Hub : Genes

MATN3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1610	0.0510	3.5e-04	0.098	NA	0.100	NA	0.107	2.0e-08	NA	1.5e-08	NA	4.4e-09
2	GTEx	Adrenal Gland	0.2860	0.0799	1.2e-04	0.203	NA	0.079	NA	0.216	8.2e-08	NA	9.0e-04	NA	2.9e-08
3	GTEx	Artery Aorta	0.3330	0.0620	1.2e-10	0.307	NA	0.253	NA	0.270	2.2e-17	NA	3.4e-14	NA	3.8e-15
4	GTEx	Artery Tibial	0.2265	0.0456	1.0e-09	0.224	NA	0.239	NA	0.221	1.9e-17	NA	1.2e-18	NA	2.8e-17
5	GTEx	Esophagus Muscularis	0.2630	0.0660	5.3e-06	0.140	NA	0.205	NA	0.142	7.7e-09	NA	1.5e-12	NA	5.7e-09
6	GTEx	Heart Atrial Appendage	0.2820	0.0730	1.4e-05	0.153	NA	0.191	NA	0.185	2.3e-07	NA	5.5e-09	NA	1.0e-08
7	GTEx	Testis	0.2400	0.0710	7.0e-04	0.022	NA	0.044	NA	0.046	3.6e-02	NA	5.0e-03	NA	4.2e-03
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0552	0.0249	5.9e-05	0.044	0.045	0.034	NA	0.037	1.0e-05	8.0e-06	8.3e-05	NA	4.9e-05
9	TCGA	Pancreatic Adenocarcinoma	0.1480	0.0650	1.2e-04	0.106	0.113	0.107	NA	0.103	3.4e-05	1.9e-05	3.1e-05	NA	4.5e-05
10	TCGA	Prostate Adenocarcinoma	0.1117	0.0464	1.7e-08	0.080	0.085	0.077	NA	0.072	1.1e-08	3.7e-09	1.7e-08	NA	4.9e-08
11	TCGA	Thyroid Carcinoma	0.0500	0.0280	3.4e-03	0.003	0.018	0.017	NA	0.002	1.7e-01	6.5e-03	7.4e-03	NA	1.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.7	1.1	3.2	-0.4	1.0	1.1	0.7	0.8	0.8	0.3	1.3	-1.8	0.4	1.7
Bipolar Disorder or Schizophrenia	0.8	2.0	4.7	-0.5	1.9	1.8	1.0	0.9	0.9	-1.0	2.2	-1.6	0.6	1.9
Depressed Affect (Nagel 2018)	0.2	0.5	3.3	-1.0	0.4	0.5	0.3	-0.1	0.1	-0.8	1.8	0.2	0.3	-0.4
Depression (Nagel 2018)	0.3	0.4	1.0	-0.9	-0.6	-0.6	-0.6	-0.6	-0.6	0.1	0.1	0.8	-0.1	-1.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	2.1	-0.8	-0.2	-0.1	-0.4	-1.4	-0.6	0.6	-0.6	-0.7	0.2	-0.5
Neuroticism (Nagel 2018)	0.3	0.7	2.7	-1.6	-0.1	-0.1	-0.4	-1.2	-0.5	-1.2	0.7	0.6	-0.2	-1.0
Schizophrenia (2018)	0.5	1.1	2.9	-0.3	1.6	1.4	0.8	0.5	0.5	-1.5	1.7	-0.5	0.5	1.1
Schizophrenia vs Biploar Disorder	0.7	0.9	3.0	0.7	0.6	0.8	0.5	0.6	0.5	-0.2	0.6	1.7	1.5	-1.4
Worry (Nagel 2018)	0.2	0.4	1.1	-1.0	-0.1	-0.0	-0.2	-0.6	-0.3	-1.1	0.2	0.9	0.1	-1.1
Alzheimer’s Disease (in mother)	0.4	0.4	2.5	-1.6	-0.0	-0.2	-0.5	0.0	-1.0	0.7	0.4	-0.2	-0.3	-0.6
Alzheimer’s Disease (in father)	0.5	0.5	1.5	0.5	0.3	0.5	0.4	0.8	-0.3	1.2	0.6	0.2	1.2	-1.0
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	-1.1	0.6	0.6	0.2	0.9	-0.4	0.6	0.8	-0.5	0.9	-1.2
Crohns Disease (2017)	0.9	2.1	8.8	-1.2	-0.2	-0.3	-0.5	-1.0	0.2	1.1	-0.7	-3.0	-2.2	2.2
Irritable Bowel Disease (IBD)	0.6	1.4	5.8	-0.1	0.4	0.4	0.3	-0.0	1.3	1.1	-0.0	-2.3	-0.9	2.4
Ulcerative Colitis (UC)	0.4	0.7	2.5	-0.1	0.6	0.6	0.5	0.3	1.3	0.9	0.6	-1.1	0.1	1.6
Major Depression (MDD)	0.3	0.3	1.3	-0.1	0.5	0.5	0.4	0.4	0.5	0.2	0.8	-0.1	1.2	-0.6
Reaction Time	2.7	5.2	8.7	-0.7	-2.9	-2.8	-3.0	-2.0	-1.8	2.7	-2.7	2.0	-1.2	-2.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.6	-1.2	-0.1	-0.1	-0.3	-1.6	0.2	0.6	-0.3	-0.6	0.3	-0.2
Breast Cancer	0.1	0.3	1.0	-0.5	-0.6	-0.7	-0.5	0.0	-0.4	0.3	-1.0	0.5	-0.7	-0.5
Ovarian Cancer	0.6	0.8	1.7	-0.1	-1.2	-1.0	-1.3	0.1	-1.2	1.0	-1.0	0.4	-0.8	-0.0
Prostate Cancer	1.2	1.7	3.5	0.2	1.4	1.6	1.5	1.9	1.4	-0.1	1.7	-0.7	1.3	0.9
Age at First Birth	0.2	0.2	1.3	1.1	-0.3	-0.0	0.3	0.2	0.2	0.1	-0.8	0.1	0.4	-0.5
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.6	0.0	0.1	-0.3	0.4	0.2	-0.3	0.6	0.1	-0.2	0.1
Body Mass Index (BMI) (2010)	1.1	1.6	2.9	-0.9	-1.4	-1.5	-1.5	-1.5	-1.2	0.5	-1.4	-1.0	-1.7	0.5
Coronary Artery Disease (CAD)	0.6	0.8	4.6	-1.0	0.6	0.6	0.1	0.2	0.5	-2.1	1.1	-0.5	-0.5	-0.3
Crohns Disease (2012)	1.1	1.8	6.7	-1.8	-0.1	-0.2	-0.4	-0.6	0.2	1.1	-0.9	-2.6	-2.2	1.6
Mean Putamen Volume	0.5	0.6	2.2	1.5	-0.7	-0.8	-0.0	0.0	0.6	-0.2	-0.3	1.5	-0.0	-0.2
Fasting Glucose	1.2	1.4	4.5	-2.1	-0.7	-0.7	-1.0	-1.1	-2.0	-0.0	-1.2	0.2	-1.2	-1.2
HbA1C	0.7	0.8	2.6	0.7	0.9	1.0	0.9	0.5	1.5	-0.4	0.5	0.2	1.6	0.1
HDL Cholesterol	0.6	1.0	1.7	-0.3	1.1	0.8	0.4	0.7	1.2	-1.0	1.3	1.3	1.3	-0.9
LDL Cholesterol	0.8	1.2	2.9	1.1	1.7	1.5	1.6	0.0	1.3	0.4	0.7	-0.3	1.3	0.5
Lupus	0.2	0.4	0.7	0.8	0.6	0.6	0.8	0.3	0.6	0.2	0.6	-0.1	0.7	0.8
