Hub : Genes

IL17D

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.1560 0.0460 1.8e-04 0.011 NA 0.064 NA 0.065 5.5e-02 NA 4.4e-05 NA 3.9e-05
2 GTEx Esophagus Muscularis 0.2060 0.0530 1.3e-05 0.143 NA 0.137 NA 0.157 5.4e-09 NA 1.1e-08 NA 9.0e-10
3 GTEx Muscle Skeletal 0.0943 0.0358 1.5e-03 0.020 NA 0.012 NA 0.022 4.0e-03 NA 2.0e-02 NA 2.8e-03
4 GTEx Testis 0.1180 0.0530 6.2e-03 0.009 NA 0.003 NA 0.024 1.2e-01 NA 2.2e-01 NA 2.9e-02
5 YFS Blood 0.0204 0.0075 8.1e-04 0.015 0.010 0.006 0.009 0.010 6.5e-06 0.00019 2.8e-03 0.00038 2.6e-04
6 TCGA Lung Adenocarcinoma 0.0410 0.0266 8.4e-03 0.019 0.019 0.006 NA 0.010 2.1e-03 0.00210 6.0e-02 NA 2.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.4 0.8 -0.0 0.4 0.8 0.2 0.8 0.9
Bipolar Disorder or Schizophrenia 0.2 0.6 1.9 -0.2 -0.5 -0.0 0.1 1.1 1.4
Depressed Affect (Nagel 2018) 0.1 0.3 0.5 0.1 -0.7 -0.6 0.1 -0.7 -0.7
Depression (Nagel 2018) 0.9 1.3 2.6 -1.3 -1.5 -1.6 0.9 -0.7 0.2
Intelligence (Savage-Jansen 2018) 2.5 7.8 15.0 3.2 2.8 3.9 -3.5 0.5 -0.9
Neuroticism (Nagel 2018) 0.5 1.2 2.4 -1.0 -1.5 -1.5 1.2 -0.3 0.6
Schizophrenia (2018) 0.3 0.5 1.1 -0.3 -0.9 -0.7 -0.1 0.8 1.1
Schizophrenia vs Biploar Disorder 1.3 1.8 3.7 -1.2 -1.1 -1.6 1.1 -1.9 -0.6
Worry (Nagel 2018) 1.9 4.0 7.1 -1.9 -2.5 -2.7 2.1 -0.0 1.7
Alzheimer’s Disease (in mother) 0.2 0.3 0.7 -0.2 -0.8 -0.6 0.3 -0.1 0.6
Alzheimer’s Disease (in father) 0.7 0.7 3.5 1.9 0.5 0.5 0.7 0.1 0.1
Alzheimer’s Disease (including proxy) 0.3 0.4 1.5 1.2 -0.4 -0.3 0.7 -0.3 0.1
Crohns Disease (2017) 0.2 0.4 0.7 0.1 -0.9 -0.7 -0.3 -0.6 -0.7
Irritable Bowel Disease (IBD) 0.3 0.7 2.5 0.1 0.8 0.8 -0.4 -0.0 -1.6
Ulcerative Colitis (UC) 0.6 1.2 2.3 0.2 1.5 1.3 -0.6 0.6 -1.5
Major Depression (MDD) 0.5 0.6 2.2 0.7 0.5 0.3 -1.5 -0.9 -0.1
Reaction Time 0.7 1.4 3.7 -0.0 1.3 1.0 -0.2 1.4 -1.9
Verbal and Numeric Reasoning (VNR) 1.9 4.5 11.8 1.4 2.2 3.4 -2.8 0.9 -0.1
Breast Cancer 1.2 2.9 6.7 -1.0 2.2 2.6 -1.3 0.5 -1.7
Ovarian Cancer 1.3 1.7 6.9 -0.1 1.1 1.2 -2.6 -0.7 -0.6
Prostate Cancer 0.3 0.5 1.6 -0.9 -0.4 -0.4 0.2 -1.3 0.2
Age at First Birth 0.2 0.3 1.4 0.4 -0.2 0.2 -0.4 -0.2 1.2
Bipolar Disorder (2011) 0.3 0.3 0.6 -0.4 0.3 0.5 -0.8 0.6 0.3
Body Mass Index (BMI) (2010) 0.8 1.0 2.5 0.4 1.3 1.0 -0.6 1.6 -0.8
Coronary Artery Disease (CAD) 1.6 2.0 4.3 1.7 1.8 1.0 0.0 -0.2 -2.1
Crohns Disease (2012) 0.3 0.5 1.3 1.1 -0.1 -0.2 0.7 -0.7 -0.9
Mean Putamen Volume 0.8 0.9 2.1 0.8 1.5 1.2 -0.0 0.1 -1.0
Fasting Glucose 0.2 0.3 0.7 0.8 0.4 0.1 0.6 0.4 -0.3
HbA1C 0.7 0.8 2.7 0.5 0.6 0.7 -1.6 -0.9 -0.4
HDL Cholesterol 0.4 0.7 1.7 -0.8 -1.0 -0.6 1.3 0.5 0.6
LDL Cholesterol 0.9 1.4 3.2 1.0 1.5 1.2 -0.6 0.5 -1.8
Lupus 0.8 1.2 3.0 0.8 -0.8 -0.8 1.7 0.6 1.3
Neuroticism (2016) 0.6 0.9 3.3 -1.8 -0.8 -0.5 0.9 -0.1 0.6
Primary Biliary Cirrhosis 0.5 0.7 3.6 0.5 0.6 0.1 0.1 -1.9 -0.4
Rheumatoid Arthritis 3.4 4.6 9.7 -0.9 -2.6 -3.1 2.8 0.5 1.6
Schizophrenia (2014) 0.2 0.3 0.7 0.2 -0.8 -0.7 0.3 0.0 0.8
Triglycerides 0.4 0.7 1.3 0.5 0.8 0.9 -1.2 -0.4 -1.1
Type 2 Diabetes (T2D) (2012) 0.0 0.1 0.1 0.1 -0.0 0.2 -0.3 0.2 0.3
