TWAS hub - NLRX1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0420	0.0200	1.0e-02	0.028	0.011	0.021	0.017	0.020	1.9e-04	0.0130	1.2e-03	0.0031	1.4e-03
2	GTEx	Adipose Visceral Omentum	0.1380	0.0530	1.3e-03	0.035	NA	0.025	NA	0.031	6.5e-03	NA	1.8e-02	NA	9.6e-03
3	GTEx	Cells Transformed fibroblasts	0.1530	0.0620	7.1e-03	0.023	NA	0.009	NA	0.008	7.7e-03	NA	6.2e-02	NA	7.2e-02
4	GTEx	Esophagus Mucosa	0.3280	0.0700	6.6e-08	0.082	NA	0.187	NA	0.221	3.8e-06	NA	1.4e-12	NA	8.0e-15
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0445	0.0276	7.0e-03	0.001	0.013	0.002	NA	0.004	2.6e-01	0.0110	1.9e-01	NA	1.0e-01
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0532	0.0301	5.3e-05	0.026	0.021	0.050	NA	0.022	5.7e-04	0.0016	2.4e-06	NA	1.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Platelet Count	24.4	282.9	552.2	23.5	7.6	16.8	-19.4	-0.8	20.7
Hearing difficulty/problems: Yes	5.3	8.1	16.4	-2.6	2.6	-2.8	3.2	4.1	0.1
Hearing difficulty/problems with background noise	5.3	8.5	16.6	-3.4	1.2	-3.1	4.1	3.0	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.0	10.6	18.9	4.3	1.9	4.1	-3.7	-1.8	2.7
Allergy	4.9	11.3	31.8	2.7	5.6	3.3	-2.9	-1.6	2.6
Arm predicted mass (left)	4.9	24.9	80.1	-4.7	-8.9	-3.8	2.3	1.1	-5.1
Arm fat-free mass (left)	4.8	24.4	78.1	-4.6	-8.8	-3.7	2.4	1.2	-5.1
Medication: Lansoprazole	4.4	5.0	8.9	-2.7	-0.7	-2.4	3.0	2.7	-0.6
Leg fat mass (left)	4.4	17.1	31.0	-5.5	-4.5	-3.9	2.3	0.3	-5.6
Hayfever, allergic rhinitis or eczema	4.3	9.4	26.1	-2.5	-5.1	-2.7	2.8	1.1	-2.8
Stomach or abdominal pain in last month	4.3	5.3	8.4	-2.8	-1.5	-2.5	2.1	1.5	-2.9
Weight	4.3	20.9	42.9	-5.3	-6.5	-4.2	2.5	0.7	-5.5
Hip circumference	4.2	18.2	30.6	-5.4	-5.1	-3.9	2.8	0.1	-5.5
Arm fat-free mass (right)	4.1	21.0	65.3	-4.3	-8.1	-3.6	2.3	1.2	-4.7
Arm fat mass (left)	4.0	16.6	29.8	-5.5	-4.3	-4.0	3.0	0.6	-5.2
Body mass index (BMI)	3.8	16.2	31.7	-5.6	-3.8	-4.1	3.2	0.7	-4.9
Basal metabolic rate	3.8	21.2	60.2	-4.6	-7.8	-3.5	2.5	0.8	-5.2
Leg fat mass (right)	3.7	14.5	26.6	-5.0	-4.3	-3.6	2.0	0.3	-5.2
Arm predicted mass (right)	3.7	19.0	61.8	-4.0	-7.9	-3.0	2.4	1.4	-4.4
Whole body water mass	3.7	20.8	64.0	-4.3	-8.0	-3.4	2.5	1.1	-4.8
Fractured/broken bones in last 5 years	3.7	4.8	9.0	2.1	1.0	2.4	-3.0	-2.3	1.8
Arm fat mass (right)	3.6	14.8	26.6	-5.2	-4.2	-3.6	2.6	0.6	-4.9
Whole body fat mass	3.5	14.7	27.8	-5.0	-4.2	-3.8	1.9	0.1	-5.3
Whole body fat-free mass	3.5	19.9	61.3	-4.2	-7.8	-3.4	2.4	1.0	-4.7
Leg predicted mass (right)	3.5	18.7	37.9	-4.9	-6.2	-3.8	3.2	1.4	-4.9
Leg fat-free mass (left)	3.4	18.0	37.4	-4.7	-6.1	-3.7	2.9	1.1	-5.0
Heel bone mineral density (BMD) T-score, automated (right)	3.4	7.7	13.8	-3.3	-3.2	-2.6	1.9	0.9	-3.7
Leg fat-free mass (right)	3.4	18.4	38.2	-4.8	-6.2	-3.7	3.2	1.4	-4.8
Leg predicted mass (left)	3.3	17.7	37.7	-4.7	-6.1	-3.6	2.8	1.1	-4.9
BMI	3.2	18.5	35.8	-6.0	-3.1	-4.8	3.1	1.1	-5.6
Trunk fat-free mass	3.2	18.4	70.7	-3.4	-8.4	-2.8	1.7	0.5	-4.1
Trunk predicted mass	3.2	18.5	70.6	-3.4	-8.4	-2.8	1.8	0.6	-4.1
Heel bone mineral density (BMD) T-score, automated (left)	2.9	6.6	10.7	-3.0	-2.8	-2.6	2.1	1.0	-3.3
