Best TWAS P=6.89e-13 · Best GWAS P=1.76e-15 conditioned to 0.08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | WDR35 | 0.25 | 0.00 | enet | 50 | 0.01 | 9.3e-02 | 4.2 | -5.8 | 5.0e-09 | 0.12 | 0.06 | 0.05 | FALSE |
| 2 | GTEx | Brain Hippocampus | TTC32 | 0.35 | 0.28 | lasso | 10 | 0.29 | 1.3e-07 | -5.9 | -6.8 | 9.2e-12 | 0.71 | 0.31 | 0.30 | TRUE |
| 3 | GTEx | Nerve Tibial | WDR35 | 0.22 | 0.05 | enet | 26 | 0.15 | 7.6e-11 | 4.2 | -6.3 | 2.6e-10 | 0.30 | 0.30 | 0.65 | TRUE |
| 4 | GTEx | Thyroid | WDR35 | 0.13 | 0.01 | lasso | 6 | 0.04 | 4.9e-04 | 3.8 | -7.1 | 1.1e-12 | 0.42 | 0.55 | 0.14 | FALSE |
| 5 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MATN3 | 0.15 | 0.11 | blup | 54 | 0.11 | 1.9e-05 | -5.9 | -6.7 | 1.8e-11 | 0.86 | 0.01 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | WDR35 | 0.09 | 0.08 | lasso | 3 | 0.07 | 1.1e-07 | -7.2 | -7.2 | 6.9e-13 | 0.53 | 0.02 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | MATN3 | 0.05 | 0.00 | blup | 53 | 0.02 | 6.5e-03 | -6.9 | 5.5 | 3.5e-08 | -0.74 | 0.01 | 0.53 | FALSE |