Best TWAS P=2.14e-17 · Best GWAS P=1.08e-18 conditioned to 0.0229
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RMI1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.4e-07 | 8.4 | -8.5 | 2.1e-17 | -0.91 | 0.13 | 0.87 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | RMI1 | 0.11 | 0.03 | lasso | 3 | 0.04 | 3.8e-04 | -6.1 | -5.3 | 1.2e-07 | -0.50 | 0.39 | 0.39 | FALSE |
| 3 | GTEx | Artery Aorta | GKAP1 | 0.15 | 0.02 | enet | 24 | 0.03 | 6.0e-03 | 5.8 | -8.0 | 9.9e-16 | -0.41 | 0.18 | 0.21 | TRUE |
| 4 | GTEx | Esophagus Mucosa | GKAP1 | 0.09 | 0.06 | lasso | 2 | 0.02 | 2.9e-02 | 5.8 | -5.8 | 8.5e-09 | -0.59 | 0.27 | 0.54 | FALSE |
| 5 | GTEx | Testis | RMI1 | 0.12 | 0.11 | enet | 15 | 0.14 | 1.3e-06 | -6.1 | -7.8 | 7.3e-15 | -0.75 | 0.08 | 0.90 | FALSE |
| 6 | METSIM | Adipose | RMI1 | 0.04 | 0.02 | lasso | 7 | 0.01 | 4.9e-03 | -5.8 | -5.5 | 3.4e-08 | -0.47 | 0.26 | 0.65 | FALSE |
| 7 | YFS | Blood | GKAP1 | 0.02 | 0.01 | blup | 614 | 0.01 | 3.2e-04 | 7.3 | -7.5 | 9.2e-14 | -0.63 | 0.21 | 0.68 | FALSE |
| 8 | YFS | Blood | RMI1 | 0.07 | 0.09 | bslmm | 528 | 0.09 | 1.5e-27 | 8.4 | 8.2 | 1.6e-16 | 0.87 | 0.11 | 0.89 | FALSE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | UBQLN1 | 0.03 | 0.02 | lasso | 2 | 0.01 | 2.3e-02 | 6.8 | -6.1 | 8.3e-10 | -0.59 | 0.07 | 0.12 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMI1 | 0.02 | 0.02 | blup | 31 | 0.01 | 8.8e-04 | 8.4 | -8.2 | 2.1e-16 | -0.85 | 0.05 | 0.62 | FALSE |
| 11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RMI1 | 0.05 | 0.04 | lasso | 2 | 0.00 | 1.8e-01 | -6.1 | -6.1 | 9.9e-10 | -0.53 | 0.02 | 0.25 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | RMI1 | 0.40 | 0.03 | lasso | 2 | 0.06 | 1.9e-04 | -6.1 | -5.2 | 1.9e-07 | -0.51 | 0.20 | 0.10 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RMI1 | 0.03 | 0.03 | lasso | 4 | 0.04 | 4.1e-05 | 8.4 | -8.4 | 5.0e-17 | -0.83 | 0.06 | 0.79 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RMI1 | 0.03 | 0.03 | blup | 31 | 0.01 | 1.2e-02 | 8.3 | -8.3 | 9.4e-17 | -0.88 | 0.09 | 0.67 | FALSE |
| 15 | The Cancer Genome Atlas | Rectum Adenocarcinoma | UBQLN1 | 0.22 | 0.02 | lasso | 3 | 0.09 | 3.5e-03 | 6.9 | -6.9 | 6.4e-12 | -0.49 | 0.03 | 0.20 | FALSE |
| 16 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RMI1 | 0.05 | 0.06 | enet | 5 | 0.06 | 2.2e-05 | -5.8 | -8.0 | 1.7e-15 | -0.73 | 0.08 | 0.64 | FALSE |
| 17 | The Cancer Genome Atlas | Stomach Adenocarcinoma | UBQLN1 | 0.06 | 0.00 | blup | 62 | 0.02 | 1.3e-02 | -2.6 | -6.9 | 5.8e-12 | -0.50 | 0.04 | 0.11 | FALSE |
| 18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C9orf64 | 0.17 | 0.05 | enet | 8 | 0.09 | 4.5e-04 | -5.9 | 5.9 | 2.9e-09 | 0.55 | 0.04 | 0.47 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | GKAP1 | 0.05 | 0.06 | lasso | 3 | 0.06 | 1.2e-06 | 5.7 | -5.7 | 1.0e-08 | -0.62 | 0.76 | 0.22 | FALSE |