Trunk fat mass	2.9	12.3	24.5	-4.6	-3.8	-3.4	1.6	0.2	-5.0
Leg pain on walking	2.9	3.6	8.3	-2.3	0.0	-2.9	2.1	1.6	-1.0
Asthma (self-reported)	2.9	5.7	16.2	-1.9	-4.0	-2.7	2.4	0.7	-0.8
Leg fat percentage (left)	2.9	10.5	22.3	-4.7	-2.4	-3.2	1.9	-0.0	-4.6
Pain experienced in last month	2.9	4.8	9.9	3.1	-0.3	2.1	-3.1	-1.6	1.5
Body Mass Index (BMI) (2010)	2.8	3.8	8.6	-2.5	-0.8	-2.9	1.2	0.1	-2.5
Rheumatoid Arthritis	2.8	3.8	5.9	-2.2	-2.2	-1.9	1.9	0.7	-2.4
Osteoarthritis (self-reported)	2.8	3.7	5.6	-2.4	0.9	-2.2	2.3	2.2	-0.8
Medication: Lisinopril	2.8	3.6	6.1	-2.0	-2.5	-2.0	2.2	1.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.3	9.8	-2.3	-0.5	-1.4	3.1	2.9	-0.7
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	8.0	-1.6	-2.8	-1.3	0.8	0.2	-2.4
Asthma	2.7	5.4	13.7	-2.0	-3.7	-2.7	2.6	0.8	-0.6
Worry too long after embarrassment	2.7	4.6	9.4	2.3	2.1	3.1	-0.9	0.7	2.7
Hearing aid user	2.7	3.0	8.9	-0.6	1.2	0.0	3.0	2.2	1.6
Knee pain experienced in last month	2.5	3.9	6.5	-2.5	-0.7	-2.5	2.5	1.4	-1.3
Number of self-reported non-cancer illnesses	2.5	4.4	9.7	-2.0	-0.9	-2.4	3.1	2.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	7.0	-2.4	-0.9	-2.0	2.6	2.0	-0.8
Medication: Seretide 50 evohaler	2.4	2.8	6.4	-2.5	-0.5	-2.5	0.9	1.1	-1.4
Long-standing illness, disability or infirmity	2.4	3.6	6.2	-2.2	-1.1	-2.4	2.5	1.7	-1.1
Commuting to job workplace: Public transport	2.4	2.9	6.2	0.5	-1.8	0.5	1.8	2.5	2.0
Impedance of leg (right)	2.3	11.2	20.3	4.5	2.2	3.4	-4.1	-1.9	3.2
Waist circumference	2.3	8.4	15.9	-4.0	-3.3	-2.7	1.8	0.4	-3.6
Arm fat percentage (right)	2.3	9.0	20.0	-4.5	-1.4	-3.0	2.1	-0.0	-4.3
Impedance of arm (left)	2.3	10.5	27.7	3.7	5.3	2.6	-2.2	-1.2	3.0
Medication: Ventolin 100micrograms inhaler	2.3	2.9	14.4	-0.7	-3.8	-1.6	-0.2	-0.4	-0.2
Body fat percentage	2.3	9.3	20.1	-4.4	-1.8	-3.1	1.7	0.0	-4.5
Impedance of whole body	2.3	11.6	18.5	4.3	4.1	3.3	-3.4	-1.6	3.1
Leg fat percentage (right)	2.2	7.9	17.1	-4.0	-2.1	-2.8	1.4	-0.2	-4.1
Arm fat percentage (left)	2.2	8.9	19.9	-4.5	-1.1	-3.0	2.3	0.2	-4.2
Osteoporosis (self-reported)	2.2	2.7	4.6	2.0	1.3	0.8	-2.1	-1.9	1.4
Depression (Nagel 2018)	2.1	3.2	7.6	-2.8	-0.1	-1.8	1.8	0.6	-2.2
Alzheimer’s Disease (in father)	2.1	2.3	7.3	-1.8	-0.5	-2.7	0.6	0.2	-1.6
Primary Biliary Cirrhosis	2.1	2.9	11.5	1.3	-3.4	-1.3	-0.8	-1.3	-0.4
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	7.2	-1.0	-2.7	-2.3	1.6	0.8	-0.6
Medication: Ramipril	2.1	2.7	7.8	1.8	1.9	0.8	-0.1	1.0	2.8
Impedance of arm (right)	2.1	9.8	21.2	3.7	4.6	2.6	-2.7	-1.6	2.7
Schizophrenia vs Biploar Disorder	2.0	2.6	5.6	-1.9	0.2	-2.3	0.8	0.3	-2.4
Major Depression (MDD)	2.0	2.4	4.0	-2.0	0.1	-1.8	1.5	-0.8	-2.0
Trunk fat percentage	2.0	7.8	16.6	-4.0	-1.9	-2.9	1.5	0.0	-4.1
Number of children fathered	2.0	2.2	4.9	-1.3	2.2	-2.2	0.3	-0.7	-1.2
Ulcerative Colitis (UC)	1.9	3.6	9.5	-1.5	-1.5	-2.3	-0.4	-1.4	-3.1
Medication: Atenolol	1.9	2.4	6.1	-0.7	0.9	0.5	2.5	1.9	1.7
Mouth/teeth dental problems	1.9	2.9	11.8	-0.9	-3.4	-0.9	1.4	0.3	-1.4
Chest pain or discomfort	1.9	2.7	4.7	-2.1	-1.0	-1.9	2.2	0.2	-1.5
