Best TWAS P=7.11e-25 · Best GWAS P=1.61e-25 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NFATC4 | 0.07 | 0.04 | blup | 538 | 0.03 | 8.5e-05 | 4.49 | -5.7 | 9.3e-09 | -0.42 | 0.28 | 0.49 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | KHNYN | 0.30 | 0.14 | lasso | 2 | 0.14 | 7.1e-12 | 5.43 | 6.1 | 1.0e-09 | 0.09 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | ADCY4 | 0.08 | 0.04 | lasso | 3 | 0.03 | 3.3e-03 | 7.62 | 8.3 | 1.6e-16 | 0.62 | 0.24 | 0.12 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | CBLN3 | 0.65 | 0.39 | lasso | 23 | 0.37 | 6.1e-32 | 5.53 | -5.4 | 7.2e-08 | -0.10 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Adipose Subcutaneous | LTB4R | 0.14 | 0.12 | lasso | 3 | 0.12 | 1.3e-09 | 7.62 | -7.7 | 1.8e-14 | -0.61 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Adipose Visceral Omentum | KHNYN | 0.19 | 0.00 | lasso | 2 | 0.00 | 3.0e-01 | 6.00 | 5.9 | 4.5e-09 | 0.13 | 0.05 | 0.05 | FALSE |
| 7 | GTEx | Artery Aorta | KHNYN | 0.19 | 0.20 | lasso | 4 | 0.20 | 1.8e-11 | 5.72 | 6.1 | 8.3e-10 | 0.07 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Artery Aorta | CBLN3 | 0.55 | 0.41 | lasso | 8 | 0.40 | 9.5e-24 | 5.53 | -5.3 | 1.0e-07 | -0.12 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Artery Coronary | CBLN3 | 0.52 | 0.20 | lasso | 7 | 0.24 | 9.7e-09 | 5.43 | -5.7 | 1.6e-08 | -0.12 | 0.96 | 0.01 | FALSE |
| 10 | GTEx | Artery Tibial | KHNYN | 0.38 | 0.12 | lasso | 5 | 0.18 | 8.8e-14 | 6.00 | 6.2 | 6.5e-10 | 0.09 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Brain Hippocampus | ADCY4 | 0.35 | 0.03 | lasso | 10 | 0.07 | 1.1e-02 | 7.43 | 7.1 | 1.4e-12 | 0.49 | 0.06 | 0.32 | FALSE |
| 12 | GTEx | Breast Mammary Tissue | LTB4R | 0.30 | 0.18 | lasso | 4 | 0.16 | 2.3e-08 | 7.68 | -7.6 | 3.5e-14 | -0.63 | 0.98 | 0.01 | FALSE |
| 13 | GTEx | Breast Mammary Tissue (Female) | CBLN3 | 0.42 | 0.20 | lasso | 4 | 0.28 | 5.9e-09 | 5.50 | -6.0 | 2.2e-09 | -0.08 | 0.85 | 0.01 | FALSE |
| 14 | GTEx | Breast Mammary Tissue (Female) | LTB4R | 0.12 | 0.02 | lasso | 2 | 0.01 | 2.1e-01 | 7.68 | -5.6 | 1.9e-08 | -0.57 | 0.06 | 0.05 | FALSE |
| 15 | GTEx | Cells Transformed fibroblasts | LTB4R | 0.12 | 0.09 | lasso | 2 | 0.06 | 4.1e-05 | 5.19 | -5.3 | 1.1e-07 | -0.53 | 0.92 | 0.01 | FALSE |
| 16 | GTEx | Colon Transverse | TGM1 | 0.20 | 0.03 | lasso | 7 | 0.02 | 2.7e-02 | 7.30 | 7.4 | 1.8e-13 | 0.61 | 0.31 | 0.40 | FALSE |
