Hub : Genes

IL17D

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1560	0.0460	1.8e-04	0.011	NA	0.064	NA	0.065	5.5e-02	NA	4.4e-05	NA	3.9e-05
2	GTEx	Esophagus Muscularis	0.2060	0.0530	1.3e-05	0.143	NA	0.137	NA	0.157	5.4e-09	NA	1.1e-08	NA	9.0e-10
3	GTEx	Muscle Skeletal	0.0943	0.0358	1.5e-03	0.020	NA	0.012	NA	0.022	4.0e-03	NA	2.0e-02	NA	2.8e-03
4	GTEx	Testis	0.1180	0.0530	6.2e-03	0.009	NA	0.003	NA	0.024	1.2e-01	NA	2.2e-01	NA	2.9e-02
5	YFS	Blood	0.0204	0.0075	8.1e-04	0.015	0.010	0.006	0.009	0.010	6.5e-06	0.00019	2.8e-03	0.00038	2.6e-04
6	TCGA	Lung Adenocarcinoma	0.0410	0.0266	8.4e-03	0.019	0.019	0.006	NA	0.010	2.1e-03	0.00210	6.0e-02	NA	2.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.4	0.8	-0.0	0.4	0.8	0.2	0.8	0.9
Bipolar Disorder or Schizophrenia	0.2	0.6	1.9	-0.2	-0.5	-0.0	0.1	1.1	1.4
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	0.1	-0.7	-0.6	0.1	-0.7	-0.7
Depression (Nagel 2018)	0.9	1.3	2.6	-1.3	-1.5	-1.6	0.9	-0.7	0.2
Intelligence (Savage-Jansen 2018)	2.5	7.8	15.0	3.2	2.8	3.9	-3.5	0.5	-0.9
Neuroticism (Nagel 2018)	0.5	1.2	2.4	-1.0	-1.5	-1.5	1.2	-0.3	0.6
Schizophrenia (2018)	0.3	0.5	1.1	-0.3	-0.9	-0.7	-0.1	0.8	1.1
Schizophrenia vs Biploar Disorder	1.3	1.8	3.7	-1.2	-1.1	-1.6	1.1	-1.9	-0.6
Worry (Nagel 2018)	1.9	4.0	7.1	-1.9	-2.5	-2.7	2.1	-0.0	1.7
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	-0.2	-0.8	-0.6	0.3	-0.1	0.6
Alzheimer’s Disease (in father)	0.7	0.7	3.5	1.9	0.5	0.5	0.7	0.1	0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	1.5	1.2	-0.4	-0.3	0.7	-0.3	0.1
Crohns Disease (2017)	0.2	0.4	0.7	0.1	-0.9	-0.7	-0.3	-0.6	-0.7
Irritable Bowel Disease (IBD)	0.3	0.7	2.5	0.1	0.8	0.8	-0.4	-0.0	-1.6
Ulcerative Colitis (UC)	0.6	1.2	2.3	0.2	1.5	1.3	-0.6	0.6	-1.5
Major Depression (MDD)	0.5	0.6	2.2	0.7	0.5	0.3	-1.5	-0.9	-0.1
Reaction Time	0.7	1.4	3.7	-0.0	1.3	1.0	-0.2	1.4	-1.9
Verbal and Numeric Reasoning (VNR)	1.9	4.5	11.8	1.4	2.2	3.4	-2.8	0.9	-0.1
Breast Cancer	1.2	2.9	6.7	-1.0	2.2	2.6	-1.3	0.5	-1.7
Ovarian Cancer	1.3	1.7	6.9	-0.1	1.1	1.2	-2.6	-0.7	-0.6
Prostate Cancer	0.3	0.5	1.6	-0.9	-0.4	-0.4	0.2	-1.3	0.2
Age at First Birth	0.2	0.3	1.4	0.4	-0.2	0.2	-0.4	-0.2	1.2
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.4	0.3	0.5	-0.8	0.6	0.3
Body Mass Index (BMI) (2010)	0.8	1.0	2.5	0.4	1.3	1.0	-0.6	1.6	-0.8
Coronary Artery Disease (CAD)	1.6	2.0	4.3	1.7	1.8	1.0	0.0	-0.2	-2.1
Crohns Disease (2012)	0.3	0.5	1.3	1.1	-0.1	-0.2	0.7	-0.7	-0.9
Mean Putamen Volume	0.8	0.9	2.1	0.8	1.5	1.2	-0.0	0.1	-1.0
Fasting Glucose	0.2	0.3	0.7	0.8	0.4	0.1	0.6	0.4	-0.3
HbA1C	0.7	0.8	2.7	0.5	0.6	0.7	-1.6	-0.9	-0.4
HDL Cholesterol	0.4	0.7	1.7	-0.8	-1.0	-0.6	1.3	0.5	0.6
LDL Cholesterol	0.9	1.4	3.2	1.0	1.5	1.2	-0.6	0.5	-1.8
Lupus	0.8	1.2	3.0	0.8	-0.8	-0.8	1.7	0.6	1.3
Neuroticism (2016)	0.6	0.9	3.3	-1.8	-0.8	-0.5	0.9	-0.1	0.6
Primary Biliary Cirrhosis	0.5	0.7	3.6	0.5	0.6	0.1	0.1	-1.9	-0.4
Rheumatoid Arthritis	3.4	4.6	9.7	-0.9	-2.6	-3.1	2.8	0.5	1.6
Schizophrenia (2014)	0.2	0.3	0.7	0.2	-0.8	-0.7	0.3	0.0	0.8
Triglycerides	0.4	0.7	1.3	0.5	0.8	0.9	-1.2	-0.4	-1.1
