TWAS hub - CDADC1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2712	0.1136	3.4e-03	0.203	NA	0.117	NA	0.180	8.2e-08	NA	5.8e-05	NA	4.7e-07
2	GTEx	Brain Cerebellum	0.2350	0.0740	3.5e-05	0.270	NA	0.221	NA	0.249	1.3e-08	NA	3.8e-07	NA	5.7e-08
3	GTEx	Esophagus Muscularis	0.1480	0.0680	6.9e-03	-0.004	NA	0.002	NA	-0.005	6.7e-01	NA	2.3e-01	NA	9.8e-01
4	GTEx	Muscle Skeletal	0.1006	0.0345	8.0e-05	0.039	NA	0.025	NA	0.019	9.3e-05	NA	1.6e-03	NA	4.7e-03
5	TCGA	Breast Invasive Carcinoma	0.0236	0.0138	3.5e-03	-0.001	0.009	0.002	NA	-0.001	8.4e-01	0.00450	8.8e-02	NA	5.5e-01
6	TCGA	Liver Hepatocellular Carcinoma	0.0770	0.0540	7.8e-03	0.029	0.025	-0.004	NA	0.005	1.6e-02	0.02400	5.3e-01	NA	1.8e-01
7	TCGA	Lung Squamous Cell Carcinoma	0.0516	0.0307	5.4e-04	0.017	0.029	0.022	NA	0.015	4.4e-03	0.00026	1.4e-03	NA	6.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Ever had bowel cancer screening	7.8	9.1	18.2	-1.6	-2.5	-1.4	2.8	4.3	3.5	3.8
Medication: Ibuprofen (e.g. Nurofen)	6.7	8.6	13.2	2.3	3.5	1.0	-3.2	-2.6	-3.6	-3.3
Medication: Ibuprofen	6.4	7.7	12.9	2.8	3.6	0.7	-3.2	-2.0	-3.5	-2.5
Average weekly fortified wine intake	4.9	5.7	9.7	-1.1	-2.7	0.9	2.6	2.7	3.1	2.6
Pulse wave Arterial Stiffness index	4.8	5.6	10.0	-0.5	-3.0	0.6	3.1	1.6	2.7	3.2
Supplements: Calcium	4.1	4.5	8.4	-2.9	-1.6	-1.3	1.0	2.5	2.4	2.4
Pulse wave peak to peak time	3.9	4.5	8.6	0.4	2.7	-1.0	-2.6	-1.5	-2.4	-2.9
Ulcerative Colitis	3.7	5.3	11.9	1.9	1.7	1.1	-1.7	-3.1	-2.3	-3.5
Medication: Cholesterol lowering	3.6	5.6	8.1	-1.8	-2.4	-2.2	1.9	2.7	2.8	2.4
Smoking status: Previous	3.5	5.2	9.8	-3.1	-2.0	-0.2	2.6	2.4	2.6	1.9
Financial difficulties in last 2 years	3.4	4.6	7.6	1.0	2.1	1.7	-2.0	-2.8	-2.4	-2.6
Glaucoma (self-reported)	3.3	3.9	10.1	-3.2	-1.5	-0.4	2.8	1.4	2.1	0.8
Myopia	3.3	4.8	7.2	-1.8	-2.3	-2.4	2.2	2.1	2.7	1.7
Medication: Lansoprazole	3.2	3.6	6.3	-0.3	-2.5	1.2	1.6	1.7	2.5	2.4
Ever had prostate specific antigen (PSA) test	3.2	3.7	8.5	-0.2	-2.3	1.7	2.9	1.2	2.0	1.9
Hearing difficulty/problems with background noise	3.0	4.8	7.7	-2.8	-1.8	-1.7	2.4	2.3	2.7	1.2
Noisy workplace	2.9	3.6	10.5	-1.2	-1.1	-0.2	1.1	3.2	2.2	2.4
Past tobacco smoking	2.6	4.9	10.8	3.3	1.7	1.4	-1.9	-2.4	-2.5	-1.6
Alcohol usually taken with meals	2.6	4.2	9.8	2.4	1.1	0.8	-0.4	-3.1	-2.2	-2.6
Alcohol intake frequency.	2.6	6.0	22.9	4.8	1.1	2.1	-2.1	-1.9	-2.3	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.0	7.3	1.8	1.8	2.7	-2.5	0.8	-1.0	0.1
Ever smoked	2.6	4.5	10.5	-3.2	-1.7	-2.5	1.4	1.8	2.2	1.5
Eye problems/disorders: Glaucoma	2.5	3.0	13.6	-3.7	-0.6	-0.5	2.2	0.8	1.2	-0.1
Medication: Bendroflumethiazide	2.5	3.8	6.7	1.3	-2.6	-0.9	2.3	1.5	2.1	2.4
Ulcerative Colitis (UC)	2.4	4.5	9.4	1.4	1.6	1.6	-1.9	-2.6	-2.1	-3.1
Pack years adult smoking proportion	2.4	3.6	13.0	0.1	2.0	-1.3	-3.6	-1.1	-2.0	-1.1
Medication: Simvastatin	2.4	3.6	4.9	-1.6	-2.1	-1.6	2.0	1.8	2.2	1.8
Type 2 Diabetes (T2D) (2012)	2.3	2.6	13.8	0.8	-0.8	-3.7	-0.0	-1.5	-0.6	-0.9
Birth weight of first child	2.3	4.2	11.1	3.3	2.2	-1.3	-1.6	-1.0	-2.3	-1.7
Waist Hip Ratio (WHR)	2.2	9.8	26.2	-0.2	-5.1	-1.0	2.6	2.0	4.1	3.7
Chronic bronchitis/emphysema (father)	2.2	2.6	4.8	-0.1	-1.7	1.6	1.5	1.5	1.8	2.2
Severe depression (siblings)	2.1	2.3	4.4	-0.5	-1.5	0.8	2.0	1.5	1.6	2.1
