TWAS hub - RB1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.106	0.032	1.3e-07	0.042	0.06	0.056	0.059	0.043	7.2e-06	7.8e-08	1.9e-07	1.1e-07	5.6e-06
2	GTEx	Adipose Visceral Omentum	0.078	0.035	8.6e-03	0.008	NA	0.008	NA	0.020	1.1e-01	NA	1.2e-01	NA	3.3e-02
3	GTEx	Brain Putamen basal ganglia	0.419	0.110	3.6e-03	-0.013	NA	-0.011	NA	-0.004	9.7e-01	NA	6.9e-01	NA	4.0e-01
4	GTEx	Cells Transformed fibroblasts	0.084	0.040	9.6e-03	0.008	NA	0.004	NA	0.001	8.2e-02	NA	1.4e-01	NA	2.4e-01
5	GTEx	Pituitary	0.302	0.140	9.0e-03	0.065	NA	0.095	NA	0.090	1.0e-02	NA	2.3e-03	NA	2.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Birth weight of first child	6.4	11.6	21.1	-4.0	-4.6	-0.6	-2.7	-3.7
Mouth/teeth dental problems: Bleeding gums	6.1	8.0	12.5	-3.5	-3.5	0.4	-3.2	-2.1
Birth weight	4.7	10.1	15.3	-3.6	-3.6	-0.0	-3.9	-2.9
Handedness (chirality/laterality): Left-handed	4.7	5.6	10.4	-3.2	-2.7	0.6	-1.5	-2.8
Eye problems/disorders: None of the above	3.8	4.4	10.9	-1.9	-3.3	-0.5	-1.9	-1.8
Medication: Paracetamol	3.5	5.7	11.7	-1.0	-3.4	-2.7	-2.7	-1.2
Eye problems/disorders: Cataract	3.3	3.8	6.4	2.5	2.5	0.6	0.9	2.3
Guilty feelings	3.2	4.8	11.6	-3.4	-1.9	-1.7	-0.4	-2.4
Qualifications: CSEs or equivalent	3.0	4.0	7.4	-2.4	-2.7	0.6	-2.3	-1.2
Hair/balding pattern: Pattern 2	2.9	3.7	6.4	-2.3	-2.3	-0.1	-1.1	-2.5
Medication: Paracetamol	2.9	4.4	7.7	-0.1	-2.8	-2.7	-2.6	-0.6
Serious illness, injury or assault to yourself	2.8	3.4	8.6	-1.7	-2.0	-2.9	-1.4	0.2
Mouth/teeth dental problems: Dentures	2.8	4.7	7.6	2.6	2.6	0.2	2.8	1.5
Diabetes (mother)	2.6	3.4	6.4	1.9	1.1	-1.7	2.5	1.6
Commuting to job workplace: Car/motor vehicle	2.5	2.9	8.0	1.4	1.8	2.8	0.2	1.0
Nervous feelings	2.4	4.5	8.4	-2.9	-1.7	-2.5	-0.9	-1.9
Exposure to tobacco smoke outside home	2.4	3.2	8.3	-2.9	-2.0	0.2	-1.5	-1.2
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	4.8	-1.2	-1.7	-1.5	-2.2	-2.0
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	4.6	-2.0	-1.6	0.7	-2.1	-1.7
Breastfed as a baby	2.3	2.9	7.9	-1.7	-1.1	0.2	-2.8	-1.5
Medication: Seretide 50 evohaler	2.3	2.6	5.6	2.4	1.2	-1.4	0.4	2.0
Depression (self-reported)	2.1	2.6	6.9	-2.6	-0.6	-1.1	0.1	-2.1
Number of children fathered	2.1	2.4	4.5	0.7	1.9	0.3	2.1	1.9
Comparative height size at age 10	2.1	11.5	23.9	-0.4	-4.9	1.8	-4.0	-3.8
Major Depression (MDD)	2.0	2.5	5.7	-0.2	1.1	2.4	1.8	1.4
Ever had hysterectomy (womb removed)	2.0	2.3	5.5	-0.3	0.9	1.8	2.4	1.4
Comparative body size at age 10	2.0	5.5	11.1	-2.1	-3.2	-0.5	-3.3	-1.2
Financial situation satisfaction	2.0	2.5	4.3	-2.1	-1.2	-0.4	-2.1	-1.5
Falls in the last year	1.9	2.6	5.7	-2.0	-2.4	0.7	-0.6	-1.5
Blood clot in the leg (DVT)	1.9	2.5	3.8	-1.0	-1.7	-1.2	-2.0	-1.8
Glaucoma (self-reported)	1.9	2.3	6.1	2.5	1.7	-0.3	1.1	1.1
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	4.2	1.5	1.6	2.0	1.3	0.7