Neuroticism (2016)	0.2	0.3	1.3	-0.3	-0.1	-0.1	0.1	-0.5	0.4	1.2	0.6	0.8	0.7	-0.5
Primary Biliary Cirrhosis	0.2	0.3	1.4	1.2	-0.4	-0.2	0.3	0.8	-0.1	0.7	-0.6	0.3	-0.1	0.2
Rheumatoid Arthritis	1.2	1.6	3.2	0.1	-1.4	-1.4	-1.6	-0.9	-0.5	1.5	-1.3	1.8	-1.1	-1.4
Schizophrenia (2014)	0.8	1.7	4.1	0.4	1.9	1.8	1.1	1.4	1.3	-0.5	2.0	0.1	1.3	0.8
Triglycerides	0.2	0.4	0.8	0.6	0.7	0.7	0.8	-0.2	0.8	0.8	0.4	-0.5	0.9	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.5	-0.3	0.4	0.4	0.7	1.2	-0.0	-1.1	0.7	-0.6	-0.0	1.2
Ulcerative Colitis	0.5	0.8	2.5	1.6	0.2	0.3	0.7	0.5	1.1	1.5	-0.2	0.1	0.2	1.3
Blood Eosinophil Count	0.6	4.3	9.6	-0.7	-2.3	-2.3	-2.9	-0.9	-3.1	-0.7	-1.7	2.4	-1.9	-2.3
Blood Platelet Count	0.1	1.5	4.3	-0.2	1.3	1.3	0.6	1.1	2.1	-1.2	1.4	0.6	1.8	-0.4
Blood Red Count	0.1	1.1	6.0	-0.5	-0.7	-0.5	-0.3	0.1	-1.1	0.2	-1.1	1.2	1.1	-2.4
Blood White Count	0.1	0.7	3.0	-1.7	0.9	0.7	0.0	0.8	0.8	-0.7	1.1	0.2	-0.5	-0.8
Heel T-Score	0.3	2.3	5.4	2.0	1.1	1.4	2.1	2.3	1.0	0.0	1.7	0.9	2.0	-0.4
BMI	0.2	1.2	8.4	0.0	-0.6	-0.4	-0.5	-0.7	-1.2	-2.9	0.0	1.0	0.4	-1.0
Height	1.3	24.4	69.4	1.1	3.6	3.0	3.5	5.3	5.1	2.9	3.6	-8.3	-4.9	8.0
Waist Hip Ratio (WHR)	0.8	3.6	7.8	1.0	2.3	2.2	2.0	1.2	1.9	-1.6	2.0	-2.8	0.3	2.2
Systolic Blood Pressure	1.1	5.5	47.1	1.8	-1.1	-0.7	-0.4	0.4	-0.5	-6.9	-0.6	2.0	1.3	-1.4
Smoking Status	0.4	0.9	3.2	1.1	0.6	0.6	0.6	1.8	0.6	-1.2	0.4	-1.2	0.0	1.0
Allergy or Eczema	0.1	0.3	1.0	0.5	-0.5	-0.4	-0.1	-0.5	1.0	-0.1	-0.7	0.1	-0.6	0.5
Cardiovascular Disease	0.2	0.8	2.0	-0.4	-0.9	-0.9	-1.1	-0.9	-1.4	-0.4	-0.3	0.9	-0.5	-1.3
Hypothyroidism (self reported)	0.8	1.9	4.3	-1.9	-1.1	-1.1	-1.5	-1.4	-1.7	-0.6	-0.8	-0.1	-2.1	-1.4
Respiratory disease	1.1	2.4	5.0	-1.6	-1.8	-1.8	-1.8	-0.5	-1.9	-0.3	-2.2	0.7	-1.0	-1.9
Type 2 Diabetes (T2D) (2018)	0.4	0.7	3.9	-0.7	-0.7	-0.8	-0.7	-2.0	-1.0	-0.3	-0.1	0.3	-0.5	0.1
Lung FEV1/FVC ratio	1.9	9.8	16.7	2.1	3.9	3.8	3.9	3.5	4.1	-0.6	3.6	-1.6	2.8	2.4
Lung FVC	0.4	2.2	6.8	2.1	0.2	0.2	0.7	0.4	1.4	1.0	0.2	2.6	2.6	-1.6
Neuroticism	0.1	0.2	0.8	-0.9	0.1	0.1	0.1	-0.7	-0.1	0.2	0.7	0.1	-0.3	-0.2
Chronotype (morning person)	1.2	2.8	5.3	0.6	1.8	1.7	1.8	1.3	2.3	1.4	1.5	-1.9	1.3	2.2
Hair Pigment	0.0	1.1	3.6	-0.8	-0.6	-0.9	-1.1	0.2	-0.9	0.5	-1.9	-0.2	-1.7	-1.2
Tanning	0.0	0.3	0.8	0.7	0.1	0.1	0.3	0.9	0.5	0.8	0.2	0.7	0.4	0.1
Hand grip strength (left)	0.8	2.1	6.1	2.3	0.9	0.9	1.5	0.5	2.5	-0.7	0.4	-1.2	1.0	2.1
Number of treatments/medications taken	0.5	0.8	4.3	-2.1	0.7	0.7	0.1	0.3	-0.3	-1.1	1.1	-0.6	-0.7	-0.5
Average weekly spirits intake	1.0	1.2	4.4	-2.1	-0.5	-0.7	-1.3	-1.3	-1.1	0.6	-0.3	0.7	-0.6	-1.5
Sensitivity / hurt feelings	0.8	1.4	2.9	-1.5	-1.2	-1.3	-1.3	-1.3	-1.7	1.0	-0.9	0.7	-0.7	-1.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.8	-0.0	-0.4	-0.4	-0.2	-0.4	0.0	0.4	0.2	0.9	-0.2	-0.4
Hearing difficulty/problems: Yes	0.3	0.4	1.8	1.1	0.0	0.2	0.5	0.8	0.1	0.4	0.8	-0.4	0.1	1.3
Relative age of first facial hair	2.0	4.2	20.9	-0.4	1.7	1.6	1.9	1.7	1.2	-0.1	1.4	-4.6	-1.2	2.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	4.5	-2.1	-0.2	-0.3	-0.6	-1.6	-0.3	-0.3	-0.5	-0.6	-0.1	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.4	-0.6	-0.3	-0.3	-0.6	-0.5	-0.3	-0.8	0.3	1.2	0.4	-1.0
Ever had hysterectomy (womb removed)	0.8	0.9	2.5	-0.3	-1.6	-1.3	-1.1	-0.7	-0.8	1.3	-1.3	0.6	-0.2	-0.5
Systolic blood pressure, automated reading	1.2	3.6	31.1	1.7	-0.3	-0.0	0.2	-0.1	0.5	-5.6	-0.1	1.5	1.5	-0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.4	-0.5	1.5	1.3	0.8	-0.1	0.4	-1.0	1.2	-1.1	-0.3	1.1
Angina	1.7	2.3	5.5	2.2	1.2	1.3	1.4	1.3	1.7	-1.3	1.3	1.2	2.3	0.2
Medication for hormone replacement therapy	1.8	2.1	4.6	0.9	1.5	1.5	0.9	0.8	1.7	-2.1	1.8	-1.2	-0.1	1.9
Vitamin and mineral supplements	0.2	0.3	0.7	0.7	0.4	0.4	0.3	0.8	-0.0	0.4	0.7	-0.4	-0.9	0.6
Supplements: Zinc	1.1	1.2	3.4	0.8	-1.1	-1.1	-0.9	-1.4	-0.4	1.7	-1.9	0.6	-0.3	-0.5
Medication: Co-codamol	1.1	1.3	4.6	-2.1	-0.8	-0.9	-1.0	-0.6	-1.6	0.3	-1.0	0.8	-0.9	-1.3
Medication: Metformin	0.7	1.0	2.4	-0.9	1.1	1.0	1.0	-0.5	0.2	-1.6	1.2	-1.2	0.4	1.1
Diabetes (father)	0.3	0.3	1.1	-0.6	-0.6	-0.5	-1.1	-0.6	-0.5	0.1	-0.3	0.7	-0.0	-0.7