Eye problems/disorders: Glaucoma	1.9	2.3	3.8	-1.7	-1.5	-1.8	2.0	1.0	-0.8
Risk taking	1.9	2.8	5.9	0.3	2.3	-0.3	-2.4	-1.9	-1.4
Medication: Co-codamol	1.8	2.1	4.6	-1.8	-1.0	-0.3	2.1	1.8	-0.6
Mouth/teeth dental problems: Dentures	1.8	3.0	10.4	1.3	3.2	0.4	-1.4	-0.4	2.0
Neuroticism (2016)	1.7	2.4	4.2	-2.1	0.2	-1.9	1.5	1.0	-1.7
Allergy or Eczema	1.7	4.4	6.0	-2.2	-2.1	-2.3	2.4	0.9	-2.2
Frequency of depressed mood in last 2 weeks	1.7	2.3	4.5	-2.1	-1.0	-0.4	2.0	0.9	-1.8
Loneliness, isolation	1.7	2.4	6.0	-1.7	0.9	-1.7	1.1	-0.3	-2.4
HbA1C	1.6	1.8	4.3	-2.1	-0.5	-1.4	0.3	1.5	-1.4
Respiratory disease	1.6	3.6	7.2	-2.3	-1.9	-2.7	1.6	-0.0	-1.8
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	5.0	-1.4	0.1	-1.5	1.4	2.2	-0.4
Serious illness, injury or assault to yourself	1.6	1.9	4.2	1.3	1.1	1.6	-1.0	0.8	2.1
High blood pressure (mother)	1.6	2.2	4.3	1.9	1.0	2.1	-0.8	-0.8	1.8
Impedance of leg (left)	1.6	7.6	13.1	3.6	1.8	2.9	-3.3	-1.4	2.7
Worrier / anxious feelings	1.6	3.0	7.4	0.7	1.4	0.7	1.8	2.7	2.1
Hair/balding pattern: Pattern 3	1.6	2.3	4.2	2.1	0.3	1.7	-0.9	1.7	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	5.3	1.0	-1.4	0.8	-1.7	-2.3	0.1
Average weekly red wine intake	1.6	2.3	7.7	-0.7	-0.5	-2.8	-0.9	-0.8	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.2	1.1	0.9	1.7	-1.4	-1.8	-0.0
Pain type(s) experienced in last month: Hip pain	1.6	2.0	5.5	-1.9	0.2	-0.9	2.3	1.4	-0.4
Worry (Nagel 2018)	1.5	3.1	8.3	-1.0	1.9	-0.5	2.1	2.9	1.1
Ever had hysterectomy (womb removed)	1.5	1.7	4.1	-1.3	-1.0	-1.4	2.0	1.3	-0.2
Medication: Allopurinol	1.5	2.0	5.2	-1.6	-1.2	-2.3	0.4	0.3	-1.6
Tinnitus: Yes, now most or all of the time	1.5	1.7	4.1	-1.2	-0.7	-0.7	2.0	1.9	-0.5
Alzheimer’s Disease (in mother)	1.4	1.7	3.5	1.6	1.2	1.9	-1.1	-1.1	0.4
Irritable Bowel Disease (IBD)	1.4	3.2	6.1	-1.6	-2.4	-2.0	-0.1	-1.2	-2.5
Waist Hip Ratio (WHR)	1.4	6.4	11.0	3.3	1.5	2.7	-2.5	-0.3	3.3
Age when periods started (menarche)	1.4	3.5	6.9	2.0	-1.8	1.2	-2.6	-2.1	-0.9
Medication: Levothyroxine sodium	1.4	2.4	10.0	0.7	3.2	0.7	0.6	0.6	1.6
Alcohol usually taken with meals	1.4	2.3	4.4	-1.9	-0.8	-2.1	1.0	0.6	-1.9
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.0	-1.5	-1.3	-1.7	1.1	-0.1	-1.4
Health satisfaction	1.4	1.9	4.3	-1.4	-0.9	-2.1	1.4	1.2	-0.7
Emphysema/chronic bronchitis	1.4	1.5	7.5	-0.2	-2.7	-0.8	-0.7	-0.5	-0.5
Overall health rating	1.4	3.0	6.5	-1.9	-0.8	-1.6	2.5	2.2	-0.2
Supplements: Vitamin C	1.4	1.7	3.8	1.1	1.9	1.9	-0.5	0.2	1.1
Medication: Blood pressure	1.4	2.6	5.9	-0.0	2.4	-0.1	2.1	1.6	1.7
Ovarian Cancer	1.3	1.7	3.5	-1.9	-0.2	-1.4	1.7	1.0	-1.1
Crohns Disease (2012)	1.3	2.1	5.9	1.2	-2.4	1.0	-1.3	-0.3	1.5
Lung FVC	1.3	6.8	18.9	3.1	2.4	4.3	-1.3	-0.3	2.4
Hand grip strength (left)	1.3	3.3	7.6	-1.9	-2.1	-1.6	0.7	1.0	-2.8
Average weekly fortified wine intake	1.3	1.5	4.1	-1.6	-0.8	-1.0	2.0	0.7	-0.6
Qualifications: CSEs or equivalent	1.3	1.7	4.5	1.4	0.3	2.1	-1.1	-1.5	0.6
Sitting height	1.3	9.5	49.0	-1.2	-7.0	-1.4	0.5	0.7	-1.9
Medication: Paracetamol	1.3	2.1	6.1	0.7	2.2	0.6	0.3	0.9	2.5