Commuting to job workplace: Walk	1.9	2.0	3.6	-1.9	-1.8	-1.3	-0.1	-1.3
Medication: Allopurinol	1.8	2.4	5.6	-0.8	-0.4	2.4	-0.1	-2.3
Suffer from ‘nerves’	1.8	2.7	7.7	-2.8	-1.6	1.0	0.7	-1.4
Asthma (self-reported)	1.8	3.6	8.3	2.9	1.5	0.8	1.2	2.4
Pain type(s) experienced in last month: Hip pain	1.8	2.2	6.2	2.5	1.8	-0.7	0.3	1.2
Fractured/broken bones in last 5 years	1.8	2.3	3.7	1.4	1.9	-1.8	0.7	1.4
Height	1.7	33.3	65.0	-3.7	-8.1	-1.4	-7.4	-5.5
Chronotype (morning person)	1.7	3.9	9.9	1.1	2.2	0.0	3.1	1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	7.3	-2.7	-1.8	-0.5	-2.3	-1.3
Medication: Blood pressure	1.7	3.1	5.3	2.2	1.8	0.8	1.3	2.3
Diabetes (father)	1.6	2.0	5.5	-2.4	-0.9	1.2	0.1	-1.4
Multivitamins +/- minerals	1.6	2.0	6.3	1.7	0.3	2.5	0.7	0.8
Sitting height	1.6	11.1	20.0	-2.2	-4.5	1.3	-3.8	-3.8
Leg predicted mass (left)	1.6	8.3	12.7	-1.4	-3.6	2.7	-3.2	-3.0
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	4.0	-1.6	-1.8	-1.0	-1.1	-2.0
Financial difficulties in last 2 years	1.6	2.2	3.9	-1.6	-1.1	0.6	-2.0	-1.6
Asthma	1.6	3.2	7.4	2.7	1.3	0.9	1.0	2.2
Standing height	1.6	15.8	30.3	-2.6	-5.0	-0.8	-5.5	-4.0
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	4.2	-1.4	-1.2	0.4	-1.3	-2.1
Leg fat-free mass (right)	1.6	8.6	13.2	-1.4	-3.6	2.6	-3.4	-3.1
Leg predicted mass (right)	1.6	8.4	12.7	-1.3	-3.6	2.7	-3.4	-3.0
Schizophrenia vs Biploar Disorder	1.5	2.0	5.1	2.3	1.2	0.3	1.2	1.5
Respiratory disease	1.5	3.3	8.2	2.9	1.8	1.4	1.2	1.3
Leg fat-free mass (left)	1.5	8.2	12.4	-1.3	-3.5	2.8	-3.1	-3.0
Headache pain in last month	1.5	2.6	5.0	-0.3	-2.2	-2.1	-1.8	-0.5
Whole body fat-free mass	1.5	8.8	13.9	-1.5	-3.7	3.0	-3.2	-2.9
Whole body water mass	1.5	8.6	13.4	-1.5	-3.7	3.1	-3.1	-2.8
Commuting to job workplace: Public transport	1.5	1.7	3.3	0.3	1.4	-1.0	1.8	1.6
Illnesses of father: High blood pressure	1.5	1.8	4.5	-0.2	2.0	0.7	2.1	0.4
Alcohol drinker status: Never	1.5	1.8	7.0	0.3	0.3	-2.6	1.0	0.8
Alzheimer’s Disease (including proxy)	1.4	2.0	4.7	-1.4	-2.2	-1.2	-0.1	-1.4
Qualifications: None of the above	1.4	2.9	9.3	0.7	2.0	0.6	3.0	0.7
Neuroticism score	1.4	2.8	8.2	-2.9	-1.6	-0.5	-0.1	-1.7
Trunk fat-free mass	1.4	8.0	13.6	-1.4	-3.7	2.9	-3.0	-2.7
Prospective memory result	1.4	1.7	3.4	0.3	1.5	-1.8	1.6	0.1
Trunk predicted mass	1.4	7.9	13.5	-1.4	-3.7	2.9	-2.9	-2.7
Arm fat-free mass (right)	1.4	7.1	12.1	-1.1	-3.2	3.5	-2.4	-2.5
Arm predicted mass (right)	1.4	7.0	12.9	-0.9	-3.2	3.6	-2.4	-2.4
Long-standing illness, disability or infirmity	1.4	2.2	4.1	2.0	1.6	0.8	1.5	1.1
Ever taken oral contraceptive pill	1.4	1.6	5.9	0.7	0.4	2.4	-0.3	1.1
Basal metabolic rate	1.4	7.8	12.5	-1.1	-3.5	2.9	-3.0	-2.8
Relative age of first facial hair	1.3	2.7	5.6	2.4	1.2	-1.8	-0.1	1.7
Weight	1.3	6.3	10.3	-0.7	-3.2	2.6	-2.8	-2.5
Worrier / anxious feelings	1.3	2.4	5.4	-2.1	-1.4	-0.3	-0.0	-2.3
Pulse wave reflection index	1.3	1.7	3.5	1.6	0.8	1.9	0.6	-1.0