Average weekly beer plus cider intake	2.1	3.0	4.0	-1.9	-1.5	-1.8	1.3	2.0	2.0	1.6
Lung FVC	2.0	10.1	37.1	6.1	3.3	0.7	-1.4	-1.7	-3.5	-2.2
Gout (self-reported)	2.0	2.7	5.0	-2.2	-1.0	-0.6	1.6	2.2	1.9	1.3
Angina	1.8	2.4	4.8	-0.3	-1.5	-2.2	1.4	1.6	1.4	1.7
Age when periods started (menarche)	1.8	4.3	14.8	-3.8	-1.1	-3.2	1.0	0.5	1.5	-0.1
Medication: Ramipril	1.8	2.3	9.6	-1.3	-0.8	-3.1	0.8	1.3	1.2	0.7
Falls in the last year	1.8	2.4	3.9	2.0	1.7	-0.2	-1.6	-1.3	-1.7	-1.6
Mouth/teeth dental problems: Loose teeth	1.8	2.2	5.1	-0.7	-1.5	-2.2	0.6	1.4	1.8	1.3
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.9	1.3	1.9	0.7	-2.0	-0.9	-1.7	-1.0
Pain all over the body in last month	1.7	1.8	3.2	1.0	1.2	-0.9	-1.2	-1.8	-1.6	-1.4
Depression (self-reported)	1.7	2.1	7.6	2.7	1.0	1.0	-2.0	-0.1	-0.9	-0.3
Headache pain in last month	1.7	2.9	4.1	1.6	1.9	1.1	-1.8	-1.6	-2.0	-1.7
Impedance of arm (left)	1.6	7.2	16.0	-3.6	-1.4	-2.0	1.0	4.0	3.0	2.2
Angina (self-reported)	1.6	2.1	3.1	-0.1	-1.5	-1.8	1.4	1.5	1.3	1.7
Number of full sisters	1.6	1.9	6.0	-0.6	-0.8	0.4	0.9	2.5	1.7	1.6
Illnesses of siblings: Diabetes	1.6	1.9	4.0	0.2	0.5	1.9	-1.7	-2.0	-1.2	-1.1
Hearing aid user	1.6	1.8	2.8	0.8	-1.1	1.5	1.7	1.4	1.3	1.7
Pack years of smoking	1.6	2.4	8.9	-0.2	1.4	-1.4	-3.0	-1.0	-1.6	-0.7
Ever had hysterectomy (womb removed)	1.5	1.7	4.3	1.3	0.5	2.1	-0.2	-1.8	-1.4	-0.5
Systolic blood pressure, automated reading	1.5	4.4	7.3	-0.7	-2.6	-1.0	1.7	2.6	2.7	2.4
Hair/balding pattern: Pattern 2	1.5	2.0	5.6	-0.4	2.0	-0.7	-2.4	0.0	-1.1	-1.5
Basal cell carcinoma (self-reported)	1.5	1.8	3.4	0.5	1.4	1.8	-1.7	-0.8	-1.1	-1.4
Time employed in main current job	1.4	1.7	4.8	-0.5	-1.6	-0.8	0.8	1.0	1.3	2.2
Irritability	1.4	2.4	11.9	3.4	0.2	2.0	-0.3	-0.3	-0.7	0.6
Lupus	1.3	2.0	7.0	-1.0	-1.8	-0.2	2.6	-0.1	1.3	0.9
Chronotype (morning person)	1.3	3.1	7.4	1.0	-1.7	0.8	2.7	1.4	1.5	2.3
Fed-up feelings	1.3	2.3	12.4	3.5	0.1	1.1	-0.4	0.6	-0.3	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	4.5	0.3	-0.3	1.8	0.2	2.1	1.0	1.9
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.8	-1.7	-0.7	1.1	0.9	1.4	1.3	1.1
Hip circumference	1.3	5.6	10.4	2.8	3.0	1.7	-1.1	-2.0	-3.2	-2.0
Exposure to tobacco smoke outside home	1.3	1.7	3.0	1.2	1.0	1.3	-1.0	-1.7	-1.5	-1.2
Breast cancer (self-reported)	1.3	1.6	2.6	-1.1	-1.6	-0.5	1.0	1.1	1.6	1.5
Osteoporosis (self-reported)	1.3	1.6	3.7	-0.7	-0.8	-1.9	0.5	1.6	1.3	1.2
Ever taken oral contraceptive pill	1.3	1.4	3.9	1.4	0.4	-0.0	0.1	-2.0	-1.1	-1.7
Commuting to job workplace: Public transport	1.3	1.5	4.2	-0.8	-1.3	-1.9	2.0	-0.2	0.8	0.3
Medication: Lisinopril	1.3	1.7	2.4	-1.4	-1.4	-0.8	1.5	1.1	1.6	1.3
Irritable Bowel Disease (IBD)	1.2	2.9	9.0	0.4	0.8	0.6	-0.7	-3.0	-1.6	-2.7
Schizophrenia (2014)	1.2	2.8	7.4	0.7	1.1	1.2	-0.9	-2.7	-2.0	-2.1
Average weekly spirits intake	1.2	1.5	3.3	-0.3	-1.0	0.3	0.8	1.8	1.4	1.8
Body mass index (BMI)	1.2	5.2	9.2	3.0	2.0	3.0	-1.4	-2.0	-2.6	-1.4
Impedance of arm (right)	1.2	5.5	12.3	-3.5	-1.1	-1.8	0.7	3.5	2.6	1.7
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	2.9	0.1	1.4	1.4	-1.4	-1.7	-1.6	-1.6
Leg fat percentage (right)	1.2	4.3	15.3	2.0	2.0	3.9	-1.9	-0.1	-1.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	4.9	1.9	-0.8	2.2	0.3	0.1	0.3	1.1