Ulcerative Colitis 0.6 0.9 1.9 0.8 1.4 1.2 -0.5 -0.2 -1.0
Blood Eosinophil Count 0.1 1.1 2.2 0.2 1.5 1.3 0.1 1.2 -1.2
Blood Platelet Count 0.1 0.7 2.6 -0.4 0.3 0.5 -1.0 0.2 -1.6
Blood Red Count 0.2 2.2 6.2 2.5 1.4 1.1 -0.3 1.8 -0.7
Blood White Count 0.3 2.0 4.7 0.7 0.9 0.9 -2.2 -1.0 -2.0
Heel T-Score 0.3 2.5 4.8 1.2 1.7 2.2 -2.0 0.8 -1.1
BMI 0.6 3.2 7.8 2.8 2.1 1.0 0.3 0.6 -2.5
Height 1.0 19.3 72.8 2.9 -2.4 -2.5 -4.6 -8.5 -1.2
Waist Hip Ratio (WHR) 0.3 1.3 2.9 0.5 0.9 0.3 1.2 1.7 -1.4
Systolic Blood Pressure 0.2 1.1 3.5 0.8 0.2 -0.4 1.4 1.9 -0.2
Smoking Status 0.3 0.8 1.5 1.2 1.2 1.0 -0.4 0.8 -0.3
Allergy or Eczema 0.6 1.6 3.3 -1.8 0.9 0.5 1.7 1.3 -0.7
Cardiovascular Disease 2.3 7.7 12.8 3.3 3.1 3.6 -2.5 2.2 -1.3
Hypothyroidism (self reported) 0.3 0.7 2.3 -0.7 0.6 0.4 -1.5 -0.5 -0.8
Respiratory disease 0.3 0.7 2.7 -0.7 0.7 -0.1 0.8 -0.2 -1.6
Type 2 Diabetes (T2D) (2018) 0.7 1.2 3.5 -1.9 -0.5 -0.7 1.2 1.0 0.9
Lung FEV1/FVC ratio 0.4 2.3 10.6 1.5 0.2 0.3 0.6 3.3 0.4
Lung FVC 0.2 0.9 2.2 0.2 0.3 1.5 -1.4 -0.5 0.8
Neuroticism 0.5 1.2 2.3 -1.5 -0.9 -0.8 1.5 0.9 0.7
Chronotype (morning person) 0.5 1.1 2.9 0.1 -0.9 -1.7 1.6 -0.6 -0.4
Hair Pigment 0.1 1.9 4.8 2.2 -1.3 -1.6 0.5 -0.9 1.0
Tanning 0.1 1.3 3.2 -0.5 -0.9 -0.7 -1.5 -1.8 1.0
Hand grip strength (left) 2.9 7.8 25.4 -1.2 -2.9 -2.5 -1.4 -5.0 1.8
Number of treatments/medications taken 0.3 0.5 1.4 0.3 1.2 0.9 -0.1 0.6 -0.6
Average weekly spirits intake 0.6 0.7 1.3 1.0 0.8 0.6 0.0 -0.9 -1.1
Sensitivity / hurt feelings 0.2 0.3 0.8 -0.5 0.0 -0.1 0.7 0.4 -0.9
Frequency of depressed mood in last 2 weeks 1.4 2.0 5.1 -0.7 -1.4 -1.9 2.3 -0.9 -0.4
Hearing difficulty/problems: Yes 0.4 0.6 1.6 -0.2 0.6 0.8 -1.3 -0.2 -1.0
Relative age of first facial hair 0.3 0.6 2.0 -0.4 -0.6 -0.2 -0.7 -1.4 0.8
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.6 -1.1 -0.3 0.6 -1.2 1.0 0.9
Ever used hormone-replacement therapy (HRT) 0.3 0.3 1.0 0.0 -0.5 -0.8 1.0 0.3 0.2
Ever had hysterectomy (womb removed) 0.2 0.2 0.5 0.7 0.2 -0.1 0.4 0.5 -0.5
Systolic blood pressure, automated reading 0.4 1.3 4.0 0.8 -0.3 -0.9 2.0 1.4 0.2
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.7 -1.1 -1.0 -0.9 0.4 -0.0 1.3
Angina 0.3 0.4 1.4 -0.1 -0.0 0.0 -0.6 0.7 -1.2
Medication for hormone replacement therapy 0.2 0.3 0.7 0.0 -0.2 0.1 -0.5 -0.8 0.7
Vitamin and mineral supplements 0.1 0.2 0.5 -0.3 0.7 -0.1 -0.0 -0.4 -0.5
Supplements: Zinc 0.2 0.2 0.3 -0.6 -0.6 -0.1 0.5 -0.2 0.3
Medication: Co-codamol 0.6 0.7 1.2 -0.4 0.7 0.5 1.1 0.9 -1.0
Medication: Metformin 0.9 1.3 2.4 0.1 1.6 1.2 -0.2 1.5 -1.3
Diabetes (father) 0.3 0.4 0.8 -0.4 -0.8 -0.9 0.5 0.7 0.2
Diabetes (mother) 0.5 0.6 1.2 0.8 0.8 0.8 -1.1 -0.7 -0.3
Severe depression (siblings) 1.0 1.2 2.8 -0.0 -1.7 -1.1 0.7 -0.6 1.5
Pack years adult smoking proportion 1.1 1.7 6.2 -2.5 -0.0 -1.0 1.4 -0.3 -1.1
Impedance of leg (right) 0.1 0.7 2.6 -1.6 0.2 0.3 1.2 0.1 -0.3
Leg fat-free mass (left) 0.6 3.2 10.0 2.1 -0.7 -1.5 -0.8 -3.2 -1.0
Trunk fat percentage 0.9 3.6 7.3 2.7 2.3 1.0 1.5 0.7 -2.3
