-reported)	0.2	0.3	0.9	0.3	-0.4	-0.9	0.4	0.8	0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.6	-0.5	-0.4	-0.3	0.2	0.2	1.2	0.9
Leg predicted mass (right)	0.2	1.3	5.1	1.2	-0.4	1.0	-0.9	-0.2	0.9	2.3
Medication: Paracetamol	0.2	0.4	1.9	0.5	0.2	0.0	0.2	-1.4	-0.7	0.0
Basal metabolic rate	0.2	1.2	2.8	-0.1	-0.9	1.1	-1.7	0.4	1.4	1.2
Mean Putamen Volume	0.1	0.1	0.4	0.0	0.2	-0.2	0.0	-0.3	-0.4	0.7
Ulcerative Colitis	0.1	0.2	1.0	-0.4	-0.1	0.3	-0.6	0.2	-0.1	-1.0
Systolic Blood Pressure	0.1	0.6	1.9	0.2	0.5	0.9	1.4	0.2	0.0	-1.0
Allergy or Eczema	0.1	0.3	0.9	-0.6	-1.0	-0.1	0.0	0.2	0.4	0.9
Hypothyroidism (self reported)	0.1	0.2	0.5	-0.7	-0.7	-0.3	-0.1	-0.0	-0.4	0.1
Tanning	0.1	0.9	3.0	0.1	1.2	1.7	0.2	0.3	-0.7	-1.2
Age when periods started (menarche)	0.1	0.1	0.4	-0.7	0.2	-0.4	0.2	-0.5	0.1	0.2
Nervous feelings	0.1	0.1	0.3	-0.2	-0.4	-0.3	-0.2	0.6	0.3	0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.7	0.2	-0.1	0.2	-0.1	0.8	0.4	-0.5
Allergy	0.1	0.3	0.7	0.1	0.8	0.6	0.4	0.2	-0.4	-0.6
Arm predicted mass (right)	0.1	0.7	2.0	-0.5	0.2	1.4	-1.1	0.5	1.0	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.7	0.0	-0.0	0.0	-0.4	-0.8	-0.6	0.0
Asthma (self-reported)	0.1	0.3	0.9	0.7	0.3	-0.5	0.3	-1.0	-0.0	0.2
Whole body water mass	0.1	0.8	1.9	0.2	-0.2	1.4	-1.4	0.3	1.0	1.1
Commuting to job workplace: Public transport	0.1	0.2	0.8	-0.3	0.3	0.9	-0.3	0.4	-0.1	-0.1
Hair Pigment	0.0	0.8	2.3	1.5	-0.0	0.7	1.0	1.0	0.1	0.8
Medication: Levothyroxine sodium	0.0	0.1	0.2	0.2	-0.3	0.2	-0.4	0.2	0.0	0.0

Hub : Genes

PLXND1

Models

Trait associations