Best TWAS P=1.06e-12 · Best GWAS P=6.17e-10 conditioned to 0.206
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | GBAS | 0.19 | 0.11 | lasso | 5 | 0.07 | 4.1e-03 | 5.5 | -6.0 | 2.2e-09 | -0.91 | 0.03 | 0.71 | FALSE |
2 | GTEx | Brain Cerebellum | GBAS | 0.24 | 0.01 | lasso | 10 | 0.03 | 4.6e-02 | -4.6 | -5.5 | 3.5e-08 | -0.54 | 0.05 | 0.50 | FALSE |
3 | GTEx | Brain Hypothalamus | GBAS | 0.21 | 0.12 | lasso | 3 | 0.08 | 6.3e-03 | 6.0 | -6.1 | 8.8e-10 | -0.89 | 0.02 | 0.76 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | GBAS | 0.16 | 0.01 | enet | 26 | 0.07 | 9.2e-06 | -1.5 | -5.9 | 4.4e-09 | -0.48 | 0.13 | 0.79 | FALSE |
5 | GTEx | Esophagus Mucosa | CCT6A | 0.06 | 0.03 | lasso | 2 | 0.02 | 1.1e-02 | -5.2 | -5.2 | 2.3e-07 | -0.31 | 0.15 | 0.19 | FALSE |
6 | GTEx | Lung | GBAS | 0.07 | 0.00 | lasso | 3 | 0.00 | 1.9e-01 | 6.0 | -6.5 | 1.0e-10 | -0.88 | 0.02 | 0.84 | FALSE |
7 | GTEx | Nerve Tibial | GBAS | 0.14 | 0.01 | lasso | 3 | 0.04 | 1.0e-03 | 6.0 | -5.2 | 2.7e-07 | -0.78 | 0.01 | 0.96 | FALSE |
8 | GTEx | Pancreas | GBAS | 0.19 | 0.05 | enet | 35 | 0.07 | 6.6e-04 | -3.6 | -5.2 | 1.7e-07 | -0.50 | 0.06 | 0.86 | FALSE |
9 | GTEx | Prostate | GBAS | 0.33 | 0.08 | lasso | 8 | 0.13 | 3.4e-04 | -5.2 | -5.8 | 4.9e-09 | -0.41 | 0.14 | 0.29 | FALSE |
10 | GTEx | Skin Not Sun Exposed Suprapubic | GBAS | 0.08 | 0.00 | lasso | 9 | 0.01 | 6.3e-02 | 6.0 | -6.9 | 5.0e-12 | -0.69 | 0.04 | 0.67 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | CHCHD2 | 0.07 | 0.09 | lasso | 5 | 0.05 | 3.6e-05 | 5.7 | 5.6 | 2.4e-08 | 0.96 | 0.02 | 0.98 | FALSE |
12 | GTEx | Skin Sun Exposed Lower leg | GBAS | 0.14 | 0.09 | enet | 32 | 0.10 | 1.3e-08 | 6.0 | -5.4 | 6.7e-08 | -0.71 | 0.02 | 0.98 | FALSE |
13 | GTEx | Stomach | GBAS | 0.19 | 0.01 | enet | 26 | 0.07 | 3.7e-04 | -5.2 | -5.3 | 8.7e-08 | -0.44 | 0.12 | 0.57 | FALSE |
14 | GTEx | Testis | GBAS | 0.17 | 0.03 | enet | 28 | 0.09 | 8.2e-05 | 6.0 | -5.4 | 6.2e-08 | -0.60 | 0.06 | 0.84 | FALSE |
15 | GTEx | Testis | ZNF713 | 0.15 | 0.00 | enet | 10 | 0.00 | 1.9e-01 | -5.6 | 5.5 | 3.7e-08 | 0.64 | 0.02 | 0.51 | FALSE |
16 | GTEx | Thyroid | GBAS | 0.31 | 0.14 | lasso | 9 | 0.30 | 1.3e-23 | -1.5 | -5.3 | 1.3e-07 | -0.46 | 0.10 | 0.90 | FALSE |
17 | METSIM | Adipose | CCT6A | 0.03 | 0.04 | lasso | 1 | 0.03 | 2.0e-05 | -6.2 | -6.2 | 7.6e-10 | -0.44 | 0.00 | 1.00 | FALSE |
