[Hub]/) : Traits : Standing height :

chr9:34,992,074-36,597,142

Best TWAS P=1.24e-15 · Best GWAS P=5.8e-13 conditioned to 0.2

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TMEM8B 0.16 0.18 lasso 3 0.17 1.2e-20 -5.6 -5.7 1.6e-08 0.80 0.91 0.09 FALSE
2 CommonMind Brain Pre-frontal Cortex TPM2 0.13 0.06 lasso 4 0.09 1.7e-11 -4.9 -5.2 2.4e-07 0.56 0.99 0.01 FALSE
3 GTEx Adipose Subcutaneous SPAG8 0.13 0.04 enet 14 0.06 8.7e-06 -6.6 -6.0 1.9e-09 0.82 0.09 0.91 FALSE
4 GTEx Adipose Subcutaneous TMEM8B 0.23 0.25 lasso 2 0.24 6.7e-20 -5.6 -5.7 9.3e-09 0.81 0.93 0.07 FALSE
5 GTEx Adrenal Gland HRCT1 0.23 0.19 lasso 3 0.15 6.4e-06 -6.7 -7.5 6.0e-14 0.85 0.01 0.98 FALSE
6 GTEx Artery Aorta SPAG8 0.11 0.10 lasso 7 0.06 2.0e-04 6.0 -6.2 5.7e-10 0.36 0.06 0.92 FALSE
7 GTEx Artery Aorta TMEM8B 0.37 0.37 lasso 3 0.36 1.4e-20 -5.6 -5.6 2.0e-08 0.80 0.96 0.04 FALSE
8 GTEx Artery Aorta HRCT1 0.15 0.10 lasso 4 0.09 1.9e-05 -5.4 -5.2 2.5e-07 0.43 0.16 0.42 FALSE
9 GTEx Artery Aorta RP11-112J3.16 0.20 0.09 lasso 5 0.11 1.6e-06 -5.9 -6.1 8.0e-10 0.66 0.26 0.73 FALSE
10 GTEx Artery Tibial TMEM8B 0.30 0.35 lasso 1 0.35 2.5e-28 -5.6 -5.6 1.8e-08 0.80 0.97 0.03 FALSE
11 GTEx Artery Tibial RP11-112J3.16 0.07 0.05 lasso 3 0.05 9.1e-05 -4.9 -6.2 7.7e-10 0.63 0.39 0.55 FALSE
12 GTEx Brain Caudate basal ganglia TMEM8B 0.33 0.25 lasso 2 0.28 7.8e-09 -5.6 -5.9 3.2e-09 0.80 0.30 0.66 FALSE
13 GTEx Brain Cerebellum SPAG8 0.19 0.11 lasso 3 0.11 3.0e-04 -6.2 -5.9 3.6e-09 0.66 0.11 0.41 FALSE
14 GTEx Brain Cerebellum TMEM8B 0.25 0.23 lasso 4 0.21 6.8e-07 -5.6 -6.2 7.1e-10 0.78 0.20 0.69 FALSE
15 GTEx Brain Cortex TMEM8B 0.37 0.29 lasso 2 0.34 2.8e-10 -5.6 -5.9 3.3e-09 0.80 0.28 0.71 FALSE
16 GTEx Brain Frontal Cortex BA9 TMEM8B 0.35 0.28 lasso 3 0.21 3.2e-06 -5.6 -5.6 1.7e-08 0.80 0.22 0.56 FALSE
17 GTEx Brain Nucleus accumbens basal ganglia TMEM8B 0.32 0.36 lasso 2 0.34 6.8e-10 -5.6 -5.6 1.7e-08 0.80 0.44 0.51 FALSE
18 GTEx Brain Putamen basal ganglia TMEM8B 0.29 0.28 lasso 4 0.22 5.4e-06 -5.6 -5.6 2.1e-08 0.80 0.08 0.58 FALSE
19 GTEx Breast Mammary Tissue TMEM8B 0.13 0.16 lasso 2 0.14 1.8e-07 -5.6 -5.4 6.2e-08 0.80 0.52 0.44 FALSE
20 GTEx Breast Mammary Tissue (Female) TMEM8B 0.23 0.12 lasso 2 0.13 1.1e-04 -5.6 -6.2 5.1e-10 0.78 0.08 0.27 FALSE