Type 2 Diabetes (T2D) (2012)	0.0	0.1	0.1	0.1	-0.0	0.2	-0.3	0.2	0.3
Ulcerative Colitis	0.6	0.9	1.9	0.8	1.4	1.2	-0.5	-0.2	-1.0
Blood Eosinophil Count	0.1	1.1	2.2	0.2	1.5	1.3	0.1	1.2	-1.2
Blood Platelet Count	0.1	0.7	2.6	-0.4	0.3	0.5	-1.0	0.2	-1.6
Blood Red Count	0.2	2.2	6.2	2.5	1.4	1.1	-0.3	1.8	-0.7
Blood White Count	0.3	2.0	4.7	0.7	0.9	0.9	-2.2	-1.0	-2.0
Heel T-Score	0.3	2.5	4.8	1.2	1.7	2.2	-2.0	0.8	-1.1
BMI	0.6	3.2	7.8	2.8	2.1	1.0	0.3	0.6	-2.5
Height	1.0	19.3	72.8	2.9	-2.4	-2.5	-4.6	-8.5	-1.2
Waist Hip Ratio (WHR)	0.3	1.3	2.9	0.5	0.9	0.3	1.2	1.7	-1.4
Systolic Blood Pressure	0.2	1.1	3.5	0.8	0.2	-0.4	1.4	1.9	-0.2
Smoking Status	0.3	0.8	1.5	1.2	1.2	1.0	-0.4	0.8	-0.3
Allergy or Eczema	0.6	1.6	3.3	-1.8	0.9	0.5	1.7	1.3	-0.7
Cardiovascular Disease	2.3	7.7	12.8	3.3	3.1	3.6	-2.5	2.2	-1.3
Hypothyroidism (self reported)	0.3	0.7	2.3	-0.7	0.6	0.4	-1.5	-0.5	-0.8
Respiratory disease	0.3	0.7	2.7	-0.7	0.7	-0.1	0.8	-0.2	-1.6
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.5	-1.9	-0.5	-0.7	1.2	1.0	0.9
Lung FEV1/FVC ratio	0.4	2.3	10.6	1.5	0.2	0.3	0.6	3.3	0.4
Lung FVC	0.2	0.9	2.2	0.2	0.3	1.5	-1.4	-0.5	0.8
Neuroticism	0.5	1.2	2.3	-1.5	-0.9	-0.8	1.5	0.9	0.7
Chronotype (morning person)	0.5	1.1	2.9	0.1	-0.9	-1.7	1.6	-0.6	-0.4
Hair Pigment	0.1	1.9	4.8	2.2	-1.3	-1.6	0.5	-0.9	1.0
Tanning	0.1	1.3	3.2	-0.5	-0.9	-0.7	-1.5	-1.8	1.0
Hand grip strength (left)	2.9	7.8	25.4	-1.2	-2.9	-2.5	-1.4	-5.0	1.8
Number of treatments/medications taken	0.3	0.5	1.4	0.3	1.2	0.9	-0.1	0.6	-0.6
Average weekly spirits intake	0.6	0.7	1.3	1.0	0.8	0.6	0.0	-0.9	-1.1
Sensitivity / hurt feelings	0.2	0.3	0.8	-0.5	0.0	-0.1	0.7	0.4	-0.9
Frequency of depressed mood in last 2 weeks	1.4	2.0	5.1	-0.7	-1.4	-1.9	2.3	-0.9	-0.4
Hearing difficulty/problems: Yes	0.4	0.6	1.6	-0.2	0.6	0.8	-1.3	-0.2	-1.0
Relative age of first facial hair	0.3	0.6	2.0	-0.4	-0.6	-0.2	-0.7	-1.4	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.6	-1.1	-0.3	0.6	-1.2	1.0	0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.0	0.0	-0.5	-0.8	1.0	0.3	0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	0.7	0.2	-0.1	0.4	0.5	-0.5
Systolic blood pressure, automated reading	0.4	1.3	4.0	0.8	-0.3	-0.9	2.0	1.4	0.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.7	-1.1	-1.0	-0.9	0.4	-0.0	1.3
Angina	0.3	0.4	1.4	-0.1	-0.0	0.0	-0.6	0.7	-1.2
Medication for hormone replacement therapy	0.2	0.3	0.7	0.0	-0.2	0.1	-0.5	-0.8	0.7
Vitamin and mineral supplements	0.1	0.2	0.5	-0.3	0.7	-0.1	-0.0	-0.4	-0.5
Supplements: Zinc	0.2	0.2	0.3	-0.6	-0.6	-0.1	0.5	-0.2	0.3
Medication: Co-codamol	0.6	0.7	1.2	-0.4	0.7	0.5	1.1	0.9	-1.0
Medication: Metformin	0.9	1.3	2.4	0.1	1.6	1.2	-0.2	1.5	-1.3
Diabetes (father)	0.3	0.4	0.8	-0.4	-0.8	-0.9	0.5	0.7	0.2
Diabetes (mother)	0.5	0.6	1.2	0.8	0.8	0.8	-1.1	-0.7	-0.3
Severe depression (siblings)	1.0	1.2	2.8	-0.0	-1.7	-1.1	0.7	-0.6	1.5
Pack years adult smoking proportion	1.1	1.7	6.2	-2.5	-0.0	-1.0	1.4	-0.3	-1.1
Impedance of leg (right)	0.1	0.7	2.6	-1.6	0.2	0.3	1.2	0.1	-0.3
Leg fat-free mass (left)	0.6	3.2	10.0	2.1	-0.7	-1.5	-0.8	-3.2	-1.0