Diabetes (mother)	0.6	0.8	2.9	-0.4	1.0	0.8	1.1	0.9	0.3	1.0	1.7	0.4	-0.2	0.6
Severe depression (siblings)	0.7	0.8	2.0	-0.7	-0.8	-0.9	-1.0	-1.4	-1.4	-0.1	-0.9	0.5	-0.4	-0.6
Pack years adult smoking proportion	0.1	0.1	0.7	0.3	-0.1	-0.2	-0.3	0.1	-0.5	0.8	-0.5	0.1	0.2	0.0
Impedance of leg (right)	0.6	2.7	10.9	-1.6	0.5	0.1	0.1	-0.1	-0.4	1.5	-1.0	-3.3	-2.8	2.1
Leg fat-free mass (left)	0.1	0.7	1.8	0.1	0.7	0.8	0.8	1.0	0.4	-1.0	1.3	-1.2	-0.2	0.9
Trunk fat percentage	0.6	2.5	10.2	-3.2	0.1	-0.1	-0.9	-1.0	-1.9	-2.7	-0.3	-1.4	-1.3	-0.7
Hand grip strength (right)	0.6	1.6	5.2	1.9	0.6	0.6	1.5	0.8	2.3	-0.7	0.1	-1.0	0.8	1.7
Townsend deprivation index at recruitment	1.0	1.5	2.6	0.7	1.1	1.1	1.4	1.0	1.2	-1.5	1.4	-1.3	0.1	1.6
Current tobacco smoking	0.3	0.5	1.7	0.4	0.8	0.8	0.7	1.2	0.5	0.1	0.7	-0.1	1.3	0.4
Average weekly fortified wine intake	0.5	0.6	1.6	0.3	-1.1	-1.1	-0.7	-0.5	-0.3	1.3	-0.7	0.5	-1.1	0.1
Maternal smoking around birth	0.8	1.2	2.7	-0.7	-1.3	-1.2	-1.3	-1.2	-1.6	1.3	-0.9	-0.3	-0.8	-0.3
Fed-up feelings	1.3	2.4	5.2	-0.2	1.9	1.9	2.0	1.6	1.9	-1.1	2.3	-0.5	1.6	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.8	0.2	-1.1	-1.0	-0.5	-0.5	0.0	-0.1	-0.2	1.3	0.6	-0.7
Relative age voice broke	0.9	1.3	7.2	-0.6	0.3	0.1	-0.0	-0.6	0.2	0.0	0.0	-2.7	-1.3	2.2
Taking other prescription medications	1.2	1.8	6.3	-2.5	-0.9	-0.9	-1.2	-1.3	-1.9	1.0	-0.3	0.2	-1.6	-1.3
Age when periods started (menarche)	0.7	1.7	3.8	-0.2	-1.5	-1.5	-1.9	-0.8	-1.5	-0.1	-1.1	1.1	-1.4	-1.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.7	-1.3	0.8	0.7	0.3	-0.1	-0.1	-1.2	0.4	-1.2	0.3	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	-0.7	-0.5	-0.7	-0.1	-0.8	-1.0	-0.2	0.0	0.4	0.3	-0.6
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.4	0.4	-1.5	-1.4	-0.9	-0.5	-0.6	-0.1	-0.5	1.0	-1.3	-0.1
Qualifications: CSEs or equivalent	2.8	3.7	6.0	2.5	1.8	1.9	2.3	2.2	2.2	-0.1	1.6	-1.0	2.0	2.2
Serious illness, injury or assault to yourself	0.2	0.2	1.0	0.1	-0.3	-0.4	-0.3	-0.3	0.5	0.4	-0.2	1.0	0.3	0.4
High blood pressure	0.5	1.5	4.8	-0.4	-1.0	-0.9	-1.1	-1.3	-1.6	0.7	-0.3	1.9	0.2	-2.2
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.2	1.1	-0.3	-0.3	0.1	-0.1	1.1	0.5	-0.5	-0.1	-0.4	0.7
Multivitamins +/- minerals	0.3	0.4	1.5	-1.2	-0.1	-0.2	-0.1	-0.5	-0.6	-0.6	-0.7	0.2	0.8	-0.7
Stomach or abdominal pain in last month	1.4	1.8	3.4	-1.0	-1.7	-1.7	-1.8	-0.4	-1.3	0.3	-1.7	1.4	-1.2	-1.1
Supplements: Glucosamine	0.6	0.8	2.8	0.1	0.7	0.8	0.4	0.9	0.5	-1.7	0.6	-1.4	-0.4	1.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.2	-0.8	-0.4	-0.7	-0.5	-0.4	-0.1	1.5	-0.2	-0.5	-0.8	1.1
Medication: Atenolol	0.2	0.2	1.1	-0.6	-0.3	-0.3	-0.4	-1.0	-0.3	-0.5	0.1	0.3	-0.4	0.3
Medication: Levothyroxine sodium	2.0	3.5	10.0	-2.8	-1.3	-1.5	-2.0	-2.1	-2.2	-1.2	-0.6	0.1	-3.2	-0.9
Sitting height	0.1	1.0	2.6	-0.5	1.2	1.0	0.6	-0.0	1.6	1.1	0.9	-1.5	-0.4	0.9
Chronic bronchitis/emphysema (father)	0.3	0.3	1.4	-1.2	0.4	0.3	-0.4	-0.6	-0.4	-0.3	-0.1	-0.7	-0.6	0.1
High blood pressure (mother)	0.9	1.2	3.5	1.4	0.8	1.0	1.6	1.0	1.1	-0.6	0.7	0.4	1.9	-0.6
Body mass index (BMI)	0.3	1.3	6.5	-0.2	0.1	0.4	0.1	-0.3	-0.8	-2.5	0.7	1.4	1.6	-1.5
Impedance of leg (left)	0.5	2.3	11.4	-1.4	0.6	0.2	0.2	-0.2	-0.0	0.6	-0.7	-3.4	-2.4	2.1
Leg predicted mass (left)	0.2	0.8	2.0	0.2	0.8	0.9	0.8	1.1	0.5	-1.0	1.4	-1.2	-0.2	0.9
Trunk fat mass	0.4	1.6	5.6	-2.4	0.4	0.3	-0.3	-0.4	-1.2	-2.3	0.3	-1.9	-1.2	0.1
Waist circumference	0.2	0.9	3.6	-0.3	1.0	1.1	0.8	0.5	-0.2	-1.9	1.2	-0.9	0.5	0.3
Number of incorrect matches in round	0.4	0.7	2.2	-1.2	-0.6	-0.5	-0.9	0.3	-0.5	-1.3	-0.5	0.4	-0.3	-1.5
Past tobacco smoking	0.5	0.9	2.5	-1.6	-0.5	-0.5	-0.5	-1.2	-0.8	1.5	-1.1	0.2	-0.4	-0.7
Alcohol usually taken with meals	0.5	0.9	7.7	0.4	0.3	0.3	0.3	1.0	0.3	2.8	-0.2	0.2	-0.2	0.0
Nervous feelings	0.5	0.9	2.3	0.2	1.1	1.2	1.1	0.6	0.7	-1.3	1.0	0.2	1.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.4	0.7	-0.2	-0.1	0.1	0.3	0.4	-0.1	0.3	1.6	0.9	-1.1
Hearing difficulty/problems with background noise	0.5	0.8	3.0	1.7	0.5	0.8	0.8	1.2	0.6	-0.2	0.5	-0.6	1.1	0.7
Hair/balding pattern: Pattern 2	1.4	1.8	5.3	0.5	-1.8	-1.8	-1.3	-1.1	-0.9	0.9	-2.3	-0.1	-1.7	0.4
