Best TWAS P=2.36e-15 · Best GWAS P=1.05e-21 conditioned to 0.000274
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | INPP5F | 0.13 | 0.01 | lasso | 5 | 0.01 | 4.0e-02 | -4.28 | 5.5 | 4.9e-08 | 0.26 | 0.14 | 0.17 | FALSE |
2 | GTEx | Breast Mammary Tissue | PRDX3 | 0.27 | 0.00 | enet | 30 | 0.02 | 3.9e-02 | 9.52 | 5.7 | 1.6e-08 | 0.64 | 0.01 | 0.91 | FALSE |
3 | GTEx | Breast Mammary Tissue (Female) | PRDX3 | 0.34 | 0.11 | enet | 31 | 0.12 | 1.9e-04 | 7.01 | 7.1 | 1.1e-12 | 0.64 | 0.03 | 0.72 | TRUE |
4 | GTEx | Esophagus Gastroesophageal Junction | FAM45A | 0.24 | 0.13 | enet | 51 | 0.09 | 2.7e-04 | 7.49 | 7.9 | 2.4e-15 | 0.36 | 0.03 | 0.80 | TRUE |
5 | GTEx | Esophagus Gastroesophageal Junction | BAG3 | 0.44 | 0.32 | lasso | 8 | 0.32 | 2.1e-12 | 4.36 | 6.0 | 2.0e-09 | 0.26 | 0.99 | 0.01 | FALSE |
6 | GTEx | Muscle Skeletal | PRDX3 | 0.10 | 0.10 | lasso | 3 | 0.10 | 4.2e-10 | 5.73 | 5.7 | 1.4e-08 | 0.14 | 1.00 | 0.00 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | CACUL1 | 0.12 | 0.08 | lasso | 4 | 0.06 | 1.2e-08 | -6.42 | 6.3 | 3.0e-10 | 0.06 | 0.97 | 0.03 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | PRDX3 | 0.13 | 0.02 | enet | 33 | 0.06 | 4.4e-08 | 0.88 | 5.6 | 2.2e-08 | 0.07 | 0.69 | 0.01 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | GRK5 | 0.12 | 0.03 | lasso | 8 | 0.06 | 1.0e-08 | 5.29 | -5.5 | 4.5e-08 | -0.28 | 0.98 | 0.01 | FALSE |
10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PRDX3 | 0.03 | 0.00 | blup | 45 | 0.01 | 5.1e-02 | -3.71 | 5.8 | 7.9e-09 | 0.13 | 0.03 | 0.15 | TRUE |
11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C10orf46 | 0.23 | 0.04 | lasso | 4 | 0.04 | 8.6e-03 | -6.42 | 6.6 | 4.8e-11 | 0.06 | 0.00 | 0.87 | TRUE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | PRDX3 | 0.06 | 0.07 | lasso | 2 | 0.05 | 5.2e-06 | 5.73 | 5.7 | 1.3e-08 | 0.13 | 0.94 | 0.01 | FALSE |