| 17 | GTEx | Colon Transverse | ADCY4 | 0.26 | -0.01 | lasso | 4 | 0.00 | 3.6e-01 | 9.28 | 5.8 | 7.6e-09 | 0.36 | 0.06 | 0.21 | FALSE |
| 18 | GTEx | Esophagus Mucosa | TGM1 | 0.14 | 0.03 | enet | 21 | 0.03 | 5.1e-03 | 7.62 | -6.9 | 4.7e-12 | -0.68 | 0.17 | 0.69 | FALSE |
| 19 | GTEx | Esophagus Mucosa | CBLN3 | 0.50 | 0.25 | lasso | 7 | 0.25 | 1.7e-16 | 5.53 | -5.3 | 9.0e-08 | -0.09 | 1.00 | 0.00 | FALSE |
| 20 | GTEx | Esophagus Muscularis | CBLN3 | 0.62 | 0.33 | enet | 23 | 0.36 | 1.8e-22 | 5.43 | -5.5 | 4.4e-08 | -0.12 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Heart Atrial Appendage | ADCY4 | 0.28 | 0.14 | lasso | 4 | 0.10 | 2.1e-05 | 9.28 | 8.5 | 2.3e-17 | 0.48 | 0.43 | 0.03 | FALSE |
| 22 | GTEx | Heart Atrial Appendage | CBLN3 | 0.58 | 0.40 | lasso | 5 | 0.38 | 2.3e-18 | 5.43 | -5.4 | 5.4e-08 | -0.11 | 1.00 | 0.00 | FALSE |
| 23 | GTEx | Heart Atrial Appendage | LTB4R | 0.17 | 0.02 | lasso | 2 | 0.06 | 8.6e-04 | 7.68 | -8.2 | 3.4e-16 | -0.47 | 0.34 | 0.16 | FALSE |
| 24 | GTEx | Heart Left Ventricle | CBLN3 | 0.35 | 0.23 | lasso | 8 | 0.21 | 1.5e-11 | 5.43 | -5.9 | 2.9e-09 | -0.16 | 1.00 | 0.00 | TRUE |
| 25 | GTEx | Lung | KHNYN | 0.14 | 0.08 | lasso | 5 | 0.05 | 9.7e-05 | 6.00 | 6.2 | 5.6e-10 | 0.08 | 0.66 | 0.01 | FALSE |
| 26 | GTEx | Lung | RABGGTA | 0.09 | 0.06 | lasso | 2 | 0.05 | 8.2e-05 | 7.35 | -6.7 | 2.5e-11 | -0.60 | 0.53 | 0.33 | FALSE |
| 27 | GTEx | Lung | CBLN3 | 0.66 | 0.29 | enet | 9 | 0.27 | 4.7e-21 | 5.43 | -5.3 | 1.3e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 28 | GTEx | Lung | LTB4R | 0.19 | 0.15 | lasso | 6 | 0.12 | 2.0e-09 | 7.62 | -8.5 | 1.8e-17 | -0.66 | 1.00 | 0.00 | FALSE |
| 29 | GTEx | Muscle Skeletal | KHNYN | 0.08 | 0.00 | enet | 25 | 0.00 | 5.7e-01 | 2.06 | -5.9 | 3.5e-09 | -0.16 | 0.08 | 0.06 | FALSE |
| 30 | GTEx | Muscle Skeletal | CBLN3 | 0.14 | 0.13 | enet | 7 | 0.13 | 4.8e-13 | 5.36 | -6.0 | 1.9e-09 | -0.13 | 1.00 | 0.00 | FALSE |
| 31 | GTEx | Nerve Tibial | KHNYN | 0.34 | 0.10 | lasso | 8 | 0.15 | 1.6e-10 | 6.00 | 6.0 | 2.1e-09 | 0.10 | 1.00 | 0.00 | FALSE |
| 32 | GTEx | Nerve Tibial | CBLN3 | 0.71 | 0.35 | enet | 18 | 0.36 | 1.9e-26 | 5.53 | -5.1 | 2.7e-07 | -0.09 | 1.00 | 0.00 | FALSE |
| 33 | GTEx | Nerve Tibial | LTB4R | 0.14 | 0.12 | lasso | 6 | 0.12 | 1.5e-08 | 7.30 | -6.4 | 2.1e-10 | -0.57 | 0.99 | 0.01 | FALSE |
