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chr7:64,679,561-67,154,651

Best TWAS P=8.42e-14 · Best GWAS P=7.49e-14 conditioned to 0.00352

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	GTEx	Brain Putamen basal ganglia	GS1-124K5.4	0.31	0.32	enet	23	0.36	1.7e-09	6.4	7.5	8.4e-14	0.74	0.26	0.71	TRUE
2	CommonMind	Brain Pre-frontal Cortex	SBDS	0.08	0.05	lasso	3	0.04	5.4e-06	7.4	7.4	1.4e-13	0.99	0.00	1.00	FALSE
50	GTEx	Spleen	GS1-124K5.4	0.28	0.17	enet	19	0.23	1.3e-06	5.6	7.3	3.9e-13	0.69	0.37	0.61	FALSE
38	GTEx	Muscle Skeletal	VKORC1L1	0.05	0.02	lasso	3	0.02	2.9e-03	6.5	7.0	3.5e-12	0.80	0.03	0.92	FALSE
53	GTEx	Thyroid	GS1-124K5.4	0.17	0.16	lasso	6	0.15	1.2e-11	6.4	6.9	6.8e-12	0.74	0.65	0.35	FALSE
17	GTEx	Brain Cortex	GS1-124K5.4	0.37	0.31	lasso	11	0.30	4.0e-09	6.4	6.8	1.3e-11	0.83	0.32	0.68	FALSE
54	GTEx	Vagina	GS1-124K5.4	0.27	0.22	lasso	3	0.19	3.5e-05	6.4	6.6	3.8e-11	0.77	0.33	0.29	FALSE
5	GTEx	Artery Aorta	GS1-124K5.4	0.11	0.08	lasso	3	0.09	9.1e-06	6.4	6.6	5.1e-11	0.70	0.86	0.12	FALSE
14	GTEx	Brain Cerebellar Hemisphere	GS1-124K5.4	0.27	0.27	lasso	8	0.24	6.0e-07	6.4	6.6	5.4e-11	0.77	0.54	0.38	FALSE
45	GTEx	Pancreas	GS1-124K5.4	0.10	0.10	lasso	5	0.05	4.2e-03	6.4	6.5	5.7e-11	0.79	0.34	0.54	FALSE
44	GTEx	Ovary	GS1-124K5.4	0.19	0.20	enet	28	0.23	1.9e-06	5.1	6.5	6.0e-11	0.75	0.20	0.75	FALSE
46	GTEx	Prostate	GS1-124K5.4	0.23	0.19	lasso	15	0.19	1.9e-05	5.4	6.5	8.5e-11	0.63	0.22	0.65	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	GS1-124K5.4	0.15	0.07	lasso	6	0.10	3.1e-04	5.5	6.5	1.1e-10	0.70	0.67	0.15	FALSE
40	GTEx	Muscle Skeletal	KCTD7	0.04	0.02	lasso	1	0.01	5.3e-02	6.4	6.4	1.3e-10	0.78	0.09	0.35	FALSE
20	GTEx	Brain Hypothalamus	GS1-124K5.11	0.10	0.09	lasso	12	0.08	5.7e-03	6.4	-6.4	1.5e-10	-0.77	0.18	0.39	FALSE
8	GTEx	Artery Tibial	GS1-124K5.4	0.21	0.20	lasso	3	0.19	1.3e-14	6.4	6.4	1.6e-10	0.77	0.79	0.21	FALSE
10	GTEx	Brain Caudate basal ganglia	GS1-124K5.4	0.21	0.25	lasso	10	0.27	2.5e-08	6.4	6.4	2.0e-10	0.76	0.71	0.27	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	GS1-124K5.4	0.30	0.29	lasso	4	0.31	3.1e-17	6.4	6.4	2.1e-10	0.75	0.74	0.26	FALSE
43	GTEx	Ovary	GS1-124K5.11	0.14	0.15	lasso	4	0.15	1.5e-04	5.5	-6.3	2.9e-10	-0.64	0.18	0.64	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASL	0.07	0.04	lasso	3	0.05	5.0e-06	5.0	-6.3	3.1e-10	-0.70	0.15	0.83	FALSE
49	GTEx	Skin Sun Exposed Lower leg	KCTD7	0.04	0.03	enet	13	0.04	1.8e-04	5.1	6.3	3.4e-10	0.73	0.26	0.68	FALSE
3	GTEx	Adipose Subcutaneous	GS1-124K5.4	0.14	0.12	lasso	5	0.14	1.6e-11	6.4	6.2	4.4e-10	0.74	0.78	0.22	FALSE
