Best TWAS P=1.13e-14 · Best GWAS P=2.47e-33 conditioned to 1.63e-27
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | GOLM1 | 0.17 | 0.00 | enet | 24 | 0.08 | 5.2e-05 | 3.5 | 7.7 | 1.1e-14 | -0.03 | 0.07 | 0.26 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C9orf170 | 0.02 | 0.01 | blup | 63 | 0.00 | 9.8e-02 | -7.1 | 7.6 | 2.4e-14 | 0.07 | 0.01 | 0.84 | TRUE |
| 4 | GTEx | Heart Atrial Appendage | CDC20P1 | 0.23 | 0.10 | enet | 21 | 0.07 | 3.6e-04 | -3.4 | -7.0 | 2.9e-12 | -0.01 | 0.52 | 0.27 | TRUE |
| 2 | GTEx | Artery Aorta | CDK20 | 0.11 | 0.00 | enet | 12 | 0.00 | 2.4e-01 | 8.4 | 6.1 | 8.2e-10 | 0.23 | 0.06 | 0.22 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | CDK20 | 0.05 | 0.02 | blup | 23 | 0.03 | 1.7e-04 | -5.1 | 5.8 | 6.8e-09 | 0.09 | 0.04 | 0.89 | TRUE |
| 5 | YFS | Blood | ISCA1 | 0.02 | 0.01 | lasso | 5 | 0.01 | 1.3e-05 | -4.9 | 5.7 | 9.8e-09 | -0.05 | 1.00 | 0.00 | TRUE |
| 10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ISCA1 | 0.13 | 0.13 | lasso | 3 | 0.13 | 3.3e-05 | 5.5 | 5.6 | 1.7e-08 | -0.04 | 0.01 | 0.94 | FALSE |
| 9 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CDK20 | 0.08 | 0.04 | blup | 23 | 0.05 | 4.7e-04 | -4.9 | 5.5 | 3.7e-08 | 0.10 | 0.03 | 0.68 | FALSE |
| 6 | YFS | Blood | ZCCHC6 | 0.06 | 0.06 | lasso | 7 | 0.06 | 1.3e-17 | 5.5 | -5.4 | 5.7e-08 | 0.05 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Esophagus Muscularis | ZCCHC6 | 0.16 | 0.08 | enet | 12 | 0.09 | 3.5e-06 | -4.9 | -5.4 | 7.3e-08 | 0.02 | 0.92 | 0.00 | FALSE |