Leg pain on walking	1.2	1.6	4.1	1.1	-1.1	-1.1	0.9	1.2	1.0	2.0
Illnesses of father: Heart disease	1.2	1.7	3.6	1.9	1.2	1.9	-0.8	1.1	-0.6	0.8
Friendships satisfaction	1.2	1.4	3.7	0.5	-1.6	-1.9	1.2	-1.4	0.4	0.0
Medication: Aspirin	1.2	1.6	3.0	-0.7	-1.2	-0.6	1.3	1.4	1.4	1.7
Guilty feelings	1.2	1.8	3.4	0.6	-0.6	1.9	1.3	1.6	1.0	1.7
Coronary Artery Disease (CAD)	1.1	1.3	5.2	-0.1	-0.6	2.3	0.7	0.8	0.6	1.4
Systolic Blood Pressure	1.1	5.4	8.7	-0.2	-2.7	-1.8	1.7	2.8	2.8	2.9
Diabetes (father)	1.1	1.3	3.2	1.6	0.7	0.5	-1.8	-0.9	-0.8	-1.2
Neuroticism score	1.1	2.2	9.7	3.1	-0.7	-0.0	0.1	1.1	0.5	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.9	4.0	2.0	1.7	1.7	-1.2	-0.1	-1.4	-0.5
Hair/balding pattern: Pattern 3	1.1	1.6	4.6	1.6	-1.3	-0.1	2.1	0.4	0.7	1.4
Illnesses of father: None of the above (group 1)	1.1	1.4	4.6	-2.1	-1.4	-0.3	1.1	0.3	1.2	0.7
Mother’s age at death	1.1	1.4	3.1	0.3	1.4	1.8	-1.2	-0.5	-1.1	-1.3
Medication: Blood pressure	1.1	2.0	4.8	0.6	-1.7	-2.2	1.2	1.2	1.5	1.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	4.8	1.2	0.2	2.2	-0.4	1.5	0.4	1.1
Leg fat percentage (left)	1.1	4.1	13.3	1.9	2.1	3.6	-2.0	-0.2	-1.7	-0.9
Impedance of whole body	1.1	5.8	15.7	-3.3	-1.1	-1.4	0.4	4.0	2.8	1.7
Prostate Cancer	1.0	1.4	3.7	-0.2	1.1	0.3	-1.9	-1.2	-1.4	-1.2
Bipolar Disorder (2011)	1.0	0.9	3.0	0.0	0.4	0.9	-0.3	-1.7	-1.0	-1.2
Body Mass Index (BMI) (2010)	1.0	1.4	3.1	1.8	0.7	1.0	-0.2	-1.4	-1.3	-1.1
BMI	1.0	5.8	8.3	2.1	2.5	2.7	-2.1	-2.3	-2.9	-2.2
Medication: Metformin	1.0	1.5	3.4	1.8	0.8	0.8	-1.6	-1.1	-1.4	-0.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	6.8	0.4	-0.5	2.6	0.7	-0.5	0.0	0.3
Qualifications: CSEs or equivalent	1.0	1.3	3.8	1.4	-0.7	-2.0	0.6	-1.5	-0.3	-0.5
Multivitamins +/- minerals	1.0	1.2	3.9	-2.0	0.2	-1.0	0.1	-1.5	-0.6	-1.0
Had menopause	1.0	1.2	2.4	-1.0	-0.8	-0.7	1.0	1.4	1.1	1.5
Number of live births	1.0	1.4	4.0	0.3	0.9	0.1	-0.2	-2.0	-1.5	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	16.0	4.0	1.4	0.3	-0.3	-0.8	-1.8	-0.7
Tense / ‘highly strung’	1.0	1.7	4.5	1.4	-1.4	-0.0	0.3	1.3	1.3	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	4.1	0.6	-1.4	0.0	0.7	1.4	1.4	2.0
Qualifications: College or University degree	1.0	3.1	6.8	1.3	1.9	-0.2	-1.7	-1.6	-2.0	-2.6
Long-standing illness, disability or infirmity	1.0	1.5	3.1	-0.4	-1.1	1.3	0.9	1.3	1.4	1.8
Depression (Nagel 2018)	0.9	1.3	3.6	0.6	-0.6	0.7	0.6	1.9	1.1	1.7
Neuroticism (Nagel 2018)	0.9	2.1	5.7	1.7	-1.2	-0.5	0.5	1.6	1.1	2.4
Blood White Count	0.9	6.9	30.4	1.9	2.0	0.2	-5.5	3.2	-0.1	0.7
Hypothyroidism (self reported)	0.9	2.2	5.2	2.3	0.7	2.2	-0.9	1.6	-0.1	1.1
Hearing difficulty/problems: Yes	0.9	1.4	2.5	-0.2	-1.3	0.2	1.4	1.4	1.6	1.4
Nervous feelings	0.9	1.7	5.0	-0.3	-1.7	-0.5	1.0	1.1	1.3	2.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.3	0.7	-0.5	1.2	1.5	1.0	0.5	1.5
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	15.7	4.0	1.0	0.5	0.2	-0.9	-1.5	-0.5
Pulse rate	0.9	1.5	2.9	0.5	-1.4	-0.9	1.3	1.2	1.4	1.7
Lung cancer (father)	0.9	1.1	3.1	-0.0	-1.0	0.4	1.1	1.2	0.9	1.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.1	1.3	1.0	1.8	-0.9	0.0	-0.9	0.5
Forced vital capacity (FVC), Best measure	0.9	3.3	13.3	3.6	1.8	-0.5	-0.2	-0.9	-1.9	-1.4
Arm fat-free mass (right)	0.9	4.7	12.5	2.9	1.0	-0.9	0.9	-3.5	-2.6	-1.7