Glaucoma (self-reported)	1.3	1.6	3.4	-1.3	-1.2	-1.8	1.2	0.9	-0.8
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	13.1	0.3	3.6	0.5	0.4	0.7	0.9
Wheeze or whistling in the chest in last year	1.3	2.2	4.1	-1.3	-1.8	-1.1	-0.1	-1.8	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	14.8	0.5	-3.9	0.8	-0.3	-0.4	-0.3
Number of operations (self-reported)	1.3	1.9	5.1	-1.8	-0.1	-1.4	0.1	0.9	-2.3
Supplements: Calcium	1.3	1.4	4.2	1.2	2.0	0.2	-1.0	-1.3	0.4
Triglycerides	1.2	1.9	4.4	-1.6	0.6	-1.6	0.0	-1.4	-2.1
Type 2 Diabetes (T2D) (2018)	1.2	2.3	3.5	-1.9	-1.2	-1.6	0.7	1.7	-1.6
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.5	-1.4	-0.8	-1.9	1.3	0.2	-1.3
Angina	1.2	1.6	4.0	1.3	0.6	2.0	-1.1	-0.2	1.5
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	5.3	1.2	-0.7	2.3	-0.8	0.0	0.8
Number of incorrect matches in round	1.2	2.1	7.2	1.0	2.7	0.4	-1.5	-1.0	0.9
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	1.9	-1.2	-1.4	-1.2	0.7	1.2	-1.3
Financial difficulties in last 2 years	1.2	1.6	2.5	-1.5	-1.1	-1.3	1.5	-0.1	-1.6
Pain all over the body in last month	1.2	1.3	2.0	-1.1	1.2	-1.3	-0.3	-1.1	-1.4
Exposure to tobacco smoke outside home	1.2	1.6	7.6	-0.5	-2.8	-0.9	0.2	-0.4	-0.8
Neck or shoulder pain in last month	1.2	1.7	2.9	-1.5	-1.7	-0.4	1.7	1.2	-0.9
Pulse rate, automated reading	1.2	4.0	10.5	2.3	-3.2	1.5	-1.7	-0.7	1.6
Medication: Atorvastatin	1.2	1.5	5.2	0.8	0.8	1.4	-0.6	0.3	2.3
Basal cell carcinoma (self-reported)	1.2	1.5	3.4	0.8	1.4	1.2	-1.1	-1.8	-0.2
HDL Cholesterol	1.1	1.9	4.4	1.1	2.1	1.7	-0.4	-0.9	1.3
Heel T-Score	1.1	8.5	27.4	-2.9	-1.3	-5.2	2.0	-0.1	-3.1
Diabetes (father)	1.1	1.4	3.3	-1.5	0.5	-1.5	1.8	0.3	-0.6
Supplements: Glucosamine	1.1	1.5	4.8	-0.8	-0.5	0.0	2.2	1.5	0.8
Medication: Simvastatin	1.1	1.6	3.0	1.0	1.7	1.4	-1.7	-0.8	0.6
Falls in the last year	1.1	1.5	4.0	0.5	2.0	1.6	0.7	-0.6	1.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	5.9	-0.3	-1.6	-0.5	1.2	2.4	-0.4
Shortness of breath walking on level ground	1.1	1.3	3.6	-1.2	-1.0	-1.9	0.3	-0.0	-1.4
Angina (self-reported)	1.1	1.5	3.8	1.2	0.9	2.0	-1.1	-0.1	1.3
Diastolic blood pressure, automated reading	1.1	3.4	11.9	1.6	-3.5	0.1	-1.8	-1.7	-0.2
Neuroticism (Nagel 2018)	1.0	2.4	9.3	-0.6	3.1	0.4	1.0	1.8	0.2
Reaction Time	1.0	1.9	3.7	1.5	1.9	1.5	0.2	0.2	1.8
Lupus	1.0	1.5	3.3	-1.0	-1.1	-1.5	1.8	-0.2	-0.9
Sensitivity / hurt feelings	1.0	1.8	9.1	-0.1	3.0	0.9	0.5	0.7	0.2
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.5	-0.4	0.5	-0.4	1.3	1.9	1.3
Multivitamins +/- minerals	1.0	1.2	3.2	-0.3	-0.1	-0.5	1.8	1.4	1.3
Diabetes (self-reported)	1.0	1.5	2.4	-1.5	-1.5	-0.7	0.2	1.2	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	7.1	2.1	-0.7	2.7	-2.5	-0.4	0.3
Standing height	1.0	9.5	52.0	-0.2	-7.2	-0.5	-0.8	0.1	-2.0
Handedness (chirality/laterality): Left-handed	1.0	1.2	5.6	0.0	2.4	0.4	-0.3	-0.7	0.9
Back pain experienced in last month	1.0	1.4	5.8	-0.6	0.1	-0.4	2.4	0.8	1.2
Medication: Paracetamol	1.0	1.6	5.5	0.7	1.7	0.1	-0.2	0.7	2.3
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.0	1.1	1.4	1.3	-0.6	0.6	1.4
