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chr2:22,911,727-26,262,948

Best TWAS P=1.92e-65 · Best GWAS P=1.78e-66 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	-14.89	17.1	1.9e-65	0.36	0.79	0.02	TRUE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	-7.12	15.3	4.5e-53	0.23	0.63	0.01	TRUE
56	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	-14.39	-14.2	1.2e-45	-0.31	1.00	0.00	TRUE
50	GTEx	Spleen	UBXN2A	0.31	0.11	enet	19	0.17	4.1e-05	11.03	-12.2	2.4e-34	-0.07	0.04	0.92	TRUE
26	GTEx	Colon Sigmoid	DNMT3A	0.19	-0.01	lasso	8	0.00	4.5e-01	-6.50	-11.8	2.2e-32	-0.41	0.05	0.40	TRUE
37	GTEx	Lung	NCOA1	0.12	0.04	lasso	7	0.06	1.9e-05	-2.53	-11.1	1.2e-28	-0.10	0.52	0.02	TRUE
49	GTEx	Small Intestine Terminal Ileum	UBXN2A	0.18	0.08	enet	33	0.16	2.5e-04	-10.62	-10.3	1.1e-24	-0.05	0.03	0.89	TRUE
94	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POMC	0.19	0.01	blup	38	0.05	1.5e-04	13.91	9.3	9.2e-21	0.26	0.02	0.20	TRUE
60	NTR	Blood	ITSN2	0.02	0.00	bslmm	345	0.01	2.9e-03	-8.56	9.2	3.3e-20	0.07	0.05	0.04	TRUE
18	GTEx	Artery Tibial	UBXN2A	0.12	0.06	enet	24	0.09	1.5e-07	-3.77	-8.4	2.9e-17	-0.06	0.86	0.14	TRUE
31	GTEx	Esophagus Mucosa	TP53I3	0.16	0.03	enet	23	0.06	8.2e-05	-0.65	-8.2	2.0e-16	-0.04	0.12	0.06	TRUE
21	GTEx	Breast Mammary Tissue (Male)	NCOA1	0.13	-0.01	lasso	3	0.04	4.8e-02	-3.86	-7.5	7.2e-14	-0.23	0.05	0.06	TRUE
81	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	POMC	0.16	0.05	blup	39	0.11	2.4e-12	13.91	6.8	8.3e-12	0.16	0.92	0.08	TRUE
33	GTEx	Esophagus Mucosa	PFN4	0.16	0.15	lasso	4	0.15	3.6e-10	-6.50	-6.7	2.0e-11	-0.01	1.00	0.00	TRUE
62	ROSMAP	Brain Pre-frontal Cortex	KLHL29	0.08	0.03	enet	27	0.02	1.1e-03	-1.05	-6.7	2.2e-11	-0.04	0.75	0.19	TRUE
65	ROSMAP	Brain Pre-frontal Cortex	UBXN2A	0.03	0.01	lasso	4	0.02	2.2e-03	-5.93	5.6	2.0e-08	-0.01	0.35	0.02	TRUE
47	GTEx	Prostate	FAM228B	0.16	0.02	enet	31	0.07	9.6e-03	-10.62	5.4	5.9e-08	0.03	0.16	0.06	TRUE
24	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	-14.89	16.5	4.4e-61	0.37	0.35	0.05	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	-14.60	16.5	8.0e-61	0.36	1.00	0.00	FALSE
43	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	-12.89	15.9	3.3e-57	0.34	0.97	0.00	FALSE
34	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	-9.90	-15.1	2.5e-51	-0.17	0.08	0.04	FALSE
83	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	-12.15	14.9	3.5e-50	0.32	0.17	0.68	FALSE
54	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	-14.60	-14.9	3.8e-50	-0.31	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	-14.89	-14.7	5.7e-49	-0.31	0.82	0.02	FALSE
53	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	-14.39	-14.4	5.7e-47	-0.31	1.00	0.00	FALSE
17	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	-12.89	-14.2	4.7e-46	-0.25	1.00	0.00	FALSE