Had menopause	0.3	0.4	0.8	-0.7	0.6	0.6	0.4	-0.9	0.0	-0.7	0.9	-0.7	0.2	0.2
Had other major operations	0.6	0.8	2.6	0.9	-0.6	-0.4	0.1	0.2	0.4	1.6	-0.4	1.1	1.3	-1.1
Forced vital capacity (FVC)	0.2	0.7	3.3	0.7	0.4	0.1	0.5	0.7	0.8	1.8	0.0	-0.8	-0.7	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.7	0.2	-0.6	-0.7	-0.1	-0.1	-0.9	0.2	0.1	1.3	0.2	-0.7
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.7	-0.6	-1.1	-1.1	-0.9	-0.8	-1.0	1.0	-0.6	1.3	-0.5	-1.6
Qualifications: None of the above	0.2	0.4	1.3	-1.1	-0.5	-0.5	-0.4	0.3	-1.1	-0.0	0.7	0.9	-0.3	-0.4
Financial difficulties in last 2 years	0.6	0.8	4.0	0.2	-0.6	-0.8	-0.2	0.6	-0.7	2.0	-0.9	0.1	-1.3	0.1
Mouth/teeth dental problems	1.2	1.8	3.1	-1.1	-1.6	-1.7	-1.8	-0.8	-1.0	1.3	-1.5	0.9	-1.7	-1.0
Heart attack	0.1	0.1	0.3	-0.3	0.4	0.3	0.1	-0.3	0.6	-0.2	0.4	0.4	0.5	-0.1
Allergy	0.2	0.4	1.2	-0.8	0.8	0.7	0.3	-0.3	-0.7	-0.5	1.1	0.1	0.9	-0.5
Pain all over the body in last month	0.6	0.7	2.3	-0.9	-0.6	-0.8	-0.6	-1.4	-0.7	-0.5	-0.2	1.5	-0.0	-0.8
Diabetes (self-reported)	0.2	0.4	1.1	0.5	0.3	0.4	0.4	-0.4	0.0	-0.9	0.5	-0.9	-0.4	1.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.3	0.2	0.7	0.6	0.8	1.2	1.5	0.9	0.8	-0.9	-0.2	1.3
Medication: Ramipril	0.9	1.1	2.2	0.5	-1.5	-1.2	-1.0	-1.2	-0.9	0.7	-1.4	1.0	-0.2	-1.3
Medication: Simvastatin	1.5	2.2	4.6	0.5	1.9	1.8	1.8	1.2	1.9	-1.8	2.1	-0.2	0.7	0.2
Fluid intelligence score	0.3	0.5	1.9	-1.4	0.2	0.1	-0.5	-1.0	0.4	-1.3	-0.1	-0.6	-0.1	-0.7
Illnesses of siblings	0.2	0.3	1.2	0.2	0.5	0.4	0.5	-0.1	0.2	-0.3	-0.3	-1.0	-0.6	1.1
Neuroticism score	0.1	0.2	0.5	-0.1	0.4	0.5	0.4	-0.4	0.1	-0.1	0.7	0.4	0.7	-0.3
Weight	0.2	1.2	2.9	-0.3	1.0	1.1	1.0	0.9	0.3	-1.7	1.4	-1.7	-0.3	1.0
Impedance of arm (right)	0.9	4.0	13.8	-3.6	0.2	-0.4	-1.1	-0.5	-1.4	0.9	-1.5	-3.7	-3.1	1.1
Arm fat percentage (right)	0.4	1.6	6.7	-2.2	-0.1	-0.1	-0.7	-0.8	-1.8	-2.6	-0.3	-0.5	-0.2	-0.9
Trunk fat-free mass	0.5	2.7	5.8	1.9	1.2	1.3	1.8	2.0	1.7	0.2	1.9	-1.8	-0.2	2.4
Hip circumference	0.2	1.0	3.7	-1.8	-0.7	-0.7	-0.8	-0.6	-1.9	-0.7	-0.4	-0.4	-1.1	-0.6
Time employed in main current job	0.3	0.4	1.7	-1.3	-0.1	-0.1	-0.9	-0.4	-0.3	-0.3	-0.1	0.4	0.1	-1.1
Alcohol intake versus 10 years previously	1.9	2.8	6.6	-0.4	2.1	2.1	1.9	1.1	1.0	-2.6	1.7	-1.6	1.1	1.4
Father’s age at death	0.5	0.6	2.7	-0.3	0.1	-0.2	-0.1	0.2	-0.1	0.3	0.4	-1.4	-1.6	1.4
Worrier / anxious feelings	0.6	1.1	2.5	-0.8	-1.2	-1.2	-1.3	-1.6	-0.9	0.3	-1.0	1.4	-0.5	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.1	-1.1	-0.2	-0.2	-0.4	0.2	-0.4	-0.0	0.1	1.2	0.3	-1.4
Falls in the last year	0.4	0.6	2.3	-0.1	-0.6	-0.7	-0.4	-0.4	-0.8	1.0	0.5	1.5	-0.8	-0.4
Hair/balding pattern: Pattern 3	0.8	1.2	10.5	0.5	0.3	0.4	0.2	0.7	0.2	-3.2	0.6	1.0	0.6	-0.2
Number of live births	0.6	0.9	4.2	-2.0	-0.3	-0.5	-0.8	-0.7	-0.9	1.0	-0.1	0.5	-1.1	-1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.6	1.2	1.0	0.8	1.2	1.2	1.6	1.6	0.9	-1.0	0.1	1.4
Pulse rate	0.2	0.4	1.5	0.0	0.7	0.7	-0.1	0.4	0.7	-0.8	0.4	-1.2	0.5	0.4
Happiness	2.4	2.9	5.9	0.4	-2.4	-2.4	-2.0	-1.1	-2.1	-0.1	-2.4	1.0	-1.8	-1.2
Noisy workplace	0.3	0.4	3.4	0.1	0.1	0.0	0.4	0.2	-0.3	1.8	0.1	-0.8	-0.3	0.6
Qualifications: A levels/AS levels or equivalent	2.1	4.7	11.6	-3.1	-1.7	-2.0	-2.0	-2.7	-2.3	0.4	-2.2	-1.1	-3.4	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.2	-0.3	0.3	0.1	-0.5	0.2	-0.0	-1.1	-0.5	-1.1	-0.6	-0.0
Mouth/teeth dental problems: Dentures	2.1	3.6	8.6	0.6	2.5	2.4	2.1	1.7	2.0	-1.5	2.9	-0.7	1.5	1.5
Asthma	0.7	1.4	2.3	-0.2	-1.4	-1.3	-1.2	1.1	-1.2	1.1	-1.5	1.4	-0.5	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.7	0.1	0.3	0.3	0.4	1.3	-0.3	-1.9	0.2	-1.1	-1.0	1.3
Medication: Cholesterol lowering	1.2	1.8	4.5	-0.1	1.5	1.6	1.2	-0.2	1.4	-2.1	2.0	0.3	1.6	-0.6
Depression (self-reported)	0.5	0.5	3.0	-0.1	-0.3	-0.6	-0.5	-0.8	-1.0	-0.1	-0.3	-0.4	-1.7	0.6
Medication: Lansoprazole	0.4	0.5	1.4	-1.2	0.9	0.8	-0.0	0.5	0.3	0.0	-0.0	-0.5	1.1	-0.8
Prospective memory result	0.3	0.4	1.5	0.6	-0.1	0.1	-0.1	0.2	-0.2	0.0	0.5	1.2	0.9	-1.1
Lung cancer (father)	1.1	1.3	3.3	-0.7	1.5	1.3	1.2	1.8	0.6	-1.1	1.7	-0.5	0.2	0.2