Comparative body size at age 10	0.9	2.5	6.8	2.6	1.8	0.2	-2.2	0.1	-1.4	-0.9
Neck or shoulder pain in last month	0.9	1.2	2.4	1.5	1.2	-0.1	-1.4	-0.8	-1.4	-0.7
Leg fat mass (right)	0.9	3.6	7.2	2.3	2.0	2.7	-1.2	-1.2	-2.2	-1.2
Arm predicted mass (right)	0.9	4.6	12.1	2.8	1.1	-0.9	0.9	-3.5	-2.5	-1.8
Medication: Aspirin	0.9	1.2	2.3	-0.6	-0.9	-0.8	1.2	1.3	1.2	1.5
Mood swings	0.9	1.7	8.2	2.9	0.4	-0.5	-0.5	1.0	-0.2	1.3
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.4	-0.6	1.5	-0.7	-1.8	0.7	-0.7	-0.3
High cholesterol (Self-reported)	0.9	1.6	2.2	-1.3	-1.4	-1.2	0.7	1.3	1.4	1.5
Arm fat-free mass (left)	0.9	4.7	12.5	2.9	1.1	-0.6	0.8	-3.5	-2.6	-1.7
Bipolar Disorder or Schizophrenia	0.8	1.9	4.3	-0.0	1.2	1.3	-0.5	-1.9	-1.3	-2.1
Depressed Affect (Nagel 2018)	0.8	1.8	5.7	2.4	-0.5	-0.5	0.2	1.5	0.7	1.8
Neuroticism (2016)	0.8	1.2	2.6	0.6	-1.4	1.6	1.1	0.4	0.8	1.2
Height	0.8	16.0	64.8	-2.2	-2.3	-8.1	5.8	0.0	1.7	0.7
Cardiovascular Disease	0.8	2.5	5.6	0.5	-1.6	-2.4	1.1	1.6	1.5	1.7
Frequency of depressed mood in last 2 weeks	0.8	1.2	3.6	1.9	0.1	1.9	-0.6	-0.1	-0.4	0.7
Trunk fat-free mass	0.8	4.4	13.2	2.2	0.2	-1.7	1.9	-3.6	-2.0	-1.4
Trunk predicted mass	0.8	4.4	13.3	2.2	0.2	-1.5	1.9	-3.6	-2.0	-1.4
Pulse wave reflection index	0.8	1.0	1.9	-0.2	-1.4	0.7	1.4	0.3	1.2	1.2
Loud music exposure frequency	0.8	0.9	2.4	-0.2	1.0	-0.7	-1.6	-0.7	-0.9	-1.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	6.1	0.8	-0.5	-2.5	0.3	-1.1	-0.4	-0.8
Number of children fathered	0.8	0.9	1.4	-1.2	-0.0	-1.2	-1.1	-1.2	-0.4	-0.8
Health satisfaction	0.8	1.0	2.8	1.7	-0.6	0.1	-0.0	1.1	0.7	1.4
Medication: Allopurinol	0.8	1.1	2.9	-1.7	-0.6	-0.1	1.5	1.0	0.9	0.5
Family relationship satisfaction	0.8	1.0	4.7	0.2	-0.7	-0.9	0.5	-2.2	-0.6	-0.5
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	4.2	-0.1	-0.8	-2.0	0.6	0.6	0.6	0.7
Hypertension (Self-reported)	0.8	2.1	5.3	0.6	-1.5	-2.3	1.6	1.2	1.4	1.0
Back pain experienced in last month	0.8	1.2	3.5	1.9	1.5	-0.0	-0.6	-0.0	-1.4	0.4
Whole body water mass	0.8	4.5	13.0	2.5	0.6	-1.4	1.6	-3.6	-2.3	-1.4
Leg fat mass (left)	0.8	3.3	5.7	2.2	2.0	2.4	-1.1	-1.3	-2.1	-1.2
Arm predicted mass (left)	0.8	4.1	11.4	2.6	0.7	-1.1	1.1	-3.4	-2.3	-1.6
Age at First Birth	0.7	1.0	5.4	-0.7	-0.5	-2.3	0.7	-0.4	0.3	-0.5
Rheumatoid Arthritis	0.7	1.0	2.2	-0.8	-1.4	-0.4	1.5	0.4	1.2	0.6
Respiratory disease	0.7	1.5	4.5	0.8	0.8	0.7	-0.7	-2.1	-1.4	-1.3
Sensitivity / hurt feelings	0.7	1.2	4.6	2.1	0.9	0.6	-1.2	-0.3	-1.1	0.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.8	2.2	0.1	-0.9	0.5	0.8	0.8	1.1	1.5
Current tobacco smoking	0.7	1.1	3.9	-0.1	1.1	-1.1	-2.0	-0.2	-0.8	-0.8
Serious illness, injury or assault to yourself	0.7	0.9	2.1	1.0	-0.3	1.3	-0.3	1.0	0.4	1.4
High blood pressure	0.7	2.0	3.9	0.7	-1.5	-2.0	1.5	1.3	1.4	1.3
Number of incorrect matches in round	0.7	1.2	3.5	1.3	-1.4	0.1	0.4	0.4	0.8	1.9
Forced vital capacity (FVC)	0.7	2.6	13.7	3.7	1.3	-0.3	0.3	-0.5	-1.4	-0.6
Arm fat percentage (right)	0.7	2.6	8.8	1.8	1.6	3.0	-0.9	-0.4	-1.5	-0.5
Standing height	0.7	7.3	26.6	-1.4	-1.7	-5.2	4.2	-0.1	1.2	0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.8	1.3	0.2	2.0	-0.3	1.3	0.3	1.2
Medication: Blood pressure	0.7	1.2	3.3	0.0	-0.5	-1.8	0.9	1.4	0.9	1.1