18 | METSIM | Adipose | CHCHD2 | 0.30 | 0.27 | bslmm | 256 | 0.27 | 4.1e-41 | 5.9 | 5.6 | 2.7e-08 | 0.96 | 0.03 | 0.97 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | GBAS | 0.17 | 0.06 | lasso | 5 | 0.11 | 2.7e-14 | -6.2 | -7.1 | 1.1e-12 | -0.75 | 0.00 | 1.00 | TRUE |
20 | YFS | Blood | CCT6A | 0.03 | 0.02 | lasso | 4 | 0.02 | 5.5e-06 | -6.2 | -5.8 | 9.0e-09 | -0.39 | 0.00 | 1.00 | FALSE |
21 | YFS | Blood | GBAS | 0.02 | 0.01 | lasso | 6 | 0.01 | 2.0e-03 | -6.2 | -5.9 | 4.7e-09 | -0.39 | 0.00 | 0.98 | FALSE |
22 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CHCHD2 | 0.06 | 0.06 | lasso | 4 | 0.06 | 1.8e-05 | 5.9 | 5.9 | 2.9e-09 | 0.95 | 0.01 | 0.99 | FALSE |
23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GBAS | 0.05 | 0.03 | blup | 48 | 0.04 | 2.8e-08 | -5.2 | -5.7 | 9.7e-09 | -0.44 | 0.14 | 0.84 | FALSE |
24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PSPH | 0.03 | 0.00 | enet | 6 | 0.02 | 3.8e-05 | 1.6 | -5.8 | 5.2e-09 | -0.30 | 0.07 | 0.27 | FALSE |
25 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CHCHD2 | 0.07 | 0.04 | enet | 8 | 0.06 | 4.2e-04 | 5.7 | 5.1 | 3.1e-07 | 0.85 | 0.01 | 0.88 | FALSE |
26 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GBAS | 0.18 | 0.06 | enet | 12 | 0.13 | 6.0e-15 | -2.0 | -5.6 | 1.8e-08 | -0.47 | 0.93 | 0.06 | FALSE |
27 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PHKG1 | 0.04 | 0.02 | blup | 36 | 0.03 | 2.7e-04 | 5.7 | 6.2 | 6.2e-10 | 0.91 | 0.01 | 0.94 | FALSE |
28 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SUMF2 | 0.04 | 0.04 | enet | 5 | 0.04 | 1.4e-05 | 5.7 | 5.7 | 1.6e-08 | 0.47 | 0.04 | 0.95 | FALSE |
29 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHCHD2 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.2e-03 | 5.9 | 5.5 | 3.7e-08 | 0.91 | 0.01 | 0.98 | FALSE |
30 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | GBAS | 0.18 | 0.00 | blup | 48 | 0.11 | 2.6e-05 | -2.0 | -5.2 | 2.0e-07 | -0.37 | 0.02 | 0.27 | FALSE |
31 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GBAS | 0.20 | 0.08 | blup | 48 | 0.21 | 8.4e-22 | -5.2 | -5.5 | 3.2e-08 | -0.36 | 0.16 | 0.84 | FALSE |
32 | The Cancer Genome Atlas | Thyroid Carcinoma | GBAS | 0.25 | 0.08 | enet | 22 | 0.26 | 5.5e-25 | -1.5 | -5.8 | 5.8e-09 | -0.45 | 0.75 | 0.24 | FALSE |
33 | The Cancer Genome Atlas | Thyroid Carcinoma | PHKG1 | 0.07 | 0.06 | enet | 4 | 0.06 | 3.9e-06 | -5.1 | -6.2 | 6.2e-10 | -0.54 | 0.04 | 0.96 | FALSE |