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chr6:115,569,351-118,613,435

Best TWAS P=2.59e-20 · Best GWAS P=2.62e-24 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Cells Transformed fibroblasts	DSE	0.07	0.01	enet	7	0.01	4.1e-02	-7.8	-9.2	2.6e-20	0.05	0.40	0.34	TRUE
4	GTEx	Adipose Subcutaneous	RP1-93H18.7	0.11	0.08	lasso	3	0.08	8.1e-07	-7.9	-8.0	1.7e-15	0.02	0.97	0.01	TRUE
16	GTEx	Cells Transformed fibroblasts	NT5DC1	0.07	0.03	enet	9	0.05	9.8e-05	4.9	-7.7	1.7e-14	-0.07	0.12	0.63	TRUE
8	GTEx	Artery Tibial	GOPC	0.11	0.08	lasso	4	0.09	9.0e-08	7.1	-7.4	1.0e-13	-0.08	0.99	0.00	TRUE
3	GTEx	Adipose Subcutaneous	TSPYL1	0.13	0.07	lasso	2	0.05	6.0e-05	-3.5	-6.5	7.7e-11	0.04	0.01	0.97	TRUE
22	GTEx	Esophagus Muscularis	RP1-93H18.7	0.17	0.02	lasso	4	0.03	5.0e-03	-7.9	-6.3	2.1e-10	-0.02	0.08	0.61	TRUE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	RFX6	0.02	0.01	lasso	3	0.01	4.2e-03	-6.5	-6.0	2.2e-09	0.26	0.00	0.98	TRUE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	FRK	0.10	0.10	lasso	7	0.09	4.2e-06	5.3	-5.5	3.0e-08	-0.08	0.10	0.90	TRUE
7	GTEx	Artery Aorta	RP3-486I3.4	0.10	0.03	enet	23	0.03	6.1e-03	6.0	5.4	8.2e-08	0.02	0.14	0.50	TRUE
18	GTEx	Cells Transformed fibroblasts	RP1-93H18.7	0.08	0.06	enet	8	0.07	3.9e-06	-7.4	-8.9	4.4e-19	0.05	0.66	0.33	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	DSE	0.13	0.09	lasso	4	0.03	3.0e-02	6.6	8.3	1.5e-16	0.02	0.10	0.60	FALSE
38	NTR	Blood	DSE	0.04	0.02	bslmm	437	0.02	1.7e-08	-7.9	-8.2	1.8e-16	-0.03	0.03	0.97	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	FAM26F	0.34	0.10	enet	32	0.32	5.8e-11	6.8	8.2	2.1e-16	0.00	0.40	0.59	FALSE
35	GTEx	Whole Blood	RP1-93H18.7	0.19	0.17	lasso	3	0.16	3.1e-14	-6.9	-7.6	3.3e-14	0.04	1.00	0.00	FALSE
30	GTEx	Testis	FAM26F	0.23	0.10	lasso	8	0.22	3.0e-10	-6.2	7.6	3.7e-14	-0.04	0.24	0.74	FALSE
28	GTEx	Skin Sun Exposed Lower leg	RP1-93H18.7	0.07	0.04	enet	5	0.03	1.1e-03	-7.9	-7.5	5.1e-14	0.03	0.42	0.11	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	RP1-93H18.7	0.16	0.06	lasso	3	0.05	5.3e-03	-7.1	-7.4	9.7e-14	0.03	0.17	0.30	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	GOPC	0.13	0.16	enet	21	0.16	1.5e-19	7.0	7.4	1.9e-13	0.07	1.00	0.00	FALSE
34	GTEx	Whole Blood	DSE	0.09	0.05	lasso	5	0.04	1.8e-04	-7.5	-7.3	3.2e-13	0.07	0.95	0.02	FALSE
6	GTEx	Artery Aorta	NT5DC1	0.23	0.08	lasso	10	0.08	4.6e-05	5.5	7.3	4.0e-13	0.05	0.85	0.02	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	DSE	0.05	0.01	blup	112	0.04	1.6e-04	-2.4	-7.2	8.4e-13	0.03	0.03	0.36	FALSE
2	CommonMind	Brain Pre-frontal Cortex	GOPC	0.12	0.11	lasso	7	0.09	2.2e-11	6.8	7.0	2.5e-12	0.10	1.00	0.00	FALSE
17	GTEx	Cells Transformed fibroblasts	FAM26F	0.29	0.19	enet	26	0.23	1.9e-17	-6.7	7.0	3.7e-12	-0.02	1.00	0.00	FALSE
23	GTEx	Lung	RP1-93H18.7	0.06	0.07	lasso	4	0.04	4.4e-04	-6.9	-6.9	6.3e-12	0.03	0.54	0.06	FALSE
