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chr12:64,415,030-67,328,072

Best TWAS P=7.79e-22 · Best GWAS P=2.36e-135 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LEMD3	0.04	0.01	enet	13	0.03	7.3e-05	-9.2	-7.0	2.2e-12	0.14	0.29	0.25	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMBIM4	0.26	0.23	lasso	11	0.25	2.0e-30	5.8	-6.1	1.1e-09	0.06	1.00	0.00	TRUE
3	GTEx	Adipose Visceral Omentum	LEMD3	0.14	0.05	lasso	8	0.05	1.1e-03	-7.4	-8.9	5.5e-19	0.12	0.36	0.24	FALSE
4	GTEx	Artery Aorta	GNS	0.23	0.28	lasso	4	0.27	2.0e-15	6.3	6.3	3.7e-10	-0.04	1.00	0.00	FALSE
5	GTEx	Artery Aorta	TMBIM4	0.21	0.12	lasso	4	0.10	2.9e-06	6.2	6.4	1.3e-10	-0.06	0.99	0.00	FALSE
6	GTEx	Artery Tibial	GNS	0.24	0.24	lasso	7	0.25	5.9e-20	6.3	6.3	2.5e-10	-0.03	1.00	0.00	FALSE
7	GTEx	Brain Hippocampus	TMBIM4	0.32	0.22	lasso	2	0.29	1.7e-07	6.0	5.5	2.9e-08	-0.07	0.80	0.01	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	TMBIM4	0.27	0.23	enet	16	0.11	8.3e-04	5.8	6.8	1.2e-11	-0.05	0.55	0.03	FALSE
9	GTEx	Cells Transformed fibroblasts	LEMD3	0.09	0.10	lasso	3	0.09	4.4e-07	-8.3	-8.3	1.1e-16	0.11	0.97	0.00	FALSE
10	GTEx	Colon Transverse	LEMD3	0.10	0.02	lasso	7	0.04	3.6e-03	-1.4	-6.4	1.6e-10	0.12	0.08	0.56	FALSE
11	GTEx	Esophagus Mucosa	GNS	0.13	0.00	enet	23	0.02	1.3e-02	6.3	6.9	5.1e-12	-0.03	0.15	0.12	FALSE
12	GTEx	Esophagus Muscularis	GNS	0.23	0.22	lasso	1	0.21	5.5e-13	6.3	6.3	2.4e-10	-0.04	1.00	0.00	FALSE
13	GTEx	Esophagus Muscularis	LEMD3	0.09	0.09	enet	7	0.09	4.3e-06	-9.2	-8.8	1.8e-18	0.12	0.98	0.01	FALSE
14	GTEx	Heart Atrial Appendage	LEMD3	0.12	0.03	enet	12	0.06	7.5e-04	-7.4	-9.6	7.8e-22	0.12	0.02	0.94	TRUE
15	GTEx	Heart Atrial Appendage	RBMS1P1	0.17	0.03	lasso	11	0.04	7.3e-03	12.5	-8.4	4.5e-17	-0.41	0.07	0.39	TRUE
16	GTEx	Nerve Tibial	GNS	0.14	0.16	lasso	2	0.14	2.6e-10	6.3	6.3	2.7e-10	-0.04	1.00	0.00	FALSE
17	GTEx	Nerve Tibial	TMBIM4	0.20	0.16	lasso	6	0.19	2.1e-13	5.8	6.0	2.6e-09	-0.06	1.00	0.00	FALSE
18	GTEx	Nerve Tibial	LEMD3	0.12	0.14	enet	13	0.16	2.0e-11	-8.3	-9.4	4.8e-21	0.12	1.00	0.00	FALSE
19	GTEx	Pituitary	TMBIM4	0.42	0.27	lasso	6	0.26	4.2e-07	6.3	6.3	2.2e-10	-0.06	0.89	0.01	FALSE
20	GTEx	Skin Sun Exposed Lower leg	TMBIM4	0.16	0.13	lasso	5	0.13	9.8e-11	6.3	6.7	2.3e-11	-0.06	1.00	0.00	TRUE
21	GTEx	Spleen	TMBIM4	0.36	0.26	lasso	6	0.22	3.2e-06	5.8	6.7	2.4e-11	-0.06	0.72	0.02	FALSE
22	GTEx	Testis	LLPH	0.19	0.21	lasso	1	0.20	4.3e-09	6.0	6.0	2.1e-09	-0.07	0.98	0.00	FALSE
23	GTEx	Testis	TMBIM4	0.54	0.46	lasso	10	0.48	5.6e-24	5.8	6.4	1.9e-10	-0.03	1.00	0.00	FALSE
24	GTEx	Testis	LEMD3	0.15	0.15	lasso	7	0.16	1.9e-07	-6.9	-7.3	2.5e-13	0.14	0.23	0.69	FALSE
25	METSIM	Adipose	GNS	0.10	0.13	lasso	2	0.13	7.7e-19	5.7	-5.7	1.5e-08	0.01	1.00	0.00	FALSE
26	METSIM	Adipose	TMBIM4	0.09	0.11	lasso	4	0.10	4.3e-14	5.8	-5.5	3.0e-08	0.03	1.00	0.00	FALSE
27	NTR	Blood	GNS	0.04	0.05	lasso	5	0.05	1.4e-14	6.2	-5.7	1.2e-08	0.00	1.00	0.00	FALSE
28	NTR	Blood	TBC1D30	0.01	0.00	bslmm	327	0.00	1.6e-02	-1.1	-7.9	3.5e-15	0.11	0.07	0.03	FALSE
29	NTR	Blood	TMBIM4	0.11	0.14	lasso	8	0.13	1.2e-40	5.8	-5.9	4.7e-09	0.03	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	LLPH	0.05	0.09	enet	12	0.09	1.2e-18	5.8	5.2	1.5e-07	-0.04	0.87	0.13	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMBIM4	0.10	0.12	enet	12	0.13	5.6e-26	5.9	-5.2	2.4e-07	0.02	0.88	0.12	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	LLPH	0.14	0.12	lasso	1	0.10	1.6e-06	5.8	5.8	5.6e-09	-0.03	0.81	0.17	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	TMBIM4	0.12	0.12	lasso	1	0.11	4.4e-07	5.8	-5.8	5.2e-09	0.03	0.84	0.13	