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	6.9	-0.7	-1.7	0.6	-2.6	-0.2
Pulse wave peak to peak time	1.3	1.5	2.8	-1.2	-1.3	-1.7	-1.2	0.1
Arm fat-free mass (left)	1.3	6.4	10.3	-1.2	-3.2	3.0	-2.4	-2.3
Worry (Nagel 2018)	1.2	2.4	5.4	-2.3	-1.4	-1.2	-0.1	-1.8
Happiness	1.2	1.5	3.9	-0.3	-1.2	-0.8	-2.0	-1.1
Worry too long after embarrassment	1.2	2.0	5.1	-1.6	-1.1	-2.3	0.1	-1.1
Chest pain or discomfort	1.2	1.7	5.1	0.3	-1.1	2.3	-1.3	-0.2
Eye problems/disorders: Glaucoma	1.2	1.4	3.9	2.0	1.4	-0.2	0.5	0.9
Basal cell carcinoma (self-reported)	1.2	1.4	4.7	0.2	-1.4	-2.2	0.3	-0.4
Primary Biliary Cirrhosis	1.1	1.6	6.7	-0.3	-0.7	2.6	-0.5	-0.8
Triglycerides	1.1	1.8	4.3	0.1	2.1	1.1	0.3	1.9
Pack years adult smoking proportion	1.1	1.7	4.8	-0.6	-1.0	1.5	-0.4	-2.2
Fluid intelligence score	1.1	2.3	6.7	2.6	0.8	1.4	-0.1	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	5.6	-2.4	-1.8	-1.2	-2.3	-1.2
Supplements: Vitamin C	1.1	1.3	3.2	-1.8	0.4	0.6	1.5	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	2.8	0.0	1.4	-1.7	0.3	1.2
Medication: Bendroflumethiazide	1.1	1.6	3.4	1.5	1.0	0.7	1.8	0.9
Verbal and Numeric Reasoning (VNR)	1.0	2.4	9.0	3.0	0.5	1.1	-0.9	0.8
Blood Red Count	1.0	9.5	26.4	-5.1	-3.0	-1.4	-2.2	-2.3
Medication for hormone replacement therapy	1.0	1.1	2.5	0.5	-0.5	-1.6	-1.5	-0.5
Medication: Atenolol	1.0	1.3	1.9	0.9	0.5	-1.4	1.3	1.3
Impedance of arm (right)	1.0	4.7	18.3	-1.2	-0.7	-4.3	-1.9	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.9	-2.2	0.8	-0.1	1.3	0.2
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.2	1.0	1.1	-0.8	1.8	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.3	-2.1	-0.5	-0.1	-0.2	-1.1
Illnesses of siblings: Diabetes	1.0	1.2	5.3	0.6	-0.2	2.3	-0.5	-0.2
Pack years of smoking	1.0	1.5	3.9	-0.6	-0.9	1.6	-0.3	-2.0
Arm predicted mass (left)	1.0	5.3	10.0	-0.9	-2.7	3.2	-2.2	-1.8
Average weekly spirits intake	0.9	1.1	3.1	0.7	-1.2	-0.0	-1.8	-0.7
Supplements: Zinc	0.9	1.0	2.8	-0.0	0.7	0.9	1.1	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.4	-1.4	-1.5	-0.4	-1.5	-0.8
Pulse wave Arterial Stiffness index	0.9	1.1	2.0	1.2	1.1	1.4	0.9	-0.1
Impedance of arm (left)	0.9	4.2	14.9	-0.6	-0.8	-3.9	-2.1	-0.7
Forced vital capacity (FVC), Best measure	0.9	3.2	7.0	-1.6	-1.9	-1.0	-2.6	-1.3
Diabetes diagnosed by doctor	0.9	1.5	2.4	-1.3	-1.6	0.9	-1.3	-0.9
Medication: Gliclazide	0.9	1.0	1.3	-1.2	-0.9	0.9	-0.9	-1.0
Medication: Lisinopril	0.9	1.1	1.9	1.3	1.4	0.1	1.0	1.1
Age started oral contraceptive pill	0.9	1.1	2.1	0.4	-1.3	0.8	-1.1	-1.5
Diastolic blood pressure, automated reading	0.9	2.8	5.0	-0.4	-2.2	-0.6	-2.2	-1.9
Neuroticism (Nagel 2018)	0.8	1.9	4.3	-2.1	-1.0	-1.3	0.3	-1.6
Blood White Count	0.8	5.7	10.0	-0.0	-2.8	-2.8	-1.8	-3.2
Neuroticism	0.8	2.0	6.5	-2.5	-1.3	-0.5	0.3	-1.3
Vitamin and mineral supplements	0.8	1.1	3.5	0.7	-0.0	-1.9	-1.3	-0.2