| 34 | GTEx | Ovary | CBLN3 | 0.62 | 0.38 | lasso | 19 | 0.39 | 1.2e-10 | 5.53 | -5.6 | 2.3e-08 | -0.10 | 0.96 | 0.00 | FALSE |
| 35 | GTEx | Skin Not Sun Exposed Suprapubic | CBLN3 | 0.41 | 0.34 | lasso | 2 | 0.30 | 3.4e-17 | 5.53 | -5.3 | 1.3e-07 | -0.11 | 1.00 | 0.00 | FALSE |
| 36 | GTEx | Spleen | NFATC4 | 0.45 | 0.00 | enet | 24 | 0.00 | 2.5e-01 | 5.53 | -6.4 | 1.7e-10 | -0.22 | 0.07 | 0.05 | TRUE |
| 37 | GTEx | Testis | LTB4R | 0.42 | 0.27 | lasso | 12 | 0.27 | 1.5e-12 | 5.19 | -6.8 | 1.4e-11 | -0.60 | 1.00 | 0.00 | FALSE |
| 38 | GTEx | Thyroid | ADCY4 | 0.13 | 0.13 | lasso | 6 | 0.09 | 1.0e-07 | 7.43 | 8.9 | 5.6e-19 | 0.51 | 0.98 | 0.02 | FALSE |
| 39 | GTEx | Thyroid | LTB4R | 0.30 | 0.18 | lasso | 2 | 0.17 | 1.0e-12 | 7.62 | -7.5 | 4.7e-14 | -0.60 | 1.00 | 0.00 | FALSE |
| 40 | GTEx | Whole Blood | KHNYN | 0.17 | 0.15 | lasso | 1 | 0.14 | 2.1e-12 | 6.00 | 6.0 | 2.0e-09 | 0.06 | 1.00 | 0.00 | FALSE |
| 41 | METSIM | Adipose | ADCY4 | 0.07 | 0.03 | lasso | 5 | 0.03 | 2.2e-05 | 9.50 | 10.3 | 7.1e-25 | 0.71 | 0.60 | 0.39 | TRUE |
| 42 | METSIM | Adipose | CBLN3 | 0.34 | 0.30 | enet | 6 | 0.31 | 1.3e-47 | 5.43 | -5.3 | 1.0e-07 | -0.11 | 1.00 | 0.00 | FALSE |
| 43 | METSIM | Adipose | KHNYN | 0.04 | 0.04 | lasso | 1 | 0.03 | 2.2e-05 | 6.00 | 6.0 | 2.0e-09 | 0.06 | 0.52 | 0.03 | FALSE |
| 44 | METSIM | Adipose | LTB4R | 0.15 | 0.07 | blup | 498 | 0.07 | 6.2e-11 | 7.68 | -6.0 | 2.5e-09 | -0.61 | 0.44 | 0.56 | FALSE |
| 45 | METSIM | Adipose | RABGGTA | 0.10 | 0.06 | lasso | 9 | 0.08 | 5.5e-12 | 8.05 | 7.3 | 4.1e-13 | 0.62 | 0.99 | 0.01 | FALSE |
| 46 | METSIM | Adipose | TGM1 | 0.18 | 0.15 | enet | 34 | 0.17 | 3.9e-24 | 3.00 | 6.1 | 1.0e-09 | 0.68 | 1.00 | 0.00 | FALSE |
| 47 | NTR | Blood | CBLN3 | 0.06 | 0.04 | lasso | 3 | 0.04 | 2.1e-13 | 5.53 | -5.5 | 3.0e-08 | -0.11 | 1.00 | 0.00 | FALSE |
| 48 | NTR | Blood | KHNYN | 0.07 | 0.06 | bslmm | 564 | 0.06 | 6.6e-19 | 5.72 | 5.8 | 6.0e-09 | 0.03 | 1.00 | 0.00 | FALSE |
| 49 | YFS | Blood | GMPR2 | 0.08 | 0.04 | bslmm | 459 | 0.05 | 5.9e-15 | -3.62 | 5.4 | 6.6e-08 | 0.13 | 1.00 | 0.00 | TRUE |
| 50 | YFS | Blood | KHNYN | 0.36 | 0.20 | enet | 50 | 0.29 | 1.2e-96 | 5.72 | 6.2 | 5.5e-10 | 0.14 | 1.00 | 0.00 | TRUE |
| 51 | YFS | Blood | LTB4R | 0.02 | 0.00 | blup | 483 | 0.01 | 6.1e-03 | 8.05 | -8.5 | 2.1e-17 | -0.61 | 0.05 | 0.92 | TRUE |
| 52 | YFS | Blood | PCK2 | 0.22 | 0.05 | enet | 54 | 0.12 | 7.6e-38 | -4.52 | -6.5 | 1.1e-10 | -0.05 | 1.00 | 0.00 | TRUE |