Hand grip strength (right) 2.1 5.6 21.0 -0.8 -2.2 -1.8 -1.8 -4.6 0.8
Townsend deprivation index at recruitment 1.0 1.3 3.2 -1.8 -1.0 -1.2 0.9 -1.3 0.2
Current tobacco smoking 0.2 0.4 1.0 1.0 0.1 0.1 -0.8 -0.8 -0.2
Average weekly fortified wine intake 1.7 2.0 5.4 0.3 0.4 0.7 -2.3 -2.1 -1.1
Maternal smoking around birth 1.9 2.8 4.3 -1.8 -1.7 -1.8 1.8 -0.1 2.1
Fed-up feelings 0.4 0.6 1.3 -0.9 -1.0 -1.1 0.8 -0.5 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.8 3.4 -1.4 -1.5 -1.6 1.8 -0.2 0.9
Relative age voice broke 2.5 3.8 8.5 -1.9 -2.2 -1.7 1.6 -0.2 2.9
Taking other prescription medications 0.6 1.0 2.3 0.8 1.0 0.9 -1.1 0.0 -1.5
Age when periods started (menarche) 0.5 1.3 4.2 -0.9 -0.6 -1.1 2.0 -0.9 0.8
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.6 1.5 -0.2 0.3 -1.6 -0.3 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 5.1 0.2 -0.4 -0.3 0.1 -2.3 0.4
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.6 -0.5 0.3 0.6 -1.3 -1.0 -0.1
Qualifications: CSEs or equivalent 0.5 0.7 2.3 -1.2 0.2 -0.1 0.2 -0.8 -1.5
Serious illness, injury or assault to yourself 1.2 1.5 5.5 -1.3 0.2 -0.0 0.9 2.3 -1.0
High blood pressure 1.0 2.8 4.7 1.6 1.8 2.2 -1.4 2.0 0.0
Hayfever, allergic rhinitis or eczema 1.1 2.5 4.1 -1.4 2.0 1.6 1.0 1.1 -2.0
Multivitamins +/- minerals 0.3 0.4 0.7 0.8 -0.6 0.1 -0.8 -0.7 0.3
Stomach or abdominal pain in last month 0.2 0.2 0.6 -0.2 -0.8 -0.3 -0.3 -0.5 0.4
Supplements: Glucosamine 0.9 1.2 1.8 1.3 1.0 1.1 -1.3 -0.7 -0.9
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 6.4 2.5 0.5 0.8 -1.1 1.1 -0.1
Medication: Atenolol 0.7 0.9 2.1 -0.9 -0.7 -0.4 0.1 1.4 1.3
Medication: Levothyroxine sodium 0.2 0.3 1.5 -0.6 0.1 0.3 -1.2 -0.3 0.1
Sitting height 1.0 7.0 26.8 1.9 -0.6 -0.6 -3.1 -5.2 -1.2
Chronic bronchitis/emphysema (father) 3.4 4.0 8.0 1.6 2.8 2.6 -0.9 0.2 -2.4
High blood pressure (mother) 0.5 0.7 1.7 0.3 1.0 1.0 -0.3 1.3 -0.3
Body mass index (BMI) 0.4 1.7 5.3 2.3 1.5 0.6 0.7 0.8 -1.3
Impedance of leg (left) 0.1 0.7 2.6 -1.6 -0.2 -0.1 1.2 -0.4 0.2
Leg predicted mass (left) 0.6 3.3 10.8 2.1 -0.7 -1.5 -0.8 -3.3 -1.1
Trunk fat mass 0.7 2.8 8.2 2.9 1.6 0.3 0.9 -0.8 -2.2
Waist circumference 0.6 2.3 6.1 2.5 1.6 0.5 -0.1 -0.2 -2.3
Number of incorrect matches in round 0.1 0.2 0.7 -0.6 -0.4 -0.3 0.9 0.1 0.1
Past tobacco smoking 0.4 0.7 2.1 -0.3 -1.0 -1.4 0.6 -0.9 -0.4
Alcohol usually taken with meals 0.2 0.4 0.8 0.6 -0.8 -0.9 0.1 -0.1 0.5
Nervous feelings 0.7 1.2 5.2 0.6 -0.1 -0.9 2.3 0.7 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 2.8 0.2 -1.4 -1.7 1.2 -1.2 0.3
Hearing difficulty/problems with background noise 2.0 3.2 7.4 2.3 1.8 1.4 -0.3 1.0 -2.7
Hair/balding pattern: Pattern 2 0.5 0.6 2.0 -0.6 0.1 0.7 -0.9 -1.4 0.2
Had menopause 1.5 1.9 3.5 0.6 -1.4 -1.8 1.9 0.6 1.4
Had other major operations 0.3 0.3 1.0 -0.0 -0.5 -0.7 1.0 -0.4 0.3
Forced vital capacity (FVC) 1.0 3.9 15.6 1.3 -1.1 -0.5 -2.1 -3.9 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 4.3 -0.0 0.1 0.0 0.5 -2.1 -0.3