Trunk fat percentage	0.9	3.6	7.3	2.7	2.3	1.0	1.5	0.7	-2.3
Hand grip strength (right)	2.1	5.6	21.0	-0.8	-2.2	-1.8	-1.8	-4.6	0.8
Townsend deprivation index at recruitment	1.0	1.3	3.2	-1.8	-1.0	-1.2	0.9	-1.3	0.2
Current tobacco smoking	0.2	0.4	1.0	1.0	0.1	0.1	-0.8	-0.8	-0.2
Average weekly fortified wine intake	1.7	2.0	5.4	0.3	0.4	0.7	-2.3	-2.1	-1.1
Maternal smoking around birth	1.9	2.8	4.3	-1.8	-1.7	-1.8	1.8	-0.1	2.1
Fed-up feelings	0.4	0.6	1.3	-0.9	-1.0	-1.1	0.8	-0.5	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	3.4	-1.4	-1.5	-1.6	1.8	-0.2	0.9
Relative age voice broke	2.5	3.8	8.5	-1.9	-2.2	-1.7	1.6	-0.2	2.9
Taking other prescription medications	0.6	1.0	2.3	0.8	1.0	0.9	-1.1	0.0	-1.5
Age when periods started (menarche)	0.5	1.3	4.2	-0.9	-0.6	-1.1	2.0	-0.9	0.8
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.6	1.5	-0.2	0.3	-1.6	-0.3	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	5.1	0.2	-0.4	-0.3	0.1	-2.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.6	-0.5	0.3	0.6	-1.3	-1.0	-0.1
Qualifications: CSEs or equivalent	0.5	0.7	2.3	-1.2	0.2	-0.1	0.2	-0.8	-1.5
Serious illness, injury or assault to yourself	1.2	1.5	5.5	-1.3	0.2	-0.0	0.9	2.3	-1.0
High blood pressure	1.0	2.8	4.7	1.6	1.8	2.2	-1.4	2.0	0.0
Hayfever, allergic rhinitis or eczema	1.1	2.5	4.1	-1.4	2.0	1.6	1.0	1.1	-2.0
Multivitamins +/- minerals	0.3	0.4	0.7	0.8	-0.6	0.1	-0.8	-0.7	0.3
Stomach or abdominal pain in last month	0.2	0.2	0.6	-0.2	-0.8	-0.3	-0.3	-0.5	0.4
Supplements: Glucosamine	0.9	1.2	1.8	1.3	1.0	1.1	-1.3	-0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	6.4	2.5	0.5	0.8	-1.1	1.1	-0.1
Medication: Atenolol	0.7	0.9	2.1	-0.9	-0.7	-0.4	0.1	1.4	1.3
Medication: Levothyroxine sodium	0.2	0.3	1.5	-0.6	0.1	0.3	-1.2	-0.3	0.1
Sitting height	1.0	7.0	26.8	1.9	-0.6	-0.6	-3.1	-5.2	-1.2
Chronic bronchitis/emphysema (father)	3.4	4.0	8.0	1.6	2.8	2.6	-0.9	0.2	-2.4
High blood pressure (mother)	0.5	0.7	1.7	0.3	1.0	1.0	-0.3	1.3	-0.3
Body mass index (BMI)	0.4	1.7	5.3	2.3	1.5	0.6	0.7	0.8	-1.3
Impedance of leg (left)	0.1	0.7	2.6	-1.6	-0.2	-0.1	1.2	-0.4	0.2
Leg predicted mass (left)	0.6	3.3	10.8	2.1	-0.7	-1.5	-0.8	-3.3	-1.1
Trunk fat mass	0.7	2.8	8.2	2.9	1.6	0.3	0.9	-0.8	-2.2
Waist circumference	0.6	2.3	6.1	2.5	1.6	0.5	-0.1	-0.2	-2.3
Number of incorrect matches in round	0.1	0.2	0.7	-0.6	-0.4	-0.3	0.9	0.1	0.1
Past tobacco smoking	0.4	0.7	2.1	-0.3	-1.0	-1.4	0.6	-0.9	-0.4
Alcohol usually taken with meals	0.2	0.4	0.8	0.6	-0.8	-0.9	0.1	-0.1	0.5
Nervous feelings	0.7	1.2	5.2	0.6	-0.1	-0.9	2.3	0.7	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.8	0.2	-1.4	-1.7	1.2	-1.2	0.3
Hearing difficulty/problems with background noise	2.0	3.2	7.4	2.3	1.8	1.4	-0.3	1.0	-2.7
Hair/balding pattern: Pattern 2	0.5	0.6	2.0	-0.6	0.1	0.7	-0.9	-1.4	0.2
Had menopause	1.5	1.9	3.5	0.6	-1.4	-1.8	1.9	0.6	1.4
Had other major operations	0.3	0.3	1.0	-0.0	-0.5	-0.7	1.0	-0.4	0.3
Forced vital capacity (FVC)	1.0	3.9	15.6	1.3	-1.1	-0.5	-2.1	-3.9	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	4.3	-0.0	0.1	0.0	0.5	-2.1	-0.3
