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chr14:23,504,021-25,605,046

Best TWAS P=7.11e-25 · Best GWAS P=1.61e-25 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
41	METSIM	Adipose	ADCY4	0.07	0.03	lasso	5	0.03	2.2e-05	9.50	10.3	7.1e-25	0.71	0.60	0.39	TRUE
51	YFS	Blood	LTB4R	0.02	0.00	blup	483	0.01	6.1e-03	8.05	-8.5	2.1e-17	-0.61	0.05	0.92	TRUE
70	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HOMEZ	0.19	0.01	blup	41	0.05	6.0e-03	4.86	8.0	1.3e-15	0.03	0.01	0.36	TRUE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	ADCY4	0.07	0.02	lasso	4	0.03	4.7e-03	5.88	7.9	3.1e-15	0.70	0.03	0.75	TRUE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NYNRIN	0.05	0.02	blup	81	0.02	4.0e-03	8.33	7.1	9.0e-13	0.65	0.07	0.54	TRUE
52	YFS	Blood	PCK2	0.22	0.05	enet	54	0.12	7.6e-38	-4.52	-6.5	1.1e-10	-0.05	1.00	0.00	TRUE
36	GTEx	Spleen	NFATC4	0.45	0.00	enet	24	0.00	2.5e-01	5.53	-6.4	1.7e-10	-0.22	0.07	0.05	TRUE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PABPN1	0.04	0.03	lasso	2	0.02	1.7e-03	5.41	6.2	4.3e-10	-0.01	0.02	0.04	TRUE
50	YFS	Blood	KHNYN	0.36	0.20	enet	50	0.29	1.2e-96	5.72	6.2	5.5e-10	0.14	1.00	0.00	TRUE
64	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TGM1	0.12	0.06	blup	61	0.04	4.3e-03	-4.02	6.0	1.8e-09	0.31	0.40	0.09	TRUE
24	GTEx	Heart Left Ventricle	CBLN3	0.35	0.23	lasso	8	0.21	1.5e-11	5.43	-5.9	2.9e-09	-0.16	1.00	0.00	TRUE
49	YFS	Blood	GMPR2	0.08	0.04	bslmm	459	0.05	5.9e-15	-3.62	5.4	6.6e-08	0.13	1.00	0.00	TRUE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY4	0.06	0.06	lasso	6	0.09	3.0e-10	9.06	10.1	3.8e-24	0.75	0.94	0.06	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	ADCY4	0.07	0.09	lasso	3	0.08	4.4e-10	7.68	9.4	6.2e-21	0.73	0.95	0.05	FALSE
71	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LTB4R	0.16	0.05	blup	73	0.08	4.9e-04	5.19	-9.1	1.3e-19	-0.70	0.02	0.62	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	LTB4R2	0.04	0.04	lasso	1	0.02	2.5e-02	9.03	-9.0	1.8e-19	-0.70	0.04	0.53	FALSE
38	GTEx	Thyroid	ADCY4	0.13	0.13	lasso	6	0.09	1.0e-07	7.43	8.9	5.6e-19	0.51	0.98	0.02	FALSE
53	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ADCY4	0.03	0.01	blup	75	0.03	1.1e-03	7.35	8.8	9.0e-19	0.71	0.08	0.56	FALSE
28	GTEx	Lung	LTB4R	0.19	0.15	lasso	6	0.12	2.0e-09	7.62	-8.5	1.8e-17	-0.66	1.00	0.00	FALSE
21	GTEx	Heart Atrial Appendage	ADCY4	0.28	0.14	lasso	4	0.10	2.1e-05	9.28	8.5	2.3e-17	0.48	0.43	0.03	FALSE
3	GTEx	Adipose Subcutaneous	ADCY4	0.08	0.04	lasso	3	0.03	3.3e-03	7.62	8.3	1.6e-16	0.62	0.24	0.12	FALSE
76	The Cancer Genome Atlas	Stomach Adenocarcinoma	LTB4R	0.04	0.01	blup	73	0.01	4.2e-02	9.03	-8.2	1.9e-16	-0.63	0.01	0.45	FALSE
23	GTEx	Heart Atrial Appendage	LTB4R	0.17	0.02	lasso	2	0.06	8.6e-04	7.68	-8.2	3.4e-16	-0.47	0.34	0.16	FALSE
63	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DHRS1	0.19	0.01	blup	77	0.07	2.3e-04	-0.41	-7.7	1.5e-14	-0.32	0.06	0.11	FALSE
5	GTEx	Adipose Subcutaneous	LTB4R	0.14	0.12	lasso	3	0.12	1.3e-09	7.62	-7.7	1.8e-14	-0.61	1.00	0.00	FALSE