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 2.4 0.2 1.6 1.2 0.1 0.0 -1.3
Qualifications: None of the above 1.2 2.6 5.8 -0.2 -1.9 -2.4 2.1 0.4 1.4
Financial difficulties in last 2 years 0.5 0.7 1.5 -1.2 -0.5 -0.8 1.0 -0.9 -0.5
Mouth/teeth dental problems 0.2 0.3 0.8 0.3 0.9 0.5 0.1 -0.4 -0.8
Heart attack 0.9 1.2 3.7 0.1 -0.7 -0.1 -1.7 -1.9 0.3
Allergy 0.5 1.1 1.9 1.3 -1.4 -0.8 -1.0 -0.1 1.2
Pain all over the body in last month 0.5 0.6 1.1 -0.2 -1.0 -0.8 0.0 -1.0 0.8
Diabetes (self-reported) 0.8 1.3 2.4 -1.5 1.4 1.0 0.2 1.2 -0.9
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 3.5 -1.1 0.6 -0.0 1.9 -0.6 -0.7
Medication: Ramipril 0.8 1.0 4.9 -0.5 -0.3 0.4 -2.2 -0.2 0.7
Medication: Simvastatin 0.5 0.8 1.8 0.6 1.3 0.9 -0.0 0.9 -1.0
Fluid intelligence score 2.5 5.2 10.8 2.0 2.9 3.3 -2.3 0.1 -1.5
Illnesses of siblings 0.7 1.0 1.7 -0.5 1.2 1.3 -1.1 -0.3 -1.2
Neuroticism score 0.5 1.0 1.7 -0.9 -1.3 -1.3 1.3 -0.0 0.2
Weight 0.6 2.8 7.3 2.7 0.2 -0.8 -0.1 -2.6 -1.3
Impedance of arm (right) 0.4 2.0 4.2 0.2 2.0 1.5 0.7 1.3 -1.8
Arm fat percentage (right) 1.2 4.9 9.6 3.1 2.8 1.6 1.0 1.6 -2.3
Trunk fat-free mass 1.3 7.6 28.2 1.6 -2.3 -2.5 -1.7 -5.3 0.4
Hip circumference 0.4 1.9 5.3 2.3 0.8 -0.2 -0.1 -1.5 -1.7
Time employed in main current job 0.3 0.3 1.0 -0.2 -1.0 -0.7 0.5 0.2 0.2
Alcohol intake versus 10 years previously 0.2 0.3 0.7 -0.2 -0.5 -0.7 0.8 0.2 -0.1
Father’s age at death 1.2 1.6 8.3 -0.6 -0.4 -0.2 -0.7 -2.9 0.5
Worrier / anxious feelings 1.3 2.4 4.5 -0.4 -1.9 -2.1 2.1 0.1 1.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 2.0 -0.3 0.2 -0.2 0.1 -0.7 -1.4
Falls in the last year 0.7 0.9 3.0 -1.7 -0.2 -0.1 0.2 1.5 0.3
Hair/balding pattern: Pattern 3 1.2 1.8 3.7 -1.3 -1.9 -1.7 1.0 -0.4 1.1
Number of live births 0.6 0.8 1.6 -0.7 -0.8 -1.2 1.3 0.7 0.1
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 7.5 1.4 -0.9 -0.5 -1.4 -2.7 0.6
Pulse rate 3.0 5.0 10.2 1.4 2.6 3.2 -2.6 0.9 -1.9
Happiness 0.5 0.6 1.7 -1.3 -1.0 -0.4 -0.5 -0.2 0.5
Noisy workplace 0.4 0.4 0.8 -0.5 -0.9 -0.9 -0.7 -0.1 0.5
Qualifications: A levels/AS levels or equivalent 2.4 5.4 11.9 1.1 2.6 3.1 -3.5 0.3 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.4 0.1 -0.5 -0.1 -0.5 -0.6 -0.0
Mouth/teeth dental problems: Dentures 0.5 0.9 2.3 -1.5 -0.7 -0.6 0.6 0.9 0.8
Asthma 0.4 0.7 2.5 -0.8 0.9 0.5 0.1 -0.4 -1.6
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.1 -1.1 -0.9 -1.5 0.2 -0.8 0.6
Medication: Cholesterol lowering 0.3 0.5 0.8 0.8 0.9 0.8 -0.6 0.4 -0.6
Depression (self-reported) 1.8 2.1 3.4 1.4 1.8 1.4 -0.8 1.4 -1.7
Medication: Lansoprazole 0.6 0.7 1.4 -1.2 -0.7 -0.9 1.2 0.5 0.0
Prospective memory result 0.2 0.2 1.2 -1.1 0.2 0.1 0.2 0.4 -0.0
Lung cancer (father) 0.3 0.3 0.9 0.4 0.5 0.4 0.6 0.9 -0.2
Illnesses of mother 0.5 0.6 1.3 0.5 0.9 0.7 -0.1 1.0 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 4.4 0.9 -0.3 -0.0 -1.6 -2.1 -0.1
Pulse wave Arterial Stiffness index 0.2 0.2 1.1 -0.1 -0.4 -0.2 -1.0 -0.2 0.3
Impedance of arm (left) 0.3 1.4 3.0 0.4 1.7 1.3 0.4 0.8 -1.7