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.4	0.2	1.6	1.2	0.1	0.0	-1.3
Qualifications: None of the above	1.2	2.6	5.8	-0.2	-1.9	-2.4	2.1	0.4	1.4
Financial difficulties in last 2 years	0.5	0.7	1.5	-1.2	-0.5	-0.8	1.0	-0.9	-0.5
Mouth/teeth dental problems	0.2	0.3	0.8	0.3	0.9	0.5	0.1	-0.4	-0.8
Heart attack	0.9	1.2	3.7	0.1	-0.7	-0.1	-1.7	-1.9	0.3
Allergy	0.5	1.1	1.9	1.3	-1.4	-0.8	-1.0	-0.1	1.2
Pain all over the body in last month	0.5	0.6	1.1	-0.2	-1.0	-0.8	0.0	-1.0	0.8
Diabetes (self-reported)	0.8	1.3	2.4	-1.5	1.4	1.0	0.2	1.2	-0.9
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	3.5	-1.1	0.6	-0.0	1.9	-0.6	-0.7
Medication: Ramipril	0.8	1.0	4.9	-0.5	-0.3	0.4	-2.2	-0.2	0.7
Medication: Simvastatin	0.5	0.8	1.8	0.6	1.3	0.9	-0.0	0.9	-1.0
Fluid intelligence score	2.5	5.2	10.8	2.0	2.9	3.3	-2.3	0.1	-1.5
Illnesses of siblings	0.7	1.0	1.7	-0.5	1.2	1.3	-1.1	-0.3	-1.2
Neuroticism score	0.5	1.0	1.7	-0.9	-1.3	-1.3	1.3	-0.0	0.2
Weight	0.6	2.8	7.3	2.7	0.2	-0.8	-0.1	-2.6	-1.3
Impedance of arm (right)	0.4	2.0	4.2	0.2	2.0	1.5	0.7	1.3	-1.8
Arm fat percentage (right)	1.2	4.9	9.6	3.1	2.8	1.6	1.0	1.6	-2.3
Trunk fat-free mass	1.3	7.6	28.2	1.6	-2.3	-2.5	-1.7	-5.3	0.4
Hip circumference	0.4	1.9	5.3	2.3	0.8	-0.2	-0.1	-1.5	-1.7
Time employed in main current job	0.3	0.3	1.0	-0.2	-1.0	-0.7	0.5	0.2	0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.7	-0.2	-0.5	-0.7	0.8	0.2	-0.1
Father’s age at death	1.2	1.6	8.3	-0.6	-0.4	-0.2	-0.7	-2.9	0.5
Worrier / anxious feelings	1.3	2.4	4.5	-0.4	-1.9	-2.1	2.1	0.1	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.0	-0.3	0.2	-0.2	0.1	-0.7	-1.4
Falls in the last year	0.7	0.9	3.0	-1.7	-0.2	-0.1	0.2	1.5	0.3
Hair/balding pattern: Pattern 3	1.2	1.8	3.7	-1.3	-1.9	-1.7	1.0	-0.4	1.1
Number of live births	0.6	0.8	1.6	-0.7	-0.8	-1.2	1.3	0.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	7.5	1.4	-0.9	-0.5	-1.4	-2.7	0.6
Pulse rate	3.0	5.0	10.2	1.4	2.6	3.2	-2.6	0.9	-1.9
Happiness	0.5	0.6	1.7	-1.3	-1.0	-0.4	-0.5	-0.2	0.5
Noisy workplace	0.4	0.4	0.8	-0.5	-0.9	-0.9	-0.7	-0.1	0.5
Qualifications: A levels/AS levels or equivalent	2.4	5.4	11.9	1.1	2.6	3.1	-3.5	0.3	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.4	0.1	-0.5	-0.1	-0.5	-0.6	-0.0
Mouth/teeth dental problems: Dentures	0.5	0.9	2.3	-1.5	-0.7	-0.6	0.6	0.9	0.8
Asthma	0.4	0.7	2.5	-0.8	0.9	0.5	0.1	-0.4	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.1	-1.1	-0.9	-1.5	0.2	-0.8	0.6
Medication: Cholesterol lowering	0.3	0.5	0.8	0.8	0.9	0.8	-0.6	0.4	-0.6
Depression (self-reported)	1.8	2.1	3.4	1.4	1.8	1.4	-0.8	1.4	-1.7
Medication: Lansoprazole	0.6	0.7	1.4	-1.2	-0.7	-0.9	1.2	0.5	0.0
Prospective memory result	0.2	0.2	1.2	-1.1	0.2	0.1	0.2	0.4	-0.0
Lung cancer (father)	0.3	0.3	0.9	0.4	0.5	0.4	0.6	0.9	-0.2
Illnesses of mother	0.5	0.6	1.3	0.5	0.9	0.7	-0.1	1.0	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.4	0.9	-0.3	-0.0	-1.6	-2.1	-0.1
Pulse wave Arterial Stiffness index	0.2	0.2	1.1	-0.1	-0.4	-0.2	-1.0	-0.2	0.3
Impedance of arm (left)	0.3	1.4	3.0	0.4	1.7	1.3	0.4	0.8	-1.7