25	GTEx	Nerve Tibial	GOPC	0.12	0.06	enet	17	0.06	3.7e-05	6.3	-6.7	2.7e-11	-0.04	0.99	0.00	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	FRK	0.12	0.07	enet	12	0.09	8.1e-04	-4.8	-6.7	2.9e-11	-0.09	0.34	0.08	FALSE
31	GTEx	Thyroid	GOPC	0.11	0.02	enet	23	0.02	1.6e-02	6.0	-6.7	2.9e-11	0.18	0.50	0.03	FALSE
46	The Cancer Genome Atlas	Glioblastoma Multiforme	FRK	0.13	0.01	blup	94	0.05	1.5e-02	-4.7	-6.6	5.1e-11	-0.04	0.02	0.32	FALSE
26	GTEx	Nerve Tibial	RP1-93H18.7	0.14	0.08	lasso	6	0.08	1.7e-06	-6.8	-6.5	7.5e-11	0.13	0.84	0.07	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FAM26F	0.40	0.20	lasso	8	0.25	2.3e-14	6.7	6.2	4.7e-10	-0.02	0.93	0.07	FALSE
5	GTEx	Artery Aorta	GOPC	0.11	0.09	enet	13	0.12	4.7e-07	6.1	-6.2	6.0e-10	-0.07	0.92	0.00	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	GOPC	0.02	0.02	lasso	1	0.02	2.1e-04	6.1	-6.1	1.3e-09	-0.10	0.14	0.76	FALSE
9	GTEx	Artery Tibial	FRK	0.16	0.10	lasso	9	0.13	1.4e-10	6.2	6.0	1.6e-09	0.07	1.00	0.00	FALSE
37	METSIM	Adipose	TSPYL1	0.13	0.06	blup	370	0.08	3.7e-12	4.6	-5.9	3.5e-09	-0.03	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Stomach Adenocarcinoma	FRK	0.03	0.00	blup	94	0.03	4.6e-03	5.3	-5.9	3.5e-09	-0.08	0.06	0.44	FALSE
33	GTEx	Thyroid	TSPYL1	0.07	0.04	lasso	2	0.00	1.5e-01	5.2	-5.8	6.6e-09	-0.04	0.07	0.33	FALSE
10	GTEx	Breast Mammary Tissue	DCBLD1	0.10	0.02	lasso	4	0.03	1.1e-02	6.3	-5.7	9.4e-09	-0.05	0.16	0.05	FALSE
41	YFS	Blood	NT5DC1	0.07	0.03	bslmm	431	0.04	6.4e-13	5.0	-5.5	4.1e-08	0.04	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FRK	0.06	0.06	lasso	2	0.05	6.1e-07	5.6	5.5	4.3e-08	-0.03	0.96	0.00	FALSE
44	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FAM26F	0.20	0.08	blup	48	0.10	1.3e-05	4.9	5.5	4.4e-08	0.00	0.18	0.51	FALSE
14	GTEx	Cells Transformed fibroblasts	FRK	0.12	0.18	lasso	5	0.16	8.0e-12	5.3	-5.5	4.5e-08	-0.12	1.00	0.00	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	FAM26F	0.15	0.10	enet	13	0.13	2.6e-16	3.5	5.4	5.9e-08	-0.01	1.00	0.00	FALSE
29	GTEx	Testis	DSE	0.36	0.41	lasso	6	0.39	1.1e-18	5.3	5.4	6.5e-08	0.01	1.00	0.00	FALSE
36	METSIM	Adipose	NT5DC1	0.11	0.08	lasso	8	0.09	8.2e-14	5.3	-5.4	7.2e-08	-0.10	1.00	0.00	FALSE
27	GTEx	Pancreas	FRK	0.09	0.13	lasso	5	0.09	1.2e-04	5.3	-5.4	8.3e-08	-0.11	0.73	0.02	FALSE
24	GTEx	Muscle Skeletal	NT5DC1	0.16	0.17	lasso	10	0.17	1.1e-16	5.3	-5.3	9.1e-08	-0.09	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	FRK	0.08	0.09	lasso	2	0.09	5.0e-09	5.3	-5.3	9.2e-08	-0.10	0.80	0.20	FALSE
21	GTEx	Esophagus Mucosa	NT5DC1	0.09	0.08	lasso	2	0.05	2.9e-04	5.3	-5.3	1.1e-07	-0.12	0.49	0.06	FALSE
19	GTEx	Colon Transverse	FRK	0.14	0.16	lasso	4	0.14	5.7e-07	5.3	-5.3	1.4e-07	-0.10	0.98	0.00	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	FRK	0.10	0.08	lasso	1	0.05	3.2e-06	5.2	-5.2	1.5e-07	-0.11	0.57	0.43	FALSE
32	GTEx	Thyroid	FRK	0.08	0.10	lasso	3	0.09	4.6e-07	5.3	-5.2	2.6e-07	-0.12	0.97	0.00	FALSE