12	GTEx	Breast Mammary Tissue	LTB4R	0.30	0.18	lasso	4	0.16	2.3e-08	7.68	-7.6	3.5e-14	-0.63	0.98	0.01	FALSE
39	GTEx	Thyroid	LTB4R	0.30	0.18	lasso	2	0.17	1.0e-12	7.62	-7.5	4.7e-14	-0.60	1.00	0.00	FALSE
16	GTEx	Colon Transverse	TGM1	0.20	0.03	lasso	7	0.02	2.7e-02	7.30	7.4	1.8e-13	0.61	0.31	0.40	FALSE
45	METSIM	Adipose	RABGGTA	0.10	0.06	lasso	9	0.08	5.5e-12	8.05	7.3	4.1e-13	0.62	0.99	0.01	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	RABGGTA	0.03	0.03	lasso	3	0.02	1.4e-03	7.35	-7.2	4.2e-13	-0.60	0.01	0.98	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	HOMEZ	0.08	0.04	blup	42	0.04	7.6e-05	4.86	7.2	5.1e-13	0.05	0.07	0.23	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	LTB4R	0.08	0.05	lasso	8	0.05	1.7e-05	7.35	-7.2	6.1e-13	-0.58	0.62	0.17	FALSE
11	GTEx	Brain Hippocampus	ADCY4	0.35	0.03	lasso	10	0.07	1.1e-02	7.43	7.1	1.4e-12	0.49	0.06	0.32	FALSE
18	GTEx	Esophagus Mucosa	TGM1	0.14	0.03	enet	21	0.03	5.1e-03	7.62	-6.9	4.7e-12	-0.68	0.17	0.69	FALSE
37	GTEx	Testis	LTB4R	0.42	0.27	lasso	12	0.27	1.5e-12	5.19	-6.8	1.4e-11	-0.60	1.00	0.00	FALSE
26	GTEx	Lung	RABGGTA	0.09	0.06	lasso	2	0.05	8.2e-05	7.35	-6.7	2.5e-11	-0.60	0.53	0.33	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	NFATC4	0.04	0.02	blup	66	0.02	1.1e-02	4.49	-6.4	1.6e-10	-0.60	0.05	0.28	FALSE
33	GTEx	Nerve Tibial	LTB4R	0.14	0.12	lasso	6	0.12	1.5e-08	7.30	-6.4	2.1e-10	-0.57	0.99	0.01	FALSE
25	GTEx	Lung	KHNYN	0.14	0.08	lasso	5	0.05	9.7e-05	6.00	6.2	5.6e-10	0.08	0.66	0.01	FALSE
10	GTEx	Artery Tibial	KHNYN	0.38	0.12	lasso	5	0.18	8.8e-14	6.00	6.2	6.5e-10	0.09	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ADCY4	0.03	0.03	enet	5	0.03	6.9e-04	8.78	6.2	6.9e-10	0.53	0.32	0.11	FALSE
7	GTEx	Artery Aorta	KHNYN	0.19	0.20	lasso	4	0.20	1.8e-11	5.72	6.1	8.3e-10	0.07	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	KHNYN	0.30	0.14	lasso	2	0.14	7.1e-12	5.43	6.1	1.0e-09	0.09	1.00	0.00	FALSE
46	METSIM	Adipose	TGM1	0.18	0.15	enet	34	0.17	3.9e-24	3.00	6.1	1.0e-09	0.68	1.00	0.00	FALSE
30	GTEx	Muscle Skeletal	CBLN3	0.14	0.13	enet	7	0.13	4.8e-13	5.36	-6.0	1.9e-09	-0.13	1.00	0.00	FALSE
40	GTEx	Whole Blood	KHNYN	0.17	0.15	lasso	1	0.14	2.1e-12	6.00	6.0	2.0e-09	0.06	1.00	0.00	FALSE
43	METSIM	Adipose	KHNYN	0.04	0.04	lasso	1	0.03	2.2e-05	6.00	6.0	2.0e-09	0.06	0.52	0.03	FALSE
31	GTEx	Nerve Tibial	KHNYN	0.34	0.10	lasso	8	0.15	1.6e-10	6.00	6.0	2.1e-09	0.10	1.00	0.00	FALSE
13	GTEx	Breast Mammary Tissue (Female)	CBLN3	0.42	0.20	lasso	4	0.28	5.9e-09	5.50	-6.0	2.2e-09	-0.08	0.85	0.01	FALSE
44	METSIM	Adipose	LTB4R	0.15	0.07	blup	498	0.07	6.2e-11	7.68	-6.0	2.5e-09	-0.61	0.44	0.56	FALSE
29	GTEx	Muscle Skeletal	KHNYN	0.08	0.00	enet	25	0.00	5.7e-01	2.06	-5.9	3.5e-09	-0.16	0.08	0.06	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RIPK3	0.24	0.02	enet	12	0.08	1.2e-03	-2.93	5.9	3.8e-09	0.32	0.08	0.06	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	LTB4R2	0.04	0.00	blup	76	0.02	2.9e-03	9.03	-5.9	4.4e-09	-0.57	0.04	0.15	FALSE
6	GTEx	Adipose Visceral Omentum	KHNYN	0.19	0.00	lasso	2	0.00	3.0e-01	6.00	5.9	4.5e-09	0.13	0.05	0.05	FALSE