Arm fat mass (right)	0.5	2.1	6.9	2.6	1.4	0.2	0.8	-0.0	-1.6
Trunk predicted mass	1.4	7.9	29.7	1.6	-2.4	-2.6	-1.7	-5.5	0.5
Standing height	1.3	13.1	58.0	1.2	-2.6	-2.9	-2.0	-7.6	-0.5
Length of working week for main job	0.4	0.5	1.2	0.1	-0.7	-1.0	1.1	-0.3	-0.2
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.3	0.5	0.3	0.6	0.1	-0.3
Breastfed as a baby	0.6	0.7	2.6	0.3	-0.0	0.1	-0.7	-1.6	-1.0
Tense / ‘highly strung’	1.2	1.9	3.8	-0.9	-2.0	-1.7	1.5	-0.4	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.1	1.1	1.4	1.4	-1.0	0.1	-1.0
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.6	0.2	-0.4	0.6	-0.7	-0.0
Birth weight of first child	1.0	1.8	7.7	0.4	-0.8	-1.0	-0.0	-2.8	1.0
Peak expiratory flow (PEF)	0.6	1.3	5.8	1.0	-0.2	-0.4	-0.9	-2.4	-0.3
Pulse wave reflection index	0.9	1.1	2.0	-0.8	-1.4	-1.2	-0.3	-0.9	1.3
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	-0.7	-0.1	-0.6	0.8	0.6	0.5
Loud music exposure frequency	0.3	0.3	0.5	-0.6	-0.5	-0.5	0.3	0.6	0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	5.0	0.3	1.1	1.5	-2.2	0.1	-0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	0.7	-0.1	0.6	-1.0	-0.6	0.6
Blood clot in the leg (DVT)	1.9	2.5	4.3	-1.6	-1.5	-2.1	1.8	-1.2	1.0
Medication: Paracetamol	1.1	1.8	3.2	-1.7	-1.6	-1.8	0.9	-0.8	1.0
Headache pain in last month	0.8	1.3	4.0	-0.0	-1.0	-1.4	0.9	-2.0	-0.3
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	3.7	-0.8	-1.8	-1.9	1.0	-1.4	1.0
Glaucoma (self-reported)	2.0	2.3	5.2	-1.7	-1.4	-1.7	2.3	0.0	0.9
Gout (self-reported)	0.1	0.2	0.8	0.0	0.1	-0.4	0.9	0.1	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.6	0.3	0.1	-0.7	-0.2	0.1
Medication: Amlodipine	0.9	1.3	2.7	1.6	0.7	1.1	-0.9	1.6	-0.0
Medication: Ventolin 100micrograms inhaler	1.2	1.5	4.2	0.2	1.7	1.4	-0.3	0.3	-2.0
Birth weight	0.7	1.6	2.9	-1.3	-1.5	-1.0	0.4	-1.3	1.7
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	-0.2	-0.7	-0.8	0.1	0.8	0.3
High blood pressure (siblings)	0.3	0.4	0.7	0.6	-0.8	-0.4	-0.5	0.6	0.8
Forced vital capacity (FVC), Best measure	0.8	2.9	12.1	1.3	-0.4	-0.2	-1.8	-3.5	-0.4
Body fat percentage	0.9	3.7	7.5	2.7	2.3	1.1	1.4	1.0	-2.2
Leg fat percentage (right)	0.8	2.8	4.7	2.2	2.2	1.2	1.3	1.1	-1.6
Arm fat-free mass (right)	1.3	6.9	23.0	1.2	-2.7	-2.9	-0.8	-4.8	0.7
Exposure to tobacco smoke outside home	0.4	0.5	1.0	1.0	-0.9	-0.6	0.0	0.3	0.9
Comparative body size at age 10	2.7	7.4	10.6	2.7	3.1	3.2	-2.5	2.4	-2.3
Number of full brothers	0.3	0.3	1.4	1.2	-0.5	-0.6	0.0	-0.3	-0.1
Worry too long after embarrassment	0.1	0.2	0.6	0.1	0.5	0.8	-0.2	-0.4	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.3	3.9	0.4	1.8	2.0	-1.6	1.4	-1.3
Wheeze or whistling in the chest in last year	0.3	0.4	1.0	-0.2	0.8	0.6	-0.7	-0.4	-1.0
Number of children fathered	0.3	0.3	1.2	-0.3	0.0	-0.0	1.1	-0.6	0.5
Reason for reducing amount of alcohol drunk: Health precaution	3.7	4.4	8.0	2.4	2.6	2.8	-0.6	1.5	-1.8
Age at first live birth	0.5	0.9	2.5	-1.6	-1.0	-0.5	-0.4	-1.2	0.5
Pulse wave peak to peak time	0.2	0.2	1.1	0.0	0.2	-0.0	1.0	-0.4	-0.4