Severe depression (siblings)	0.8	0.9	3.0	-1.7	0.6	-0.9	0.3	0.1
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.2	-0.2	0.4	1.8	1.1	-0.1
High blood pressure	0.8	2.1	4.3	2.1	1.0	1.0	1.5	1.5
Hair/balding pattern: Pattern 3	0.8	1.1	4.8	-0.1	0.4	0.3	2.2	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	3.5	-0.8	-1.9	1.0	-0.0	-0.5
Gout (self-reported)	0.8	1.1	2.4	0.1	-0.4	1.5	-0.9	-1.5
Number of full sisters	0.8	1.0	2.4	1.3	0.6	1.6	-0.7	-0.2
Overall health rating	0.8	1.6	4.4	-0.6	-2.1	0.7	-1.2	-1.2
Arm fat mass (left)	0.8	3.1	5.4	0.4	-2.1	2.3	-1.9	-1.3
Mother’s age at death	0.8	1.0	3.7	0.1	0.2	-0.1	1.1	1.9
Alcohol drinker status: Previous	0.8	0.9	3.7	-1.9	-0.1	0.1	-0.8	0.1
LDL Cholesterol	0.7	1.1	2.8	-1.7	0.4	1.4	-0.4	-0.5
Schizophrenia (2014)	0.7	1.5	3.9	-0.6	-2.0	1.6	0.5	-0.6
Hearing difficulty/problems: Yes	0.7	1.0	4.7	0.4	-0.4	2.2	-0.4	-0.3
Average weekly fortified wine intake	0.7	0.8	3.1	1.8	0.3	0.7	-0.2	0.1
Chronic bronchitis/emphysema (father)	0.7	0.8	2.6	-0.7	-1.6	-0.6	0.2	-0.7
Trunk fat mass	0.7	3.1	5.2	-0.0	-2.3	1.7	-2.2	-1.6
Number of incorrect matches in round	0.7	1.1	3.6	-1.2	0.2	-1.9	0.6	-0.1
Hip circumference	0.7	3.1	5.0	-0.0	-2.2	1.9	-1.9	-1.8
Alcohol intake versus 10 years previously	0.7	1.1	1.4	-1.2	-1.0	0.7	-1.0	-1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	4.0	-1.9	-2.0	-0.9	-1.5	-1.1
Tense / ‘highly strung’	0.7	1.2	3.6	-1.9	-1.0	-0.8	-0.1	-0.9
Number of full brothers	0.7	0.9	2.1	1.5	1.3	-0.0	0.6	0.7
Had major operations	0.7	0.8	2.0	0.2	-0.8	0.9	-1.4	-0.8
Hypertension (Self-reported)	0.7	2.0	3.3	1.5	1.1	0.8	1.8	1.5
Qualifications: nursing, teaching	0.7	1.1	2.5	0.9	-0.3	-1.6	0.1	1.4
Miserableness	0.7	1.3	2.9	-1.7	-1.4	-0.7	0.4	-1.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.1	-1.8	0.3	-0.7	0.1	0.5
Medication: Atorvastatin	0.7	0.9	3.2	0.4	-1.8	-0.4	0.7	-0.8
Unable to work because of sickness or disability	0.7	0.9	1.8	-1.3	0.5	1.2	0.8	-0.5
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.8	-1.9	-1.3	-0.6	-1.6	-1.1
Impedance of whole body	0.7	3.4	16.3	-0.2	0.1	-4.0	-0.7	0.3
Alzheimer’s Disease (in father)	0.6	0.7	2.1	-0.2	-1.4	-0.8	-0.3	-0.8
Reaction Time	0.6	1.2	4.0	-0.1	-0.2	-0.9	1.1	2.0
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.0	-1.4	-0.5	-0.5	-1.1	-0.1
Blood Eosinophil Count	0.6	4.9	10.6	2.8	2.1	0.5	1.1	3.2
Smoking Status	0.6	1.4	4.4	0.9	1.0	-0.1	0.9	2.1
Cardiovascular Disease	0.6	1.8	3.0	1.7	1.3	0.3	1.7	1.2
Sensitivity / hurt feelings	0.6	1.1	3.7	-1.9	-0.7	-0.2	-1.0	-0.6
Impedance of leg (right)	0.6	2.9	9.5	0.7	1.2	-3.1	1.1	1.4
Relative age voice broke	0.6	0.9	1.6	1.3	-0.3	-1.1	-1.1	0.5
Supplements: Glucosamine	0.6	0.8	2.5	-0.1	-0.9	-1.6	-0.1	-0.8
High blood pressure (mother)	0.6	0.8	2.8	0.7	0.9	0.3	0.2	1.7
Body mass index (BMI)	0.6	2.4	10.1	0.5	-1.1	3.2	-0.4	-0.7