Arm fat mass (right) 0.5 2.1 6.9 2.6 1.4 0.2 0.8 -0.0 -1.6
Trunk predicted mass 1.4 7.9 29.7 1.6 -2.4 -2.6 -1.7 -5.5 0.5
Standing height 1.3 13.1 58.0 1.2 -2.6 -2.9 -2.0 -7.6 -0.5
Length of working week for main job 0.4 0.5 1.2 0.1 -0.7 -1.0 1.1 -0.3 -0.2
Exposure to tobacco smoke at home 0.1 0.1 0.4 0.3 0.5 0.3 0.6 0.1 -0.3
Breastfed as a baby 0.6 0.7 2.6 0.3 -0.0 0.1 -0.7 -1.6 -1.0
Tense / ‘highly strung’ 1.2 1.9 3.8 -0.9 -2.0 -1.7 1.5 -0.4 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 2.1 1.1 1.4 1.4 -1.0 0.1 -1.0
Hair/balding pattern: Pattern 4 0.1 0.2 0.5 -0.6 0.2 -0.4 0.6 -0.7 -0.0
Birth weight of first child 1.0 1.8 7.7 0.4 -0.8 -1.0 -0.0 -2.8 1.0
Peak expiratory flow (PEF) 0.6 1.3 5.8 1.0 -0.2 -0.4 -0.9 -2.4 -0.3
Pulse wave reflection index 0.9 1.1 2.0 -0.8 -1.4 -1.2 -0.3 -0.9 1.3
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.7 -0.7 -0.1 -0.6 0.8 0.6 0.5
Loud music exposure frequency 0.3 0.3 0.5 -0.6 -0.5 -0.5 0.3 0.6 0.7
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 5.0 0.3 1.1 1.5 -2.2 0.1 -0.5
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.9 0.7 -0.1 0.6 -1.0 -0.6 0.6
Blood clot in the leg (DVT) 1.9 2.5 4.3 -1.6 -1.5 -2.1 1.8 -1.2 1.0
Medication: Paracetamol 1.1 1.8 3.2 -1.7 -1.6 -1.8 0.9 -0.8 1.0
Headache pain in last month 0.8 1.3 4.0 -0.0 -1.0 -1.4 0.9 -2.0 -0.3
Medication for cholesterol, blood pressure or diabetes 1.1 1.9 3.7 -0.8 -1.8 -1.9 1.0 -1.4 1.0
Glaucoma (self-reported) 2.0 2.3 5.2 -1.7 -1.4 -1.7 2.3 0.0 0.9
Gout (self-reported) 0.1 0.2 0.8 0.0 0.1 -0.4 0.9 0.1 -0.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.5 -0.6 0.3 0.1 -0.7 -0.2 0.1
Medication: Amlodipine 0.9 1.3 2.7 1.6 0.7 1.1 -0.9 1.6 -0.0
Medication: Ventolin 100micrograms inhaler 1.2 1.5 4.2 0.2 1.7 1.4 -0.3 0.3 -2.0
Birth weight 0.7 1.6 2.9 -1.3 -1.5 -1.0 0.4 -1.3 1.7
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.7 -0.2 -0.7 -0.8 0.1 0.8 0.3
High blood pressure (siblings) 0.3 0.4 0.7 0.6 -0.8 -0.4 -0.5 0.6 0.8
Forced vital capacity (FVC), Best measure 0.8 2.9 12.1 1.3 -0.4 -0.2 -1.8 -3.5 -0.4
Body fat percentage 0.9 3.7 7.5 2.7 2.3 1.1 1.4 1.0 -2.2
Leg fat percentage (right) 0.8 2.8 4.7 2.2 2.2 1.2 1.3 1.1 -1.6
Arm fat-free mass (right) 1.3 6.9 23.0 1.2 -2.7 -2.9 -0.8 -4.8 0.7
Exposure to tobacco smoke outside home 0.4 0.5 1.0 1.0 -0.9 -0.6 0.0 0.3 0.9
Comparative body size at age 10 2.7 7.4 10.6 2.7 3.1 3.2 -2.5 2.4 -2.3
Number of full brothers 0.3 0.3 1.4 1.2 -0.5 -0.6 0.0 -0.3 -0.1
Worry too long after embarrassment 0.1 0.2 0.6 0.1 0.5 0.8 -0.2 -0.4 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.3 3.9 0.4 1.8 2.0 -1.6 1.4 -1.3
Wheeze or whistling in the chest in last year 0.3 0.4 1.0 -0.2 0.8 0.6 -0.7 -0.4 -1.0
Number of children fathered 0.3 0.3 1.2 -0.3 0.0 -0.0 1.1 -0.6 0.5
Reason for reducing amount of alcohol drunk: Health precaution 3.7 4.4 8.0 2.4 2.6 2.8 -0.6 1.5 -1.8
Age at first live birth 0.5 0.9 2.5 -1.6 -1.0 -0.5 -0.4 -1.2 0.5
Pulse wave peak to peak time 0.2 0.2 1.1 0.0 0.2 -0.0 1.0 -0.4 -0.4