Chest pain or discomfort	0.7	1.0	1.6	-0.1	-1.2	-0.4	1.1	1.0	1.3	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.8	0.9	0.7	1.0	-1.4	-0.7	-0.9	-0.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.7	-0.0	0.8	0.2	0.1	-1.2	-1.0	-1.7
Whole body fat-free mass	0.7	4.2	11.7	2.4	0.6	-1.5	1.6	-3.4	-2.2	-1.4
Arm fat percentage (left)	0.7	2.6	7.4	1.9	1.8	2.7	-1.1	-0.3	-1.6	-0.6
Osteoarthritis (self-reported)	0.7	0.9	3.7	-0.2	1.0	0.5	-1.9	-0.4	-0.8	-0.7
Arm fat mass (left)	0.7	2.8	6.1	2.5	1.6	1.9	-0.5	-1.5	-2.0	-1.1
Wears glasses or contact lenses	0.7	0.8	1.8	0.7	-1.4	0.2	1.0	0.3	0.8	1.3
Alcohol drinker status: Never	0.7	0.9	5.2	2.3	-0.2	0.3	-0.2	0.1	-0.2	0.9
Basal metabolic rate	0.7	3.7	9.7	2.5	0.8	-0.9	1.3	-3.1	-2.2	-1.3
Vascular/heart problems diagnosed by doctor	0.7	2.0	2.8	-0.4	1.7	1.5	-1.7	-1.3	-1.5	-1.4
Bipolar Disorder (2018)	0.6	1.0	2.8	0.4	0.8	1.7	-0.4	-1.2	-0.8	-1.1
Worry (Nagel 2018)	0.6	1.3	3.4	0.6	-1.3	-1.5	0.4	0.8	1.0	1.8
Breast Cancer	0.6	1.4	3.3	-0.4	-1.5	1.4	1.8	0.3	1.1	1.1
Crohns Disease (2012)	0.6	1.0	3.2	-0.0	0.6	0.2	-0.3	-1.8	-1.0	-1.5
Heel T-Score	0.6	4.5	10.9	-3.3	-2.5	1.2	1.6	1.0	2.6	1.4
Neuroticism	0.6	1.4	4.3	2.1	-1.1	-0.7	0.4	0.6	0.5	1.7
Impedance of leg (right)	0.6	3.0	7.9	-2.7	-0.7	0.7	-0.3	2.8	2.0	0.8
Leg fat-free mass (left)	0.6	3.0	6.7	2.4	0.9	-1.1	1.3	-2.6	-2.0	-0.8
Taking other prescription medications	0.6	0.9	1.5	0.8	-1.2	1.0	0.7	0.3	1.0	1.2
Stomach or abdominal pain in last month	0.6	0.7	1.8	-0.1	-1.1	-0.3	0.3	0.9	1.1	1.4
Medication: Levothyroxine sodium	0.6	1.0	4.2	1.5	-0.2	2.0	0.1	-0.1	0.0	0.7
Impedance of leg (left)	0.6	2.7	7.7	-2.8	-0.5	0.3	-0.5	2.7	1.8	0.6
Diabetes (self-reported)	0.6	1.0	4.1	0.6	0.8	0.1	-2.0	-0.8	-1.0	-0.0
Fluid intelligence score	0.6	1.2	4.7	-0.3	0.7	-2.2	-0.2	-0.5	-0.8	-1.5
Happiness	0.6	0.8	1.8	1.3	-1.3	-0.8	0.7	-0.3	0.5	0.7
Prospective memory result	0.6	0.7	2.1	0.2	-0.5	0.7	-0.1	1.4	1.0	1.1
Arm fat mass (right)	0.6	2.5	5.3	2.3	1.4	2.1	-0.3	-1.3	-1.8	-0.8
Exposure to tobacco smoke at home	0.6	0.7	2.8	0.9	0.3	1.7	0.6	-0.6	-0.6	-0.0
Breastfed as a baby	0.6	0.8	2.0	0.7	0.4	-1.0	-0.7	-0.9	-0.6	-1.4
Medication: Paracetamol	0.6	1.0	3.0	-0.0	1.3	-0.2	-1.7	-0.5	-1.1	-1.0
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.6	1.0	0.7	1.3	-0.3	-0.8	-0.8	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.9	-1.0	-0.6	-1.4	0.8	-0.7	0.2	-0.8
Age at first live birth	0.6	1.1	2.3	-1.5	-0.7	-1.5	0.6	1.0	1.2	0.2
Shortness of breath walking on level ground	0.6	0.8	3.9	-0.1	-0.0	2.0	-0.1	0.8	0.2	0.9
Emphysema/chronic bronchitis	0.6	0.6	1.7	-0.2	0.6	0.9	-1.3	1.0	0.0	0.7
Medication: Omeprazole	0.6	0.8	3.4	0.5	-0.3	-0.2	-0.4	1.0	0.6	1.8
Whole body fat mass	0.6	2.4	3.9	2.0	1.8	1.9	-0.7	-1.0	-1.9	-0.9
Commuting to job workplace: Walk	0.6	0.7	1.4	1.0	-0.1	-1.1	-0.5	1.2	0.6	0.7
Mineral and other dietary supplements	0.6	0.8	3.5	1.1	0.1	1.9	-0.5	-0.6	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	4.2	2.0	-0.5	1.1	1.0	1.1	0.6	0.7
Average weekly champagne plus white wine intake	0.6	0.8	3.3	1.8	-0.7	0.9	0.9	-0.5	-0.0	-0.0
Miserableness	0.6	1.1	4.5	2.1	-0.4	0.7	0.3	1.1	0.6	0.9
Illnesses of father: High blood pressure	0.6	0.7	3.5	1.9	0.1	1.0	-0.4	0.0	-0.5	0.6
Age started oral contraceptive pill	0.6	0.8	2.0	-0.1	-0.9	-1.4	0.5	0.7	0.9	1.0