Impedance of leg (left)	0.6	2.9	10.8	0.7	1.1	-3.3	0.7	1.2
Waist circumference	0.6	2.3	4.0	-0.1	-2.0	1.5	-1.7	-1.6
Hearing difficulty/problems with background noise	0.6	1.0	2.3	0.2	1.1	1.5	1.0	-0.2
Had other major operations	0.6	0.7	1.4	-0.2	1.2	0.2	1.1	1.0
Forced vital capacity (FVC)	0.6	2.4	4.0	-1.4	-2.0	-1.3	-1.8	-1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	3.0	0.5	1.7	0.4	-0.0	0.7
Qualifications: A levels/AS levels or equivalent	0.6	1.2	3.8	-0.2	-2.0	-0.2	-1.5	-0.3
Arm fat mass (right)	0.6	2.6	5.1	0.1	-1.9	2.3	-1.7	-1.2
Loud music exposure frequency	0.6	0.6	1.1	-0.6	0.7	-1.1	-0.7	0.9
Age at first live birth	0.6	1.0	3.5	1.9	-0.6	0.4	-1.0	0.1
Health satisfaction	0.6	0.7	2.8	0.0	-0.7	0.6	-1.7	0.1
Qualifications: College or University degree	0.6	1.8	3.8	1.9	0.1	-1.2	-0.6	1.9
Medication: Omeprazole	0.6	0.7	2.1	1.4	0.5	0.2	0.2	1.0
Whole body fat mass	0.6	2.5	4.3	0.1	-1.9	2.1	-1.6	-1.3
Age at last live birth	0.6	0.9	2.3	0.0	-0.9	0.4	-1.5	-1.1
Leg pain on walking	0.6	0.7	1.9	-0.6	-0.7	0.6	-1.4	-0.7
Average weekly red wine intake	0.6	0.9	2.0	-0.6	-1.2	0.3	-1.4	-0.8
Loneliness, isolation	0.6	0.9	2.1	-1.5	-0.8	0.1	0.1	-1.3
Breast cancer (self-reported)	0.6	0.7	2.1	0.5	-1.0	-1.5	-0.6	0.2
Average weekly champagne plus white wine intake	0.6	0.8	1.5	0.5	0.8	-0.9	0.8	1.2
Bipolar Disorder or Schizophrenia	0.5	1.2	3.6	-1.1	-1.9	1.0	0.1	-0.5
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.6	1.9	0.1	1.0	-1.7	0.7
Schizophrenia (2018)	0.5	1.0	3.5	-0.7	-1.9	0.7	-0.4	-0.8
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	-0.9	-0.7	-1.1	0.4	-0.5
Ulcerative Colitis (UC)	0.5	0.9	3.1	0.5	-0.2	1.8	-1.0	-0.4
Ovarian Cancer	0.5	0.7	2.2	0.9	-1.5	-0.8	-0.0	-0.0
Neuroticism (2016)	0.5	0.8	3.4	-0.2	0.6	0.1	1.8	0.4
Rheumatoid Arthritis	0.5	0.7	2.5	0.6	-0.2	1.6	0.3	0.6
Ulcerative Colitis	0.5	0.7	1.5	0.8	-0.4	1.2	-1.0	-0.0
Lung FEV1/FVC ratio	0.5	2.6	9.0	-3.0	-1.0	-1.7	-0.2	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	4.1	1.2	0.2	-0.3	2.0	-0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.5	-0.7	0.1	-1.6	0.1	-0.0
Alcohol usually taken with meals	0.5	0.8	1.7	-1.2	-1.3	0.6	-0.7	-0.3
Diabetes (self-reported)	0.5	0.7	1.5	-0.8	-1.2	0.2	-1.1	-0.4
Illnesses of siblings	0.5	0.7	1.7	-0.1	0.5	-1.3	1.3	-0.4
Father’s age at death	0.5	0.7	1.7	1.3	1.0	0.4	0.2	0.8
Noisy workplace	0.5	0.6	2.3	-1.5	-0.3	-0.2	-0.8	0.0
Exposure to tobacco smoke at home	0.5	0.6	2.1	-0.3	-0.1	1.4	0.7	-0.5
Medication: Amlodipine	0.5	0.7	1.1	0.9	0.8	-0.5	1.1	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.5	-1.2	-0.5	0.3	0.9	-0.8
Wheeze or whistling in the chest in last year	0.5	1.0	4.8	2.2	0.0	-0.1	-0.1	0.2
Medication: Ibuprofen	0.5	0.5	1.1	-1.0	-1.1	0.6	-0.2	0.5
Heart disease (mother)	0.5	0.6	1.4	-0.3	-0.9	-0.1	-1.2	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	0.8	-0.5	-0.9	-0.8	0.5	-0.9