Health satisfaction	0.5	0.6	3.1	0.4	-0.0	-0.1	0.5	1.8	-0.2
Shortness of breath walking on level ground	0.7	0.8	3.4	0.5	0.6	0.4	0.7	1.8	0.5
Qualifications: College or University degree	0.6	1.8	4.6	0.3	1.3	1.9	-2.1	0.8	-0.4
Eye problems/disorders: None of the above	2.9	3.3	5.8	1.6	2.3	2.4	-2.0	1.3	-0.8
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.9	-0.6	-1.0	-1.1	0.8	-1.4	0.6
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.3	-0.2	-0.0	-0.8	0.6	0.0
Medication for pain relief, constipation, heartburn	0.3	0.5	0.9	0.4	0.8	0.8	0.4	1.0	-0.6
Neck or shoulder pain in last month	0.3	0.4	0.8	0.6	-0.7	-0.8	0.0	-0.9	0.5
Medication: Blood pressure	1.5	2.6	4.4	1.3	1.9	2.1	-1.5	1.4	-1.2
Angina (self-reported)	0.2	0.3	1.3	0.1	-0.2	-0.2	-0.5	0.5	-1.2
Migraine (self-reported)	2.3	2.8	8.4	1.0	1.6	2.0	-2.9	0.5	-0.6
Medication: Ibuprofen	2.7	3.3	6.2	-2.3	-1.9	-2.5	0.9	-1.3	1.4
Medication: Allopurinol	0.9	1.1	2.2	1.1	1.5	1.2	-0.8	0.4	-1.2
Medication: Omeprazole	1.2	1.4	3.4	-0.6	-1.8	-1.7	0.6	-0.9	0.9
Medication: Seretide 50 evohaler	0.9	1.0	4.7	-0.1	0.9	0.6	0.1	2.2	-0.5
Mean time to correctly identify matches	1.0	1.8	2.9	0.4	1.6	1.7	-1.0	1.3	-1.7
Heart disease (mother)	1.3	1.6	5.4	-0.5	-1.6	-0.8	0.2	-0.7	2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.0	6.0	11.6	1.5	3.4	3.3	-1.5	2.0	-2.2
Whole body fat mass	0.5	2.2	7.0	2.7	1.1	-0.1	0.8	-0.8	-1.8
Leg fat mass (right)	0.4	1.4	4.0	2.0	1.0	-0.2	1.2	-0.4	-1.5
Arm predicted mass (right)	1.1	5.8	19.7	1.3	-2.3	-2.5	-1.1	-4.4	0.3
Pulse rate, automated reading	1.7	5.6	10.7	2.5	3.1	2.6	-0.6	0.5	-3.3
Alcohol intake frequency.	0.8	1.8	4.5	-0.2	-1.3	-2.1	2.1	-0.0	0.6
Comparative height size at age 10	0.8	4.2	15.6	1.2	-1.5	-2.1	-1.0	-3.9	-0.8
Number of full sisters	1.5	1.9	3.4	-1.7	-1.2	-1.8	1.9	0.4	0.3
Suffer from ‘nerves’	1.0	1.5	3.0	-0.5	-1.7	-1.3	1.1	0.8	1.5
Overall health rating	0.7	1.6	4.5	-0.8	-0.5	-1.1	2.1	1.7	-0.4
Chest pain or discomfort	0.6	0.9	3.2	0.5	-0.5	-0.3	-1.2	-1.8	-0.4
Had major operations	0.1	0.1	0.7	-0.1	-0.2	0.2	0.2	0.1	0.8
Age at last live birth	1.5	2.2	6.3	-2.5	-1.5	-1.3	0.2	-1.2	1.1
Family relationship satisfaction	0.5	0.6	1.6	-1.3	-0.9	-0.2	-0.7	0.4	0.7
Leg pain on walking	0.2	0.2	0.5	0.7	-0.1	-0.2	-0.4	0.7	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.2	-1.9	-1.5	-2.0	1.0	0.1	0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.6	1.3	0.1	-0.0	0.8	0.2	0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.6	0.8	0.7	0.5	-0.7	0.0	-0.6
Medication: Aspirin	0.8	1.1	2.3	0.2	1.0	1.2	-1.5	-1.0	-0.8
Supplements: Vitamin C	0.4	0.4	1.4	0.1	-0.6	-0.5	1.2	-0.0	0.7
Knee pain experienced in last month	0.2	0.3	0.8	0.6	0.3	0.0	0.1	0.7	-0.9
Hypertension (Self-reported)	1.2	3.2	5.5	1.8	1.9	2.3	-1.7	2.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.0	-0.6	-1.4	-0.9	-0.1	-0.5	1.4
Illnesses of father: Heart disease	0.3	0.4	2.2	0.4	0.1	0.2	-0.3	1.5	0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.5	0.0	-0.5	0.8	0.3	0.1