Illnesses of mother	0.9	1.2	2.2	-1.2	-1.2	-1.3	-1.4	-1.1	-0.8	0.8	-1.5	0.6	-0.7	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.2	0.8	1.0	0.9	1.1	1.2	1.5	1.0	0.7	-0.9	0.2	0.9
Pulse wave Arterial Stiffness index	0.5	0.6	2.8	0.6	0.1	0.3	0.5	0.1	0.3	-1.7	-0.1	-1.0	-0.3	1.4
Impedance of arm (left)	0.9	4.2	13.3	-3.5	-0.4	-0.9	-1.5	-0.7	-1.6	0.9	-2.0	-3.1	-3.6	0.6
Arm fat mass (right)	0.2	0.8	4.8	-1.4	0.1	0.2	-0.2	-0.3	-1.2	-2.2	0.3	-0.7	-0.3	-0.3
Trunk predicted mass	0.5	2.7	5.9	1.9	1.2	1.3	1.8	2.0	1.7	0.2	1.9	-1.9	-0.2	2.4
Standing height	1.1	11.1	45.2	-0.3	2.2	1.8	2.0	2.7	2.3	1.6	1.7	-6.7	-4.1	5.5
Length of working week for main job	0.6	0.7	2.3	1.5	0.4	0.6	0.4	1.1	0.6	-1.0	0.3	0.3	1.2	-0.0
Exposure to tobacco smoke at home	0.7	0.8	4.0	0.1	0.8	0.9	0.9	0.5	0.8	0.2	0.0	-2.0	-0.1	1.0
Breastfed as a baby	0.6	0.8	1.8	0.1	-0.7	-0.7	-1.0	-0.2	-1.3	-1.1	-1.1	0.4	-1.0	-1.2
Tense / ‘highly strung’	0.2	0.4	1.1	-0.4	0.7	0.7	0.6	0.3	0.2	-1.1	1.0	-0.0	0.5	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	-0.2	-0.9	-0.8	-0.4	-1.0	-0.9	-0.6	-0.6	0.5	-0.2	-0.6
Hair/balding pattern: Pattern 4	0.6	1.5	6.9	0.4	-0.2	-0.1	0.2	-0.5	-0.9	2.6	-0.1	1.9	1.7	-1.5
Birth weight of first child	0.9	1.6	5.7	2.4	0.7	0.7	0.9	1.9	1.9	0.2	0.4	0.6	0.9	1.1
Peak expiratory flow (PEF)	0.3	0.7	1.8	1.3	-0.0	-0.1	0.6	-0.0	1.1	1.0	-0.1	1.1	1.3	0.2
Pulse wave reflection index	0.8	1.0	3.6	-0.5	-0.4	-0.5	0.1	-1.0	-0.5	-1.9	-0.7	-1.1	-1.0	1.5
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	0.8	-0.5	-0.3	-0.2	0.8	-0.6	-0.8	-0.1	-0.5	0.1	0.1
Loud music exposure frequency	2.5	2.7	9.6	0.1	1.3	1.2	1.3	0.4	1.4	-2.4	2.3	-1.6	-0.2	3.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.0	0.2	-0.8	-0.7	-0.5	-0.6	-0.2	-1.1	-1.4	-0.8	-1.0	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.9	-0.3	-0.9	-0.7	-0.6	-0.6	-1.0	0.0	-1.1	0.3	0.2	-1.4
Blood clot in the leg (DVT)	0.3	0.4	1.5	-1.0	-0.1	-0.2	-0.0	0.2	0.1	-1.2	0.5	-0.4	-1.0	0.7
Medication: Paracetamol	0.3	0.4	1.5	-0.5	-0.5	-0.5	-0.6	-0.2	-1.2	-0.3	-1.0	0.0	-0.8	-0.3
Headache pain in last month	1.1	1.8	3.5	-1.7	-1.3	-1.2	-1.3	-1.6	-1.6	0.6	-1.8	0.7	-0.2	-1.9
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	3.0	0.3	-0.9	-1.1	-1.0	-0.1	-0.7	1.1	-1.7	-0.5	-1.3	0.7
Glaucoma (self-reported)	5.7	6.8	13.7	-2.9	-2.4	-2.6	-3.0	-3.7	-3.4	0.9	-2.2	-1.1	-3.5	-0.2
Gout (self-reported)	1.3	1.8	3.9	2.0	1.0	1.0	1.0	1.5	1.6	-2.0	1.1	0.8	1.5	0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.4	-1.1	-0.2	-0.3	-0.7	-0.6	-1.0	-1.8	0.4	0.2	-1.2	-1.1
Medication: Amlodipine	0.3	0.4	1.3	-0.5	0.1	0.1	0.5	-0.1	-0.7	1.0	0.7	1.1	0.3	-1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.7	-1.2	-0.8	-1.0	-1.2	-0.9	-1.0	1.9	-0.7	1.1	-0.9	-1.4
Birth weight	0.9	2.0	4.4	1.3	1.1	1.1	1.0	0.8	1.9	1.8	1.0	1.8	2.1	-0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	0.6	-0.2	-0.2	-0.2	-0.5	-0.0	0.0	-0.5	-0.5	-0.1	0.9
High blood pressure (siblings)	0.5	0.7	2.0	0.7	-0.4	-0.3	-0.4	0.0	0.7	1.0	-0.2	1.4	1.2	-1.3
Forced vital capacity (FVC), Best measure	0.1	0.4	1.3	0.4	0.5	0.4	0.5	0.7	0.8	1.1	0.2	-0.7	-0.4	0.5
Body fat percentage	0.4	1.7	7.3	-2.5	0.3	0.3	-0.4	-0.7	-1.5	-2.7	0.1	-1.1	-0.7	-0.6
Leg fat percentage (right)	0.2	0.8	4.6	-1.2	0.6	0.6	0.2	-0.0	-1.0	-2.1	0.4	-0.3	0.3	-0.4
Arm fat-free mass (right)	0.3	1.5	3.3	1.5	1.0	1.1	1.4	1.4	1.3	-0.8	1.8	-0.9	0.2	1.4
Exposure to tobacco smoke outside home	0.3	0.4	2.3	0.6	0.4	0.5	0.5	1.5	0.1	0.6	0.6	0.1	-0.0	0.4
Comparative body size at age 10	0.2	0.6	2.7	-0.2	-0.1	0.1	0.1	-0.8	0.5	-0.2	0.2	1.5	1.6	-0.8
Number of full brothers	1.4	1.8	5.0	1.6	1.2	1.3	1.6	2.2	1.1	-0.7	1.3	0.1	1.7	0.2
Worry too long after embarrassment	0.2	0.4	2.1	-0.9	0.6	0.5	0.3	-1.5	0.3	0.4	0.5	0.4	0.5	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.9	-0.9	-0.5	-0.7	-0.4	-1.3	-0.9	-0.7	-0.1	-1.4	-1.2	1.1
Wheeze or whistling in the chest in last year	0.4	0.8	2.3	-0.1	-0.7	-0.7	-1.0	0.5	-1.4	-0.6	-0.4	1.5	-0.8	-1.1
Number of children fathered	1.5	1.6	4.0	-0.1	-1.6	-1.5	-1.2	-0.9	-1.3	1.9	-2.0	0.3	-1.0	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.2	-0.9	-0.9	-0.8	-0.9	-1.5	-1.2	-1.1	-0.9	0.2	-0.4	-1.0