Mean Putamen Volume	0.9	1.0	2.6	1.2	0.4	0.1	-1.6	-1.0	0.8
Ulcerative Colitis	0.9	1.3	3.1	-0.8	-0.3	-1.4	-0.1	-1.5	-1.8
Blood White Count	0.9	6.5	15.5	-3.9	-0.5	-2.8	2.3	0.4	-3.2
Neuroticism	0.9	2.3	4.8	-1.2	1.3	-1.1	2.1	2.2	-0.5
Number of treatments/medications taken	0.9	1.5	3.3	-1.0	1.1	-0.6	1.8	1.3	1.2
Relative age of first facial hair	0.9	1.8	3.9	0.7	1.5	-0.7	-2.0	-1.5	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	3.6	-1.2	-0.7	-0.8	0.5	0.4	-1.9
Nervous feelings	0.9	1.8	5.0	-0.3	0.6	0.2	1.8	2.2	1.3
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	9.8	2.1	-0.3	3.1	-1.7	-0.1	0.8
Illnesses of mother	0.9	1.1	4.4	-0.9	-2.1	-1.1	0.1	0.1	-0.6
Length of working week for main job	0.9	1.0	2.9	0.9	-0.5	0.9	-1.7	-1.1	0.3
Birth weight of first child	0.9	1.6	8.1	-0.5	-2.8	-0.1	0.1	0.2	-1.1
Forced vital capacity (FVC), Best measure	0.9	3.4	6.8	2.1	-2.0	2.6	-2.2	0.0	0.8
Number of full brothers	0.9	1.1	3.8	0.2	0.2	-0.3	-1.4	-1.9	-0.9
Migraine (self-reported)	0.9	1.1	3.5	0.6	1.4	0.0	0.7	0.8	1.9
Diabetes diagnosed by doctor	0.9	1.5	3.0	-1.6	-1.3	-0.9	-0.1	0.9	-1.7
Medication: Gliclazide	0.9	1.0	2.3	1.1	-1.4	1.5	-0.7	-0.3	0.1
Average weekly champagne plus white wine intake	0.9	1.2	2.4	0.5	-1.4	1.6	-1.5	-0.6	-0.3
Depressed Affect (Nagel 2018)	0.8	1.7	5.8	-1.2	2.4	-0.7	1.1	0.5	-1.1
Cardiovascular Disease	0.8	2.6	8.6	-1.5	0.1	-0.6	2.9	1.9	0.8
Lung FEV1/FVC ratio	0.8	3.9	13.9	1.8	1.4	0.7	-3.7	-1.5	-1.3
Chronotype (morning person)	0.8	1.9	3.9	-1.8	1.2	-2.0	0.4	0.7	-1.6
Past tobacco smoking	0.8	1.5	6.9	0.6	-0.1	0.5	-0.9	-2.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.6	-0.7	-0.8	-0.8	1.6	1.6	-0.0
Qualifications: None of the above	0.8	1.7	3.9	-0.6	1.3	0.0	2.0	0.6	1.9
Exposure to tobacco smoke at home	0.8	0.9	2.9	1.2	-1.7	-0.2	-0.8	-0.3	0.3
Breastfed as a baby	0.8	1.0	2.0	-0.8	-1.2	-1.4	0.3	0.8	-1.1
Loud music exposure frequency	0.8	0.8	2.5	0.9	-0.4	0.8	-0.9	-1.6	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.5	-1.6	1.3	-0.9	0.7	-0.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.9	0.1	1.1	0.1	-1.4	-0.9	-1.4
Suffer from ‘nerves’	0.8	1.3	5.3	-0.4	-2.3	-0.0	1.4	0.5	-0.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.0	0.6	1.7	0.0	-0.8	0.8	1.1
Mood swings	0.8	1.5	6.6	-0.4	2.6	0.3	1.1	0.8	0.1
Eye problems/disorders: Cataract	0.8	1.0	1.7	1.3	0.6	1.1	-0.8	0.1	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.1	-0.1	1.4	-0.1	1.0	0.9	1.2
Breast cancer (self-reported)	0.8	1.0	2.3	1.4	-0.4	1.1	-0.5	0.4	1.5
Illnesses of father: None of the above (group 1)	0.8	0.9	2.3	0.9	1.5	1.1	-0.4	0.2	1.0
Wears glasses or contact lenses	0.8	0.9	1.9	-0.8	0.7	-1.4	1.1	0.6	-0.7
High cholesterol (Self-reported)	0.8	1.4	5.9	-0.9	2.4	-0.5	0.9	0.7	0.5
Hypothyroidism (self reported)	0.7	1.6	5.5	-0.2	2.3	-0.2	0.8	1.7	0.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.3	-0.9	0.0	-1.5	0.3	1.1	-0.7
Townsend deprivation index at recruitment	0.7	1.0	2.7	-0.0	-0.2	-0.2	1.6	1.0	1.4
Chronic bronchitis/emphysema (father)	0.7	0.8	3.0	-0.4	-1.7	-1.1	0.0	0.5	-0.3
Hair/balding pattern: Pattern 2	0.7	0.9	2.4	-0.9	-1.0	-1.6	-0.2	0.0	-1.1
