Best TWAS P=1.9e-10 · Best GWAS P=3.98e-11 conditioned to 0.0218
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC25A37 | 0.08 | 0.05 | lasso | 5 | 0.05 | 4.8e-07 | -4.8 | 5.4 | 6.8e-08 | -0.70 | 0.05 | 0.95 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SLC25A37 | 0.13 | 0.05 | lasso | 5 | 0.04 | 3.0e-04 | -6.4 | 6.4 | 1.9e-10 | -0.83 | 0.01 | 0.99 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STC1 | 0.04 | 0.05 | enet | 7 | 0.06 | 8.9e-12 | -5.0 | 5.3 | 1.1e-07 | -0.01 | 0.01 | 0.99 | TRUE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC25A37 | 0.11 | 0.09 | lasso | 5 | 0.09 | 7.8e-10 | -5.2 | -5.7 | 1.5e-08 | 0.67 | 0.90 | 0.10 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOXL2 | 0.16 | 0.03 | lasso | 4 | 0.05 | 1.2e-03 | -5.1 | 5.9 | 3.3e-09 | -0.50 | 0.02 | 0.79 | FALSE |