| 53 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ADCY4 | 0.03 | 0.01 | blup | 75 | 0.03 | 1.1e-03 | 7.35 | 8.8 | 9.0e-19 | 0.71 | 0.08 | 0.56 | FALSE |
| 54 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADCY4 | 0.04 | 0.02 | blup | 75 | 0.04 | 3.8e-09 | 4.26 | 5.5 | 3.7e-08 | 0.61 | 0.81 | 0.19 | FALSE |
| 55 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CBLN3 | 0.34 | 0.15 | lasso | 5 | 0.14 | 2.4e-07 | 5.50 | -5.7 | 1.1e-08 | -0.17 | 0.92 | 0.00 | FALSE |
| 56 | The Cancer Genome Atlas | Colon Adenocarcinoma | ADCY4 | 0.07 | 0.02 | lasso | 4 | 0.03 | 4.7e-03 | 5.88 | 7.9 | 3.1e-15 | 0.70 | 0.03 | 0.75 | TRUE |
| 57 | The Cancer Genome Atlas | Colon Adenocarcinoma | CBLN3 | 0.24 | 0.14 | enet | 8 | 0.13 | 4.0e-08 | 5.50 | -5.7 | 1.2e-08 | -0.14 | 1.00 | 0.00 | FALSE |
| 58 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ADCY4 | 0.03 | 0.03 | enet | 5 | 0.03 | 6.9e-04 | 8.78 | 6.2 | 6.9e-10 | 0.53 | 0.32 | 0.11 | FALSE |
| 59 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PABPN1 | 0.04 | 0.03 | lasso | 2 | 0.02 | 1.7e-03 | 5.41 | 6.2 | 4.3e-10 | -0.01 | 0.02 | 0.04 | TRUE |
| 60 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CBLN3 | 0.33 | 0.33 | enet | 13 | 0.35 | 2.3e-40 | 5.43 | -5.1 | 3.0e-07 | -0.11 | 1.00 | 0.00 | FALSE |
| 61 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY4 | 0.06 | 0.06 | lasso | 6 | 0.09 | 3.0e-10 | 9.06 | 10.1 | 3.8e-24 | 0.75 | 0.94 | 0.06 | FALSE |
| 62 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RABGGTA | 0.03 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | 7.35 | -7.2 | 4.2e-13 | -0.60 | 0.01 | 0.98 | FALSE |
| 63 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DHRS1 | 0.19 | 0.01 | blup | 77 | 0.07 | 2.3e-04 | -0.41 | -7.7 | 1.5e-14 | -0.32 | 0.06 | 0.11 | FALSE |
| 64 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | TGM1 | 0.12 | 0.06 | blup | 61 | 0.04 | 4.3e-03 | -4.02 | 6.0 | 1.8e-09 | 0.31 | 0.40 | 0.09 | TRUE |
| 65 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADCY4 | 0.07 | 0.09 | lasso | 3 | 0.08 | 4.4e-10 | 7.68 | 9.4 | 6.2e-21 | 0.73 | 0.95 | 0.05 | FALSE |
| 66 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ADCY4 | 0.05 | 0.05 | lasso | 6 | 0.08 | 3.7e-09 | 4.08 | 5.3 | 1.3e-07 | 0.66 | 0.31 | 0.68 | FALSE |