Heart disease (siblings)	0.6	0.7	1.7	0.7	0.6	0.1	0.1	-1.1	-1.0	-1.3
Intelligence (Savage-Jansen 2018)	0.5	1.6	8.9	-0.6	0.8	-3.0	0.5	0.7	-0.1	-0.6
Schizophrenia (2018)	0.5	1.1	3.1	-0.4	0.9	0.3	-0.3	-1.5	-1.1	-1.8
Alzheimer’s Disease (in mother)	0.5	0.6	2.2	-1.5	1.0	0.9	0.4	0.4	-0.4	0.1
Alzheimer’s Disease (in father)	0.5	0.5	1.0	-0.4	-0.6	-0.6	0.2	1.0	0.8	0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.3	5.0	-1.1	0.2	-2.2	0.8	1.4	0.6	-0.1
Ovarian Cancer	0.5	0.7	1.8	0.5	0.4	1.3	-0.6	-1.0	-0.8	-0.6
HbA1C	0.5	0.6	1.7	0.6	-0.0	-1.3	0.8	0.9	0.3	0.7
Smoking Status	0.5	1.1	2.8	-1.7	-0.5	-1.4	-0.1	1.3	1.0	0.5
Number of treatments/medications taken	0.5	0.8	2.0	0.9	-0.9	1.1	0.6	0.6	0.6	1.4
High blood pressure (mother)	0.5	0.6	3.2	1.8	-0.5	0.1	0.0	0.4	0.2	0.9
Leg predicted mass (left)	0.5	2.9	6.4	2.3	0.9	-1.0	1.3	-2.5	-2.0	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	6.3	-0.6	-0.8	2.5	-0.4	-0.2	0.6	0.2
Qualifications: None of the above	0.5	1.0	4.3	-0.8	-0.3	2.1	0.5	0.5	0.5	1.2
Weight	0.5	2.3	4.9	2.2	1.3	0.6	0.4	-2.0	-2.0	-1.0
Father’s age at death	0.5	0.6	1.9	0.5	0.4	0.6	-1.4	-0.2	-0.3	-1.2
Asthma	0.5	1.0	2.1	1.2	0.6	0.9	-0.3	-1.5	-1.0	-1.2
Illnesses of mother	0.5	0.6	1.5	0.4	0.9	-0.4	-0.8	-0.6	-0.7	-1.2
Birth weight	0.5	1.1	3.2	0.9	1.8	0.1	-1.5	0.2	-1.1	-0.6
Body fat percentage	0.5	2.1	6.1	1.1	1.9	2.5	-1.2	0.2	-1.3	-0.6
Wheeze or whistling in the chest in last year	0.5	0.9	3.0	-0.4	-0.7	0.5	0.9	0.9	0.8	1.7
Medication for pain relief, constipation, heartburn	0.5	0.8	1.7	-0.7	-1.3	-0.7	1.3	0.3	1.1	0.4
Heart disease (mother)	0.5	0.6	1.6	-1.1	-0.4	-0.7	1.2	0.5	0.6	0.6
Leg fat-free mass (right)	0.5	2.9	6.6	2.3	0.7	-1.4	1.4	-2.6	-1.9	-0.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.6	1.6	-0.3	0.2	-0.4	-1.1	-0.6	-0.2
Loneliness, isolation	0.5	0.7	3.6	1.9	0.5	0.2	-0.6	0.2	-0.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.7	0.7	0.6	-0.2	-1.3	1.0	0.0	0.6
Asthma (self-reported)	0.5	1.1	2.5	0.9	0.7	0.8	-0.3	-1.6	-1.1	-1.3
Smoking status: Current	0.5	0.9	2.4	-0.5	0.7	-1.4	-1.6	-0.2	-0.5	-0.8
Leg predicted mass (right)	0.5	2.8	6.2	2.2	0.6	-1.5	1.4	-2.5	-1.8	-0.7
Medication: Paracetamol	0.5	0.8	2.7	0.3	1.3	0.0	-1.6	-0.2	-0.9	-0.8
Diastolic blood pressure, automated reading	0.5	1.6	2.9	1.7	-1.2	-0.5	0.3	1.7	1.2	1.6
Unable to work because of sickness or disability	0.5	0.6	1.2	1.0	0.0	1.0	0.6	-1.1	-0.6	-0.4
Commuting to job workplace: Cycle	0.5	0.6	1.5	-0.0	0.8	-0.2	-0.3	-1.0	-1.0	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.7	0.4	1.0	1.3	-0.9	0.9	-0.3	0.5
Schizophrenia vs Biploar Disorder	0.4	0.6	2.0	0.1	0.9	1.4	-0.6	0.2	-0.7	-0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	2.2	-0.9	1.5	0.4	-0.6	0.6	-0.7	0.1
Crohns Disease (2017)	0.4	0.8	3.2	-0.9	0.3	-0.1	0.3	-1.8	-0.6	-1.1
Major Depression (MDD)	0.4	0.5	0.8	0.5	-0.9	-0.9	0.7	0.3	0.5	0.7
LDL Cholesterol	0.4	0.6	2.0	0.0	0.5	-0.1	-0.4	-1.4	-1.0	-0.9
Diabetes (mother)	0.4	0.5	1.2	-1.1	-0.0	-0.1	-0.7	0.8	0.5	1.1
Townsend deprivation index at recruitment	0.4	0.5	1.6	0.2	0.9	0.3	-1.3	-0.4	-0.8	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	4.8	-0.4	-0.3	2.2	-0.8	-0.3	0.2	-0.2
Medication: Atenolol	0.4	0.6	1.6	0.5	-0.5	-1.3	0.1	0.9	0.5	0.8