Forced vital capacity (FVC)	0.7	2.7	6.4	1.8	-1.9	2.5	-1.6	-0.1	0.6
Alcohol intake versus 10 years previously	0.7	1.0	3.9	0.6	2.0	0.8	-0.0	-0.5	0.9
Medication: Amlodipine	0.7	0.9	3.5	0.8	0.9	1.9	-0.4	0.0	0.7
Birth weight	0.7	1.4	4.1	1.4	-0.7	0.4	-2.0	-1.2	-0.6
Medication for pain relief, constipation, heartburn	0.7	1.3	4.2	-0.6	-2.1	-1.0	0.1	-0.4	-1.4
Medication: Omeprazole	0.7	0.8	1.5	0.9	1.1	1.2	-0.6	0.3	0.9
Comparative height size at age 10	0.7	4.0	19.5	-1.3	-4.4	-0.5	1.0	0.7	-1.0
Hypertension (Self-reported)	0.7	1.8	5.6	-1.1	0.6	-1.0	2.4	1.2	1.2
Smoking status: Previous	0.7	1.1	5.3	-0.8	-0.1	-0.6	0.6	2.3	0.2
Commuting to job workplace: Walk	0.7	0.8	2.6	0.8	-1.6	0.3	0.7	0.3	0.9
Mineral and other dietary supplements	0.7	0.9	2.9	0.9	-1.2	0.6	-1.7	-0.3	-0.3
Medication: Bendroflumethiazide	0.7	1.1	2.1	-0.8	0.9	0.7	1.4	1.2	0.9
Illnesses of father: High blood pressure	0.7	0.9	2.4	-0.1	-1.5	1.2	1.0	0.6	0.2
Bipolar Disorder (2018)	0.6	1.0	3.6	0.1	0.7	-0.3	-1.1	-1.9	-0.5
Bipolar Disorder or Schizophrenia	0.6	1.4	4.7	0.5	1.1	-0.2	-1.3	-2.2	-0.9
Blood Eosinophil Count	0.6	4.8	11.6	-3.4	0.9	-0.7	3.1	1.7	-1.8
Blood Red Count	0.6	6.0	22.4	2.6	0.3	2.0	-0.0	1.7	4.7
Average weekly spirits intake	0.6	0.7	1.9	-0.8	0.5	-0.2	0.5	-1.0	-1.4
Supplements: Zinc	0.6	0.6	1.9	-0.1	1.4	-0.1	1.0	0.0	1.0
Severe depression (siblings)	0.6	0.6	2.0	-0.2	-0.4	0.8	0.9	1.4	0.5
Relative age voice broke	0.6	0.9	2.6	0.8	0.6	-0.5	-1.6	-1.1	-0.7
High blood pressure	0.6	1.7	5.3	-1.2	0.7	-0.8	2.3	1.2	1.1
Happiness	0.6	0.7	1.9	-0.7	-1.1	-0.3	0.1	0.8	-1.4
Qualifications: A levels/AS levels or equivalent	0.6	1.4	6.7	-0.4	-2.6	-0.0	0.3	0.9	-0.7
Medication: Cholesterol lowering	0.6	0.9	2.7	-0.1	1.7	1.6	-0.3	-0.1	0.5
Lung cancer (father)	0.6	0.7	2.2	0.8	-0.7	0.2	-0.9	-1.5	0.4
Pulse wave Arterial Stiffness index	0.6	0.7	2.6	0.9	-0.8	-0.3	-0.4	0.1	1.6
Pulse wave reflection index	0.6	0.7	2.5	-0.2	1.1	-0.3	-0.2	1.6	0.5
Headache pain in last month	0.6	1.0	2.3	-0.7	1.5	-0.6	1.4	0.9	-0.1
Pulse wave peak to peak time	0.6	0.7	3.2	-1.0	0.0	0.1	0.5	0.1	-1.8
Eye problems/disorders: None of the above	0.6	0.7	1.6	0.4	0.3	0.8	-1.1	-1.3	-0.8
Age at last live birth	0.6	0.9	2.8	-0.6	-0.9	0.0	1.1	1.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	4.9	-0.6	2.2	-0.4	0.2	0.1	-0.6
Medication: Aspirin	0.6	0.8	2.5	-0.8	-0.0	-0.6	1.0	1.6	-0.0
Miserableness	0.6	1.1	3.8	-1.1	0.0	-0.1	2.0	1.1	-0.6
Guilty feelings	0.6	0.9	2.9	0.8	1.7	0.9	-1.0	0.2	-0.2
Average weekly beer plus cider intake	0.6	0.9	2.7	0.8	-0.9	0.2	-1.1	-1.6	0.0
Age at First Birth	0.5	0.7	1.6	0.6	0.7	1.1	0.2	0.9	1.3
Schizophrenia (2014)	0.5	1.0	2.1	0.9	1.3	0.2	-1.1	-1.5	-0.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.1	-0.3	-0.3	-0.2	1.2	1.5	-0.1
Systolic blood pressure, automated reading	0.5	1.4	5.2	-0.8	-2.3	-1.1	1.0	0.3	-0.0
Hand grip strength (right)	0.5	1.2	2.8	-0.9	-1.7	-0.5	0.4	0.9	-1.6
Current tobacco smoking	0.5	0.8	1.8	0.1	-0.8	-1.4	-0.8	-0.7	-0.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.4	-0.8	0.1	-0.2	1.5	0.3	-0.2