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LEMD3	0.02	0.02	blup	36	0.02	5.9e-03	-9.5	-9.2	3.3e-20	0.13	0.01	0.78	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LLPH	0.04	0.01	blup	74	0.01	8.3e-03	5.8	6.5	9.7e-11	-0.07	0.08	0.42	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNS	0.02	0.01	blup	38	0.02	1.7e-03	4.9	-5.7	1.1e-08	0.04	0.02	0.67	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LLPH	0.12	0.18	lasso	8	0.19	1.3e-20	5.8	5.9	3.1e-09	-0.04	0.89	0.11	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMBIM4	0.21	0.28	enet	22	0.28	1.3e-31	5.8	-6.9	6.3e-12	0.04	0.90	0.10	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GNS	0.05	0.03	blup	38	0.04	3.6e-03	6.7	-6.9	6.3e-12	0.02	0.01	0.88	TRUE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMBIM4	0.38	0.24	lasso	4	0.23	2.6e-13	5.8	-6.1	1.1e-09	0.03	0.88	0.12	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	LEMD3	0.06	0.01	blup	36	0.02	6.8e-04	-8.3	-5.8	6.7e-09	0.03	0.02	0.14	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	LLPH	0.16	0.20	lasso	7	0.20	1.8e-22	5.8	6.7	2.5e-11	-0.05	0.65	0.35	FALSE
43	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	LLPH	0.14	0.11	lasso	3	0.11	8.5e-06	5.9	6.2	7.7e-10	-0.04	0.63	0.29	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	LLPH	0.09	0.13	lasso	7	0.13	3.4e-15	5.8	5.5	2.8e-08	-0.04	0.81	0.19	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	TMBIM4	0.11	0.16	lasso	2	0.15	1.7e-17	5.8	-5.9	4.6e-09	0.03	0.89	0.11	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LLPH	0.04	0.03	blup	71	0.02	2.8e-03	3.8	6.2	4.0e-10	-0.06	0.33	0.34	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMBIM4	0.15	0.15	lasso	4	0.14	3.9e-16	5.8	-5.7	1.3e-08	0.02	0.89	0.11	FALSE
48	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LLPH	0.05	0.05	lasso	8	0.03	2.4e-03	5.8	6.0	1.8e-09	-0.03	0.18	0.15	FALSE
49	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMBIM4	0.15	0.13	enet	15	0.15	2.9e-10	6.1	-6.1	1.2e-09	0.06	0.64	0.36	FALSE
50	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LLPH	0.19	0.11	blup	74	0.12	9.2e-06	6.2	6.4	1.3e-10	-0.04	0.42	0.48	TRUE
51	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMBIM4	0.17	0.11	lasso	5	0.08	2.5e-04	5.8	-5.8	8.9e-09	0.03	0.47	0.31	FALSE
52	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LLPH	0.25	0.24	enet	9	0.25	2.3e-10	6.3	7.1	1.4e-12	-0.05	0.40	0.60	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	LLPH	0.24	0.26	lasso	4	0.26	2.0e-27	5.8	6.1	8.9e-10	-0.04	0.89	0.11	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMBIM4	0.25	0.29	lasso	2	0.29	4.8e-31	5.8	-6.0	1.5e-09	0.03	0.89	0.11	FALSE
55	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMBIM4	0.16	0.14	lasso	3	0.12	1.9e-07	5.8	-5.3	1.2e-07	0.03	0.86	0.13	TRUE
56	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMBIM4	0.08	0.09	blup	63	0.10	1.2e-07	5.4	-5.5	4.3e-08	0.02	0.89	0.11	FALSE
57	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LLPH	0.39	0.32	lasso	8	0.31	1.3e-11	6.2	6.3	3.3e-10	-0.06	0.51	0.49	FALSE
58	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMBIM4	0.09	0.05	lasso	2	0.06	4.6e-03	5.4	-7.0	3.4e-12	0.06	0.02	0.51	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	LLPH	0.35	0.45	lasso	4	0.46	1.1e-49	5.8	6.1	1.0e-09	-0.04	0.89	0.11	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	TMBIM4	0.26	0.34	lasso	5	0.33	8.2e-33	5.8	-6.0	1.8e-09	0.04	0.88	0.12	FALSE
61	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	LLPH	0.12	0.12	enet	13	0.09	1.7e-03	5.8	6.5	6.1e-11	-0.05	0.10	0.32	FALSE