Leg fat mass (right)	0.5	1.8	5.4	0.4	-1.4	2.3	-0.9	-0.8
Family relationship satisfaction	0.5	0.6	1.7	-0.1	-0.7	-1.3	-0.9	0.0
Arm fat percentage (left)	0.5	1.9	3.5	0.6	-1.5	1.9	-1.5	-1.1
Mood swings	0.5	0.9	3.2	-0.0	0.4	-1.0	1.8	0.5
Illnesses of father: None of the above (group 1)	0.5	0.7	1.2	0.6	1.1	-0.1	0.8	1.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.6	0.2	0.8	-0.0	1.1	1.3
Ever smoked	0.5	0.8	1.4	-1.1	-1.2	0.7	-1.1	0.0
Irritability	0.5	0.9	1.9	-0.9	-1.4	0.2	0.3	-1.2
Ever depressed for a whole week	0.5	0.6	1.7	-0.8	1.3	-0.0	0.8	0.4
Commuting to job workplace: Cycle	0.5	0.6	2.4	1.5	-0.0	-0.4	-0.5	-0.0
Supplements: Calcium	0.5	0.6	1.0	-0.9	-1.0	-0.4	1.0	0.1
Leg fat mass (left)	0.5	1.9	5.8	0.3	-1.5	2.4	-1.1	-0.7
Bipolar Disorder (2018)	0.4	0.6	1.1	-1.1	-0.7	0.8	0.7	-0.3
HDL Cholesterol	0.4	0.6	1.2	1.1	-0.8	-1.1	0.1	-0.3
Lupus	0.4	0.6	1.2	-1.1	0.2	0.9	0.8	-0.6
Blood Platelet Count	0.4	5.1	6.7	2.1	2.5	-1.9	2.6	2.1
BMI	0.4	2.4	9.2	0.1	-0.9	3.0	-0.0	-1.5
Tanning	0.4	5.3	10.3	1.7	2.6	0.6	3.2	2.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	0.7	1.0	-0.0	0.9	-0.4
Trunk fat percentage	0.4	1.5	2.8	0.4	-1.5	1.1	-1.7	-1.0
Maternal smoking around birth	0.4	0.6	1.8	-0.4	1.3	0.7	0.5	0.6
Fed-up feelings	0.4	0.8	2.6	-1.6	-0.1	-0.4	-0.9	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.6	-1.2	-0.4	0.5	-0.8	-0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.0	0.3	0.5	-0.6	-1.1
Past tobacco smoking	0.4	0.8	1.9	1.4	0.3	-1.1	0.1	-0.9
Had menopause	0.4	0.6	1.2	-0.2	0.7	-0.8	1.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.4	1.0	0.5	0.7	1.5	0.0
Time employed in main current job	0.4	0.5	1.4	0.4	0.9	-0.4	-1.2	-0.2
Hair/balding pattern: Pattern 4	0.4	0.9	2.4	1.5	0.8	-0.4	0.9	0.5
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.9	-0.7	-0.3	0.0	-1.4	0.0
Shortness of breath walking on level ground	0.4	0.5	1.5	0.1	0.8	0.7	1.2	-0.2
Medication for pain relief, constipation, heartburn	0.4	0.7	2.6	0.7	1.6	0.6	-0.1	0.2
Mean time to correctly identify matches	0.4	0.8	1.1	-1.1	-0.6	-0.8	0.8	1.1
Pulse rate, automated reading	0.4	1.4	2.5	-1.5	-1.6	-0.1	-1.1	-1.0
Medication: Aspirin	0.4	0.6	1.7	-0.8	0.5	0.5	1.3	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	0.8	1.0	-0.8	-0.1	0.6
Smoking status: Previous	0.4	0.6	1.1	-0.6	0.2	0.8	0.7	1.1
Ever had bowel cancer screening	0.4	0.5	1.2	-1.1	0.7	-0.7	0.2	0.6
Friendships satisfaction	0.4	0.5	1.0	1.0	0.4	-0.8	-0.0	0.8
Medication for cholesterol	0.4	0.6	2.3	-1.5	-0.5	0.3	0.0	-0.6
Osteoarthritis (self-reported)	0.4	0.5	1.8	0.2	-0.0	-0.7	-0.6	-1.3
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	1.1	0.8	0.3	1.3	0.3
Hearing aid user	0.4	0.5	1.4	1.2	-0.5	0.2	0.3	0.9
Average weekly beer plus cider intake	0.4	0.5	1.7	1.3	0.9	-0.4	-0.1	0.1
Myopia	0.4	0.6	0.7	0.8	0.7	0.9	0.8	0.6
Irritable Bowel Disease (IBD)	0.3	0.8	2.6	0.4	-0.4	1.6	-0.6	-0.8