Fluid intelligence score	0.5	1.1	2.1	0.7	-1.4	1.2	-1.2	-0.1	-1.1
Neuroticism score	0.5	1.0	2.3	0.1	1.3	0.0	1.2	1.5	0.5
Time employed in main current job	0.5	0.6	1.3	0.9	-1.2	-0.1	-0.2	0.1	1.1
Noisy workplace	0.5	0.6	1.4	-1.2	1.1	-0.1	0.4	-0.2	-1.0
Depression (self-reported)	0.5	0.6	1.3	-0.4	1.1	-1.1	0.6	0.6	0.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.4	0.5	1.6	0.4	-0.7	-0.3	0.6
Age at first live birth	0.5	0.9	2.6	1.1	-0.8	1.6	-1.0	0.4	0.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.3	-1.0	1.0	-0.9	1.1	0.2	-0.2
Ever smoked	0.5	0.8	3.5	-0.6	0.4	-0.7	0.5	1.9	0.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.2	0.2	-1.0	0.2	0.7	1.1	0.7
Ever depressed for a whole week	0.5	0.6	1.3	-1.1	-0.1	-0.8	0.7	0.2	-1.1
Unable to work because of sickness or disability	0.5	0.6	1.7	-1.3	0.8	-0.8	0.5	0.2	-0.7
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.8	0.9	-0.7	0.3	-1.9	-1.1	-1.1
Alcohol drinker status: Previous	0.5	0.6	2.6	-0.5	1.6	-0.7	0.2	-0.1	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	2.2	0.3	1.5	0.4	-0.6	-0.9	-0.5
Crohns Disease (2017)	0.4	0.9	4.2	-0.8	-2.0	-0.7	0.2	-0.3	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.1	4.3	-0.1	-2.1	0.3	-0.7	-0.1	-1.2
Fasting Glucose	0.4	0.5	1.2	-1.0	0.0	-0.3	0.6	-0.1	-1.1
Vitamin and mineral supplements	0.4	0.5	1.1	-0.2	-0.9	-0.1	-1.1	-0.0	-1.0
Medication: Metformin	0.4	0.6	0.8	0.7	-0.8	0.8	-0.7	0.4	0.9
Diabetes (mother)	0.4	0.6	1.3	-0.9	-0.3	-0.2	1.1	-0.2	-1.1
Maternal smoking around birth	0.4	0.6	2.2	-0.1	1.5	0.6	0.3	-0.1	-0.8
Had menopause	0.4	0.5	1.3	0.3	-0.3	-0.8	0.5	1.2	0.8
Prospective memory result	0.4	0.5	1.1	-0.1	0.6	-0.5	0.6	1.1	0.9
Tense / ‘highly strung’	0.4	0.6	1.7	-0.8	1.3	-0.4	0.1	0.5	-1.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	-0.4	-1.0	-0.3	0.7	1.0	-0.1
Blood clot in the leg (DVT)	0.4	0.5	1.4	0.3	-1.2	0.7	0.7	0.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.4	-0.1	-1.0	-1.2	0.1	0.4	-0.9
High blood pressure (siblings)	0.4	0.6	1.3	-0.6	0.1	0.6	1.0	1.1	0.5
Mean time to correctly identify matches	0.4	0.8	2.9	0.2	1.7	0.4	0.9	0.2	0.9
Had major operations	0.4	0.5	2.3	-0.0	0.3	0.1	-1.5	-0.7	-0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.2	-0.7	0.3	0.0	-0.8	-0.1	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	0.8	-0.5	-0.7	0.2	-0.6	1.1
Smoking status: Current	0.4	0.6	1.4	0.2	-0.6	-1.2	-0.6	-0.8	-0.7
Mother’s age at death	0.4	0.5	1.0	0.1	0.1	1.0	0.7	0.9	0.7
Alcohol drinker status: Never	0.4	0.5	0.9	0.1	-0.9	-0.7	0.7	-0.9	0.5
Irritability	0.4	0.7	1.1	1.0	0.2	1.0	-0.6	1.0	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	-1.2	0.4	-0.3	-0.1	1.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.3	0.7	-0.8	1.2	0.6	0.3	0.7
Intelligence (Savage-Jansen 2018)	0.3	1.1	4.3	0.1	-2.1	0.2	-0.0	1.1	-0.9
Schizophrenia (2018)	0.3	0.6	1.6	0.7	0.8	0.0	-0.8	-1.2	-0.7
Bipolar Disorder (2011)	0.3	0.3	1.0	0.6	-0.3	0.1	-0.1	-1.0	0.6
Medication for hormone replacement therapy	0.3	0.3	0.7	0.2	-0.7	0.7	-0.8	-0.3	0.4
Fed-up feelings	0.3	0.5	1.3	-0.4	0.8	0.1	1.1	0.8	-0.5