Health satisfaction 0.5 0.6 3.1 0.4 -0.0 -0.1 0.5 1.8 -0.2
Shortness of breath walking on level ground 0.7 0.8 3.4 0.5 0.6 0.4 0.7 1.8 0.5
Qualifications: College or University degree 0.6 1.8 4.6 0.3 1.3 1.9 -2.1 0.8 -0.4
Eye problems/disorders: None of the above 2.9 3.3 5.8 1.6 2.3 2.4 -2.0 1.3 -0.8
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.9 -0.6 -1.0 -1.1 0.8 -1.4 0.6
Emphysema/chronic bronchitis 0.2 0.2 0.6 -0.3 -0.2 -0.0 -0.8 0.6 0.0
Medication for pain relief, constipation, heartburn 0.3 0.5 0.9 0.4 0.8 0.8 0.4 1.0 -0.6
Neck or shoulder pain in last month 0.3 0.4 0.8 0.6 -0.7 -0.8 0.0 -0.9 0.5
Medication: Blood pressure 1.5 2.6 4.4 1.3 1.9 2.1 -1.5 1.4 -1.2
Angina (self-reported) 0.2 0.3 1.3 0.1 -0.2 -0.2 -0.5 0.5 -1.2
Migraine (self-reported) 2.3 2.8 8.4 1.0 1.6 2.0 -2.9 0.5 -0.6
Medication: Ibuprofen 2.7 3.3 6.2 -2.3 -1.9 -2.5 0.9 -1.3 1.4
Medication: Allopurinol 0.9 1.1 2.2 1.1 1.5 1.2 -0.8 0.4 -1.2
Medication: Omeprazole 1.2 1.4 3.4 -0.6 -1.8 -1.7 0.6 -0.9 0.9
Medication: Seretide 50 evohaler 0.9 1.0 4.7 -0.1 0.9 0.6 0.1 2.2 -0.5
Mean time to correctly identify matches 1.0 1.8 2.9 0.4 1.6 1.7 -1.0 1.3 -1.7
Heart disease (mother) 1.3 1.6 5.4 -0.5 -1.6 -0.8 0.2 -0.7 2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.0 6.0 11.6 1.5 3.4 3.3 -1.5 2.0 -2.2
Whole body fat mass 0.5 2.2 7.0 2.7 1.1 -0.1 0.8 -0.8 -1.8
Leg fat mass (right) 0.4 1.4 4.0 2.0 1.0 -0.2 1.2 -0.4 -1.5
Arm predicted mass (right) 1.1 5.8 19.7 1.3 -2.3 -2.5 -1.1 -4.4 0.3
Pulse rate, automated reading 1.7 5.6 10.7 2.5 3.1 2.6 -0.6 0.5 -3.3
Alcohol intake frequency. 0.8 1.8 4.5 -0.2 -1.3 -2.1 2.1 -0.0 0.6
Comparative height size at age 10 0.8 4.2 15.6 1.2 -1.5 -2.1 -1.0 -3.9 -0.8
Number of full sisters 1.5 1.9 3.4 -1.7 -1.2 -1.8 1.9 0.4 0.3
Suffer from ‘nerves’ 1.0 1.5 3.0 -0.5 -1.7 -1.3 1.1 0.8 1.5
Overall health rating 0.7 1.6 4.5 -0.8 -0.5 -1.1 2.1 1.7 -0.4
Chest pain or discomfort 0.6 0.9 3.2 0.5 -0.5 -0.3 -1.2 -1.8 -0.4
Had major operations 0.1 0.1 0.7 -0.1 -0.2 0.2 0.2 0.1 0.8
Age at last live birth 1.5 2.2 6.3 -2.5 -1.5 -1.3 0.2 -1.2 1.1
Family relationship satisfaction 0.5 0.6 1.6 -1.3 -0.9 -0.2 -0.7 0.4 0.7
Leg pain on walking 0.2 0.2 0.5 0.7 -0.1 -0.2 -0.4 0.7 -0.0
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 4.2 -1.9 -1.5 -2.0 1.0 0.1 0.4
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.6 1.3 0.1 -0.0 0.8 0.2 0.4
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.6 0.8 0.7 0.5 -0.7 0.0 -0.6
Medication: Aspirin 0.8 1.1 2.3 0.2 1.0 1.2 -1.5 -1.0 -0.8
Supplements: Vitamin C 0.4 0.4 1.4 0.1 -0.6 -0.5 1.2 -0.0 0.7
Knee pain experienced in last month 0.2 0.3 0.8 0.6 0.3 0.0 0.1 0.7 -0.9
Hypertension (Self-reported) 1.2 3.2 5.5 1.8 1.9 2.3 -1.7 2.0 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 2.0 -0.6 -1.4 -0.9 -0.1 -0.5 1.4
Illnesses of father: Heart disease 0.3 0.4 2.2 0.4 0.1 0.2 -0.3 1.5 0.1
Illnesses of siblings: Diabetes 0.2 0.2 0.6 -0.5 0.0 -0.5 0.8 0.3 0.1
Smoking status: Previous 1.0 1.5 4.2 0.4 1.3 1.6 -0.1 2.1 0.6