Age at first live birth	0.5	0.9	3.4	0.5	-1.0	-1.1	-0.7	-0.2	-1.3	-0.2	-1.1	0.2	-1.8	0.3
Pulse wave peak to peak time	0.5	0.6	3.8	-0.8	-0.1	-0.3	-0.5	0.1	-0.3	2.0	0.3	0.4	-0.2	-1.0
Health satisfaction	1.8	2.4	4.4	-0.1	-1.8	-1.9	-1.5	-1.4	-1.3	2.1	-1.6	1.7	-1.0	-1.4
Shortness of breath walking on level ground	0.8	1.0	2.3	-1.2	-0.8	-1.1	-1.3	-1.5	-0.9	-0.4	-1.2	0.2	-0.5	-0.9
Qualifications: College or University degree	0.1	0.3	0.9	-1.0	-0.0	-0.0	-0.1	-0.7	0.7	-0.6	-0.4	-0.6	-0.6	-0.1
Eye problems/disorders: None of the above	1.4	1.6	5.4	1.3	0.8	1.0	1.4	1.9	1.5	0.4	0.5	0.6	2.3	-0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.4	0.4	0.4	0.0	0.5	0.4	0.5	0.7	-0.3	0.6	0.5
Emphysema/chronic bronchitis	0.4	0.5	1.0	-0.8	-0.7	-0.7	-0.7	-0.5	-0.3	-0.6	-0.7	-1.0	-1.0	-0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	1.1	0.5	-0.4	-0.4	-0.2	-0.3	1.0	0.7	-0.3	-0.3	0.1	0.6
Neck or shoulder pain in last month	1.6	2.2	4.2	0.1	1.8	1.9	1.9	1.8	2.1	-0.4	1.3	-1.3	1.5	0.9
Medication: Blood pressure	0.5	0.8	3.0	-1.1	-0.3	-0.2	-0.3	-1.1	-0.9	0.1	0.7	1.5	0.4	-1.7
Angina (self-reported)	1.7	2.2	5.7	2.2	1.2	1.4	1.4	1.2	1.8	-1.0	1.3	1.2	2.4	0.3
Migraine (self-reported)	0.7	0.9	5.0	0.2	-1.2	-1.0	-0.6	-0.6	-0.4	2.2	-0.8	0.3	-0.8	-0.4
Medication: Ibuprofen	0.5	0.6	2.0	-0.5	-0.3	-0.4	-0.5	0.9	-0.9	-1.2	-0.6	-0.7	-1.4	0.4
Medication: Allopurinol	1.2	1.6	3.5	-0.0	-1.3	-1.3	-1.4	-1.0	-1.4	-1.9	-1.1	1.8	-0.6	-1.1
Medication: Omeprazole	0.4	0.4	1.2	-0.6	-0.4	-0.4	-0.3	-0.8	-1.0	-0.2	-0.6	1.1	0.7	-0.5
Medication: Seretide 50 evohaler	0.6	0.7	1.7	-0.1	-1.1	-0.9	-1.1	-0.4	-0.8	0.2	-1.1	1.0	0.3	-1.3
Mean time to correctly identify matches	2.8	5.4	10.1	-0.7	-2.9	-2.7	-3.2	-1.6	-2.1	2.5	-2.6	2.0	-1.4	-2.7
Heart disease (mother)	0.9	1.1	3.5	0.0	1.3	1.4	1.3	1.0	0.9	0.2	1.9	-0.8	0.8	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.4	-0.2	-0.0	-0.1	-0.4	-0.5	0.0	-0.3	-0.3	-0.0	0.5
Whole body fat mass	0.3	1.2	5.9	-1.7	0.5	0.5	-0.0	-0.3	-0.9	-2.4	0.4	-1.4	-0.7	0.1
Leg fat mass (right)	0.2	1.0	5.7	-1.1	0.7	0.8	0.4	0.1	-0.7	-2.4	0.9	-1.1	0.0	0.2
Arm predicted mass (right)	0.2	1.2	2.9	1.3	0.8	0.9	1.2	1.2	0.9	-0.8	1.7	-0.9	-0.1	1.3
Pulse rate, automated reading	1.5	5.0	9.3	2.4	2.5	2.6	2.5	2.1	3.0	-1.2	1.3	-1.9	2.4	1.9
Alcohol intake frequency.	1.9	4.3	9.7	-1.1	3.1	2.9	2.9	1.0	1.7	-1.1	2.5	-2.0	1.2	1.8
Comparative height size at age 10	0.9	5.1	18.3	-2.1	1.5	1.0	1.0	1.6	0.5	1.9	1.7	-4.3	-3.1	3.1
Number of full sisters	0.8	1.0	2.3	0.3	-1.4	-1.5	-1.1	-0.7	-1.3	0.6	-0.5	0.6	-1.4	0.4
Suffer from ‘nerves’	0.5	0.8	3.4	0.1	0.9	0.9	1.0	0.5	0.3	-1.9	0.7	-1.0	0.5	0.7
Overall health rating	0.2	0.4	1.8	-1.1	0.2	0.1	-0.3	-0.0	-0.3	0.0	0.2	1.1	0.6	-1.3
Chest pain or discomfort	0.2	0.3	1.3	0.0	-0.0	0.0	0.2	0.8	0.0	0.5	-0.0	0.4	0.6	-1.1
Had major operations	1.9	2.2	3.9	-1.8	-1.6	-1.7	-1.8	-1.9	-0.8	0.5	-1.7	-1.1	-2.0	0.4
Age at last live birth	0.9	1.3	3.7	-1.0	-1.0	-1.1	-1.2	-1.0	-1.6	-1.2	-0.3	0.4	-1.9	0.2
Family relationship satisfaction	0.5	0.6	2.6	1.2	-0.1	-0.2	0.1	0.3	-0.2	-1.6	0.4	0.5	-0.4	1.1
Leg pain on walking	1.1	1.3	2.6	-0.7	-1.6	-1.6	-1.4	-1.1	-1.4	-0.0	-1.2	0.8	-0.7	-1.2
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.8	5.5	1.8	1.7	2.0	2.0	2.4	1.4	0.8	1.3	-0.7	2.3	1.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.3	1.0	-0.4	-0.3	-0.3	1.1	-0.7	-0.1	-0.7	0.2	0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	0.1	0.6	0.6	0.5	-0.3	0.1	-0.5	-0.1	-0.0	0.3	-0.4
Medication: Aspirin	0.5	0.6	3.1	-0.7	0.8	0.9	0.6	-0.3	-0.1	0.0	1.8	0.5	0.4	-0.9
Supplements: Vitamin C	0.7	0.8	1.5	-0.7	-1.1	-1.1	-0.7	-1.2	-0.9	1.2	-0.7	0.9	-0.5	-0.8
Knee pain experienced in last month	0.1	0.1	0.8	-0.4	-0.1	-0.1	-0.1	-0.2	-0.9	-0.2	-0.0	0.0	-0.5	0.0
Hypertension (Self-reported)	0.4	1.1	4.4	-0.2	-0.6	-0.5	-0.8	-1.0	-1.1	0.7	0.0	1.8	0.6	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	2.0	0.4	0.5	0.6	0.6	0.4	0.4	0.2	0.3	0.5	1.4	0.1
Illnesses of father: Heart disease	1.2	1.7	6.7	1.3	0.1	0.5	0.2	0.1	1.1	-0.5	-0.2	1.9	2.6	-2.1