Sitting height	0.4	2.6	8.4	0.5	0.3	-2.9	2.0	-1.9	-1.1	-0.8
Illnesses of siblings	0.4	0.6	2.3	-0.0	0.9	-1.5	0.0	0.9	0.0	-0.0
Alcohol intake versus 10 years previously	0.4	0.6	3.3	1.8	-0.4	0.2	-0.4	-0.5	-0.3	0.3
Mouth/teeth dental problems: Dentures	0.4	0.6	2.9	0.4	0.0	1.7	-0.7	0.5	0.1	0.8
Blood clot in the leg (DVT)	0.4	0.5	0.9	0.3	0.8	1.0	-0.9	0.8	-0.2	0.5
Medication: Amlodipine	0.4	0.6	1.5	1.2	-0.3	-1.1	-0.9	-0.6	-0.2	-0.2
Number of full brothers	0.4	0.5	1.1	0.4	0.8	1.1	-0.7	-0.4	-0.6	-0.8
Eye problems/disorders: None of the above	0.4	0.5	1.2	0.7	0.8	0.6	-1.1	-0.2	-0.6	-0.4
Migraine (self-reported)	0.4	0.6	1.2	-0.5	-0.6	-0.6	0.3	1.0	0.8	1.1
Mean time to correctly identify matches	0.4	0.7	2.0	-0.2	-1.4	-0.7	1.0	-0.2	0.7	0.8
Age at last live birth	0.4	0.6	2.1	-1.2	-0.3	-1.4	0.5	0.3	0.5	0.2
Supplements: Vitamin C	0.4	0.5	1.1	0.8	0.0	1.1	0.7	-0.9	-0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.4	1.0	1.1	-1.0	-0.1	-0.9	-1.2	-0.8
Average weekly red wine intake	0.4	0.6	1.8	0.4	0.5	1.0	0.2	-0.9	-0.7	-1.3
Qualifications: nursing, teaching	0.4	0.6	3.1	0.5	0.5	-1.8	0.1	-0.1	-0.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.9	1.2	0.9	1.4	-0.2	0.3	-0.5	-0.7
Medication for cholesterol	0.4	0.6	2.1	-0.2	1.0	1.5	0.0	-0.2	-0.8	-0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.9	-1.1	0.2	-1.4	0.6	0.4	0.1	0.1
Number of operations (self-reported)	0.4	0.6	2.9	1.7	-0.6	0.4	-0.6	0.3	0.3	0.5
Cholesterol lowering medication	0.4	0.6	1.4	-0.4	-1.2	-0.7	0.8	-0.2	0.6	1.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.4	0.5	-0.1	0.4	-0.4	0.7	0.3	1.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.7	0.4	-0.6	0.6	0.9	0.1	0.1	1.3
Mean Putamen Volume	0.3	0.3	0.7	-0.4	-0.8	-0.5	0.0	0.7	0.8	0.6
Fasting Glucose	0.3	0.4	1.5	1.2	0.2	-0.2	0.4	0.9	0.4	-0.0
Blood Platelet Count	0.3	3.0	7.4	2.6	0.3	1.2	-1.6	2.7	0.5	1.6
Hand grip strength (left)	0.3	0.8	2.0	0.3	1.4	0.3	-1.0	-0.4	-0.8	-1.1
Relative age of first facial hair	0.3	0.5	1.4	-0.9	-0.4	0.3	0.5	1.2	1.0	0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.1	1.0	-0.0	0.7	-0.8	-0.1	-0.3	0.1
Vitamin and mineral supplements	0.3	0.4	1.2	1.1	-0.3	0.4	-0.2	0.8	0.4	0.6
Supplements: Zinc	0.3	0.3	0.9	0.6	0.5	-0.2	-1.0	-0.4	-0.7	0.1
Hand grip strength (right)	0.3	0.7	1.4	0.6	0.8	-0.6	-0.4	-1.2	-1.0	-1.1
Relative age voice broke	0.3	0.4	1.6	-1.2	-0.6	0.4	0.5	0.3	0.8	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	1.1	0.8	0.9	-0.6	-0.2	-0.7	0.4
Mouth/teeth dental problems	0.3	0.5	1.3	0.1	0.8	-1.1	-0.1	-0.5	-0.6	-0.8
Heart attack	0.3	0.4	1.4	0.4	-0.5	0.5	0.8	0.2	0.0	1.2
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.5	0.8	0.7	0.1	-0.7	-1.0	-1.1	-1.2
High blood pressure (siblings)	0.3	0.4	1.5	-0.2	-1.2	-0.6	0.4	0.1	0.8	0.6
Comparative height size at age 10	0.3	1.4	3.2	1.6	-0.6	-1.8	1.7	-0.4	-0.2	0.9
Suffer from ‘nerves’	0.3	0.5	2.0	1.4	-0.1	-0.5	-0.8	-0.6	-0.4	0.3
Overall health rating	0.3	0.6	1.7	1.1	-0.5	0.7	0.5	0.3	0.2	1.3
Had major operations	0.3	0.3	1.0	0.1	-0.5	1.0	-0.2	0.3	0.3	0.8
Knee pain experienced in last month	0.3	0.4	0.8	0.1	-0.4	-0.6	0.6	0.9	0.8	0.8
Risk taking	0.3	0.4	2.2	0.1	0.2	1.5	0.5	-0.5	-0.1	-0.5
Fractured/broken bones in last 5 years	0.3	0.4	0.8	-0.0	0.3	-0.8	-0.7	0.9	0.2	0.7