13	GTEx	Adrenal Gland	PTRHD1	0.32	0.28	lasso	3	0.26	8.3e-10	13.67	-13.9	8.7e-44	-0.21	0.98	0.00	FALSE
45	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	-12.89	13.8	3.7e-43	0.28	0.74	0.02	FALSE
19	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	-12.89	-13.7	1.8e-42	-0.32	0.90	0.02	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	-15.20	12.5	7.5e-36	0.26	1.00	0.00	FALSE
14	GTEx	Artery Aorta	NCOA1	0.15	0.00	enet	15	0.01	1.4e-01	-12.25	-12.4	3.1e-35	-0.21	0.07	0.04	FALSE
79	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	12.08	12.1	1.4e-33	0.33	0.55	0.06	FALSE
8	GTEx	Adipose Subcutaneous	RP11-443B20.1	0.04	0.00	enet	10	0.00	1.2e-01	-6.54	-11.5	8.3e-31	-0.28	0.35	0.08	FALSE
28	GTEx	Colon Transverse	UBXN2A	0.11	0.01	enet	8	0.03	8.7e-03	-9.75	-11.3	1.7e-29	-0.09	0.08	0.69	FALSE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	-8.63	11.2	2.6e-29	0.17	0.82	0.11	FALSE
70	YFS	Blood	POMC	0.35	0.05	enet	71	0.19	5.7e-59	13.91	10.7	7.9e-27	0.24	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Glioblastoma Multiforme	ADCY3	0.36	0.14	enet	7	0.13	8.9e-05	-10.43	10.6	2.0e-26	0.11	0.04	0.06	FALSE
86	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	-5.27	10.6	4.9e-26	0.25	0.56	0.34	FALSE
78	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADCY3	0.08	0.03	enet	16	0.03	1.5e-04	-8.65	10.5	1.3e-25	0.04	0.03	0.03	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	CENPO	0.08	0.04	enet	5	0.05	2.6e-07	8.18	10.0	1.0e-23	0.16	1.00	0.00	FALSE
96	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EFR3B	0.26	0.01	lasso	4	0.05	3.8e-03	-9.90	-10.0	2.1e-23	-0.22	0.03	0.16	FALSE
55	GTEx	Whole Blood	UBXN2A	0.17	0.07	lasso	8	0.09	2.1e-08	-4.16	-9.7	3.5e-22	-0.05	0.04	0.96	FALSE
38	GTEx	Lung	UBXN2A	0.09	0.06	enet	7	0.07	6.1e-06	-4.14	-8.7	2.5e-18	-0.06	0.36	0.63	FALSE
40	GTEx	Muscle Skeletal	POMC	0.38	0.10	lasso	9	0.09	2.9e-09	2.80	8.4	3.1e-17	0.26	1.00	0.00	FALSE
68	YFS	Blood	CENPO	0.09	0.06	lasso	6	0.07	6.7e-21	-7.88	8.3	9.9e-17	0.10	1.00	0.00	FALSE
16	GTEx	Artery Coronary	DNAJC27	0.12	0.03	lasso	7	0.00	2.4e-01	-5.30	-8.2	1.7e-16	-0.25	0.16	0.07	FALSE
7	GTEx	Adipose Subcutaneous	UBXN2A	0.06	0.04	lasso	5	0.04	5.2e-04	-9.79	-8.2	2.1e-16	-0.06	0.28	0.69	FALSE
87	The Cancer Genome Atlas	Lung Adenocarcinoma	NCOA1	0.02	0.01	blup	77	0.01	1.2e-02	4.08	8.2	2.1e-16	0.15	0.08	0.28	FALSE
5	GTEx	Adipose Subcutaneous	TP53I3	0.11	0.03	enet	48	0.04	3.8e-04	-2.82	8.0	1.6e-15	0.05	0.18	0.48	FALSE
10	GTEx	Adipose Visceral Omentum	UBXN2A	0.10	0.08	enet	29	0.03	9.8e-03	-10.71	-8.0	1.9e-15	-0.05	0.09	0.89	FALSE
48	GTEx	Skin Sun Exposed Lower leg	UBXN2A	0.08	0.04	enet	17	0.03	1.3e-03	-9.73	-7.7	1.6e-14	-0.07	0.56	0.35	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	SF3B14	0.10	0.01	lasso	8	0.00	3.5e-01	-4.71	-7.7	1.8e-14	-0.03	0.10	0.18	FALSE
