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chr9:34,992,074-36,597,142

Best TWAS P=1.24e-15 · Best GWAS P=5.8e-13 conditioned to 0.2

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TMEM8B	0.16	0.18	lasso	3	0.17	1.2e-20	-5.6	-5.7	1.6e-08	0.80	0.91	0.09	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TPM2	0.13	0.06	lasso	4	0.09	1.7e-11	-4.9	-5.2	2.4e-07	0.56	0.99	0.01	FALSE
3	GTEx	Adipose Subcutaneous	SPAG8	0.13	0.04	enet	14	0.06	8.7e-06	-6.6	-6.0	1.9e-09	0.82	0.09	0.91	FALSE
4	GTEx	Adipose Subcutaneous	TMEM8B	0.23	0.25	lasso	2	0.24	6.7e-20	-5.6	-5.7	9.3e-09	0.81	0.93	0.07	FALSE
5	GTEx	Adrenal Gland	HRCT1	0.23	0.19	lasso	3	0.15	6.4e-06	-6.7	-7.5	6.0e-14	0.85	0.01	0.98	FALSE
6	GTEx	Artery Aorta	SPAG8	0.11	0.10	lasso	7	0.06	2.0e-04	6.0	-6.2	5.7e-10	0.36	0.06	0.92	FALSE
7	GTEx	Artery Aorta	TMEM8B	0.37	0.37	lasso	3	0.36	1.4e-20	-5.6	-5.6	2.0e-08	0.80	0.96	0.04	FALSE
8	GTEx	Artery Aorta	HRCT1	0.15	0.10	lasso	4	0.09	1.9e-05	-5.4	-5.2	2.5e-07	0.43	0.16	0.42	FALSE
9	GTEx	Artery Aorta	RP11-112J3.16	0.20	0.09	lasso	5	0.11	1.6e-06	-5.9	-6.1	8.0e-10	0.66	0.26	0.73	FALSE
10	GTEx	Artery Tibial	TMEM8B	0.30	0.35	lasso	1	0.35	2.5e-28	-5.6	-5.6	1.8e-08	0.80	0.97	0.03	FALSE
11	GTEx	Artery Tibial	RP11-112J3.16	0.07	0.05	lasso	3	0.05	9.1e-05	-4.9	-6.2	7.7e-10	0.63	0.39	0.55	FALSE
12	GTEx	Brain Caudate basal ganglia	TMEM8B	0.33	0.25	lasso	2	0.28	7.8e-09	-5.6	-5.9	3.2e-09	0.80	0.30	0.66	FALSE
13	GTEx	Brain Cerebellum	SPAG8	0.19	0.11	lasso	3	0.11	3.0e-04	-6.2	-5.9	3.6e-09	0.66	0.11	0.41	FALSE
14	GTEx	Brain Cerebellum	TMEM8B	0.25	0.23	lasso	4	0.21	6.8e-07	-5.6	-6.2	7.1e-10	0.78	0.20	0.69	FALSE
15	GTEx	Brain Cortex	TMEM8B	0.37	0.29	lasso	2	0.34	2.8e-10	-5.6	-5.9	3.3e-09	0.80	0.28	0.71	FALSE
16	GTEx	Brain Frontal Cortex BA9	TMEM8B	0.35	0.28	lasso	3	0.21	3.2e-06	-5.6	-5.6	1.7e-08	0.80	0.22	0.56	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	TMEM8B	0.32	0.36	lasso	2	0.34	6.8e-10	-5.6	-5.6	1.7e-08	0.80	0.44	0.51	FALSE
18	GTEx	Brain Putamen basal ganglia	TMEM8B	0.29	0.28	lasso	4	0.22	5.4e-06	-5.6	-5.6	2.1e-08	0.80	0.08	0.58	FALSE
19	GTEx	Breast Mammary Tissue	TMEM8B	0.13	0.16	lasso	2	0.14	1.8e-07	-5.6	-5.4	6.2e-08	0.80	0.52	0.44	FALSE