Ever depressed for a whole week	0.3	0.3	0.7	-0.4	-0.6	0.8	0.8	0.2	0.5	0.7
Primary Biliary Cirrhosis	0.2	0.3	0.9	0.9	-0.3	0.4	-0.5	-0.9	-0.2	-0.2
Blood Eosinophil Count	0.2	1.4	4.4	2.1	-0.3	1.6	-1.1	0.7	0.4	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.2	0.5	-0.2	-0.2	-1.1	-0.3	-0.2	0.6
Tanning	0.2	2.0	3.5	-0.7	1.6	-1.9	-0.7	-1.1	-1.5	-1.8
Trunk fat percentage	0.2	0.8	2.7	0.5	1.2	1.6	-0.5	0.9	-0.5	0.1
Supplements: Glucosamine	0.2	0.3	0.7	-0.3	0.8	-0.7	-0.3	0.1	-0.6	-0.6
Trunk fat mass	0.2	0.8	1.8	1.1	1.3	1.1	-0.2	-0.3	-1.2	-0.5
Waist circumference	0.2	0.8	3.6	1.9	-0.3	1.0	0.6	-0.8	-0.5	0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	-0.7	0.4	-0.3	-0.6	-0.3	-0.2	-0.7
Worrier / anxious feelings	0.2	0.4	2.0	1.4	-0.0	-0.1	0.1	-0.3	-0.5	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	0.1	0.4	0.7	-0.8	0.3	-0.2	0.1
Length of working week for main job	0.2	0.2	0.6	0.5	0.2	0.4	-0.3	-0.8	-0.3	-0.5
Hair/balding pattern: Pattern 4	0.2	0.6	2.7	0.1	0.9	1.6	-0.4	0.1	-0.7	-0.1
Peak expiratory flow (PEF)	0.2	0.5	1.7	0.7	-0.1	0.7	1.3	-0.7	-0.3	-0.4
Worry too long after embarrassment	0.2	0.4	1.9	0.2	-0.3	-1.4	0.2	0.6	0.3	0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.8	0.4	0.3	0.9	-0.2	0.5	0.2	0.2
Pulse rate, automated reading	0.2	0.7	1.9	0.6	-1.4	-0.7	0.9	0.3	0.9	0.9
Diabetes diagnosed by doctor	0.2	0.3	1.0	0.8	-0.1	0.2	-1.0	-0.6	-0.4	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	-0.3	0.8	-0.1	-0.4	-0.3	-0.8	-0.3
Number of self-reported non-cancer illnesses	0.2	0.4	1.2	0.4	-0.4	0.5	-0.3	0.6	0.6	1.1
Medication: Atorvastatin	0.2	0.3	0.8	-0.3	0.0	0.1	-0.8	-0.9	-0.5	0.0
Pain experienced in last month	0.2	0.4	2.0	0.2	-0.6	1.4	0.1	0.3	0.5	0.0
Alcohol drinker status: Previous	0.2	0.2	0.5	-0.7	-0.4	0.4	-0.1	0.4	0.4	0.4
Reaction Time	0.1	0.2	0.7	0.6	-0.8	-0.4	0.4	-0.5	0.1	0.1
HDL Cholesterol	0.1	0.1	0.4	-0.3	-0.1	0.1	0.1	0.7	0.4	0.5
Triglycerides	0.1	0.2	0.6	-0.6	0.2	-0.6	-0.2	0.1	0.0	-0.8
Blood Red Count	0.1	1.2	4.1	2.0	0.1	1.9	-0.4	-0.6	-0.5	0.1
Lung FEV1/FVC ratio	0.1	0.7	2.1	0.7	0.4	1.4	-1.5	0.3	-0.4	0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	-0.2	-0.5	0.1	-0.4	0.3	0.5	0.7
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.2	-0.1	-0.3	-0.1	-0.5	0.1	-0.5
Medication: Co-codamol	0.1	0.2	0.7	0.1	-0.4	-0.8	-0.1	0.0	0.3	0.3
Maternal smoking around birth	0.1	0.2	0.4	-0.7	0.4	-0.4	-0.2	-0.3	-0.3	-0.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.9	0.1	0.2	-0.0	-0.2	-0.6	-0.2	-0.9
Had other major operations	0.1	0.1	0.3	0.3	0.1	0.5	-0.3	0.5	0.1	0.1
Allergy	0.1	0.3	0.6	-0.8	-0.4	-0.7	0.5	0.5	0.4	0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	0.6	-0.2	-0.3	-0.2	-0.6	-0.3	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	0.5	0.4	0.4	-0.7	0.2	-0.0	-0.0
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.3	0.4	0.1	-0.5	-0.1	-0.2	-0.1
Medication: Gliclazide	0.1	0.1	0.3	-0.5	-0.2	0.4	-0.1	-0.3	0.1	-0.1
Financial situation satisfaction	0.1	0.1	0.2	-0.5	-0.2	-0.0	-0.4	-0.1	0.1	0.3
Allergy or Eczema	0.0	0.1	0.2	0.0	-0.2	0.1	0.2	0.4	0.5	0.2
Hair Pigment	0.0	0.8	2.0	1.4	0.4	0.3	-0.5	-1.3	-1.2	-0.5
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	0.3	-0.3	-0.1	-0.4	-0.0	0.1	0.2

Hub : Genes

CDADC1

Models

Trait associations