21 GTEx Breast Mammary Tissue (Female) HRCT1 0.10 0.03 enet 9 0.01 1.2e-01 2.4 -5.9 3.6e-09 0.53 0.03 0.44 FALSE
22 GTEx Colon Transverse HRCT1 0.16 0.04 enet 27 0.08 7.8e-05 -5.4 -5.7 1.4e-08 0.63 0.09 0.73 FALSE
23 GTEx Esophagus Gastroesophageal Junction TMEM8B 0.26 0.21 lasso 2 0.19 2.5e-07 -5.6 -5.4 7.6e-08 0.77 0.31 0.50 FALSE
24 GTEx Esophagus Muscularis TMEM8B 0.20 0.22 lasso 1 0.21 5.1e-13 -5.6 -5.6 1.8e-08 0.80 0.89 0.11 FALSE
25 GTEx Heart Atrial Appendage TMEM8B 0.17 0.26 lasso 1 0.25 1.9e-11 -5.6 -5.6 1.8e-08 0.80 0.38 0.62 FALSE
26 GTEx Heart Atrial Appendage RP11-112J3.16 0.15 0.02 lasso 5 0.05 1.9e-03 -5.9 -7.9 3.6e-15 0.58 0.08 0.44 FALSE
27 GTEx Heart Left Ventricle TMEM8B 0.13 0.16 lasso 1 0.18 8.1e-10 -5.6 -5.6 1.8e-08 0.80 0.31 0.69 FALSE
28 GTEx Heart Left Ventricle NPR2 0.13 0.00 lasso 5 0.00 3.1e-01 -5.9 5.5 5.0e-08 -0.56 0.07 0.17 FALSE
29 GTEx Liver NPR2 0.18 0.04 lasso 3 0.02 1.1e-01 6.7 -6.1 1.0e-09 0.36 0.06 0.61 FALSE
30 GTEx Lung TMEM8B 0.24 0.17 lasso 3 0.16 2.2e-12 -5.6 -5.6 1.9e-08 0.80 0.84 0.16 FALSE
31 GTEx Lung HRCT1 0.08 0.01 enet 14 0.02 5.5e-03 -7.2 -6.7 2.0e-11 0.68 0.01 0.90 FALSE
32 GTEx Muscle Skeletal TMEM8B 0.23 0.24 lasso 2 0.24 1.1e-23 -5.6 -5.5 3.8e-08 0.79 0.97 0.03 FALSE
33 GTEx Muscle Skeletal RP11-112J3.16 0.06 0.07 lasso 3 0.05 2.7e-05 -5.9 -6.1 1.3e-09 0.69 0.67 0.29 FALSE
34 GTEx Nerve Tibial SPAG8 0.13 0.09 lasso 4 0.08 5.2e-06 -6.6 -7.3 2.3e-13 0.95 0.00 1.00 FALSE
35 GTEx Nerve Tibial TMEM8B 0.54 0.50 lasso 5 0.50 1.5e-40 -5.6 -5.8 7.6e-09 0.80 0.97 0.03 FALSE
36 GTEx Nerve Tibial NPR2 0.13 0.03 lasso 4 0.08 3.1e-06 4.2 -5.8 5.2e-09 0.35 0.69 0.04 FALSE
37 GTEx Nerve Tibial RP11-112J3.16 0.13 0.07 lasso 2 0.06 8.8e-05 -5.9 -6.0 2.4e-09 0.68 0.59 0.33 FALSE
38 GTEx Ovary TMEM8B 0.23 0.01 lasso 5 0.02 1.0e-01 -5.0 -6.0 1.9e-09 0.64 0.08 0.26 FALSE
39 GTEx Pituitary TMEM8B 0.29 0.25 lasso 3 0.20 8.5e-06 -6.4 -5.7 1.2e-08 0.89 0.01 0.96 FALSE
40 GTEx Skin Not Sun Exposed Suprapubic TMEM8B 0.12 0.14 lasso 2 0.11 1.9e-06 -5.6 -6.0 2.2e-09 0.80 0.30 0.68 FALSE
41 GTEx Skin Sun Exposed Lower leg TMEM8B 0.19 0.16 enet 29 0.19 6.5e-16 -5.6 -6.3 3.1e-10 0.72 0.47 0.53 FALSE