Smoking status: Previous	1.0	1.5	4.2	0.4	1.3	1.6	-0.1	2.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	10.8	0.9	-0.4	-1.0	-0.8	-3.3	-1.2
Whole body fat-free mass	1.0	5.7	20.4	1.8	-1.8	-2.3	-1.3	-4.5	-0.1
Leg fat-free mass (right)	0.7	3.8	12.5	2.1	-1.0	-1.8	-1.0	-3.5	-0.7
Arm fat percentage (left)	1.1	4.2	9.8	3.1	2.5	1.4	0.9	1.3	-2.2
Average weekly red wine intake	0.4	0.7	1.1	1.0	0.9	0.4	1.0	0.8	-0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	-0.5	-0.5	-0.2	1.1	0.2	1.1
Mood swings	0.5	0.9	1.5	-0.5	-0.9	-1.2	1.2	-0.8	-1.0
Loneliness, isolation	0.8	1.1	2.2	0.5	1.3	1.4	-0.7	-0.2	-1.5
Long-standing illness, disability or infirmity	0.3	0.4	1.1	-0.8	0.3	0.1	1.0	0.8	-0.0
Ever had bowel cancer screening	1.1	1.3	2.9	1.6	0.5	1.3	-1.7	-0.4	-0.2
Diabetes diagnosed by doctor	0.6	1.0	3.1	-1.8	1.0	0.5	0.7	0.8	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.8	-0.5	-1.4	-1.2	1.1	-0.7	0.4
Friendships satisfaction	0.5	0.6	2.3	-0.3	0.2	0.7	-1.5	0.1	-0.6
Qualifications: nursing, teaching	0.1	0.2	0.5	0.5	0.0	0.4	-0.7	0.3	0.2
Commuting to job workplace: Walk	0.8	0.9	2.3	-0.2	0.9	0.9	-0.7	0.9	-1.5
Eye problems/disorders: Cataract	1.0	1.2	2.6	-0.5	-1.5	-1.3	0.5	-1.6	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.0	0.8	-1.4	-0.9	-0.2	0.7	1.3
Medication for cholesterol	0.1	0.2	0.5	0.0	-0.7	-0.6	0.4	-0.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	0.9	-0.8	-0.1	-0.5	-0.4	0.4
Back pain experienced in last month	0.2	0.4	0.7	-0.8	-0.6	-0.5	-0.2	-0.5	0.7
Mineral and other dietary supplements	0.3	0.4	1.9	-0.5	0.5	-0.0	0.3	1.4	-0.3
Breast cancer (self-reported)	0.9	1.1	2.0	-1.0	-1.2	-1.4	1.4	-0.3	0.8
Asthma (self-reported)	0.4	0.8	3.3	-0.6	0.9	0.4	-0.0	-0.4	-1.8
Osteoporosis (self-reported)	0.9	1.1	1.8	-0.9	-1.2	-0.9	1.1	0.8	1.3
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.4	-0.2	-0.4	-0.2	0.2	0.4
Medication: Aspirin	1.0	1.3	3.4	-0.5	1.0	1.1	-1.9	-1.1	-0.8
Medication: Gliclazide	2.2	2.5	3.5	-1.9	-1.7	-1.8	1.8	0.7	1.3
Illnesses of father: None of the above (group 1)	0.5	0.7	2.4	0.0	-0.8	-1.0	-0.1	-1.5	-0.2
Smoking status: Current	0.3	0.4	1.3	0.8	-0.0	0.1	-1.1	-0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.1	1.5	-0.3	-0.1	0.5	0.1	1.2
Whole body water mass	1.0	5.7	20.5	1.7	-1.9	-2.3	-1.4	-4.5	0.0
Leg predicted mass (right)	0.7	3.8	12.9	2.2	-1.0	-1.7	-0.9	-3.6	-0.7
Arm fat mass (left)	0.5	1.9	7.2	2.7	1.1	0.1	0.6	-0.4	-1.5
Number of self-reported non-cancer illnesses	0.6	1.1	1.8	1.0	1.2	1.3	-0.7	0.2	-1.3
Average weekly champagne plus white wine intake	0.4	0.5	1.3	0.1	0.6	1.0	-1.1	-0.6	0.1
Miserableness	0.2	0.3	0.8	0.0	-0.5	-0.6	0.4	-0.9	-0.4
Guilty feelings	0.2	0.3	0.9	-0.6	-0.2	-0.5	1.0	-0.3	0.4
Wears glasses or contact lenses	0.3	0.3	1.0	0.5	0.7	1.0	0.1	0.3	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.8	0.1	0.1	-0.6	-0.4	-0.2
Hearing aid user	1.2	1.3	3.5	-0.6	-1.5	-0.7	-0.8	0.8	1.9
Mother’s age at death	0.7	0.9	1.5	0.2	1.0	1.0	-0.8	-1.2	-1.0
Financial situation satisfaction	0.8	1.0	4.0	-0.6	-0.4	0.2	-2.0	-0.9	0.7
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.5	0.9	0.8	1.2	-1.9	-1.8	-0.1