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.4 10.8 0.9 -0.4 -1.0 -0.8 -3.3 -1.2
Whole body fat-free mass 1.0 5.7 20.4 1.8 -1.8 -2.3 -1.3 -4.5 -0.1
Leg fat-free mass (right) 0.7 3.8 12.5 2.1 -1.0 -1.8 -1.0 -3.5 -0.7
Arm fat percentage (left) 1.1 4.2 9.8 3.1 2.5 1.4 0.9 1.3 -2.2
Average weekly red wine intake 0.4 0.7 1.1 1.0 0.9 0.4 1.0 0.8 -0.6
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.3 -0.5 -0.5 -0.2 1.1 0.2 1.1
Mood swings 0.5 0.9 1.5 -0.5 -0.9 -1.2 1.2 -0.8 -1.0
Loneliness, isolation 0.8 1.1 2.2 0.5 1.3 1.4 -0.7 -0.2 -1.5
Long-standing illness, disability or infirmity 0.3 0.4 1.1 -0.8 0.3 0.1 1.0 0.8 -0.0
Ever had bowel cancer screening 1.1 1.3 2.9 1.6 0.5 1.3 -1.7 -0.4 -0.2
Diabetes diagnosed by doctor 0.6 1.0 3.1 -1.8 1.0 0.5 0.7 0.8 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.8 -0.5 -1.4 -1.2 1.1 -0.7 0.4
Friendships satisfaction 0.5 0.6 2.3 -0.3 0.2 0.7 -1.5 0.1 -0.6
Qualifications: nursing, teaching 0.1 0.2 0.5 0.5 0.0 0.4 -0.7 0.3 0.2
Commuting to job workplace: Walk 0.8 0.9 2.3 -0.2 0.9 0.9 -0.7 0.9 -1.5
Eye problems/disorders: Cataract 1.0 1.2 2.6 -0.5 -1.5 -1.3 0.5 -1.6 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 2.0 0.8 -1.4 -0.9 -0.2 0.7 1.3
Medication for cholesterol 0.1 0.2 0.5 0.0 -0.7 -0.6 0.4 -0.1 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.8 0.9 -0.8 -0.1 -0.5 -0.4 0.4
Back pain experienced in last month 0.2 0.4 0.7 -0.8 -0.6 -0.5 -0.2 -0.5 0.7
Mineral and other dietary supplements 0.3 0.4 1.9 -0.5 0.5 -0.0 0.3 1.4 -0.3
Breast cancer (self-reported) 0.9 1.1 2.0 -1.0 -1.2 -1.4 1.4 -0.3 0.8
Asthma (self-reported) 0.4 0.8 3.3 -0.6 0.9 0.4 -0.0 -0.4 -1.8
Osteoporosis (self-reported) 0.9 1.1 1.8 -0.9 -1.2 -0.9 1.1 0.8 1.3
Osteoarthritis (self-reported) 0.1 0.1 0.2 0.4 -0.2 -0.4 -0.2 0.2 0.4
Medication: Aspirin 1.0 1.3 3.4 -0.5 1.0 1.1 -1.9 -1.1 -0.8
Medication: Gliclazide 2.2 2.5 3.5 -1.9 -1.7 -1.8 1.8 0.7 1.3
Illnesses of father: None of the above (group 1) 0.5 0.7 2.4 0.0 -0.8 -1.0 -0.1 -1.5 -0.2
Smoking status: Current 0.3 0.4 1.3 0.8 -0.0 0.1 -1.1 -0.8 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.1 1.5 -0.3 -0.1 0.5 0.1 1.2
Whole body water mass 1.0 5.7 20.5 1.7 -1.9 -2.3 -1.4 -4.5 0.0
Leg predicted mass (right) 0.7 3.8 12.9 2.2 -1.0 -1.7 -0.9 -3.6 -0.7
Arm fat mass (left) 0.5 1.9 7.2 2.7 1.1 0.1 0.6 -0.4 -1.5
Number of self-reported non-cancer illnesses 0.6 1.1 1.8 1.0 1.2 1.3 -0.7 0.2 -1.3
Average weekly champagne plus white wine intake 0.4 0.5 1.3 0.1 0.6 1.0 -1.1 -0.6 0.1
Miserableness 0.2 0.3 0.8 0.0 -0.5 -0.6 0.4 -0.9 -0.4
Guilty feelings 0.2 0.3 0.9 -0.6 -0.2 -0.5 1.0 -0.3 0.4
Wears glasses or contact lenses 0.3 0.3 1.0 0.5 0.7 1.0 0.1 0.3 0.1
Ever taken oral contraceptive pill 0.2 0.2 0.7 0.8 0.1 0.1 -0.6 -0.4 -0.2
Hearing aid user 1.2 1.3 3.5 -0.6 -1.5 -0.7 -0.8 0.8 1.9
Mother’s age at death 0.7 0.9 1.5 0.2 1.0 1.0 -0.8 -1.2 -1.0
Financial situation satisfaction 0.8 1.0 4.0 -0.6 -0.4 0.2 -2.0 -0.9 0.7
Tinnitus: Yes, now most or all of the time 1.4 1.6 3.5 0.9 0.8 1.2 -1.9 -1.8 -0.1