Prostate Cancer	0.3	0.4	1.6	-0.5	0.3	-0.5	0.3	1.3
Bipolar Disorder (2011)	0.3	0.3	0.9	-0.4	0.6	-0.9	0.0	0.4
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	-0.4	0.1	0.8	-0.8	-0.6
Fasting Glucose	0.3	0.3	0.9	0.1	-0.7	-0.5	-0.1	0.9
HbA1C	0.3	0.3	0.6	0.8	0.2	-0.6	0.4	-0.6
Heel T-Score	0.3	2.4	3.8	1.9	1.4	0.1	1.7	1.9
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	-0.7	-0.7	0.3	-0.1	-1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.1	-0.2	-0.1	-1.1	0.1	0.5
Hand grip strength (right)	0.3	0.7	1.3	0.3	-0.5	1.1	-0.9	-1.0
Age when periods started (menarche)	0.3	0.6	1.9	0.5	1.4	-0.4	-0.8	0.4
Medication: Ramipril	0.3	0.4	1.0	-1.0	-0.7	0.5	0.6	0.3
Arm fat percentage (right)	0.3	1.2	2.7	0.4	-1.1	1.6	-1.2	-0.6
Pulse rate	0.3	0.4	0.9	-0.9	0.0	0.3	0.6	0.9
Illnesses of mother	0.3	0.4	1.7	1.3	0.4	-0.3	-0.1	-0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	0.1	-0.4	0.9	-0.7	-0.2
Neck or shoulder pain in last month	0.3	0.5	1.4	-0.1	1.2	0.6	-0.5	0.5
Migraine (self-reported)	0.3	0.3	1.2	1.1	-0.4	-0.2	-0.5	-0.1
Alcohol intake frequency.	0.3	0.7	1.5	-1.2	-0.9	-1.0	-0.5	-0.1
Illnesses of father: Heart disease	0.3	0.4	1.4	0.3	0.6	-0.0	-1.2	0.5
Back pain experienced in last month	0.3	0.5	2.2	-1.5	0.5	0.2	0.2	-0.1
Medication: Aspirin	0.3	0.4	1.6	-0.4	0.5	0.2	1.3	-0.1
High cholesterol (Self-reported)	0.3	0.5	1.3	0.7	0.5	-0.6	1.2	0.2
Risk taking	0.3	0.4	1.0	-0.6	0.2	0.1	1.0	0.8
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.9	-1.0	0.3	0.7	-0.3	0.6
Cholesterol lowering medication	0.3	0.4	1.5	0.1	-0.1	1.2	0.8	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.8	0.7	0.2	0.9	-0.2	0.5
Pain experienced in last month	0.3	0.5	1.6	-0.1	-1.2	0.5	0.5	-0.7
Depressed Affect (Nagel 2018)	0.2	0.4	1.6	-0.6	0.2	-0.1	1.2	-0.0
Depression (Nagel 2018)	0.2	0.3	0.7	0.3	0.6	-0.1	0.8	0.7
Coronary Artery Disease (CAD)	0.2	0.2	0.8	-0.4	0.1	-0.1	0.2	0.9
Crohns Disease (2012)	0.2	0.3	0.9	0.4	-0.0	0.9	0.7	-0.4
Systolic Blood Pressure	0.2	1.1	2.7	1.4	0.6	-1.6	0.6	0.5
Hypothyroidism (self reported)	0.2	0.5	1.3	-0.1	0.7	-0.8	-0.0	1.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	-0.9	-0.6	0.5	-0.7	-0.5
Lung FVC	0.2	0.9	2.1	-1.1	-1.4	-0.3	0.3	-1.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	0.7	0.2	-0.2	0.5	0.6
Medication: Co-codamol	0.2	0.2	0.8	-0.1	-0.0	0.9	-0.6	-0.2
Medication: Metformin	0.2	0.2	1.0	-0.3	0.1	1.0	-0.1	0.1
Townsend deprivation index at recruitment	0.2	0.3	1.1	0.4	-0.3	-0.3	-0.2	-1.0
Current tobacco smoking	0.2	0.3	0.8	0.6	0.2	-0.9	-0.6	0.1
Taking other prescription medications	0.2	0.3	0.7	0.9	-0.3	0.6	0.0	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.8	0.5	0.7	-0.2	-0.2	0.9
Stomach or abdominal pain in last month	0.2	0.3	0.7	0.3	0.6	0.8	-0.2	0.6
Medication: Levothyroxine sodium	0.2	0.4	1.3	-0.0	0.7	-0.5	-0.0	1.1