Heart attack	0.3	0.4	0.9	-1.0	0.4	-0.2	-0.3	1.0	-0.5
Illnesses of siblings	0.3	0.4	1.4	0.8	0.3	-0.1	-0.5	-1.2	-0.1
Number of live births	0.3	0.4	1.4	-0.5	1.2	-0.7	0.6	-0.1	0.2
Pulse rate	0.3	0.5	1.7	0.6	-1.3	0.1	-0.8	-0.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.9	-0.4	0.8	0.6	0.3	-0.3	-0.9
Hair/balding pattern: Pattern 4	0.3	0.7	2.0	-1.1	-0.3	-0.7	1.4	0.6	-0.3
Heart disease (mother)	0.3	0.4	1.3	0.3	0.8	1.1	0.2	0.6	0.2
Financial situation satisfaction	0.3	0.4	1.8	0.5	-0.3	1.4	0.1	-0.0	0.6
Age started oral contraceptive pill	0.3	0.4	1.1	0.3	-1.1	-0.7	-0.5	0.4	-0.0
Heart disease (siblings)	0.3	0.3	1.1	-0.2	-0.4	0.3	-1.0	-0.4	-0.7
Prostate Cancer	0.2	0.3	0.9	0.4	-0.4	0.8	0.1	0.9	-0.0
Coronary Artery Disease (CAD)	0.2	0.2	1.1	-0.0	0.2	0.2	1.0	-0.1	0.0
LDL Cholesterol	0.2	0.4	1.7	-0.0	1.3	-0.6	0.3	0.4	0.2
Systolic Blood Pressure	0.2	0.8	1.3	0.2	-0.7	0.8	1.0	1.1	1.1
Smoking Status	0.2	0.6	1.6	-0.4	-0.3	-1.2	-0.5	0.1	-1.2
Pack years adult smoking proportion	0.2	0.4	0.7	0.7	-0.7	0.6	-0.8	-0.4	-0.3
Taking other prescription medications	0.2	0.3	0.7	-0.1	0.5	-0.4	0.7	0.3	0.9
Had other major operations	0.2	0.3	1.0	-0.2	0.2	0.5	0.4	1.0	-0.2
Peak expiratory flow (PEF)	0.2	0.4	1.1	0.3	-1.0	0.4	0.2	0.8	-0.6
Gout (self-reported)	0.2	0.3	0.6	-0.1	-0.7	-0.2	-0.8	-0.3	-0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.9	-0.2	0.9	-0.3	-0.2	0.4	-0.3
Medication: Ibuprofen	0.2	0.3	0.6	0.3	0.6	0.8	-0.3	-0.5	-0.5
Alcohol intake frequency.	0.2	0.4	1.1	-0.3	0.2	0.2	0.9	0.4	1.0
Family relationship satisfaction	0.2	0.3	1.5	0.3	1.2	-0.2	-0.2	0.2	-0.3
Medication: Aspirin	0.2	0.2	0.6	-0.4	0.4	0.1	0.4	0.8	0.3
Illnesses of father: Heart disease	0.2	0.2	0.5	-0.7	-0.2	0.3	0.6	0.6	-0.3
Illnesses of siblings: Diabetes	0.2	0.3	0.8	0.6	0.3	0.4	-0.2	0.0	0.9
Friendships satisfaction	0.2	0.3	0.6	0.2	0.8	-0.4	-0.6	-0.6	-0.4
Medication for cholesterol	0.2	0.4	1.5	-0.6	-0.2	-0.6	-0.1	0.1	-1.2
Commuting to job workplace: Cycle	0.2	0.3	0.6	0.2	-0.2	-0.7	-0.7	-0.8	-0.3
Cholesterol lowering medication	0.2	0.3	0.7	0.2	0.8	-0.5	0.1	0.3	0.8
Breast Cancer	0.1	0.3	0.5	-0.2	0.7	-0.2	-0.7	-0.4	-0.7
Height	0.1	1.7	4.5	0.6	-2.1	0.0	-1.5	0.2	-1.8
Hair Pigment	0.1	2.3	6.9	1.5	1.8	-0.3	-2.6	-1.2	0.4
Tanning	0.1	1.0	5.1	0.1	2.2	0.1	-0.2	-0.7	-0.4
Father’s age at death	0.1	0.2	0.5	-0.4	0.2	0.3	0.2	0.7	-0.6
Comparative body size at age 10	0.1	0.3	0.6	-0.8	-0.8	0.5	0.5	0.2	-0.3
Qualifications: College or University degree	0.1	0.3	0.5	0.6	-0.1	0.7	-0.3	-0.7	-0.6
Medication: Blood pressure	0.1	0.2	0.9	-0.3	-0.0	0.2	0.2	0.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.2	-0.2	-0.3	0.7	0.5	0.3
Number of full sisters	0.1	0.1	0.3	0.1	0.5	-0.3	-0.0	-0.5	-0.3
Ever had bowel cancer screening	0.1	0.2	0.6	0.1	-0.8	-0.2	0.5	-0.2	0.2
Qualifications: nursing, teaching	0.1	0.2	1.0	0.4	-0.2	0.2	-1.0	0.2	-0.2
Ever taken oral contraceptive pill	0.1	0.1	0.4	-0.6	0.2	-0.0	-0.1	0.0	-0.5
Myopia	0.1	0.2	0.6	0.4	-0.8	0.0	0.5	0.0	-0.2
Pack years of smoking	0.1	0.2	0.5	0.4	-0.7	0.1	-0.5	-0.2	-0.3

Hub : Genes

NLRX1

Models

Trait associations