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chr13:48,117,912-52,109,040

Best TWAS P=1.08e-55 · Best GWAS P=8.15e-103 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
27	GTEx	Nerve Tibial	DLEU2	0.11	0.05	lasso	3	0.02	7.8e-03	15.41	15.7	1.1e-55	-0.17	0.51	0.02	TRUE
36	GTEx	Testis	EBPL	0.33	0.17	lasso	6	0.24	8.4e-11	9.98	-12.1	1.8e-33	0.05	0.99	0.01	TRUE
37	GTEx	Thyroid	EBPL	0.36	0.14	enet	33	0.30	5.1e-23	9.87	-11.9	1.6e-32	0.12	1.00	0.00	TRUE
39	NTR	Blood	DLEU7	0.07	0.02	enet	22	0.06	1.3e-19	-6.54	-11.6	3.5e-31	0.63	0.52	0.48	TRUE
28	GTEx	Pancreas	EBPL	0.18	0.10	enet	5	0.09	1.6e-04	12.20	-11.3	1.4e-29	0.10	0.36	0.08	TRUE
15	GTEx	Brain Putamen basal ganglia	EBPL	0.31	-0.01	enet	18	0.05	2.9e-02	10.00	-10.6	4.2e-26	0.11	0.04	0.43	TRUE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EBPL	0.21	0.09	enet	10	0.13	4.9e-06	12.20	-9.4	7.2e-21	0.11	0.00	1.00	TRUE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EBPL	0.21	0.14	enet	15	0.19	3.6e-21	-4.29	-8.9	4.0e-19	0.12	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	DLEU7	0.05	0.00	blup	581	0.02	1.6e-03	1.81	7.8	9.0e-15	-0.35	0.10	0.03	TRUE
20	GTEx	Cells Transformed fibroblasts	RB1	0.08	0.01	enet	9	0.00	1.4e-01	5.40	-5.5	3.6e-08	-0.08	0.03	0.66	TRUE
23	GTEx	Esophagus Muscularis	CDADC1	0.15	0.00	enet	20	0.00	2.3e-01	0.67	-5.2	2.5e-07	-0.10	0.06	0.04	TRUE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DLEU2	0.03	0.01	blup	61	0.02	2.4e-03	15.20	14.8	2.9e-49	-0.20	0.01	0.96	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TRIM13	0.15	0.04	lasso	5	0.12	1.1e-14	15.20	-12.1	1.1e-33	0.35	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM13	0.04	0.00	blup	26	0.02	8.5e-03	15.45	-12.1	1.8e-33	0.01	0.00	0.46	FALSE
11	GTEx	Brain Cerebellum	EBPL	0.50	0.30	enet	23	0.36	1.8e-11	12.20	-11.1	1.9e-28	0.07	0.86	0.02	FALSE
31	GTEx	Skin Sun Exposed Lower leg	EBPL	0.28	0.21	lasso	5	0.20	2.5e-16	10.01	-10.6	2.5e-26	0.02	1.00	0.00	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	EBPL	0.27	0.24	enet	14	0.26	4.6e-10	9.87	-10.5	6.5e-26	0.02	0.97	0.03	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EBPL	0.28	0.18	blup	59	0.19	4.3e-08	10.00	-10.4	2.7e-25	0.13	0.01	0.98	FALSE
57	The Cancer Genome Atlas	Stomach Adenocarcinoma	EBPL	0.10	0.07	enet	7	0.08	2.8e-06	12.20	-10.2	1.7e-24	0.17	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EBPL	0.27	0.16	blup	59	0.22	1.0e-12	-4.29	-10.1	4.1e-24	0.12	0.29	0.71	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	EBPL	0.08	0.01	blup	59	0.04	6.4e-05	10.00	-10.1	5.5e-24	0.12	0.01	0.89	FALSE
12	GTEx	Brain Cortex	EBPL	0.36	0.08	enet	24	0.14	1.5e-04	12.20	-10.1	6.0e-24	0.15	0.19	0.10	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DLEU2	0.08	0.02	lasso	2	0.01	1.6e-02	-8.03	9.8	1.2e-22	0.01	0.13	0.25	FALSE
2	CommonMind	Brain Pre-frontal Cortex	EBPL	0.34	0.16	bslmm	399	0.33	2.5e-41	2.22	-9.7	2.1e-22	0.08	1.00	0.00	FALSE
25	GTEx	Heart Atrial Appendage	EBPL	0.17	0.04	lasso	5	0.05	2.2e-03	12.20	-9.7	4.9e-22	0.10	0.12	0.57	FALSE
10	GTEx	Brain Cerebellar Hemisphere	EBPL	0.54	0.32	enet	17	0.34	1.2e-09	2.22	-9.6	5.8e-22	0.12	0.62	0.07	FALSE
24	GTEx	Esophagus Muscularis	EBPL	0.39	0.16	enet	36	0.29	9.2e-18	9.99	-9.5	1.4e-21	0.04	1.00	0.00	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	EBPL	0.43	0.28	lasso	8	0.43	7.3e-60	9.87	-9.5	2.0e-21	0.04	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	EBPL	0.27	0.03	enet	17	0.20	1.4e-10	12.20	-9.4	5.6e-21	0.16	0.77	0.14	FALSE