89	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ADCY3	0.06	0.01	enet	9	0.02	1.0e-03	-8.56	7.6	2.2e-14	0.05	0.06	0.04	FALSE
35	GTEx	Heart Atrial Appendage	UBXN2A	0.08	0.02	lasso	3	0.02	5.2e-02	-5.97	-7.6	2.8e-14	-0.03	0.23	0.28	FALSE
36	GTEx	Heart Left Ventricle	PFN4	0.23	0.28	lasso	6	0.28	4.1e-15	-6.51	-7.5	5.3e-14	-0.03	1.00	0.00	FALSE
52	GTEx	Testis	FAM228B	0.14	0.09	enet	11	0.10	3.3e-05	8.14	7.5	8.4e-14	0.03	0.64	0.02	FALSE
82	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NCOA1	0.08	0.07	blup	77	0.05	5.8e-04	1.09	-7.4	1.7e-13	-0.05	0.14	0.51	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	PFN4	0.18	0.13	lasso	12	0.12	8.9e-05	-6.50	-7.3	2.0e-13	-0.01	0.34	0.04	FALSE
9	GTEx	Adipose Visceral Omentum	NCOA1	0.11	0.02	enet	17	0.02	2.1e-02	-7.62	-7.2	4.0e-13	-0.12	0.18	0.04	FALSE
67	YFS	Blood	ADCY3	0.07	0.02	bslmm	343	0.04	7.3e-14	-15.16	7.1	9.3e-13	0.11	1.00	0.00	FALSE
58	METSIM	Adipose	POMC	0.18	0.06	lasso	9	0.09	5.5e-13	6.24	7.1	1.0e-12	0.13	1.00	0.00	FALSE
41	GTEx	Muscle Skeletal	UBXN2A	0.10	0.04	lasso	7	0.03	5.5e-04	-4.16	-7.1	1.2e-12	-0.05	0.25	0.74	FALSE
59	METSIM	Adipose	UBXN2A	0.07	0.03	bslmm	403	0.06	5.3e-10	-9.73	-7.0	2.2e-12	-0.03	0.91	0.09	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	FKBP1B	0.04	0.02	blup	41	0.02	3.6e-05	-6.50	7.0	3.1e-12	0.03	0.44	0.04	FALSE
57	METSIM	Adipose	EFR3B	0.04	0.00	bslmm	357	0.00	9.7e-02	5.12	6.9	7.0e-12	-0.06	0.06	0.03	FALSE
92	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBXN2A	0.03	0.02	blup	46	0.03	5.7e-04	-4.12	-6.7	2.1e-11	-0.05	0.26	0.40	FALSE
101	The Cancer Genome Atlas	Rectum Adenocarcinoma	PFN4	0.38	0.11	lasso	5	0.05	2.8e-02	-6.50	-6.6	3.2e-11	-0.02	0.02	0.06	FALSE
29	GTEx	Colon Transverse	PFN4	0.14	0.07	lasso	2	0.04	3.3e-03	-6.51	-6.6	4.5e-11	-0.02	0.09	0.25	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	DNAJC27	0.10	0.06	blup	330	0.06	3.7e-08	-5.27	6.6	4.6e-11	0.29	0.99	0.01	FALSE
25	GTEx	Cells Transformed fibroblasts	UBXN2A	0.12	0.07	enet	12	0.12	4.7e-09	-9.19	-6.6	5.3e-11	-0.04	0.46	0.53	FALSE
4	CommonMind	Brain Pre-frontal Cortex	UBXN2A	0.22	0.18	enet	28	0.24	3.0e-28	-7.75	6.5	6.0e-11	0.03	1.00	0.00	FALSE
97	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PFN4	0.20	0.18	lasso	1	0.16	4.3e-07	-6.51	-6.5	7.5e-11	-0.02	0.84	0.05	FALSE
74	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PFN4	0.19	0.16	lasso	2	0.15	5.5e-08	-6.50	-6.5	7.8e-11	-0.02	0.98	0.00	FALSE
80	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PFN4	0.10	0.07	lasso	2	0.06	1.1e-07	-6.50	-6.5	9.3e-11	-0.02	0.98	0.00	FALSE
51	GTEx	Stomach	UBXN2A	0.13	0.14	enet	5	0.14	3.6e-07	-3.77	-6.4	1.2e-10	-0.07	0.59	0.31	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	PFN4	0.05	0.03	lasso	1	0.03	1.7e-04	-6.41	-6.4	1.4e-10	-0.02	0.41	0.02	FALSE
