Best TWAS P=8.23e-16 · Best GWAS P=1.65e-18 conditioned to 2.91e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARHGEF40 | 0.08 | 0.04 | enet | 20 | 0.07 | 7.2e-09 | -8.2 | -6.3 | 3.8e-10 | 0.69 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Aorta | ARHGEF40 | 0.34 | 0.32 | enet | 17 | 0.31 | 1.5e-17 | -8.2 | -8.1 | 8.2e-16 | 0.94 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | TOX4 | 0.19 | 0.06 | lasso | 7 | 0.05 | 6.6e-05 | -6.8 | -6.2 | 5.4e-10 | -0.05 | 0.70 | 0.06 | FALSE |
| 4 | GTEx | Testis | TOX4 | 0.31 | 0.00 | enet | 24 | 0.04 | 6.8e-03 | -6.8 | -7.0 | 2.8e-12 | -0.07 | 0.08 | 0.07 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | METTL3 | 0.03 | 0.04 | lasso | 1 | 0.04 | 3.1e-08 | -6.6 | -6.6 | 3.5e-11 | -0.06 | 0.41 | 0.59 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | METTL3 | 0.04 | 0.04 | lasso | 2 | 0.04 | 2.5e-05 | -6.7 | -6.7 | 1.8e-11 | -0.05 | 0.25 | 0.52 | FALSE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | METTL3 | 0.17 | 0.03 | lasso | 2 | 0.04 | 1.5e-02 | -6.7 | -6.9 | 6.5e-12 | -0.05 | 0.04 | 0.12 | FALSE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RAB2B | 0.12 | 0.04 | blup | 52 | 0.07 | 2.1e-03 | -3.8 | -5.3 | 1.3e-07 | -0.08 | 0.02 | 0.05 | FALSE |