Illnesses of siblings: Diabetes	0.6	0.7	2.7	-1.0	0.4	0.2	0.2	0.7	-0.4	0.6	0.7	-1.6	-1.2	1.0
Smoking status: Previous	0.4	0.6	2.3	1.0	0.6	0.5	0.3	1.0	0.9	-1.5	0.9	0.3	0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	8.1	-0.4	1.2	1.1	1.2	1.9	0.7	-0.9	1.1	-2.9	-1.2	2.6
Whole body fat-free mass	0.3	1.7	3.3	1.2	1.1	1.2	1.4	1.6	1.3	-0.4	1.8	-1.5	-0.1	1.7
Leg fat-free mass (right)	0.1	0.8	2.1	0.4	0.7	0.8	0.8	1.0	0.5	-1.3	1.4	-1.0	0.0	0.8
Arm fat percentage (left)	0.4	1.5	6.8	-2.2	-0.1	-0.1	-0.7	-0.7	-1.8	-2.6	-0.3	-0.3	-0.3	-1.1
Average weekly red wine intake	2.3	3.4	8.6	-0.1	-2.9	-2.6	-2.6	-0.7	-1.7	0.8	-2.1	1.4	-1.8	-1.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.3	1.1	0.1	0.2	0.6	0.2	0.4	0.5	0.6	-0.0	0.3	1.1
Mood swings	0.2	0.4	1.3	-0.1	-0.2	-0.1	-0.3	-0.2	-0.6	-0.3	0.8	1.1	1.0	-0.9
Loneliness, isolation	0.7	1.0	4.0	-0.1	0.8	0.7	1.0	0.5	0.7	-1.0	2.0	-1.2	-0.2	1.5
Long-standing illness, disability or infirmity	0.3	0.5	1.5	-1.0	-0.5	-0.6	-0.8	-1.2	-0.4	0.2	0.4	-0.3	-1.0	-0.1
Ever had bowel cancer screening	0.2	0.2	0.7	-0.2	-0.1	-0.2	-0.3	0.3	0.8	-0.1	-0.8	-0.3	-0.5	0.2
Diabetes diagnosed by doctor	0.5	0.9	3.3	-0.4	0.6	0.5	0.5	-0.4	-0.2	-1.8	0.9	-1.4	-0.6	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.9	-0.0	0.7	0.6	0.9	1.7	0.4	-0.2	1.7	0.2	-0.2	0.9
Friendships satisfaction	1.2	1.5	4.1	-0.6	-1.2	-1.3	-1.6	-1.6	-2.0	-0.6	-0.5	1.3	-0.8	-0.8
Qualifications: nursing, teaching	0.4	0.6	2.2	-0.8	-0.3	-0.3	-0.3	-1.2	0.0	1.5	-0.6	0.8	0.1	-0.9
Commuting to job workplace: Walk	2.6	2.8	4.8	-1.5	-1.4	-1.6	-1.8	-1.0	-1.9	2.2	-1.9	1.0	-1.6	-2.2
Eye problems/disorders: Cataract	0.3	0.4	1.7	-0.0	0.8	0.7	0.3	-0.2	0.4	0.3	0.9	-0.5	0.0	1.3
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	5.4	1.8	1.6	1.8	2.3	0.7	1.1	-2.3	1.2	-1.0	2.1	2.0
Medication for cholesterol	0.8	1.2	2.7	-1.0	-1.4	-1.4	-1.1	-1.6	-1.4	0.9	-1.3	0.7	-0.2	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.4	-0.8	-0.3	-0.4	-0.5	-0.4	-0.2	0.1	-0.1	1.2	0.4	-0.9
Back pain experienced in last month	0.1	0.2	0.6	-0.3	0.2	0.1	0.1	0.7	0.4	0.5	0.4	0.7	0.2	-0.3
Mineral and other dietary supplements	1.1	1.5	7.5	0.9	1.0	1.1	1.2	0.6	1.2	0.3	0.6	1.2	2.7	-0.5
Breast cancer (self-reported)	0.3	0.3	0.8	0.0	-0.9	-0.7	-0.7	-0.3	-0.1	0.8	-0.8	-0.2	-0.5	-0.2
Asthma (self-reported)	0.5	1.0	2.1	0.0	-1.0	-0.9	-0.9	1.3	-1.0	0.7	-1.1	1.4	-0.3	-1.4
Osteoporosis (self-reported)	0.3	0.4	1.1	0.9	-0.4	-0.2	0.2	-0.1	0.7	0.9	-1.1	0.4	-0.2	0.4
Osteoarthritis (self-reported)	0.4	0.5	1.7	-0.5	-0.6	-0.5	-0.4	0.4	-0.9	-1.3	-0.4	-0.5	-0.9	0.3
Medication: Aspirin	0.6	0.8	3.7	-0.6	1.2	1.3	1.1	0.0	0.4	-0.3	1.9	-0.2	0.6	-0.3
Medication: Gliclazide	0.4	0.4	1.6	-0.9	-0.5	-0.5	-0.6	-1.2	-0.9	0.4	0.1	-0.2	-0.7	0.0
Illnesses of father: None of the above (group 1)	0.8	1.0	4.5	-0.4	1.1	0.6	1.1	0.4	0.6	-0.5	0.9	-1.3	-0.7	2.1
Smoking status: Current	0.2	0.3	1.0	0.5	0.4	0.4	0.5	1.0	0.3	0.2	0.3	-0.3	0.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.5	7.8	-0.8	-2.1	-2.1	-2.0	-1.9	-1.4	0.6	-1.7	2.8	0.4	-2.8
Whole body water mass	0.3	1.5	3.0	1.2	1.0	1.1	1.4	1.6	1.1	-0.4	1.7	-1.3	-0.0	1.5
Leg predicted mass (right)	0.1	0.8	2.0	0.4	0.7	0.8	0.8	1.0	0.6	-1.2	1.4	-1.1	0.0	0.8
Arm fat mass (left)	0.2	0.8	3.3	-1.6	0.0	0.0	-0.3	-0.4	-1.3	-1.8	0.2	-0.6	-0.6	-0.5
Number of self-reported non-cancer illnesses	0.2	0.4	1.5	-1.2	0.4	0.5	0.5	0.2	0.3	-0.3	1.2	-0.0	0.8	-0.3
Average weekly champagne plus white wine intake	0.4	0.5	2.2	1.0	-0.7	-0.6	-0.5	0.1	-0.4	0.8	-1.5	0.7	-0.1	-0.4
Miserableness	0.1	0.1	0.3	-0.1	-0.1	-0.1	-0.3	0.0	0.0	-0.5	0.5	0.4	0.0	-0.5
Guilty feelings	0.2	0.3	0.8	0.4	0.5	0.7	0.9	-0.2	0.3	-0.2	0.7	-0.1	0.7	0.1
Wears glasses or contact lenses	0.9	1.1	2.6	0.9	1.3	1.3	0.9	1.2	1.6	-0.0	0.9	-0.9	0.9	0.7
Ever taken oral contraceptive pill	0.3	0.3	2.0	0.0	0.1	0.3	0.3	0.2	0.5	-1.4	0.2	-0.7	0.3	0.3
Hearing aid user	0.3	0.3	1.5	0.8	-0.2	-0.3	-0.1	0.5	0.1	0.5	-0.2	1.2	-0.4	-0.4
Mother’s age at death	0.6	0.7	1.3	-0.5	-1.0	-1.0	-1.1	-0.6	-0.9	1.2	-0.7	0.6	-0.3	-1.0
Financial situation satisfaction	0.7	0.9	2.5	0.4	-0.8	-1.1	-0.9	-0.1	-1.5	0.3	-1.4	-0.3	-1.6	-0.2
