Best TWAS P=4.02e-42 · Best GWAS P=2.93e-62 conditioned to 1.8e-10
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | C14orf39 | 0.08 | 0.05 | lasso | 8 | 0.06 | 2.1e-05 | 9.9 | -10.0 | 1.9e-23 | -0.41 | 0.92 | 0.02 | FALSE |
2 | GTEx | Cells EBV-transformed lymphocytes | GPR135 | 0.33 | 0.04 | enet | 23 | 0.15 | 1.7e-05 | 3.9 | -5.8 | 7.5e-09 | -0.11 | 0.13 | 0.11 | TRUE |
3 | GTEx | Cells Transformed fibroblasts | RP11-193F5.4 | 0.06 | 0.00 | enet | 16 | 0.01 | 6.5e-02 | 9.4 | 6.7 | 2.6e-11 | 0.33 | 0.11 | 0.11 | FALSE |
4 | GTEx | Liver | MNAT1 | 0.21 | 0.00 | lasso | 4 | -0.01 | 5.4e-01 | 3.4 | -10.7 | 9.9e-27 | -0.44 | 0.08 | 0.20 | TRUE |
5 | GTEx | Muscle Skeletal | C14orf39 | 0.06 | 0.05 | lasso | 3 | 0.05 | 2.7e-05 | 9.9 | -13.6 | 4.0e-42 | -0.67 | 0.12 | 0.86 | TRUE |
6 | GTEx | Pituitary | C14orf39 | 0.39 | 0.38 | enet | 20 | 0.35 | 1.0e-09 | 9.9 | -8.5 | 1.8e-17 | -0.34 | 0.98 | 0.00 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | PCNXL4 | 0.15 | 0.05 | enet | 15 | 0.12 | 6.2e-07 | 2.2 | -10.7 | 8.1e-27 | -0.61 | 0.76 | 0.09 | TRUE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | C14orf39 | 0.02 | 0.02 | blup | 37 | 0.02 | 4.2e-03 | 9.7 | -12.2 | 4.2e-34 | -0.55 | 0.06 | 0.47 | FALSE |
9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C14orf39 | 0.08 | 0.05 | blup | 37 | 0.05 | 4.2e-03 | 9.1 | -11.5 | 9.9e-31 | -0.51 | 0.10 | 0.33 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C14orf39 | 0.08 | 0.09 | blup | 37 | 0.11 | 1.8e-11 | 9.4 | -11.5 | 2.1e-30 | -0.51 | 0.99 | 0.01 | FALSE |