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chr7:55,291,079-56,840,887

Best TWAS P=1.06e-12 · Best GWAS P=6.17e-10 conditioned to 0.206

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	ROSMAP	Brain Pre-frontal Cortex	GBAS	0.17	0.06	lasso	5	0.11	2.7e-14	-6.2	-7.1	1.1e-12	-0.75	0.00	1.00	TRUE
10	GTEx	Skin Not Sun Exposed Suprapubic	GBAS	0.08	0.00	lasso	9	0.01	6.3e-02	6.0	-6.9	5.0e-12	-0.69	0.04	0.67	FALSE
6	GTEx	Lung	GBAS	0.07	0.00	lasso	3	0.00	1.9e-01	6.0	-6.5	1.0e-10	-0.88	0.02	0.84	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	PHKG1	0.04	0.02	blup	36	0.03	2.7e-04	5.7	6.2	6.2e-10	0.91	0.01	0.94	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	PHKG1	0.07	0.06	enet	4	0.06	3.9e-06	-5.1	-6.2	6.2e-10	-0.54	0.04	0.96	FALSE
17	METSIM	Adipose	CCT6A	0.03	0.04	lasso	1	0.03	2.0e-05	-6.2	-6.2	7.6e-10	-0.44	0.00	1.00	FALSE
3	GTEx	Brain Hypothalamus	GBAS	0.21	0.12	lasso	3	0.08	6.3e-03	6.0	-6.1	8.8e-10	-0.89	0.02	0.76	FALSE
1	GTEx	Brain Caudate basal ganglia	GBAS	0.19	0.11	lasso	5	0.07	4.1e-03	5.5	-6.0	2.2e-09	-0.91	0.03	0.71	FALSE
22	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CHCHD2	0.06	0.06	lasso	4	0.06	1.8e-05	5.9	5.9	2.9e-09	0.95	0.01	0.99	FALSE
4	GTEx	Cells Transformed fibroblasts	GBAS	0.16	0.01	enet	26	0.07	9.2e-06	-1.5	-5.9	4.4e-09	-0.48	0.13	0.79	FALSE
21	YFS	Blood	GBAS	0.02	0.01	lasso	6	0.01	2.0e-03	-6.2	-5.9	4.7e-09	-0.39	0.00	0.98	FALSE
9	GTEx	Prostate	GBAS	0.33	0.08	lasso	8	0.13	3.4e-04	-5.2	-5.8	4.9e-09	-0.41	0.14	0.29	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSPH	0.03	0.00	enet	6	0.02	3.8e-05	1.6	-5.8	5.2e-09	-0.30	0.07	0.27	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	GBAS	0.25	0.08	enet	22	0.26	5.5e-25	-1.5	-5.8	5.8e-09	-0.45	0.75	0.24	FALSE
20	YFS	Blood	CCT6A	0.03	0.02	lasso	4	0.02	5.5e-06	-6.2	-5.8	9.0e-09	-0.39	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBAS	0.05	0.03	blup	48	0.04	2.8e-08	-5.2	-5.7	9.7e-09	-0.44	0.14	0.84	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUMF2	0.04	0.04	enet	5	0.04	1.4e-05	5.7	5.7	1.6e-08	0.47	0.04	0.95	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	GBAS	0.18	0.06	enet	12	0.13	6.0e-15	-2.0	-5.6	1.8e-08	-0.47	0.93	0.06	FALSE
11	GTEx	Skin Sun Exposed Lower leg	CHCHD2	0.07	0.09	lasso	5	0.05	3.6e-05	5.7	5.6	2.4e-08	0.96	0.02	0.98	FALSE
18	METSIM	Adipose	CHCHD2	0.30	0.27	bslmm	256	0.27	4.1e-41	5.9	5.6	2.7e-08	0.96	0.03	0.97	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	GBAS	0.20	0.08	blup	48	0.21	8.4e-22	-5.2	-5.5	3.2e-08	-0.36	0.16	0.84	FALSE
2	GTEx	Brain Cerebellum	GBAS	0.24	0.01	lasso	10	0.03	4.6e-02	-4.6	-5.5	3.5e-08	-0.54	0.05	0.50	FALSE
15	GTEx	Testis	ZNF713	0.15	0.00	enet	10	0.00	1.9e-01	-5.6	5.5	3.7e-08	0.64	0.02	0.51	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	CHCHD2	0.03	0.02	lasso	2	0.02	1.2e-03	5.9	5.5	3.7e-08	0.91	0.01	0.98	FALSE
14	GTEx	Testis	GBAS	0.17	0.03	enet	28	0.09	8.2e-05	6.0	-5.4	6.2e-08	-0.60	0.06	0.84	FALSE
12	GTEx	Skin Sun Exposed Lower leg	GBAS	0.14	0.09	enet	32	0.10	1.3e-08	6.0	-5.4	6.7e-08	-0.71	0.02	0.98	FALSE
13	GTEx	Stomach	GBAS	0.19	0.01	enet	26	0.07	3.7e-04	-5.2	-5.3	8.7e-08	-0.44	0.12	0.57	FALSE
16	GTEx	Thyroid	GBAS	0.31	0.14	lasso	9	0.30	1.3e-23	-1.5	-5.3	1.3e-07	-0.46	0.10	0.90	FALSE
8	GTEx	Pancreas	GBAS	0.19	0.05	enet	35	0.07	6.6e-04	-3.6	-5.2	1.7e-07	-0.50	0.06	0.86	FALSE
30	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GBAS	0.18	0.00	blup	48	0.11	2.6e-05	-2.0	-5.2	2.0e-07	-0.37	0.02	0.27	FALSE
5	GTEx	Esophagus Mucosa	CCT6A	0.06	0.03	lasso	2	0.02	1.1e-02	-5.2	-5.2	2.3e-07	-0.31	0.15	0.19	FALSE
7	GTEx	Nerve Tibial	GBAS	0.14	0.01	lasso	3	0.04	1.0e-03	6.0	-5.2	2.7e-07	-0.78	0.01	0.96	FALSE
25	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHCHD2	0.07	0.04	enet	8	0.06	4.2e-04	5.7	5.1	3.1e-07	0.85	0.01	0.88	FALSE