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chr10:63,856,856-66,034,105

Best TWAS P=7.23e-20 · Best GWAS P=4.81e-14 conditioned to 0.762

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	NTR	Blood	NRBF2	0.03	0.01	bslmm	386	0.01	3.4e-05	3.6	9.1	7.2e-20	0.32	0.18	0.14	TRUE
7	GTEx	Muscle Skeletal	RP11-436D10.3	0.08	0.04	enet	13	0.06	3.2e-06	-4.2	6.0	1.5e-09	0.80	0.02	0.98	TRUE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADO	0.07	0.06	blup	53	0.05	2.5e-06	7.5	7.8	6.7e-15	0.89	0.00	1.00	FALSE
10	GTEx	Testis	ADO	0.21	0.23	lasso	7	0.22	6.6e-10	7.1	-7.1	1.0e-12	-0.95	0.03	0.97	FALSE
6	GTEx	Muscle Skeletal	ADO	0.15	0.16	lasso	8	0.16	1.1e-15	7.1	7.1	1.7e-12	0.91	0.05	0.95	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBF2	0.10	0.06	lasso	7	0.08	3.5e-09	-6.1	-6.8	1.3e-11	0.05	0.00	1.00	FALSE
3	GTEx	Brain Cortex	NRBF2	0.30	0.26	enet	24	0.21	1.4e-06	-5.8	-6.6	4.4e-11	0.06	0.46	0.50	FALSE
4	GTEx	Brain Frontal Cortex BA9	NRBF2	0.25	0.17	lasso	6	0.16	6.1e-05	5.9	-6.6	5.1e-11	0.08	0.32	0.44	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	NRBF2	0.34	0.46	lasso	5	0.46	3.1e-66	5.9	-6.4	1.2e-10	0.08	0.99	0.01	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NRBF2	0.04	0.04	enet	5	0.03	1.3e-04	5.8	-6.4	1.6e-10	0.07	0.01	0.96	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADO	0.03	0.02	blup	53	0.03	1.8e-06	4.2	6.4	1.8e-10	0.81	0.02	0.98	FALSE
9	GTEx	Testis	NRBF2	0.14	0.08	lasso	12	0.09	6.7e-05	5.8	-6.4	2.0e-10	0.06	0.72	0.11	FALSE
2	GTEx	Adipose Subcutaneous	REEP3	0.10	0.03	lasso	3	0.03	7.2e-04	-6.3	6.2	5.0e-10	0.02	0.25	0.56	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBF2	0.08	0.09	lasso	6	0.08	9.7e-09	5.8	-6.2	7.6e-10	0.08	0.01	0.99	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	REEP3	0.10	0.11	lasso	8	0.09	7.2e-12	-5.6	6.1	9.8e-10	-0.01	0.85	0.15	FALSE
5	GTEx	Esophagus Mucosa	NRBF2	0.14	0.11	lasso	10	0.11	6.4e-08	5.8	-6.1	1.2e-09	0.06	0.98	0.01	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADO	0.10	0.03	enet	6	0.06	4.6e-07	7.5	6.0	2.5e-09	0.84	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Skin Cutaneous Melanoma	EGR2	0.12	0.10	blup	56	0.10	1.4e-03	4.9	5.9	4.3e-09	0.58	0.03	0.11	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBF2	0.05	0.06	lasso	2	0.06	5.5e-12	5.9	-5.8	7.2e-09	0.09	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	NRBF2	0.08	0.08	enet	6	0.08	4.3e-09	5.9	-5.8	7.3e-09	0.07	0.01	0.99	FALSE
8	GTEx	Stomach	NRBF2	0.09	0.04	lasso	6	0.03	1.6e-02	-4.3	-5.7	1.5e-08	-0.02	0.12	0.07	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	JMJD1C	0.04	0.01	blup	88	0.01	9.7e-03	5.9	-5.6	1.7e-08	0.05	0.02	0.81	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	REEP3	0.04	0.04	blup	59	0.05	1.8e-06	-6.3	5.6	1.9e-08	-0.01	0.06	0.93	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	NRBF2	0.14	0.10	enet	16	0.09	8.1e-09	5.8	-5.6	2.1e-08	0.09	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	ADO	0.12	0.10	lasso	5	0.09	5.2e-09	-4.2	5.4	8.1e-08	0.77	0.94	0.06	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ADO	0.04	0.01	blup	465	0.02	1.8e-03	7.5	5.3	1.4e-07	0.69	0.01	0.92	FALSE
22	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NRBF2	0.18	0.13	enet	11	0.08	2.5e-04	5.8	-5.2	2.1e-07	0.09	0.01	0.96	FALSE