6	GTEx	Artery Aorta	EBPL	0.43	0.20	enet	78	0.28	8.1e-16	9.99	-9.3	1.7e-20	0.17	0.99	0.01	FALSE
29	GTEx	Pituitary	EBPL	0.44	0.32	enet	29	0.37	3.1e-10	9.99	-9.2	2.8e-20	-0.03	0.71	0.23	FALSE
26	GTEx	Nerve Tibial	EBPL	0.33	0.09	enet	25	0.27	4.6e-19	9.87	-9.0	1.9e-19	0.13	1.00	0.00	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	EBPL	0.25	0.11	enet	21	0.11	7.9e-04	10.00	-8.9	5.9e-19	0.14	0.11	0.23	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	EBPL	0.34	0.26	enet	12	0.30	4.0e-17	9.99	-8.8	1.1e-18	-0.02	1.00	0.00	FALSE
7	GTEx	Artery Coronary	EBPL	0.48	0.03	enet	99	0.12	9.7e-05	12.20	-8.7	2.8e-18	0.09	0.16	0.44	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	EBPL	0.07	0.03	enet	11	0.06	2.1e-12	10.00	-8.7	4.4e-18	0.05	0.06	0.94	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	EBPL	0.22	0.12	enet	7	0.18	2.5e-20	2.22	-8.7	5.1e-18	0.07	0.88	0.12	FALSE
13	GTEx	Brain Frontal Cortex BA9	EBPL	0.50	0.20	enet	18	0.34	7.0e-10	2.22	-8.6	6.6e-18	0.05	0.33	0.31	FALSE
19	GTEx	Cells Transformed fibroblasts	EBPL	0.29	0.17	lasso	3	0.22	1.8e-16	-4.29	-8.6	8.2e-18	0.06	1.00	0.00	FALSE
34	GTEx	Spleen	RCBTB1	0.37	0.02	lasso	5	0.04	3.5e-02	0.82	-8.6	1.0e-17	0.03	0.04	0.10	FALSE
38	METSIM	Adipose	EBPL	0.32	0.12	lasso	7	0.27	1.4e-39	9.98	-8.6	1.2e-17	0.04	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	EBPL	0.28	0.10	enet	17	0.26	7.7e-25	-4.29	-8.4	3.4e-17	0.04	0.24	0.76	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	EBPL	0.20	0.04	blup	59	0.11	6.8e-07	-4.29	-8.4	3.6e-17	0.14	0.60	0.24	FALSE
17	GTEx	Breast Mammary Tissue (Male)	EBPL	0.20	0.05	enet	6	0.03	7.9e-02	2.01	-8.2	2.0e-16	0.17	0.04	0.18	FALSE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DLEU1	0.13	0.04	lasso	3	0.04	2.6e-03	9.70	-8.1	4.9e-16	-0.04	0.24	0.03	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	EBPL	0.07	0.02	blup	59	0.03	8.9e-05	2.22	-8.1	7.6e-16	0.13	0.02	0.81	FALSE
9	GTEx	Brain Caudate basal ganglia	EBPL	0.41	0.06	lasso	7	0.12	2.1e-04	9.87	-8.0	1.2e-15	0.02	0.12	0.08	FALSE
16	GTEx	Breast Mammary Tissue	EBPL	0.21	0.15	enet	20	0.17	2.8e-09	-4.29	-8.0	1.6e-15	0.17	0.91	0.04	FALSE
21	GTEx	Colon Transverse	EBPL	0.24	0.19	enet	13	0.11	8.8e-06	-4.29	-7.8	4.5e-15	0.09	0.97	0.01	FALSE
8	GTEx	Artery Tibial	EBPL	0.55	0.32	enet	28	0.46	4.5e-40	2.22	-7.5	8.9e-14	0.08	1.00	0.00	FALSE
40	NTR	Blood	EBPL	0.07	0.03	blup	401	0.04	3.8e-13	2.22	-7.3	2.9e-13	0.07	1.00	0.00	FALSE
35	GTEx	Stomach	EBPL	0.25	0.17	enet	10	0.20	7.0e-10	2.22	-6.8	8.6e-12	0.07	0.98	0.00	FALSE
4	GTEx	Adipose Subcutaneous	EBPL	0.45	0.29	enet	37	0.39	1.5e-33	2.22	-6.8	1.1e-11	0.10	1.00	0.00	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	EBPL	0.41	0.36	lasso	10	0.37	3.8e-13	-4.29	-6.4	1.6e-10	0.07	0.99	0.00	FALSE
33	GTEx	Spleen	EBPL	0.58	0.33	enet	28	0.35	7.1e-10	-4.29	-5.9	3.3e-09	0.01	0.71	0.03	FALSE
43	YFS	Blood	EBPL	0.52	0.36	lasso	8	0.48	4.8e-183	-4.29	-5.7	1.0e-08	0.03	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Glioblastoma Multiforme	EBPL	0.45	0.24	blup	59	0.24	5.3e-08	-4.29	-5.7	1.2e-08	0.09	0.35	0.26	FALSE
41	NTR	Blood	ITM2B	0.02	0.02	enet	7	0.02	1.5e-07	5.40	5.4	5.3e-08	0.05	0.07	0.93	FALSE
32	GTEx	Small Intestine Terminal Ileum	EBPL	0.39	0.10	lasso	8	0.14	4.3e-04	-4.29	-5.2	2.3e-07	0.06	0.07	0.11	FALSE