42 GTEx Testis TMEM8B 0.16 0.19 lasso 2 0.16 1.2e-07 -6.6 -6.5 5.9e-11 0.83 0.12 0.87 FALSE
43 GTEx Thyroid SPAG8 0.15 0.00 enet 17 0.02 5.0e-03 -7.2 -6.2 6.0e-10 0.74 0.00 0.99 FALSE
44 GTEx Thyroid TMEM8B 0.32 0.37 lasso 1 0.36 1.3e-28 -5.6 -5.6 1.8e-08 0.80 0.98 0.02 FALSE
45 GTEx Thyroid RP11-112J3.16 0.26 0.13 lasso 7 0.13 1.9e-10 4.9 -6.6 3.9e-11 0.65 0.50 0.50 FALSE
46 METSIM Adipose TMEM8B 0.06 0.09 lasso 4 0.08 1.1e-12 -5.6 -5.7 1.2e-08 0.80 0.68 0.32 FALSE
47 ROSMAP Brain Pre-frontal Cortex TMEM8B 0.28 0.26 lasso 7 0.30 1.8e-39 -5.6 -6.1 1.4e-09 0.76 0.96 0.04 FALSE
48 ROSMAP Brain Pre-frontal Cortex RP11-112J3.16 0.11 0.12 bslmm 410 0.11 1.5e-13 4.9 -5.3 1.1e-07 0.39 0.36 0.64 FALSE
49 YFS Blood SPAG8 0.04 0.03 lasso 7 0.02 2.6e-08 -7.2 -7.4 1.1e-13 1.00 0.00 1.00 FALSE
50 The Cancer Genome Atlas Bladder Urothelial Carcinoma RGP1 0.07 0.00 lasso 5 0.03 8.1e-04 -2.4 -6.9 4.2e-12 0.35 0.01 0.12 TRUE
51 The Cancer Genome Atlas Breast Invasive Carcinoma SPAG8 0.06 0.02 blup 47 0.02 6.7e-06 -6.6 5.6 2.6e-08 -0.69 0.00 0.99 FALSE
52 The Cancer Genome Atlas Breast Invasive Carcinoma TMEM8B 0.04 0.02 blup 58 0.02 5.6e-05 -6.6 -6.2 5.4e-10 0.77 0.06 0.94 FALSE
53 The Cancer Genome Atlas Colon Adenocarcinoma C9orf128 0.07 0.03 blup 50 0.06 2.3e-04 4.3 -5.4 5.4e-08 0.51 0.16 0.26 FALSE
54 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SPAG8 0.07 0.06 lasso 3 0.06 5.5e-07 -7.2 7.2 6.3e-13 -0.99 0.00 1.00 FALSE
55 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TMEM8B 0.05 0.03 enet 15 0.03 3.7e-04 -5.6 -5.2 1.9e-07 0.65 0.04 0.62 FALSE
56 The Cancer Genome Atlas Rectum Adenocarcinoma C9orf128 0.26 0.06 enet 7 0.14 4.6e-04 -6.4 -6.2 4.4e-10 0.84 0.01 0.89 FALSE
57 The Cancer Genome Atlas Rectum Adenocarcinoma HRCT1 0.26 0.03 blup 49 0.11 1.5e-03 -6.8 -8.0 1.2e-15 0.47 0.00 0.46 TRUE
58 The Cancer Genome Atlas Stomach Adenocarcinoma C9orf128 0.04 0.06 lasso 2 0.05 2.8e-04 6.3 -6.4 2.0e-10 0.37 0.08 0.20 FALSE
59 The Cancer Genome Atlas Thyroid Carcinoma SPAG8 0.08 0.02 lasso 2 0.02 3.5e-03 -7.2 7.2 6.0e-13 -1.00 0.00 1.00 FALSE
60 The Cancer Genome Atlas Thyroid Carcinoma TMEM8B 0.18 0.08 lasso 3 0.10 1.6e-09 3.0 -5.3 1.1e-07 0.76 0.42 0.58 FALSE