| 67 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NYNRIN | 0.05 | 0.02 | blup | 81 | 0.02 | 4.0e-03 | 8.33 | 7.1 | 9.0e-13 | 0.65 | 0.07 | 0.54 | TRUE |
| 68 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CBLN3 | 0.20 | 0.11 | lasso | 3 | 0.11 | 5.1e-08 | 5.53 | -5.4 | 7.4e-08 | -0.14 | 1.00 | 0.00 | FALSE |
| 69 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CBLN3 | 0.37 | 0.35 | lasso | 4 | 0.34 | 4.4e-15 | 5.43 | -5.4 | 7.7e-08 | -0.09 | 1.00 | 0.00 | FALSE |
| 70 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | HOMEZ | 0.19 | 0.01 | blup | 41 | 0.05 | 6.0e-03 | 4.86 | 8.0 | 1.3e-15 | 0.03 | 0.01 | 0.36 | TRUE |
| 71 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LTB4R | 0.16 | 0.05 | blup | 73 | 0.08 | 4.9e-04 | 5.19 | -9.1 | 1.3e-19 | -0.70 | 0.02 | 0.62 | FALSE |
| 72 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CBLN3 | 0.38 | 0.30 | lasso | 9 | 0.30 | 2.7e-32 | 5.53 | -5.4 | 7.7e-08 | -0.12 | 1.00 | 0.00 | FALSE |
| 73 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LTB4R2 | 0.04 | 0.00 | blup | 76 | 0.02 | 2.9e-03 | 9.03 | -5.9 | 4.4e-09 | -0.57 | 0.04 | 0.15 | FALSE |
| 74 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CBLN3 | 0.22 | 0.18 | lasso | 3 | 0.17 | 2.2e-10 | 5.53 | -5.5 | 3.8e-08 | -0.11 | 1.00 | 0.00 | FALSE |
| 75 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CBLN3 | 0.30 | 0.26 | lasso | 1 | 0.24 | 1.4e-17 | 5.36 | -5.4 | 8.3e-08 | -0.11 | 1.00 | 0.00 | FALSE |
| 76 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LTB4R | 0.04 | 0.01 | blup | 73 | 0.01 | 4.2e-02 | 9.03 | -8.2 | 1.9e-16 | -0.63 | 0.01 | 0.45 | FALSE |
| 77 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LTB4R2 | 0.04 | 0.04 | lasso | 1 | 0.02 | 2.5e-02 | 9.03 | -9.0 | 1.8e-19 | -0.70 | 0.04 | 0.53 | FALSE |
| 78 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RIPK3 | 0.24 | 0.02 | enet | 12 | 0.08 | 1.2e-03 | -2.93 | 5.9 | 3.8e-09 | 0.32 | 0.08 | 0.06 | FALSE |
| 79 | The Cancer Genome Atlas | Thyroid Carcinoma | HOMEZ | 0.08 | 0.04 | blup | 42 | 0.04 | 7.6e-05 | 4.86 | 7.2 | 5.1e-13 | 0.05 | 0.07 | 0.23 | FALSE |
| 80 | The Cancer Genome Atlas | Thyroid Carcinoma | LTB4R | 0.08 | 0.05 | lasso | 8 | 0.05 | 1.7e-05 | 7.35 | -7.2 | 6.1e-13 | -0.58 | 0.62 | 0.17 | FALSE |
| 81 | The Cancer Genome Atlas | Thyroid Carcinoma | NFATC4 | 0.04 | 0.02 | blup | 66 | 0.02 | 1.1e-02 | 4.49 | -6.4 | 1.6e-10 | -0.60 | 0.05 | 0.28 | FALSE |