63	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NCRNA00174	0.06	0.04	blup	27	0.06	9.0e-08	5.0	-6.2	6.3e-10	-0.72	0.02	0.98	FALSE
51	GTEx	Thyroid	GS1-124K5.11	0.24	0.17	lasso	16	0.22	1.3e-16	6.4	-6.2	6.6e-10	-0.78	0.22	0.78	FALSE
6	GTEx	Artery Coronary	GS1-124K5.4	0.13	0.11	lasso	3	0.12	6.7e-05	5.1	6.1	8.3e-10	0.72	0.75	0.14	FALSE
36	GTEx	Esophagus Muscularis	GS1-124K5.4	0.13	0.11	lasso	4	0.13	4.1e-08	6.4	6.1	8.5e-10	0.73	0.81	0.19	FALSE
27	GTEx	Cells Transformed fibroblasts	ASL	0.08	0.04	lasso	4	0.03	2.3e-03	6.3	-6.1	1.1e-09	-0.78	0.03	0.70	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	ASL	0.11	0.05	blup	21	0.07	1.8e-07	5.1	-6.0	1.5e-09	-0.56	0.17	0.47	FALSE
4	GTEx	Adipose Visceral Omentum	GS1-124K5.4	0.20	0.19	enet	29	0.18	1.1e-09	6.5	6.0	1.6e-09	0.71	0.78	0.22	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	GS1-124K5.4	0.12	0.19	lasso	13	0.22	7.9e-28	5.0	6.0	1.6e-09	0.72	0.98	0.02	FALSE
31	GTEx	Cells Transformed fibroblasts	KCTD7	0.09	0.10	lasso	5	0.10	2.7e-08	5.0	6.0	1.7e-09	0.67	0.84	0.16	FALSE
32	GTEx	Colon Transverse	GS1-124K5.4	0.11	0.11	lasso	5	0.10	2.5e-05	5.5	6.0	2.0e-09	0.61	0.87	0.11	FALSE
37	GTEx	Lung	GS1-124K5.4	0.17	0.17	lasso	8	0.16	3.9e-12	6.4	6.0	2.2e-09	0.73	0.76	0.24	FALSE
39	GTEx	Muscle Skeletal	GS1-124K5.4	0.18	0.16	lasso	3	0.21	3.1e-20	5.0	5.9	3.2e-09	0.71	0.97	0.03	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	KCTD7	0.02	0.01	blup	28	0.01	1.6e-02	5.1	5.9	3.4e-09	0.57	0.02	0.31	FALSE
30	GTEx	Cells Transformed fibroblasts	GS1-124K5.4	0.14	0.12	lasso	5	0.14	2.4e-10	6.4	5.9	4.7e-09	0.71	0.80	0.20	FALSE
55	GTEx	Whole Blood	GS1-124K5.4	0.18	0.14	enet	18	0.12	1.5e-11	6.4	5.8	6.8e-09	0.62	0.80	0.20	FALSE
34	GTEx	Esophagus Gastroesophageal Junction	GS1-124K5.4	0.14	0.14	lasso	7	0.11	1.0e-04	5.1	5.8	7.4e-09	0.68	0.24	0.71	FALSE
35	GTEx	Esophagus Mucosa	KCTD7	0.04	0.04	lasso	4	0.05	3.2e-04	4.9	5.8	8.6e-09	0.69	0.60	0.12	FALSE
7	GTEx	Artery Tibial	GS1-124K5.11	0.05	0.03	lasso	9	0.03	2.6e-03	6.3	-5.8	9.1e-09	-0.68	0.13	0.68	FALSE
12	GTEx	Brain Cerebellar Hemisphere	GS1-124K5.11	0.19	0.28	lasso	2	0.29	4.6e-08	5.1	-5.7	1.0e-08	-0.67	0.60	0.37	FALSE
48	GTEx	Skin Sun Exposed Lower leg	GS1-124K5.4	0.24	0.32	lasso	3	0.32	2.9e-27	5.1	5.7	1.1e-08	0.67	1.00	0.00	FALSE
62	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KCTD7	0.04	0.02	blup	28	0.02	6.7e-03	5.1	5.7	1.1e-08	0.57	0.02	0.36	FALSE
56	METSIM	Adipose	GS1-124K5.4	0.05	0.07	lasso	9	0.07	1.2e-10	5.0	5.6	1.9e-08	0.66	0.97	0.03	FALSE