Tinnitus: Yes, now most or all of the time	2.9	3.4	8.6	1.6	1.6	1.9	2.4	1.5	2.4	-1.1	2.0	-0.2	2.9	0.9
Commuting to job workplace: Public transport	1.2	1.4	4.7	-1.5	-1.0	-1.1	-1.2	-2.2	-1.2	1.2	-0.3	0.1	-1.5	-0.3
Eye problems/disorders: Glaucoma	7.6	9.0	19.5	-3.5	-2.7	-3.0	-3.4	-4.2	-3.3	1.1	-2.8	-1.2	-4.4	-0.3
Medication: Blood pressure	0.2	0.3	0.8	-0.6	0.2	0.2	0.2	0.1	-0.2	0.9	0.7	0.7	0.2	-0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.5	-1.6	-0.2	-0.3	-0.8	-0.5	-0.7	0.9	-0.3	0.4	-0.3	-1.1
Supplements: Fish oil (including cod liver oil)	2.0	2.6	9.7	-1.3	-1.7	-1.8	-1.8	-1.2	-2.2	0.1	-1.0	-1.0	-3.1	0.0
High cholesterol (Self-reported)	1.3	2.2	4.3	0.3	2.0	1.9	1.8	1.1	2.1	-1.4	2.1	-0.2	1.1	0.3
Medication: Bendroflumethiazide	0.5	0.7	2.0	-1.2	-0.3	-0.3	-0.6	-1.3	-1.1	0.6	0.4	0.7	-0.0	-1.4
Medication: Paracetamol	0.7	1.1	3.1	-0.5	-0.9	-0.9	-1.0	-0.5	-1.8	-0.7	-1.7	0.0	-1.4	-0.7
Medication: Lisinopril	1.7	2.2	6.0	-0.3	2.0	1.9	1.4	1.7	0.8	-2.4	2.0	-0.6	0.9	0.2
Medication: Atorvastatin	0.3	0.3	1.3	-1.1	-0.0	-0.1	-0.5	-0.6	-0.2	1.2	-0.0	-0.3	-0.1	-0.5
Illnesses of father: High blood pressure	1.6	2.0	4.5	-0.3	-1.9	-1.7	-1.3	-0.7	-1.9	0.1	-1.4	2.1	-0.5	-1.7
Alcohol drinker status: Never	0.8	1.0	2.1	-1.3	1.1	0.9	1.4	0.5	0.3	-1.1	0.6	-1.3	-0.2	1.0
Ever smoked	0.6	1.1	3.5	1.9	0.6	0.6	0.8	1.4	0.8	-1.1	1.2	-0.7	0.3	1.4
Basal metabolic rate	0.2	1.3	2.4	0.7	0.9	1.0	1.2	1.3	0.8	-0.8	1.5	-1.6	-0.3	1.5
Leg fat percentage (left)	0.3	1.1	7.4	-1.0	0.8	0.9	0.5	-0.0	-0.6	-2.7	0.8	-0.3	0.7	-0.4
Arm fat-free mass (left)	0.2	1.2	2.5	0.9	0.9	1.0	1.2	1.1	0.9	-0.6	1.5	-1.4	-0.3	1.6
Number of operations (self-reported)	0.4	0.6	1.4	-0.5	-1.2	-1.1	-0.8	-0.4	-0.5	0.7	-0.8	0.6	0.0	-0.9
Average weekly beer plus cider intake	0.7	1.0	4.2	-0.2	-0.2	0.0	-0.2	0.2	-0.8	0.3	1.1	2.0	1.9	-1.0
Irritability	0.1	0.1	0.7	0.0	0.1	0.2	-0.1	-0.2	-0.2	-0.8	0.4	-0.1	-0.0	-0.2
Risk taking	1.4	2.0	4.4	2.0	1.0	1.1	1.5	1.8	1.3	-1.1	1.5	-0.4	0.8	2.1
Ever had prostate specific antigen (PSA) test	0.3	0.4	3.1	0.3	-0.2	-0.1	-0.2	-0.1	-0.0	-1.8	0.3	-0.0	-1.0	0.2
Fractured/broken bones in last 5 years	0.9	1.1	3.8	-1.0	-0.8	-0.9	-0.9	-1.4	-1.7	0.4	-0.4	0.2	-1.9	0.2
Age started oral contraceptive pill	0.4	0.5	1.7	-1.3	0.5	0.4	0.3	-1.0	0.2	0.9	0.5	-0.6	-0.4	0.7
Diastolic blood pressure, automated reading	1.5	4.6	11.5	3.1	1.0	1.4	1.5	2.0	1.9	3.3	1.0	1.9	3.4	-0.9
Ever depressed for a whole week	1.5	1.8	3.8	1.0	-1.9	-1.8	-1.2	-0.7	-1.3	-0.4	-1.6	1.6	-0.6	-1.8
Unable to work because of sickness or disability	0.2	0.2	0.8	0.2	0.5	0.4	0.5	0.6	0.5	0.0	0.5	0.4	0.9	0.2
Commuting to job workplace: Cycle	0.1	0.1	0.7	0.0	0.0	0.0	0.1	0.0	0.5	-0.4	0.4	0.5	0.8	-0.1
Myopia	0.4	0.6	1.8	1.1	0.8	0.7	0.7	0.3	1.3	-0.7	0.5	0.0	1.0	0.7
Vascular/heart problems diagnosed by doctor	0.5	1.4	5.9	0.3	0.7	0.6	0.8	0.9	1.2	-0.4	0.0	-2.2	-0.6	2.4
Cholesterol lowering medication	0.9	1.3	3.0	0.9	1.3	1.4	1.5	1.4	1.7	1.0	0.9	-0.8	0.6	0.2
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.6	-1.0	-1.1	-1.2	-0.9	-1.5	-1.6	0.5	-1.5	0.9	-0.5	-0.4
Pain experienced in last month	1.0	1.7	4.9	1.1	1.3	1.2	1.6	0.7	0.8	-0.1	1.3	-2.1	-0.1	2.2
Supplements: Calcium	0.5	0.6	3.2	-0.6	-0.2	-0.3	-0.1	-0.8	-0.4	1.8	-0.7	-0.5	-0.8	0.4
Basal cell carcinoma (self-reported)	4.8	5.8	10.0	-0.6	-3.2	-2.9	-2.8	-3.1	-2.2	-0.0	-2.5	2.9	-0.3	-2.8
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.7	-0.1	0.5	0.4	0.3	-0.1	0.8	-0.2	0.5	0.6	0.8	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	-1.1	-0.1	-0.2	-0.0	0.1	0.1	-1.0	0.5	-0.4	-1.1	0.6
Heart disease (siblings)	0.4	0.5	1.8	0.4	0.3	0.5	0.6	0.3	0.4	-1.3	0.9	-1.0	0.3	1.1
Alcohol drinker status: Previous	0.4	0.5	1.1	-0.8	1.0	0.8	0.9	-0.2	0.6	0.7	0.9	-0.2	0.5	0.1
Pack years of smoking	0.1	0.1	0.5	0.1	-0.0	-0.1	-0.3	0.1	-0.6	0.7	-0.3	0.1	0.1	-0.0
Impedance of whole body	0.7	3.8	13.0	-3.0	0.0	-0.5	-0.9	-0.8	-0.9	1.0	-1.6	-3.6	-3.4	1.3
Leg fat mass (left)	0.3	1.1	6.9	-1.0	0.8	0.8	0.5	0.1	-0.5	-2.6	1.0	-1.0	0.2	0.2
Arm predicted mass (left)	0.2	1.1	2.1	1.1	0.9	1.0	1.2	1.2	1.0	-0.6	1.4	-1.1	0.0	1.3