20	GTEx	Breast Mammary Tissue (Female)	TMEM8B	0.23	0.12	lasso	2	0.13	1.1e-04	-5.6	-6.2	5.1e-10	0.78	0.08	0.27	FALSE
21	GTEx	Breast Mammary Tissue (Female)	HRCT1	0.10	0.03	enet	9	0.01	1.2e-01	2.4	-5.9	3.6e-09	0.53	0.03	0.44	FALSE
22	GTEx	Colon Transverse	HRCT1	0.16	0.04	enet	27	0.08	7.8e-05	-5.4	-5.7	1.4e-08	0.63	0.09	0.73	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	TMEM8B	0.26	0.21	lasso	2	0.19	2.5e-07	-5.6	-5.4	7.6e-08	0.77	0.31	0.50	FALSE
24	GTEx	Esophagus Muscularis	TMEM8B	0.20	0.22	lasso	1	0.21	5.1e-13	-5.6	-5.6	1.8e-08	0.80	0.89	0.11	FALSE
25	GTEx	Heart Atrial Appendage	TMEM8B	0.17	0.26	lasso	1	0.25	1.9e-11	-5.6	-5.6	1.8e-08	0.80	0.38	0.62	FALSE
26	GTEx	Heart Atrial Appendage	RP11-112J3.16	0.15	0.02	lasso	5	0.05	1.9e-03	-5.9	-7.9	3.6e-15	0.58	0.08	0.44	FALSE
27	GTEx	Heart Left Ventricle	TMEM8B	0.13	0.16	lasso	1	0.18	8.1e-10	-5.6	-5.6	1.8e-08	0.80	0.31	0.69	FALSE
28	GTEx	Heart Left Ventricle	NPR2	0.13	0.00	lasso	5	0.00	3.1e-01	-5.9	5.5	5.0e-08	-0.56	0.07	0.17	FALSE
29	GTEx	Liver	NPR2	0.18	0.04	lasso	3	0.02	1.1e-01	6.7	-6.1	1.0e-09	0.36	0.06	0.61	FALSE
30	GTEx	Lung	TMEM8B	0.24	0.17	lasso	3	0.16	2.2e-12	-5.6	-5.6	1.9e-08	0.80	0.84	0.16	FALSE
31	GTEx	Lung	HRCT1	0.08	0.01	enet	14	0.02	5.5e-03	-7.2	-6.7	2.0e-11	0.68	0.01	0.90	FALSE
32	GTEx	Muscle Skeletal	TMEM8B	0.23	0.24	lasso	2	0.24	1.1e-23	-5.6	-5.5	3.8e-08	0.79	0.97	0.03	FALSE
33	GTEx	Muscle Skeletal	RP11-112J3.16	0.06	0.07	lasso	3	0.05	2.7e-05	-5.9	-6.1	1.3e-09	0.69	0.67	0.29	FALSE
34	GTEx	Nerve Tibial	SPAG8	0.13	0.09	lasso	4	0.08	5.2e-06	-6.6	-7.3	2.3e-13	0.95	0.00	1.00	FALSE
35	GTEx	Nerve Tibial	TMEM8B	0.54	0.50	lasso	5	0.50	1.5e-40	-5.6	-5.8	7.6e-09	0.80	0.97	0.03	FALSE
36	GTEx	Nerve Tibial	NPR2	0.13	0.03	lasso	4	0.08	3.1e-06	4.2	-5.8	5.2e-09	0.35	0.69	0.04	FALSE
37	GTEx	Nerve Tibial	RP11-112J3.16	0.13	0.07	lasso	2	0.06	8.8e-05	-5.9	-6.0	2.4e-09	0.68	0.59	0.33	FALSE
38	GTEx	Ovary	TMEM8B	0.23	0.01	lasso	5	0.02	1.0e-01	-5.0	-6.0	1.9e-09	0.64	0.08	0.26	FALSE
39	GTEx	Pituitary	TMEM8B	0.29	0.25	lasso	3	0.20	8.5e-06	-6.4	-5.7	1.2e-08	0.89	0.01	0.96	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	TMEM8B	0.12	0.14	lasso	2	0.11	1.9e-06	-5.6	-6.0	2.2e-09	0.80	0.30	0.68	FALSE
41	GTEx	Skin Sun Exposed Lower leg	TMEM8B	0.19	0.16	enet	29	0.19	6.5e-16	-5.6	-6.3	3.1e-10	0.72	0.47	0.53	FALSE