88	The Cancer Genome Atlas	Lung Adenocarcinoma	PFN4	0.15	0.09	lasso	3	0.09	7.3e-11	-6.41	-6.4	1.4e-10	-0.02	1.00	0.00	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	PFN4	0.12	0.08	lasso	6	0.07	6.3e-08	-6.50	-6.2	5.1e-10	-0.02	0.99	0.00	FALSE
42	GTEx	Muscle Skeletal	PFN4	0.12	0.09	lasso	4	0.09	5.6e-09	-6.50	-6.2	6.1e-10	-0.02	1.00	0.00	FALSE
76	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PFN4	0.13	0.07	lasso	4	0.06	4.4e-07	-6.50	-6.1	1.1e-09	-0.02	1.00	0.00	FALSE
85	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBXN2A	0.04	0.04	lasso	1	0.03	1.4e-04	-5.94	5.9	2.9e-09	0.01	0.36	0.14	FALSE
27	GTEx	Colon Transverse	SF3B14	0.09	0.05	lasso	9	0.02	4.9e-02	-2.75	-5.8	5.8e-09	0.01	0.35	0.38	FALSE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	PFN4	0.09	0.07	blup	43	0.08	5.3e-09	-6.41	-5.7	9.7e-09	-0.02	0.99	0.00	FALSE
20	GTEx	Brain Putamen basal ganglia	PFN4	0.32	0.17	lasso	5	0.12	1.1e-03	-6.41	-5.7	1.1e-08	-0.01	0.07	0.06	FALSE
77	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POMC	0.06	0.00	enet	12	0.03	9.3e-05	-1.06	5.7	1.5e-08	0.13	0.02	0.07	FALSE
11	GTEx	Adrenal Gland	UBXN2A	0.42	0.08	enet	35	0.22	2.6e-08	-4.12	-5.7	1.6e-08	-0.05	0.05	0.95	FALSE
15	GTEx	Artery Aorta	UBXN2A	0.20	0.09	lasso	6	0.08	4.1e-05	-3.77	-5.6	1.8e-08	-0.04	0.85	0.15	FALSE
90	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PFN4	0.10	0.07	enet	5	0.08	5.5e-09	-6.41	-5.6	2.3e-08	-0.02	1.00	0.00	FALSE
44	GTEx	Nerve Tibial	PFN4	0.25	0.16	lasso	5	0.20	3.8e-14	-6.50	-5.5	5.1e-08	-0.02	1.00	0.00	FALSE
39	GTEx	Lung	PFN4	0.14	0.12	enet	8	0.15	7.6e-12	-6.50	-5.4	6.3e-08	-0.02	1.00	0.00	FALSE
32	GTEx	Esophagus Mucosa	ADCY3	0.06	0.05	lasso	3	0.03	6.8e-03	-5.30	-5.3	9.9e-08	-0.15	0.59	0.04	FALSE
91	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TP53I3	0.03	0.01	enet	12	0.03	3.2e-04	-5.93	5.3	1.0e-07	-0.01	0.06	0.24	FALSE
12	GTEx	Adrenal Gland	PFN4	0.20	0.15	lasso	2	0.18	3.9e-07	-6.41	-5.3	1.3e-07	-0.02	0.22	0.05	FALSE
46	GTEx	Pituitary	PFN4	0.34	0.03	lasso	14	0.02	1.1e-01	-6.41	-5.3	1.4e-07	0.00	0.04	0.06	FALSE
93	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DNAJC27	0.04	0.04	lasso	1	0.02	1.2e-02	-5.27	5.3	1.4e-07	0.15	0.09	0.05	FALSE
95	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DNAJC27	0.12	0.12	lasso	2	0.09	1.7e-04	-5.27	5.3	1.4e-07	0.15	0.59	0.10	FALSE
98	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DNAJC27	0.07	0.09	lasso	2	0.10	8.2e-05	-5.27	5.3	1.4e-07	0.15	0.21	0.13	FALSE
71	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PFN4	0.11	0.00	enet	8	0.03	9.2e-04	-6.50	-5.2	1.5e-07	-0.02	0.55	0.04	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	POMC	0.11	0.08	enet	7	0.09	1.6e-09	-1.06	5.2	1.9e-07	0.10	0.97	0.02	FALSE
3	CommonMind	Brain Pre-frontal Cortex	DNAJC27	0.14	0.14	lasso	5	0.14	2.0e-16	-5.20	5.2	2.0e-07	0.15	1.00	0.00	FALSE
69	YFS	Blood	DNMT3A	0.04	0.00	bslmm	369	0.01	4.2e-05	3.33	-5.2	2.5e-07	-0.29	0.26	0.10	FALSE