48	NTR	Blood	KHNYN	0.07	0.06	bslmm	564	0.06	6.6e-19	5.72	5.8	6.0e-09	0.03	1.00	0.00	FALSE
17	GTEx	Colon Transverse	ADCY4	0.26	-0.01	lasso	4	0.00	3.6e-01	9.28	5.8	7.6e-09	0.36	0.06	0.21	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NFATC4	0.07	0.04	blup	538	0.03	8.5e-05	4.49	-5.7	9.3e-09	-0.42	0.28	0.49	FALSE
55	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CBLN3	0.34	0.15	lasso	5	0.14	2.4e-07	5.50	-5.7	1.1e-08	-0.17	0.92	0.00	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	CBLN3	0.24	0.14	enet	8	0.13	4.0e-08	5.50	-5.7	1.2e-08	-0.14	1.00	0.00	FALSE
9	GTEx	Artery Coronary	CBLN3	0.52	0.20	lasso	7	0.24	9.7e-09	5.43	-5.7	1.6e-08	-0.12	0.96	0.01	FALSE
14	GTEx	Breast Mammary Tissue (Female)	LTB4R	0.12	0.02	lasso	2	0.01	2.1e-01	7.68	-5.6	1.9e-08	-0.57	0.06	0.05	FALSE
34	GTEx	Ovary	CBLN3	0.62	0.38	lasso	19	0.39	1.2e-10	5.53	-5.6	2.3e-08	-0.10	0.96	0.00	FALSE
47	NTR	Blood	CBLN3	0.06	0.04	lasso	3	0.04	2.1e-13	5.53	-5.5	3.0e-08	-0.11	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY4	0.04	0.02	blup	75	0.04	3.8e-09	4.26	5.5	3.7e-08	0.61	0.81	0.19	FALSE
74	The Cancer Genome Atlas	Soft Tissue Sarcoma	CBLN3	0.22	0.18	lasso	3	0.17	2.2e-10	5.53	-5.5	3.8e-08	-0.11	1.00	0.00	FALSE
20	GTEx	Esophagus Muscularis	CBLN3	0.62	0.33	enet	23	0.36	1.8e-22	5.43	-5.5	4.4e-08	-0.12	1.00	0.00	FALSE
22	GTEx	Heart Atrial Appendage	CBLN3	0.58	0.40	lasso	5	0.38	2.3e-18	5.43	-5.4	5.4e-08	-0.11	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	CBLN3	0.65	0.39	lasso	23	0.37	6.1e-32	5.53	-5.4	7.2e-08	-0.10	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CBLN3	0.20	0.11	lasso	3	0.11	5.1e-08	5.53	-5.4	7.4e-08	-0.14	1.00	0.00	FALSE
69	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CBLN3	0.37	0.35	lasso	4	0.34	4.4e-15	5.43	-5.4	7.7e-08	-0.09	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	CBLN3	0.38	0.30	lasso	9	0.30	2.7e-32	5.53	-5.4	7.7e-08	-0.12	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Stomach Adenocarcinoma	CBLN3	0.30	0.26	lasso	1	0.24	1.4e-17	5.36	-5.4	8.3e-08	-0.11	1.00	0.00	FALSE
19	GTEx	Esophagus Mucosa	CBLN3	0.50	0.25	lasso	7	0.25	1.7e-16	5.53	-5.3	9.0e-08	-0.09	1.00	0.00	FALSE
8	GTEx	Artery Aorta	CBLN3	0.55	0.41	lasso	8	0.40	9.5e-24	5.53	-5.3	1.0e-07	-0.12	1.00	0.00	FALSE
42	METSIM	Adipose	CBLN3	0.34	0.30	enet	6	0.31	1.3e-47	5.43	-5.3	1.0e-07	-0.11	1.00	0.00	FALSE
15	GTEx	Cells Transformed fibroblasts	LTB4R	0.12	0.09	lasso	2	0.06	4.1e-05	5.19	-5.3	1.1e-07	-0.53	0.92	0.01	FALSE
27	GTEx	Lung	CBLN3	0.66	0.29	enet	9	0.27	4.7e-21	5.43	-5.3	1.3e-07	-0.09	1.00	0.00	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	CBLN3	0.41	0.34	lasso	2	0.30	3.4e-17	5.53	-5.3	1.3e-07	-0.11	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ADCY4	0.05	0.05	lasso	6	0.08	3.7e-09	4.08	5.3	1.3e-07	0.66	0.31	0.68	FALSE
32	GTEx	Nerve Tibial	CBLN3	0.71	0.35	enet	18	0.36	1.9e-26	5.53	-5.1	2.7e-07	-0.09	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CBLN3	0.33	0.33	enet	13	0.35	2.3e-40	5.43	-5.1	3.0e-07	-0.11	1.00	0.00	FALSE