Commuting to job workplace: Public transport	0.6	0.7	1.2	0.8	1.0	0.8	-1.0	0.3	-1.1
Eye problems/disorders: Glaucoma	3.2	3.8	8.1	-2.0	-2.0	-2.4	2.8	0.0	1.2
Medication: Blood pressure	0.5	0.9	2.9	1.0	0.7	0.8	-0.3	1.7	0.7
Pain type(s) experienced in last month: Hip pain	1.0	1.2	5.3	-1.2	-0.5	-0.2	-0.7	-2.3	-0.2
Supplements: Fish oil (including cod liver oil)	1.6	2.1	4.5	-0.2	-2.1	-1.5	0.4	-1.4	1.9
High cholesterol (Self-reported)	1.2	2.1	4.0	1.1	2.0	1.9	-0.9	1.7	-0.5
Medication: Bendroflumethiazide	0.2	0.3	1.2	0.7	-0.0	-0.1	0.2	0.6	1.1
Medication: Paracetamol	1.9	2.9	5.4	-2.3	-1.9	-2.1	0.8	-1.4	1.1
Medication: Lisinopril	3.4	4.4	7.6	2.1	2.6	2.8	-0.9	1.9	-1.7
Medication: Atorvastatin	0.6	0.8	2.5	1.2	0.1	0.6	-1.6	0.2	0.3
Illnesses of father: High blood pressure	0.1	0.2	0.6	0.0	0.2	0.2	-0.5	-0.7	0.5
Alcohol drinker status: Never	1.3	1.6	3.2	1.6	1.1	1.1	-1.8	-0.7	-0.7
Ever smoked	0.6	1.0	2.5	0.2	1.3	1.6	-0.8	1.0	-0.5
Basal metabolic rate	0.8	4.6	16.7	2.1	-1.3	-2.0	-1.0	-4.1	-0.5
Leg fat percentage (left)	0.6	2.2	4.5	2.1	1.9	1.0	1.3	0.8	-1.4
Arm fat-free mass (left)	1.1	5.7	19.0	1.2	-2.4	-2.6	-0.9	-4.4	0.8
Number of operations (self-reported)	0.4	0.6	1.4	0.0	-1.2	-0.9	0.1	-0.5	0.9
Average weekly beer plus cider intake	0.2	0.2	0.7	-0.2	-0.8	-0.5	-0.6	0.1	0.2
Irritability	0.4	0.7	1.7	0.1	-1.3	-0.9	1.1	0.4	0.6
Risk taking	1.9	2.8	5.7	-2.0	-2.0	-1.5	0.7	0.0	2.4
Ever had prostate specific antigen (PSA) test	0.2	0.3	1.1	1.0	0.2	0.2	-0.2	0.2	0.6
Fractured/broken bones in last 5 years	2.8	3.6	6.0	-1.3	-2.4	-2.5	1.0	-1.5	2.1
Age started oral contraceptive pill	0.4	0.5	1.3	0.7	1.1	1.0	-0.4	0.0	-0.2
Diastolic blood pressure, automated reading	0.4	1.3	3.5	1.7	0.4	0.0	0.9	1.9	-0.3
Ever depressed for a whole week	2.4	3.0	6.5	1.4	2.6	2.2	-0.9	-0.5	-1.8
Unable to work because of sickness or disability	1.1	1.5	6.7	0.6	0.3	-0.4	2.6	1.2	-0.4
Commuting to job workplace: Cycle	1.9	2.3	5.0	-2.2	-1.7	-0.7	-0.6	-1.4	1.8
Myopia	1.5	2.1	5.5	-1.1	1.6	2.3	-1.8	0.1	0.4
Vascular/heart problems diagnosed by doctor	1.6	4.4	8.4	-1.7	-2.4	-2.9	2.4	-1.9	0.5
Cholesterol lowering medication	0.2	0.3	1.0	0.3	0.6	0.6	-0.0	1.0	0.4
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	4.2	-1.0	-2.1	-2.0	1.3	-0.6	1.3
Pain experienced in last month	0.1	0.1	0.7	0.8	-0.3	-0.1	-0.0	-0.1	0.2
Supplements: Calcium	0.4	0.5	0.9	-0.6	-1.0	-0.5	0.6	-0.9	0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	-0.3	-0.6	-0.8	0.6	-0.3	0.0
Heart attack/myocardial infarction (self-reported)	1.0	1.2	3.9	-0.1	-0.7	-0.1	-1.7	-2.0	0.2
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.0	-1.6	-1.3	-2.0	1.9	-1.0	0.8
Heart disease (siblings)	1.6	2.0	4.1	0.6	-1.6	-2.0	1.8	-0.2	1.3
Alcohol drinker status: Previous	0.6	0.7	2.5	-0.3	-0.6	-1.1	1.6	-0.1	0.3
Pack years of smoking	0.9	1.4	5.1	-2.2	0.3	-0.6	1.0	-0.2	-1.3
Impedance of whole body	0.2	0.8	1.5	-0.5	1.2	1.0	0.9	0.6	-1.1
Leg fat mass (left)	0.3	1.4	4.0	2.0	0.9	-0.2	1.0	-0.6	-1.4
Arm predicted mass (left)	1.1	5.5	19.6	1.3	-2.2	-2.5	-0.9	-4.4	0.6