Commuting to job workplace: Public transport 0.6 0.7 1.2 0.8 1.0 0.8 -1.0 0.3 -1.1
Eye problems/disorders: Glaucoma 3.2 3.8 8.1 -2.0 -2.0 -2.4 2.8 0.0 1.2
Medication: Blood pressure 0.5 0.9 2.9 1.0 0.7 0.8 -0.3 1.7 0.7
Pain type(s) experienced in last month: Hip pain 1.0 1.2 5.3 -1.2 -0.5 -0.2 -0.7 -2.3 -0.2
Supplements: Fish oil (including cod liver oil) 1.6 2.1 4.5 -0.2 -2.1 -1.5 0.4 -1.4 1.9
High cholesterol (Self-reported) 1.2 2.1 4.0 1.1 2.0 1.9 -0.9 1.7 -0.5
Medication: Bendroflumethiazide 0.2 0.3 1.2 0.7 -0.0 -0.1 0.2 0.6 1.1
Medication: Paracetamol 1.9 2.9 5.4 -2.3 -1.9 -2.1 0.8 -1.4 1.1
Medication: Lisinopril 3.4 4.4 7.6 2.1 2.6 2.8 -0.9 1.9 -1.7
Medication: Atorvastatin 0.6 0.8 2.5 1.2 0.1 0.6 -1.6 0.2 0.3
Illnesses of father: High blood pressure 0.1 0.2 0.6 0.0 0.2 0.2 -0.5 -0.7 0.5
Alcohol drinker status: Never 1.3 1.6 3.2 1.6 1.1 1.1 -1.8 -0.7 -0.7
Ever smoked 0.6 1.0 2.5 0.2 1.3 1.6 -0.8 1.0 -0.5
Basal metabolic rate 0.8 4.6 16.7 2.1 -1.3 -2.0 -1.0 -4.1 -0.5
Leg fat percentage (left) 0.6 2.2 4.5 2.1 1.9 1.0 1.3 0.8 -1.4
Arm fat-free mass (left) 1.1 5.7 19.0 1.2 -2.4 -2.6 -0.9 -4.4 0.8
Number of operations (self-reported) 0.4 0.6 1.4 0.0 -1.2 -0.9 0.1 -0.5 0.9
Average weekly beer plus cider intake 0.2 0.2 0.7 -0.2 -0.8 -0.5 -0.6 0.1 0.2
Irritability 0.4 0.7 1.7 0.1 -1.3 -0.9 1.1 0.4 0.6
Risk taking 1.9 2.8 5.7 -2.0 -2.0 -1.5 0.7 0.0 2.4
Ever had prostate specific antigen (PSA) test 0.2 0.3 1.1 1.0 0.2 0.2 -0.2 0.2 0.6
Fractured/broken bones in last 5 years 2.8 3.6 6.0 -1.3 -2.4 -2.5 1.0 -1.5 2.1
Age started oral contraceptive pill 0.4 0.5 1.3 0.7 1.1 1.0 -0.4 0.0 -0.2
Diastolic blood pressure, automated reading 0.4 1.3 3.5 1.7 0.4 0.0 0.9 1.9 -0.3
Ever depressed for a whole week 2.4 3.0 6.5 1.4 2.6 2.2 -0.9 -0.5 -1.8
Unable to work because of sickness or disability 1.1 1.5 6.7 0.6 0.3 -0.4 2.6 1.2 -0.4
Commuting to job workplace: Cycle 1.9 2.3 5.0 -2.2 -1.7 -0.7 -0.6 -1.4 1.8
Myopia 1.5 2.1 5.5 -1.1 1.6 2.3 -1.8 0.1 0.4
Vascular/heart problems diagnosed by doctor 1.6 4.4 8.4 -1.7 -2.4 -2.9 2.4 -1.9 0.5
Cholesterol lowering medication 0.2 0.3 1.0 0.3 0.6 0.6 -0.0 1.0 0.4
Medication: Omeprazole (e.g. Zanprol) 1.7 2.1 4.2 -1.0 -2.1 -2.0 1.3 -0.6 1.3
Pain experienced in last month 0.1 0.1 0.7 0.8 -0.3 -0.1 -0.0 -0.1 0.2
Supplements: Calcium 0.4 0.5 0.9 -0.6 -1.0 -0.5 0.6 -0.9 0.6
Basal cell carcinoma (self-reported) 0.2 0.3 0.7 -0.3 -0.6 -0.8 0.6 -0.3 0.0
Heart attack/myocardial infarction (self-reported) 1.0 1.2 3.9 -0.1 -0.7 -0.1 -1.7 -2.0 0.2
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 4.0 -1.6 -1.3 -2.0 1.9 -1.0 0.8
Heart disease (siblings) 1.6 2.0 4.1 0.6 -1.6 -2.0 1.8 -0.2 1.3
Alcohol drinker status: Previous 0.6 0.7 2.5 -0.3 -0.6 -1.1 1.6 -0.1 0.3
Pack years of smoking 0.9 1.4 5.1 -2.2 0.3 -0.6 1.0 -0.2 -1.3
Impedance of whole body 0.2 0.8 1.5 -0.5 1.2 1.0 0.9 0.6 -1.1
Leg fat mass (left) 0.3 1.4 4.0 2.0 0.9 -0.2 1.0 -0.6 -1.4
Arm predicted mass (left) 1.1 5.5 19.6 1.3 -2.2 -2.5 -0.9 -4.4 0.6