42	GTEx	Testis	TMEM8B	0.16	0.19	lasso	2	0.16	1.2e-07	-6.6	-6.5	5.9e-11	0.83	0.12	0.87	FALSE
43	GTEx	Thyroid	SPAG8	0.15	0.00	enet	17	0.02	5.0e-03	-7.2	-6.2	6.0e-10	0.74	0.00	0.99	FALSE
44	GTEx	Thyroid	TMEM8B	0.32	0.37	lasso	1	0.36	1.3e-28	-5.6	-5.6	1.8e-08	0.80	0.98	0.02	FALSE
45	GTEx	Thyroid	RP11-112J3.16	0.26	0.13	lasso	7	0.13	1.9e-10	4.9	-6.6	3.9e-11	0.65	0.50	0.50	FALSE
46	METSIM	Adipose	TMEM8B	0.06	0.09	lasso	4	0.08	1.1e-12	-5.6	-5.7	1.2e-08	0.80	0.68	0.32	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	TMEM8B	0.28	0.26	lasso	7	0.30	1.8e-39	-5.6	-6.1	1.4e-09	0.76	0.96	0.04	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	RP11-112J3.16	0.11	0.12	bslmm	410	0.11	1.5e-13	4.9	-5.3	1.1e-07	0.39	0.36	0.64	FALSE
49	YFS	Blood	SPAG8	0.04	0.03	lasso	7	0.02	2.6e-08	-7.2	-7.4	1.1e-13	1.00	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RGP1	0.07	0.00	lasso	5	0.03	8.1e-04	-2.4	-6.9	4.2e-12	0.35	0.01	0.12	TRUE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	SPAG8	0.06	0.02	blup	47	0.02	6.7e-06	-6.6	5.6	2.6e-08	-0.69	0.00	0.99	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM8B	0.04	0.02	blup	58	0.02	5.6e-05	-6.6	-6.2	5.4e-10	0.77	0.06	0.94	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	C9orf128	0.07	0.03	blup	50	0.06	2.3e-04	4.3	-5.4	5.4e-08	0.51	0.16	0.26	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SPAG8	0.07	0.06	lasso	3	0.06	5.5e-07	-7.2	7.2	6.3e-13	-0.99	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM8B	0.05	0.03	enet	15	0.03	3.7e-04	-5.6	-5.2	1.9e-07	0.65	0.04	0.62	FALSE
56	The Cancer Genome Atlas	Rectum Adenocarcinoma	C9orf128	0.26	0.06	enet	7	0.14	4.6e-04	-6.4	-6.2	4.4e-10	0.84	0.01	0.89	FALSE
57	The Cancer Genome Atlas	Rectum Adenocarcinoma	HRCT1	0.26	0.03	blup	49	0.11	1.5e-03	-6.8	-8.0	1.2e-15	0.47	0.00	0.46	TRUE
58	The Cancer Genome Atlas	Stomach Adenocarcinoma	C9orf128	0.04	0.06	lasso	2	0.05	2.8e-04	6.3	-6.4	2.0e-10	0.37	0.08	0.20	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	SPAG8	0.08	0.02	lasso	2	0.02	3.5e-03	-7.2	7.2	6.0e-13	-1.00	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM8B	0.18	0.08	lasso	3	0.10	1.6e-09	3.0	-5.3	1.1e-07	0.76	0.42	0.58	FALSE