22	GTEx	Brain Putamen basal ganglia	GS1-124K5.11	0.13	0.14	lasso	2	0.08	4.8e-03	5.5	-5.6	2.0e-08	-0.53	0.26	0.30	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NCRNA00174	0.23	0.32	lasso	2	0.32	1.9e-36	5.6	-5.6	2.6e-08	-0.50	0.19	0.81	FALSE
16	GTEx	Brain Cerebellum	GS1-124K5.4	0.26	0.26	lasso	3	0.22	2.8e-07	6.4	5.5	2.8e-08	0.67	0.72	0.23	FALSE
29	GTEx	Cells Transformed fibroblasts	GS1-124K5.2	0.20	0.08	lasso	4	0.12	5.7e-09	7.0	5.5	2.9e-08	0.35	0.14	0.86	FALSE
19	GTEx	Brain Hypothalamus	CCT6P1	0.24	-0.01	lasso	7	0.01	1.9e-01	6.6	-5.5	3.0e-08	-0.17	0.02	0.09	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	TPST1	0.07	0.03	blup	75	0.05	3.5e-06	5.0	5.5	3.0e-08	0.70	0.09	0.90	FALSE
24	GTEx	Breast Mammary Tissue	GS1-124K5.4	0.19	0.13	enet	25	0.18	2.0e-09	6.3	5.5	3.1e-08	0.67	0.84	0.16	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	GS1-124K5.11	0.46	0.04	lasso	5	0.11	6.8e-05	3.4	-5.5	4.0e-08	-0.61	0.03	0.78	FALSE
21	GTEx	Brain Hypothalamus	GTF2IRD1P1	0.15	0.16	lasso	11	0.11	1.8e-03	5.4	-5.5	5.1e-08	-0.50	0.22	0.22	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	KCTD7	0.08	0.07	enet	20	0.08	8.4e-11	5.6	-5.4	5.7e-08	-0.54	1.00	0.00	FALSE
52	GTEx	Thyroid	GTF2IRD1P1	0.30	0.36	lasso	9	0.38	2.1e-30	4.9	5.4	5.9e-08	0.65	1.00	0.00	FALSE
13	GTEx	Brain Cerebellar Hemisphere	GTF2IRD1P1	0.16	0.21	lasso	5	0.21	5.4e-06	5.4	-5.4	6.0e-08	-0.51	0.59	0.20	FALSE
15	GTEx	Brain Cerebellum	GS1-124K5.11	0.12	0.17	lasso	3	0.14	8.7e-05	5.1	-5.3	8.8e-08	-0.58	0.73	0.14	FALSE
41	GTEx	Nerve Tibial	GS1-124K5.4	0.17	0.20	enet	27	0.25	7.5e-18	5.0	5.3	1.1e-07	0.68	0.98	0.02	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	RABGEF1	0.25	0.33	lasso	6	0.35	2.6e-35	4.9	5.3	1.2e-07	0.58	0.90	0.10	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	GS1-124K5.11	0.15	0.16	enet	29	0.19	2.7e-24	5.1	-5.3	1.3e-07	-0.63	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ASL	0.18	0.13	lasso	3	0.14	3.7e-16	5.1	-5.2	1.5e-07	-0.66	1.00	0.00	FALSE
9	GTEx	Brain Caudate basal ganglia	GS1-124K5.11	0.09	0.06	enet	14	0.07	4.4e-03	5.1	-5.2	1.5e-07	-0.58	0.19	0.42	FALSE
28	GTEx	Cells Transformed fibroblasts	GS1-124K5.3	0.10	0.03	enet	15	0.05	2.3e-04	5.5	5.2	1.5e-07	0.31	0.77	0.12	FALSE
11	GTEx	Brain Caudate basal ganglia	RP11-792A8.4	0.14	0.13	lasso	2	0.10	6.4e-04	5.5	5.2	1.8e-07	0.38	0.12	0.13	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	RP11-792A8.4	0.25	0.10	lasso	5	0.14	2.2e-05	5.5	5.1	2.8e-07	0.32	0.24	0.51	FALSE
42	GTEx	Nerve Tibial	CRCP	0.03	0.05	lasso	1	0.04	8.7e-04	5.1	5.1	2.8e-07	0.59	0.40	0.12	FALSE
18	GTEx	Brain Hippocampus	GS1-124K5.11	0.09	0.13	lasso	2	0.03	6.6e-02	5.1	-5.1	2.9e-07	-0.59	0.09	0.43	FALSE