Mouth/teeth dental problems	0.2	0.4	1.4	0.6	-0.3	-1.2	-0.3	-0.1
Heart attack	0.2	0.3	0.6	0.0	-0.4	0.2	0.7	0.7
Allergy	0.2	0.4	1.3	-1.1	0.1	-0.3	0.6	-0.4
Pain all over the body in last month	0.2	0.2	0.6	-0.8	0.2	-0.2	0.1	0.7
Medication: Simvastatin	0.2	0.3	0.7	-0.4	0.8	0.8	0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.1	-0.7	-0.2	-0.7	0.0
Length of working week for main job	0.2	0.3	0.5	-0.3	-0.5	-0.5	-0.5	-0.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.6	0.7	0.3	0.2	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.2	-0.3	0.1	-0.6	-0.3	1.1
Body fat percentage	0.2	0.9	1.9	0.4	-1.0	1.4	-0.9	-0.7
Leg fat percentage (right)	0.2	0.8	2.3	1.0	-0.1	1.5	0.6	0.4
Emphysema/chronic bronchitis	0.2	0.3	0.5	-0.7	0.6	0.3	-0.3	-0.6
Angina (self-reported)	0.2	0.3	0.9	0.4	0.5	-0.3	0.3	0.9
Knee pain experienced in last month	0.2	0.4	1.4	-0.1	-0.0	-0.3	-1.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	-0.2	0.9	0.4	0.4	0.3
Mineral and other dietary supplements	0.2	0.3	0.6	0.2	0.2	0.8	-0.3	-0.7
Osteoporosis (self-reported)	0.2	0.3	0.7	0.2	0.8	0.2	0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.9	-1.0	0.0	-0.5	0.6	0.2
Leg fat percentage (left)	0.2	0.7	2.6	0.8	-0.1	1.6	0.2	0.3
Heart disease (siblings)	0.2	0.2	0.5	-0.2	0.3	-0.7	-0.2	0.6
Crohns Disease (2017)	0.1	0.3	1.4	0.1	-0.3	0.2	0.1	-1.2
Breast Cancer	0.1	0.2	0.6	-0.1	-0.6	0.3	-0.1	-0.8
Age at First Birth	0.1	0.1	0.3	0.4	0.4	0.5	-0.0	0.1
Mean Putamen Volume	0.1	0.1	0.4	-0.1	0.4	-0.2	-0.0	0.7
Waist Hip Ratio (WHR)	0.1	0.3	1.1	0.4	-0.3	-1.0	0.0	0.1
Allergy or Eczema	0.1	0.3	0.6	0.7	0.7	0.0	-0.1	0.8
Hand grip strength (left)	0.1	0.3	0.7	0.8	-0.1	0.9	-0.3	0.1
Number of treatments/medications taken	0.1	0.1	0.3	-0.0	-0.2	0.1	0.6	0.3
Systolic blood pressure, automated reading	0.1	0.3	1.2	0.3	-0.1	-1.1	0.1	-0.4
Angina	0.1	0.2	0.5	0.4	0.4	-0.4	0.2	0.7
Number of live births	0.1	0.1	0.4	-0.3	0.2	-0.6	0.2	0.1
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.0	-0.3	0.2	-0.5	-0.4
Lung cancer (father)	0.1	0.1	0.4	-0.6	0.4	-0.1	0.3	-0.1
Peak expiratory flow (PEF)	0.1	0.2	0.7	-0.0	-0.4	-0.3	-0.5	-0.8
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.1	0.4	-0.5	-0.6	0.4
High blood pressure (siblings)	0.1	0.2	0.7	0.1	-0.9	0.5	-0.3	0.1
Medication: Blood pressure	0.1	0.2	0.5	-0.4	-0.7	0.5	0.5	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	-0.1	-0.0	-0.7	0.2	-0.5
Smoking status: Current	0.1	0.2	0.6	0.1	0.1	-0.7	-0.8	0.2
Wears glasses or contact lenses	0.1	0.2	0.5	0.2	-0.2	-0.7	0.5	0.2
Number of operations (self-reported)	0.1	0.2	0.4	0.6	0.3	-0.2	0.7	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.5	-0.3	-0.7	0.4	0.3	0.4
Hair Pigment	0.0	0.3	0.8	-0.3	0.4	0.6	0.0	-0.9
Medication: Lansoprazole	0.0	0.0	0.1	-0.1	-0.1	0.2	0.1	-0.3

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Trait associations